Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit
Iain J Abbott, Adam WJ Jenney, Denis W Spelman, David V Pilcher, Hanna E Sidjabat, Leisha J Richardson, David L Paterson, Anton Y Peleg
Pathology | ELSEVIER SCIENCE BV | Published : 2015
A short-term program of performing serial active screening cultures (ASC) in the intensive care unit was instituted to establish a method for the detection of antibiotic-resistant Gram-negative bacteria (GNB) and the local rates of colonisation. Of all submitted ASC, 25.9% (30/116 collected swabs) isolated an antibiotic-resistant GNB. ChromID ESBL agar (bioMérieux, France) identified the majority of these organisms, with the additional antibiotic-impregnated media [MacConkey agar (MCA) with ciprofloxacin, MCA with gentamicin and MCA with ceftazidime] adding limited benefit. Compared to swabs performed on admission, 37.8% (14/37) of patients cultured a new antibiotic-resistant isolate on disc..View full abstract
Awarded by Australian National Health and Medical Research Council Career Development Fellowship
This work was supported by Alfred Research Trusts Small Project Grants and Royal Australian College of Physicians Richard Kemp Memorial Fellowship. AYP acknowledges funding support from an Australian National Health and Medical Research Council Career Development Fellowship (1047916).