Accuracy and Utility of Deformable Image Registration in Ga-68 4D PET/CT Assessment of Pulmonary Perfusion Changes During and After Lung Radiation Therapy
Nicholas Hardcastle, Michael S Hofman, Rodney J Hicks, Jason Callahan, Tomas Kron, Michael P MacManus, David L Ball, Price Jackson, Shankar Siva
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | ELSEVIER SCIENCE INC | Published : 2015
PURPOSE: Measuring changes in lung perfusion resulting from radiation therapy dose requires registration of the functional imaging to the radiation therapy treatment planning scan. This study investigates registration accuracy and utility for positron emission tomography (PET)/computed tomography (CT) perfusion imaging in radiation therapy for non-small cell lung cancer. METHODS: (68)Ga 4-dimensional PET/CT ventilation-perfusion imaging was performed before, during, and after radiation therapy for 5 patients. Rigid registration and deformable image registration (DIR) using B-splines and Demons algorithms was performed with the CT data to obtain a deformation map between the functional images..View full abstract
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Awarded by Cancer Australia Priority-drive Collaborative Cancer Research Scheme Grant
Awarded by National Health and Medical Research Council
The authors thank Mathias Bressel for advice on statistical analysis. This research has been partially supported by Cancer Australia Priority-drive Collaborative Cancer Research Scheme Grant 2013, APP1060919. Dr Shankar Siva has received National Health and Medical Research Council scholarship funding for this research, APP1038399.