Journal article
Chronic intermittent toluene inhalation in adolescent rats results in metabolic dysfunction with altered glucose homeostasis
ALW Dick, A Simpson, A Qama, Z Andrews, AJ Lawrence, JR Duncan
British Journal of Pharmacology | WILEY | Published : 2015
DOI: 10.1111/bph.13284
Abstract
Background and Purpose Abuse of toluene-containing inhalants is an increasing public health problem, especially among adolescents. Abuse during adolescence is associated with emaciation, while industrial exposure leads to altered glycaemic control suggesting metabolic instability. However, the relationship between adolescent inhalant abuse and metabolic dysfunction remains unknown. Experimental Approach To model human abuse patterns, we exposed male adolescent Wistar rats [postnatal day (PND) 27] to chronic intermittent inhaled toluene (CIT, 10000ppm) or air (control) for 1h·day-1, three times a week for 4weeks. Feeding and body composition were monitored. After 4weeks, circulating metabolic..
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Funding Acknowledgements
The authors would like to thank Dr Michael Mathai (Victoria University) for access to the Echo-MRI and Mr Martin Axelsson for assistance with the saccharin preference studies. This study was supported by the National Health and Medical Research Council of Australia of which A. J. L. is a principal research fellow (1020737), the Australian Research Council (DP 110100379) of which J. R. D. was a future fellow during the time of the study (100100235) and the Victorian Government's Operational Infrastructure Support Scheme. The funding source had no involvement in the design, analysis and decision to publish.