Journal article
Short-term dietary salt supplementation blunts telmisartan induced increases in plasma renin activity in hypertensive patients with type 2 diabetes mellitus
AX Chen, G Jerums, S Baqar, E Lambert, G Somarajah, G Thomas, C O'Callaghan, RJ MacIsaac, EI Ekinci
Clinical Science | Published : 2015
DOI: 10.1042/CS20140536
Abstract
Current guidelines recommend low dietary salt intake (LDS) in patients with diabetes to reduce blood pressure (BP). However, low salt intake has been associated with higher mortality rates in people with diabetes. Our aim is to examine the effect of angiotensin II receptor blocker (ARB), telmisartan, with and without dietary sodium chloride (NaCl) supplementation, on BP [mean arterial pressure (MAP)], plasma renin activity (PRA), serum aldosterone level and estimated glomerular filtration rate (eGFR) in hypertensive patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled study (RCT), 28 patients with type 2 diabetes, treated with telmisartan (40 mg daily), received 2..
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Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) postgraduate scholarship [grant number APP466611 (to E.I.E.)]; the NHMRC early career fellowship [grant number APP1054312] and the Heart Foundation scholarship [grant number 100287 (to S.B.)].