Journal article
Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: An open, randomised controlled trial
MJ Chisti, MA Salam, JH Smith, T Ahmed, MAC Pietroni, KM Shahunja, ASMSB Shahid, ASG Faruque, H Ashraf, PK Bardhan, undefined Sharifuzzaman, SM Graham, T Duke
Lancet | Published : 2015
Abstract
Background In developing countries, mortality in children with very severe pneumonia is high, even with the provision of appropriate antibiotics, standard oxygen therapy, and other supportive care. We assessed whether oxygen therapy delivered by bubble continuous positive airway pressure (CPAP) improved outcomes compared with standard low-flow and high-flow oxygen therapies. Methods This open, randomised, controlled trial took place in Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh. We randomly assigned children younger than 5 years with severe pneumonia and hypoxaemia to receive oxygen therapy by either bubble CPAP (5 L/min starting at a CPAP level of..
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Awarded by Australian Agency for International Development
Funding Acknowledgements
International Centre for Diarrhoeal Disease Research, Bangladesh, and Centre for International Child Health, University of Melbourne.This research was partly funded by the Centre for International Child Health, through a Knowledge Hubs for Health grant from Australian Agency for International Development (AusAID; grant number Gr 00837). MJC received a PhD scholarship from University of Melbourne to complete this study. We thank Colin Robertson for support as a member of MJC's PhD Advisory Panel and staff at the Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute for statistical advice. We thank the physicians, clinical fellows, nurses, and members of nutrition team for their contribution during patient enrolment and data collection. We thank the parents of children involved in this study for their generous participation. We thank the governments of Australia, Bangladesh, Canada, Sweden, and the UK for providing core or unrestricted support to the International Centre for Diarrhoeal Disease Research, Bangladesh.