A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP)

G Thomalla; JB Fiebach; L Østergaard; S Pedraza; V Thijs; N Nighoghossian; P Roy; KW Muir; M Ebinger; B Cheng; I Galinovic; TH Cho; J Puig; F Boutitie; CZ Simonsen; M Endres; J Fiehler; C Gerloff

Journal article

A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP)

G Thomalla, JB Fiebach, L Østergaard, S Pedraza, V Thijs, N Nighoghossian, P Roy, KW Muir, M Ebinger, B Cheng, I Galinovic, TH Cho, J Puig, F Boutitie, CZ Simonsen, M Endres, J Fiehler, C Gerloff

International Journal of Stroke | Published : 2014

DOI: 10.1111/ijs.12011

Abstract

Rationale: In about 20% of acute ischemic stroke patients stroke occurs during sleep. These patients are generally excluded from intravenous thrombolysis. MRI can identify patients within the time-window for thrombolysis (≤4·5h from symptom onset) by a mismatch between the acute ischemic lesion visible on diffusion weighted imaging (DWI) but not visible on fluid-attenuated inversion recovery (FLAIR) imaging. Aims and hypothesis: The study aims to test the efficacy and safety of MRI-guided thrombolysis with tissue plasminogen activator (rtPA) in ischemic stroke patients with unknown time of symptom onset, e.g., waking up with stroke symptoms. We hypothesize that stroke patients with unknown t..

View full abstract