Journal article

Inverse association between fasting plasma glucose and risk of ventricular arrhythmias

Francesco Zaccardi, David R Webb, Sudhir Kurl, Kamlesh Khunti, Melanie J Davies, Jari A Laukkanen

DIABETOLOGIA | SPRINGER | Published : 2015


AIMS/HYPOTHESIS: In nondiabetic individuals, low values of fasting plasma glucose (FPG) have been associated with an increased risk of cardiovascular events. Identification of the potential mechanisms behind this association could help to elucidate the relationship between glycaemia and cardiovascular disease. We aimed to determine the association between FPG and ventricular arrhythmias. METHODS: FPG and other cardiometabolic risk factors were measured in a population-based cohort of 2,482 men without a known history of type 2 diabetes mellitus at baseline. Associations between FPG levels and incident cases of ventricular arrhythmias (ventricular tachycardia or fibrillation events ascertaine..

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Funding Acknowledgements

The research was supported by the NIHR Diet, Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of Leicester and Loughborough University; and the NIHR CLARHC East Midlands. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the UK Department of Health.