Journal article

Development, Homeostasis, and Heterogeneity of NK Cells and ILC1

Cyril Seillet, Gabrielle T Belz, Nicholas D Huntington, E Vivier (ed.), J DiSanto (ed.), A Moretta (ed.)

NATURAL KILLER CELLS | SPRINGER INTERNATIONAL PUBLISHING AG | Published : 2016

Abstract

Natural killer (NK) cells are a population of cytotoxic innate lymphocytes that evolved prior to their adaptive counterparts and constitute one of the first lines of defense against infected or mutated cells. NK cells are rapidly activated, expressing an array of germ-line encoded receptors that allow them to scan for protein irregularities on cells and kill those deemed "altered-self." NK cells rapidly produce a broad range of cytokines and chemokines following activation by virus, bacterial, or parasitic infection and are thus key in orchestrating inflammation. NK cells have previously been viewed to represent a relatively homogeneous group of IFN-γ-producing cells that express the surface..

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