Journal article
Clinical and genetic characterization of pituitary gigantism: An international collaborative study in 208 patients
L Rostomyan, AF Daly, P Petrossians, E Nachev, AR Lila, AL Lecoq, B Lecumberri, G Trivellin, R Salvatori, AG Moraitis, I Holdaway, DJ Kranenburg-Van Klaveren, MC Zatelli, N Palacios, C Nozieres, M Zacharin, T Ebeling, M Ojaniemi, L Rozhinskaya, E Verrua Show all
Endocrine Related Cancer | Published : 2015
DOI: 10.1530/ERC-15-0320
Abstract
Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients.We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 S.D. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasellar..
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Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
This study was supported by an educational grant from the JABBS Foundation (UK Charity Number: 1128402) and from the Fonds d'Investissement de Recherche Scientifique of the Centre Hospitalier Universitaire de Liege, to A Beckers. This study is based in part on confidential data provided by Eurostat, the statistical office of the European Union: European Health Interview Survey (EHIS) 1 microdata. The responsibility for all conclusions drawn from the data lies entirely with the authors.