Comparison of Segmentation Methods for MRI Measurement of Cardiac Function in Rats
Johannes Riegler, King K Cheung, Yiu Fung Man, Jon O Cleary, Anthony N Price, Mark F Lythgoe
Journal of Magnetic Resonance Imaging | WILEY | Published : 2010
PURPOSE: To establish the accuracy, intra- and inter-observer variabilities of four different segmentation methods for measuring cardiac functional parameters in healthy and infarcted rat hearts. MATERIALS AND METHODS: Six Wistar rats were imaged before and after myocardial infarction using an electrocardiogram and respiratory-gated spoiled gradient echo sequence. Blinded and randomized datasets were analyzed by various semi-automatic and manual segmentation methods to compare their measurement bias and variability. In addition, the accuracy of these methods was assessed by comparison with reference measurements acquired from high-resolution three-dimensional (3D) datasets of a heart phantom..View full abstract
Contract grant sponsors: the British Heart Foundation; the Biotechnology and Biological Sciences Research Council; the Engineering and Physical Sciences Research Council.