Journal article

Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases

Yun R Li, Jin Li, Sihai D Zhao, Jonathan P Bradfield, Frank D Mentch, S Melkorka Maggadottir, Cuiping Hou, Debra J Abrams, Diana Chang, Feng Gao, Yiran Guo, Zhi Wei, John J Connolly, Christopher J Cardinale, Marina Bakay, Joseph T Glessner, Dong Li, Charlly Kao, Kelly A Thomas, Haijun Qiu Show all

Nature Medicine | NATURE PUBLISHING GROUP | Published : 2015

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Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by Medical Research Council


Awarded by Medical Research Foundation


Awarded by Crohn"s and Colitis UK


Awarded by Chief Scientist Office


Funding Acknowledgements

We thank the subjects and their families for their participation in genotyping studies and the Biobank Repository at the Center for Applied Genomics at the Children's Hospital of Philadelphia. We acknowledge M.V. Holmes, H. Matsunami, L. Steel and E. Carrigan for their technical assistance and review of the manuscript. We are also thankful for the contributions of the Italian IBD Group, including S. Cucchiara (Roma), P. Lionetti (Firenze), G. Barabino (Genova), G. L. de Angelis (Parma), G. Guariso (Padova), C. Catassi (Ancona), G. Lombardi (Pescara), A.M. Staiano (Napoli), D. De Venuto (Bari), C. Romano (Messina), R. D'inca (Padova), M. Vecchi (Milano), A. Andriulli and F. Bossa (S. Giovanni Rotondo). The data sets used for the replication analyses were obtained through dbGaP accession numbers phs000344, phs000127, phs000274, phs000171, phs000224, phs000130, phs000019, phs000091, phs000206, phs000168, phs000138, phs000125 and phs000092. We thank the NIH data repository, the investigators who contributed the phenotype data and DNA samples from their original studies, and the primary funding organizations that supported these contributing investigators. This study made use of data generated by the Wellcome Trust Case Control Consortium. A full list of the investigators who contributed to the generation of the data is available from http://www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113. Y.R.L. is supported by the Paul and Daisy Soros Fellowship for New Americans and the NIH F30 Individual NRSA Training Grant. This study was supported by Institutional Development Funds from The Children's Hospital of Philadelphia and by DP3DK085708, RC1AR058606, U01HG006830, the Crohn's & Colitis Foundation of America, the Juvenile Diabetes Research Foundation, NIH grant CA127334 (to H. L. and S.D.Z.), the UK National Institutes of Healthcare Research (to H. C.) and a grant from the Lupus Research Institute (to E.T.L.P.). This work was supported in part by the NIH (grant R01-HG006849 to A.K.). F.G. is a Howard Hughes Medical Institute International Student Research fellow.