Journal article
Relevance of tumor-infiltrating lymphocytes in breast cancer
Sathana Dushyanthen, Paul A Beavis, Peter Savas, Zhi Ling Teo, Chenhao Zhou, Mariam Mansour, Phillip K Darcy, Sherene Loi
BMC MEDICINE | BMC | Published : 2015
Abstract
While breast cancer has not been considered a cancer amenable to immunotherapeutic approaches, recent studies have demonstrated evidence of significant immune cell infiltration via tumor-infiltrating lymphocytes in a subset of patient tumors. In this review we present the current evidence highlighting the clinical relevance and utility of tumor-infiltrating lymphocytes in breast cancer. Retrospective and prospective studies have shown that the presence of tumor-infiltrating lymphocytes is a prognostic marker for higher responses to neoadjuvant chemotherapy and better survival, particularly in triple negative and HER2-positive early breast cancer. Further work is required to determine the imm..
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Grants
Awarded by National Breast Cancer Fellowship
Awarded by NHMRC Senior Research Fellowship
Awarded by National Breast Cancer Foundation
Funding Acknowledgements
SL is supported by Cancer Council Victoria, Australia; the National Health and Medical Research Council (NHMRC) National Breast Cancer Foundation (NBCF) of Australia, and the Breast Cancer Research Foundation (BCRF), NY. PAB was supported by a National Breast Cancer Fellowship (ID# PF-14-008). PKD was supported by an NHMRC Senior Research Fellowship (1041828).