Spencer Williams

Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism.

Alexander JD Snow, Mahima Sharma, Palika Abayakoon, Spencer J Williams, James N Blaza, Gideon J Davies

Journal article  |  2023  |  Structure

Sulfoquinovose (SQ) is a key component of plant sulfolipids (sulfoquinovosyl diacylglycerols) and a major environmental reservoir ..

A subfamily classification to choreograph the diverse activities within Glycoside Hydrolase family 31 (GH31).

Thimali Arumapperuma, Jinling Li, Bastian Hornung, Niccolay Madiedo Soler, Ethan D Goddard-Borger, Nicolas Terrapon, Spencer J Williams

Journal article  |  2023  |  J Biol Chem

The Carbohydrate-Active Enzyme classification groups enzymes that breakdown, assemble or decorate glycans into protein families ba..

Remodeling of Carbon Metabolism during Sulfoglycolysis in Escherichia coli

Janice W-Y Mui, David P De Souza, Eleanor C Saunders, Malcolm J McConville, Spencer J Williams

Journal article  |  2023  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sulfoquinovose (SQ) is a major metabolite in the global sulfur cycle produced by nearly all photosynthetic organisms. One of the m..

Structure, Function and Mechanism of N-Glycan Processing Enzymes: endo-alpha-1,2-Mannanase and endo-alpha-1,2-Mannosidase

Laura Burchill, Alexandra Males, Arashdeep Kaur, Gideon J Davies, Spencer J Williams

Journal article  |  2022  |  ISRAEL JOURNAL OF CHEMISTRY

While most glycosidases that act on N-linked glycans remove a single sugar residue at a time, endo-α-1,2-mannosidases and endo-α-1..

Synthesis and structure of clozapine N-oxide hemi(hydrochloride): an infinite hydrogen-bonded poly[n]catenane

Phillip L van der Peet, Rohan D Joyce, Holger Ott, Sebastian M Marcuccio, Jonathan M White, Spencer J Williams

Journal article  |  2022  |  ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS

The structure of the title compound, 2C18H19ClN4O·HCl or (CNO)2·HCl (C36H39Cl3N8O2), at 100 K has tetra-gonal (I4/m) symmetry. The..

Chemistry and biology of the aminosulfonate cysteinolic acid: discovery, distribution, synthesis and metabolism

Laura Burchill, Spencer J Williams

Journal article  |  2022  |  ORGANIC & BIOMOLECULAR CHEMISTRY

D-Cysteinolic acid is a zwitterionic aminosulfonate found in marine (and occasionally freshwater) environments. It is distributed ..

Synthesis of the Alkylsulfonate Metabolites Cysteinolic Acid, 3-Amino-2-hydroxypropanesulfonate, and 2,3-Dihydroxypropanesulfonate

Laura Burchill, Luca Zudich, Phillip L van der Peet, Jonathan M White, Spencer J Williams

Journal article  |  2022  |  JOURNAL OF ORGANIC CHEMISTRY

Chiral hydroxy- and aminohydroxysulfonic acids are widespread in the marine and terrestrial environment. Here we report simple met..

Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway

Arashdeep Kaur, Phillip L van der Peet, Janice W-Y Mui, Marion Herisse, Sacha Pidot, Spencer J Williams

Journal article  |  2022  |  ARCHIVES OF MICROBIOLOGY

Sulfoglycolysis pathways enable the breakdown of the sulfosugar sulfoquinovose and environmental recycling of its carbon and sulfu..

Characterization of Mycobacterium tuberculosis Mycolic Acids by Multiple-Stage Linear Ion-Trap Mass Spectrometry

Cheryl Frankfater, Hideji Fujiwara, Spencer J Williams, Adriaan Minnaard, Fong-Fu Hsu

Journal article  |  2022  |  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mycobacterium tuberculosis (Mtb) cells are known to synthesize very long chain (C60-90) structurally complex mycolic acids with va..

The sulfoquinovosyl glycerol binding protein SmoF binds and accommodates plant sulfolipids.

Alexander JD Snow, Mahima Sharma, James P Lingford, Yunyang Zhang, Janice W-Y Mui, Ruwan Epa, Ethan D Goddard-Borger, Spencer J Williams, Gideon J Davies

Journal article  |  2022  |  Curr Res Struct Biol

Sulfoquinovose (SQ) is the anionic headgroup of the ubiquitous plant sulfolipid, sulfoquinovosyl diacylglycerol (SQDG). SQDG can u..