Accelerated Intestinal Glucose Absorption in Morbidly Obese Humans: Relationship to Glucose Transporters, Incretin Hormones, and Glycemia
Nam Q Nguyen, Tamara L Debreceni, Jenna E Bambrick, Bridgette Chia, Judith Wishart, Adam M Deane, Chris K Rayner, Michael Horowitz, Richard L Young
The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2015
CONTEXT: Intestinal glucose absorption is mediated by sodium-dependent glucose transporter 1 (SGLT-1) and glucose transporter 2 (GLUT2), which are linked to sweet taste receptor (STR) signaling and incretin responses. OBJECTIVE: This study aimed to examine intestinal glucose absorption in morbidly obese humans and its relationship to the expression of STR and glucose transporters, glycemia, and incretin responses. DESIGN/SETTING/PARTICIPANTS: Seventeen nondiabetic, morbidly obese subjects (body mass index [BMI], 48 ± 4 kg/m(2)) and 11 lean controls (BMI, 25 ± 1 kg/m(2)) underwent endoscopic duodenal biopsies before and after a 30-minute intraduodenal glucose infusion (30 g glucose and 3 g 3-..View full abstract
Awarded by Royal Adelaide Hospital, South Australia
This work was supported by Project grant no. 104362 from the Royal Adelaide Hospital, South Australia.