Spencer Williams

(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis

SJ Williams, S Zammit, DJ Kelly, W James

Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation

DJ Kelly, SJ Williams, S Zammit

Preparation of dithiole derivatives as cyclooxygenase inhibitors

B JARROTT, S ZANATTA, S WILLIAMS

Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity

S ZAMMIT, R GILBERT, H KRUM, S WILLIAMS, D KELLY

Improved flavonols

S WILLIAMS, O WOODMAN, SW YAP

Mycobacterial sulfation pathway proteins and methods of use thereof

R Bertozzi, S WILLIAMS, D Mougous

Mycobacterial sulfation pathway proteins and methods of use thereof

R Bertozzi, S WILLIAMS, D Mougous

Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.

Masahiro Nagata, Kenji Toyonaga, Eri Ishikawa, Shojiro Haji, Nobuyuki Okahashi, Masatomo Takahashi, Yoshihiro Izumi, Akihiro Imamura, Koichi Takato, Hideharu Ishida, Shigenori Nagai, Petr Illarionov, Bridget L Stocker, Mattie SM Timmer, Dylan GM Smith, Spencer J Williams, Takeshi Bamba, Tomofumi Miyamoto, Makoto Arita, Ben J Appelmelk, et al.

Journal article  |  2021  |  Journal of Experimental Medicine

Helicobacter pylori causes gastritis, which has been attributed to the development of H. pylori-specific T cells during infection...

Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

Lukasz F Sobala, Pearl Z Fernandes, Zalihe Hakki, Andrew J Thompson, Jonathon D Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D Butters, Dominic S Alonzi, Spencer J Williams, Gideon J Davies

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Mammalian protein N-linked glycosylation is critical for glycoprotein folding, quality control, trafficking, recognition, and func..

Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle.

Tram Nguyen, Yuki Hosono, Takashi Shimizu, Sho Yamasaki, Spencer J Williams

Journal article  |  2020  |  Chemical Communications

The C-type lectin receptor Mincle binds Candida albicans and has been implicated in its pathobiology, but the molecular effectors ..

Cholesteryl 6-O-acyl-alpha-glucosides from diverseHelicobacterspp. signal through the C-type lectin receptor Mincle

Dylan GM Smith, Emi Ito, Sho Yamasaki, Spencer J Williams

Journal article  |  2020  |  Organic & Biomolecular Chemistry

Helicobacter spp. are Gram-negative bacteria that cause a spectrum of disease in the gut, biliary tree and liver. Many Helicobacte..

The Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis

Mahima Sharma, Palika Abayakoon, Yi Jin, Ruwan Epa, James Lingford, Tomohiro Shimada, Masahiro Nakano, Janice Mui, Akira Ishihama, Ethan D Goddard-Borger, Gideon Davies, Spencer Williams

Journal article  |  2020

The sulfosugar sulfoquinovose (SQ) is produced by essentially all photosynthetic organisms on earth and is metabolized bacteria th..

A Sulfoglycolytic Entner-Doudoroff Pathway in Rhizobium leguminosarum bv. trifolii SRDI565

Jinling Li, Ruwan Epa, Nichollas E Scott, Dominik Skoneczny, Mahima Sharma, Alexander JD Snow, James P Lingford, Ethan D Goddard-Borger, Gideon J Davies, Malcolm J McConville, Spencer J Williams

Journal article  |  2020  |  Applied and Environmental Microbiology

Rhizobia are nitrogen-fixing bacteria that engage in symbiotic relationships with plant hosts but can also persist as free-living ..

alpha-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19

Spencer J Williams, Ethan D Goddard-Borger

Journal article  |  2020  |  Biochemical Society Transactions

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipi..

Mannosidase mechanism: at the intersection of conformation and catalysis

Carme Rovira, Alexandra Males, Gideon J Davies, Spencer J Williams

Journal article  |  2020  |  Current Opinion in Structural Biology

Mannosidases are a diverse group of enzymes that are important in the biological processing of mannose-containing polysaccharides ..

An Epoxide Intermediate in Glycosidase Catalysis

Lukasz F Sobala, Gaetano Speciale, Sha Zhu, Lluis Raich, Natalia Sannikova, Andrew J Thompson, Zalihe Hakki, Dan Lu, Saeideh Shamsi Kazem Abadi, Andrew R Lewis, Victor Rojas-Cervellera, Ganeko Bernardo-Seisdedos, Yongmin Zhang, Oscar Millet, Jesus Jimenez-Barbero, Andrew J Bennet, Matthieu Sollogoub, Carme Rovira, Gideon J Davies, Spencer J Williams

Journal article  |  2020  |  ACS Central Science

Retaining glycoside hydrolases cleave their substrates through stereochemical retention at the anomeric position. Typically, this ..

Design of potent Mincle signalling agonists based on an alkyl beta-glucoside template

Dylan GM Smith, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer J Williams

Journal article  |  2020  |  Chemical Communications

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerg..