Journal article
Hypoglycemia and risk of cardiovascular disease and all-Causemortality in insulin-treated people with type 1 and type 2 diabetes: A cohort study
K Khunti, M Davies, A Majeed, BL Thorsted, ML Wolden, SK Paul
Diabetes Care | Published : 2015
DOI: 10.2337/dc14-0920
Abstract
OBJECTIVE Hypoglycemia has been associated with an increased risk of cardiovascular (CV) events and all-cause mortality. This study assessed whether, in a nationally representative population, there is an association between hypoglycemia, the risk of CV events, and all-cause mortality among insulin-treated people with type 1 diabetes or type 2 diabetes. RESEARCH DESIGN AND METHODS This retrospective cohort study used data from the Clinical Practice Research Datalink database and included all insulin-treated patients (≥30 years of age) with a diagnosis of diabetes. RESULTS In patients who experienced hypoglycemia, hazard ratios (HRs) for CV events in people with type 1 diabetes were 1.51 (95%..
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Funding Acknowledgements
This work was supported by both the East Midlands National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) and the NIHR CLAHRC for Northwest London; the Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit; the Imperial NIHR Biomedical Research Centre; and the Imperial Centre for Patient Safety and Service Quality and received infrastructure support from Therapeutic Innovation Australia. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the NIHR, the Biomedical Research Centre, or the Imperial Centre for Patient Safety and Service Quality.