Journal article

Comparison of Segmentation Methods for MRI Measurement of Cardiac Function in Rats

Johannes Riegler, King K Cheung, Yiu Fung Man, Jon O Cleary, Anthony N Price, Mark F Lythgoe

Journal of Magnetic Resonance Imaging | WILEY | Published : 2010


PURPOSE: To establish the accuracy, intra- and inter-observer variabilities of four different segmentation methods for measuring cardiac functional parameters in healthy and infarcted rat hearts. MATERIALS AND METHODS: Six Wistar rats were imaged before and after myocardial infarction using an electrocardiogram and respiratory-gated spoiled gradient echo sequence. Blinded and randomized datasets were analyzed by various semi-automatic and manual segmentation methods to compare their measurement bias and variability. In addition, the accuracy of these methods was assessed by comparison with reference measurements acquired from high-resolution three-dimensional (3D) datasets of a heart phantom..

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University of Melbourne Researchers