Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration
Jeffrey R Liddell
NEURODEGENERATIVE DISEASE MANAGEMENT | FUTURE MEDICINE LTD | Published : 2015
Mitochondrial impairment and metal dyshomeostasis are suggested to be associated with many neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and Friedreich's ataxia. Treatments aimed at restoring metal homeostasis are highly effective in models of these diseases, and clinical trials hold promise. However, in general, the effect of these treatments on mitochondrial metal homeostasis is unclear, and the contribution of mitochondrial metal dyshomeostasis to disease pathogenesis requires further investigation. This review describes the role of metals in mitochondria in health, how mitochondrial metals are disrupted..View full abstract
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JR Liddell is supported by a National Health and Medical Research Council Peter Doherty Fellowship. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.