Journal article
Preventing the progression to Type 2 diabetes mellitus in adults at high risk: A systematic review and network meta-analysis of lifestyle, pharmacological and surgical interventions
JW Stevens, K Khunti, R Harvey, M Johnson, L Preston, HB Woods, M Davies, E Goyder
Diabetes Research and Clinical Practice | Published : 2015
Abstract
Aims: Individuals with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) have an increased risk of progression to Type 2 diabetes mellitus. The objective of this review was to quantify the effectiveness of lifestyle, pharmacological and surgical interventions in reducing the progression to Type 2 diabetes mellitus in people with IFG or IGT. Methods: A systematic review was carried out. A network meta-analysis (NMA) of log-hazard ratios was performed. Results are presented as hazard ratios and the probabilities of treatment rankings. Results: 30 studies were included in the NMA. There was a reduced hazard of progression to Type 2 diabetes mellitus associated with all interven..
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Funding Acknowledgements
We would like to thank Clare Gillies for providing us with the data from the earlier review that was published in the British Medical Journal; Roy Jones and Crystal Freeman for providing systematic review support; Nick Payne for providing clinical expertise; and Emma Everson-Hock for double checking the updated review. We acknowledge support from the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care - East Midlands (NIHR CLAHRC - EM), the Leicester Clinical Trials Unit and the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.