Journal article

Hypothermia for Traumatic Brain Injury in Children-A Phase II Randomized Controlled Trial

John Beca, Brent McSharry, Simon Erickson, Michael Yung, Andreas Schibler, Anthony Slater, Barry Wilkins, Ash Singhal, Gary Williams, Claire Sherring, Warwick Butt



OBJECTIVES: To perform a pilot study to assess the feasibility of performing a phase III trial of therapeutic hypothermia started early and continued for at least 72 hours in children with severe traumatic brain injury. DESIGN: Multicenter prospective randomized controlled phase II trial. SETTING: All eight of the PICUs in Australia and New Zealand and one in Canada. PATIENTS: Children 1-15 years old with severe traumatic brain injury and who could be randomized within 6 hours of injury. INTERVENTIONS: The control group had strict normothermia to a temperature of 36-37°C for 72 hours. The intervention group had therapeutic hypothermia to a temperature of 32-33°C for 72 hours followed by slow..

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University of Melbourne Researchers


Funding Acknowledgements

[ "Supported, in part, by grants from the Victorian Transport Accident Commission, the Neurotrauma Research Programme of the West Australia Institute for Medical Research, and the Intensive Care Foundation of Australia and New Zealand.", "Dr. Erickson served as a board member for the Australia and New Zealand Intensive Care Society (ANZICS) (no financial remuneration apart from travel to board meetings or other), consulted for Ikaria, is employed by Princess Margaret Hospital (primary employment), provided expert opinion for medicolegal cases (various legal entities), and received grant support from Hospira and the Princess Margaret Hospital Foundation (unrestricted study grants for other studies). Dr. Slater received support for travel from the Malaysian Intensive Care Society (travel and accommodation to attend the Malaysian Intensive Care Society Annual Scientific Meeting), APLS Australia (travel and accommodation for instructing on courses), and the ANZICS (travel and accommodation for ANZICS core business). His institution received grant support from the Royal Children's Hospital Foundation (grants for hospital equipment and for research projects and innovation grants). Dr. Wilkins is employed by Children's Hospital at Westmead. Dr. Singhal is employed by the University of British Columbia and the British Columbia Children's Hospital and received grant support from Brain Tumor Foundation of Canada, BC Children's Hospital Foundation, and the Rare Disease Foundation (unrelated research). Dr. Williams is employed by the Sydney Children's Hospital" ]