Experimental Traumatic Brain Injury Results in Long-Term Recovery of Functional Responsiveness in Sensory Cortex but Persisting Structural Changes and Sensorimotor, Cognitive, and Emotional Deficits
Victoria PA Johnstone, David K Wright, Kendrew Wong, Terence J O'Brien, Ramesh Rajan, Sandy R Shultz
Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2015
Traumatic brain injury (TBI) is a leading cause of death worldwide. In recent studies, we have shown that experimental TBI caused an immediate (24-h post) suppression of neuronal processing, especially in supragranular cortical layers. We now examine the long-term effects of experimental TBI on the sensory cortex and how these changes may contribute to a range of TBI morbidities. Adult male Sprague-Dawley rats received either a moderate lateral fluid percussion injury (n=14) or a sham surgery (n=12) and 12 weeks of recovery before behavioral assessment, magnetic resonance imaging, and electrophysiological recordings from the barrel cortex. TBI rats demonstrated sensorimotor deficits, cogniti..View full abstract
The authors acknowledge the facilities as well as the scientific and technical assistance of the National Imaging Facility at the Florey Institute of Neuroscience and Mental Health (Parkville, VIC, Australia). This work was supported by grants to T.O. and S.S. from the NHMRC, the Victorian Transport Accident Commission, the Royal Melbourne Hospital Neuroscience Foundation, and the Canadian Institute of Health Research.