Journal article
Preoperative biomarkers of tumour vascularity are elevated in patients with glioblastoma multiforme
Iwan E Bennett, Hui Guo, Nicole Kountouri, Giovanna M D'abaco, Christopher M Hovens, Bradford A Moffat, Patricia Desmond, Katharine Drummond, Andrew H Kaye, Andrew P Morokoff
JOURNAL OF CLINICAL NEUROSCIENCE | ELSEVIER SCI LTD | Published : 2015
Abstract
We investigated the correlation between the circulating and imaging biomarkers of tumour vascularity, and examined whether they are prognostic of outcomes in patients with glioblastoma multiforme (GBM). Despite the increasing use of anti-angiogenic agents within neuro-oncology, there are still no validated biomarkers to monitor for a treatment response or relapse. The pre- and postoperative circulating endothelial cell (CEC) and progenitor cell (CEP) levels were assessed. Preoperative perfusion-weighted MRI (PWI) was also performed, and the relative cerebral blood volume (rCBV) histogram statistics of the contrast-enhancing tumour were analysed. A novel PWI parameter (rCBVload) was developed..
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Funding Acknowledgements
This study was supported, in part, by funding received from The Brain Foundation Australia, the Neurosurgical Society of Australasia, the Royal Australasian College of Surgeons, and The Royal Melbourne Hospital Neuroscience Foundation. The authors also wish to thank Ms. Luisa Barassi, Mr. Simon Salinas and Dr. Christopher Steward for their assistance in this project.