Intestinal-specific activatable Myb initiates colon tumorigenesis in mice
J Malaterre, L Pereira, T Putoczki, R Millen, S Paquet-Fifield, M Germann, J Liu, D Cheasley, S Sampurno, SA Stacker, MG Achen, RL Ward, P Waring, T Mantamadiotis, M Ernst, RG Ramsay
ONCOGENE | NATURE PUBLISHING GROUP | Published : 2016
Transcription factor Myb is overexpressed in most colorectal cancers (CRC). Patients with CRC expressing the highest Myb are more likely to relapse. We previously showed that mono-allelic loss of Myb in an Adenomatous polyposis coli (APC)-driven CRC mouse model (Apc(Min/+)) significantly improves survival. Here we directly investigated the association of Myb with poor prognosis and how Myb co-operates with tumor suppressor genes (TSGs) (Apc) and cell cycle regulator, p27. Here we generated the first intestinal-specific, inducible transgenic model; a MybER transgene encoding a tamoxifen-inducible fusion protein between Myb and the estrogen receptor-α ligand-binding domain driven by the intest..View full abstract
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The authors thank the Peter MacCallum Histology and Microscopy departments and animal facility as well as the NHMRC Senior Research Fellowship Scheme (RR, ME) and Program Grant scheme (RGR, JM and ME).