Sensitization to milk, egg and peanut from birth to 18 years: A longitudinal study of a cohort at risk of allergic disease
Shatha A Alduraywish, Caroline J Lodge, Don Vicendese, Adrian J Lowe, Bircan Erbas, Melanie C Matheson, John Hopper, David J Hill, Christine Axelrad, Michael J Abramson, Katrina J Allen, Shyamali C Dharmage
PEDIATRIC ALLERGY AND IMMUNOLOGY | WILEY | Published : 2016
BACKGROUND: Longitudinal data on the natural history of food sensitization beyond early childhood are scarce. We aimed to investigate the natural history of milk, egg and peanut sensitization from infancy to 18 years and assess whether early food sensitization predicted adolescent food allergy. METHODS: Sensitization to cow's milk, hen's egg and peanut was measured by skin prick testing at ages 6 months, 1, 2, 12 and 18 years in a high-risk allergy birth cohort (n = 620). Generalized additive models investigated interactions with sex, eczema and aeroallergen sensitization in infancy. Logistic regression assessed the relationships between early food sensitization and adolescent sensitization ..View full abstract
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SAA has scholarship from King Saud University, Riyadh, Saudi Arabia, represented by Saudi Arabian Cultural Mission in Canberra, Australia; CJL is funded by The National Health and Medical Research Council of Australia (NHMRC); AJL, MCM and SCD are funded by the NHMRC; KJA is funded by the Charles and Sylvia Viertel Charitable Foundation. MJA holds investigator initiated research grants from Pfizer and Boehringer Ingelheim. He received support to attend the ERS Congress from Boehringer Ingelheim and attended a Respiratory Symposium funded by Novartis. He has been paid honoraria by Astra Zeneca and Novartis. These do not constitute substantial sources of income. CA, DJH, BE and DV have no personal funding relationships to declare. Initial funding for the first 6 years of the study was from Nestec (a subsidiary of Nestle Australia). The 12-year follow-up was supported by the Asthma Foundation of Victoria. The 18-year follow-up was supported by National Health and Medical Research Council (NHMRC) Australia. The funding bodies had no role in the study design, collection, analysis or interpretation of data, nor in writing this report or the decision to publish. The results, conclusions and opinions reported in the manuscript are those of the authors and are independent from the funding sources.