Laser capture microdissection as a tool to evaluate human papillomavirus genotyping and methylation as biomarkers of persistence and progression of anal lesions
Alyssa M Cornall, Jennifer M Roberts, Monica Molano, Dorothy A Machalek, Samuel Phillips, Richard J Hillman, Andrew E Grulich, Fengyi Jin, I Mary Poynten, David J Templeton, Suzanne M Garland, Sepehr N Tabrizi
BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2015
INTRODUCTION: Anal squamous cell carcinoma is preceded by persistent infection with high-risk human papillomavirus (HPV) and the cancer precursor, high-grade squamous intraepithelial lesion (HSIL). Detection of specific HPV genotypes and HPV-related biomarkers may be an option for primary anal screening. However, more data on the natural history of HPV-related anal lesions are required. The outcomes from this study will enhance our understanding of the clinical and biological behaviour of HPV-related anal lesions and inform the development of future HPV genotype and/or biomarker screening tests. METHODS AND ANALYSIS: HIV-negative and HIV-positive men who have sex with men, aged 35 years and ..View full abstract
Awarded by Australian Commonwealth Government National Health and Medical Research Council
Awarded by Cancer Council New South Wales Strategic Research Partnership Program grant
The SPANC study is funded by Australian Commonwealth Government National Health and Medical Research Council Program grants (#568971 and #1071269) and a Cancer Council New South Wales Strategic Research Partnership Program grant (#13-11).