Spencer Williams

(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis

SJ Williams, S Zammit, DJ Kelly, W James

Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation

DJ Kelly, SJ Williams, S Zammit

Preparation of dithiole derivatives as cyclooxygenase inhibitors

B JARROTT, S ZANATTA, S WILLIAMS

Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

Improved flavonols

S WILLIAMS, O WOODMAN, SW YAP

Mycobacterial sulfation pathway proteins and methods of use thereof

R Bertozzi, S WILLIAMS, D Mougous

Mycobacterial sulfation pathway proteins and methods of use thereof

R Bertozzi, S WILLIAMS, D Mougous

Unimolecular, Bimolecular, and Intramolecular Hydrolysis Mechanisms of 4-Nitrophenyl β-d-Glucopyranoside.

Amani Alhifthi, Spencer J Williams

Journal article  |  2021  |  J Org Chem

1,2-trans-Glycosides hydrolyze through different mechanisms at different pH values, but systematic studies are lacking. Here, we r..

Editorial overview: Protein-carbohydrate complexes and glycosylation: A new age of discovery in the glycosciences

Jiaoyang Jiang, Spencer J Williams

Journal article  |  2021  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma, Palika Abayakoon, Ruwan Epa, Yi Jin, James P Lingford, Tomohiro Shimada, Masahiro Nakano, Janice W-Y Mui, Akira Ishihama, Ethan D Goddard-Borger, Gideon J Davies, Spencer J Williams

Journal article  |  2021  |  ACS CENTRAL SCIENCE

The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on Earth and is metabolized by bacteria..

Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors

Masahiro Nagata, Kenji Toyonaga, Eri Ishikawa, Shojiro Haji, Nobuyuki Okahashi, Masatomo Takahashi, Yoshihiro Izumi, Akihiro Imamura, Koichi Takato, Hideharu Ishida, Shigenori Nagai, Petr Illarionov, Bridget L Stocker, Mattie SM Timmer, Dylan GM Smith, Spencer J Williams, Takeshi Bamba, Tomofumi Miyamoto, Makoto Arita, Ben J Appelmelk, et al.

Journal article  |  2021  |  JOURNAL OF EXPERIMENTAL MEDICINE

Helicobacter pylori causes gastritis, which has been attributed to the development of H. pylori-specific T cells during infection...

Candida albicans steryl 6-O-acyl-alpha-d-mannosides agonize signalling through Mincle

Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams

Journal article  |  2020  |  Chemical Communications

The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors ..

Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

Lukasz F Sobala, Pearl Z Fernandes, Zalihe Hakki, Andrew J Thompson, Jonathon D Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D Butters, Dominic S Alonzi, Spencer J Williams, Gideon J Davies

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of the United States of America

Mammalian protein N-linked glycosylation is critical for glycoprotein folding, quality control, trafficking, recognition, and func..

Cholesteryl 6-O-acyl-alpha-glucosides from diverseHelicobacterspp. signal through the C-type lectin receptor Mincle

Dylan GM Smith, Emi Ito, Sho Yamasaki, Spencer J Williams

Journal article  |  2020  |  ORGANIC & BIOMOLECULAR CHEMISTRY

Helicobacter spp. are Gram-negative bacteria that cause a spectrum of disease in the gut, biliary tree and liver. Many Helicobacte..

The Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma, Palika Abayakoon, Yi Jin, Ruwan Epa, James Lingford, Tomohiro Shimada, Masahiro Nakano, Janice Mui, Akira Ishihama, Ethan D Goddard-Borger, Gideon Davies, Spencer Williams

Journal article  |  2020

The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on earth and is metabolized bacteria th..

A Sulfoglycolytic Entner-Doudoroff Pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li, Ruwan Epa, Nichollas E Scott, Dominik Skoneczny, Mahima Sharma, Alexander JD Snow, James P Lingford, Ethan D Goddard-Borger, Gideon J Davies, Malcolm J McConville, Spencer J Williams

Journal article  |  2020  |  APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Rhizobia are nitrogen-fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as free-living ..

Mannosidase mechanism: at the intersection of conformation and catalysis

Carme Rovira, Alexandra Males, Gideon J Davies, Spencer J Williams

Journal article  |  2020  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Mannosidases are a diverse group of enzymes that are important in the biological processing of mannose-containing polysaccharides ..