Journal article
Composite outcome measures in a pragmatic clinical trial of chronic heart failure management: A comparative assessment
S Chang, PM Davidson, PJ Newton, P Macdonald, MJ Carrington, TH Marwick, JD Horowitz, H Krum, CM Reid, YK Chan, PA Scuffham, D Sibbritt, S Stewart
International Journal of Cardiology | Published : 2015
Abstract
Background A number of composite outcomes have been developed to capture the perspective of the patient, clinician and objective measures of health in assessing heart failure outcomes. To date there has been a limited examination in the composition of these outcomes. Methods and results Three commonly used scoring systems in heart failure trials: Packer's composite, Patient Journey and the African American Heart Failure Trial (A-HeFT) scores were compared in assessing outcomes from the Which heart failure intervention is most cost-effective & consumer friendly in reducing hospital care (WHICH(?)) Trial. Comparability and interpretability of these outcomes and the influence of each component ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
SC is supported by a Chancellor's Post-Doctoral Research Fellowship from the University of Technology, Sydney. The WHICH? Study is funded by the National Health and Medical Research Council of Australia (Number 418967) and individual investigators (SS, CMR and MC) are supported by the National Health and Medical Research Council of Australia.