Journal article

Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients

Liliya Rostomyan, Adrian F Daly, Patrick Petrossians, Emil Nachev, Anurag R Lila, Anne-Lise Lecoq, Beatriz Lecumberri, Giampaolo Trivellin, Roberto Salvatori, Andreas G Moraitis, Ian Holdaway, Dianne J Kranenburg-van Klaveren, Maria Chiara Zatelli, Nuria Palacios, Cecile Nozieres, Margaret Zacharin, Tapani Ebeling, Marja Ojaniemi, Liudmila Rozhinskaya, Elisa Verrua Show all

Endocrine Related Cancer | BIOSCIENTIFICA LTD | Published : 2015

Abstract

Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasella..

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Grants

Awarded by JABBS Foundation (UK)


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Funding Acknowledgements

This study was supported by an educational grant from the JABBS Foundation (UK Charity Number: 1128402) and from the Fonds d'Investissement de Recherche Scientifique of the Centre Hospitalier Universitaire de Liege, to A Beckers. This study is based in part on confidential data provided by Eurostat, the statistical office of the European Union: European Health Interview Survey (EHIS) 1 microdata. The responsibility for all conclusions drawn from the data lies entirely with the authors.