Journal article

Objectively measured sedentary time and associations with insulin sensitivity: Importance of reallocating sedentary time to physical activity

Thomas Yates, Joseph Henson, Charlotte Edwardson, David Dunstan, Danielle H Bodicoat, Kamlesh Khunti, Melanie J Davies



OBJECTIVE: The aim of this study is to quantify associations between objectively measured sedentary time and markers of insulin sensitivity by considering allocation into light-intensity physical activity or moderate- to vigorous-intensity physical activity (MVPA). METHODS: Participants with an increased risk of impaired glucose regulation (IGR) were recruited (Leicestershire, United Kingdom, 2010-2011). Sedentary, light-intensity physical activity and MVPA time were measured using accelerometers. Fasting and 2-hour post-challenge insulin and glucose were assessed; insulin sensitivity was calculated by HOMA-IS and Matsuda-ISI. Isotemporal substitution regression models were used. Data were a..

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University of Melbourne Researchers


Funding Acknowledgements

The authors would like to acknowledge the participants who volunteered for this study. The Walking Away trial was funded by The National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care for Leicestershire, Northamptonshire and Rutland. The analysis reported in this paper was further supported by the NIHR Lifestyle and Physical Activity Biomedical Research Unit which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester and the NIHR Collaboration for Leadership in Applied Health Research and Care-East Midlands (NIHR CLAHRC-EM). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Dunstan is supported by an Australian Research Council Future Fellowship. Analysis of fasting and 2-h insulin levels was funded by Unilever R&D, UK.