Journal article

Diet-induced obesity causes ghrelin resistance in reward processing tasks

Sarah H Lockie, Tara Dinan, Andrew J Lawrence, Sarah J Spencer, Zane B Andrews

Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015

Abstract

Diet-induced obesity (DIO) causes ghrelin resistance in hypothalamic Agouti-related peptide (AgRP) neurons. However, ghrelin promotes feeding through actions at both the hypothalamus and mesolimbic dopamine reward pathways. Therefore, we hypothesized that DIO would also establish ghrelin resistance in the ventral tegmental area (VTA), a major site of dopaminergic cell bodies important in reward processing. We observed reduced sucrose and saccharin consumption in Ghrelin KO vs Ghrelin WT mice. Moreover, DIO reduced saccharin consumption relative to chow-fed controls. These data suggest that the deletion of ghrelin and high fat diet both cause anhedonia. To assess if these are causally related..

View full abstract

Grants

Awarded by Australia Research Council Future Fellowship


Awarded by NHMRC Early Career Fellowship


Awarded by NHMRC


Awarded by Australian Research Council


Funding Acknowledgements

Zane Andrews: Salary support while work was undertaken. Monash Fellowship, Monash University, Australia; an Australia Research Council Future Fellowship (FT100100966).Sarah Lockie: Salary support while work was undertaken NHMRC Early Career Fellowship (NHMRC 1072364) to S.H.L. NHMRC project grants (NHMRC 1011274, 10030037) to Z.B.A.Tara Dinan: Salary support. Discovery Project Grant from the Australian Research Council (DP130100508 to SJS).Support for experimental procedures: NHMRC project grants (NHMRC 1011274, 10030037) to Z.B.A. Discovery Project Grant from the Australian Research Council (DP130100508 to SJS).