Journal article

Infection-Related Hospitalization in Childhood and Adult Metabolic Outcomes

David P Burgner, Matthew A Sabin, Costan G Magnussen, Michael Cheung, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Eero Jokinen, Tomi Laitinen, Leena Taittonen, Paivi Tossavainen, Terence Dwyer, Jorma SA Viikari, Olli T Raitakari, Markus Juonala

Pediatrics | AMER ACAD PEDIATRICS | Published : 2015

Abstract

BACKGROUND AND OBJECTIVES: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, well-phenotyped longitudinal cohort. METHODS: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (..

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Grants

Awarded by Academy of Finland


Awarded by Turku University Hospital Medical Funds


Awarded by National Health and Medical Research Council (Australia) fellowships


Awarded by Royal Children's Hospital (RCH) Foundation


Funding Acknowledgements

The Cardiovascular Risk in Young Finns Study was financially supported by the Academy of Finland (grants 126925, 121584, 124282, 129378 [Salve], 117787 [Gendi], 41071 [Skidi], and 134309 [eye]); the Social Insurance Institution of Finland; the Kuopio, Tampere, and Turku University Hospital Medical Funds (grant 9N035 to Dr Lehtimaki); the Paulo Foundation; the Juho Vainio Foundation; the Paavo Nurmi Foundation; the Finnish Foundation of Cardiovascular Research; the Finnish Cultural Foundation, the Finnish Medical Foundation, the Sigrid Juselius Foundation; the Maud Kuistila Foundation; the Tampere Tuberculosis Foundation; and the Emil Aaltonen Foundation. Dr Burgner (APP5/2504, APP1064629), Dr Sabin (APP1012201), and Dr Magnussen (APP1037559) are supported by National Health and Medical Research Council (Australia) fellowships. Dr Burgner is an Honorary Future Leader Fellow of the National Heart Foundation of Australia. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group at Murdoch Children's Research Institute is supported by the Royal Children's Hospital (RCH) Foundation and RCH100.