Journal article

Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit

Iain J Abbott, Adam WJ Jenney, Denis W Spelman, David V Pilcher, Hanna E Sidjabat, Leisha J Richardson, David L Paterson, Anton Y Peleg

Pathology | ELSEVIER SCIENCE BV | Published : 2015

Abstract

A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9% (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMérieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8% (14/37) of patients cultured a new antibiotic-resistant isolate on disc..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council Career Development Fellowship


Funding Acknowledgements

This work was supported by Alfred Research Trusts Small Project Grants and Royal Australian College of Physicians Richard Kemp Memorial Fellowship. AYP acknowledges funding support from an Australian National Health and Medical Research Council Career Development Fellowship (1047916).