Peter Colman

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura CA Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David CS Huang, Andreas Strasser, Marc Kvansakul, Martin Rowe, Gemma L Kelly

Journal article  |  2020  |  Cell Death & Differentiation

Epstein-Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Richard W Birkinshaw, Jia-nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David CS Huang, Peter M Colman, Peter E Czabotar

Journal article  |  2019  |  Nature Communications

Ensemble Properties of Bax Determine Its Function

Adeline Y Robin, Sweta Iyer, Richard W Birkinshaw, Jarrod Sandow, Ahmad Wardak, Cindy S Luo, Melissa Shi, Andrew Webb, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2018  |  Structure

ColinWesleyWard 1943-2017

Peter M Colman, Antony W Burgess

Journal article  |  2018  |  Historical Records of Australian Science

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Czabotar

Journal article  |  2017  |  Molecular Cell

Vale Colin Ward-A Leader in Receptor Structural Biology

Michael C Lawrence, Peter M Colman

Journal article  |  2017  |  Frontiers in Endocrinology

Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Journal article  |  2016  |  Trends in Cancer

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Erinna F Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M Kluck, Marlyse A Debrincat, Daniel H Gray, Matthew T Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M Lane, Peter E Czabotar, Peter M Colman, Brian J Smith, Benjamin T Kile, W Douglas Fairlie

Journal article  |  2016  |  Genes & Development

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

AY Robin, K Krishna Kumar, D Westphal, AZ Wardak, GV Thompson, G Dewson, PM Colman, PE Czabotar

Journal article  |  2015  |  Cell Death & Disease

Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim

B Marshall, H Puthalakath, S Caria, S Chugh, M Doerflinger, PM Colman, M Kvansakul

Journal article  |  2015  |  Cell Death & Disease

The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains

Erinna F Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Grace J Gold, Haoran Zhu, Peter M Colman, W Douglas Fairlie

Journal article  |  2014  |  Journal of Biological Chemistry

Discovery of a Potent and Selective BCL-X-L Inhibitor with in Vivo Activity

Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Chang H Park, Erwin R Boghaert, Nathaniel D Catron, Jun Chen, Peter M Colman, Peter E Czabotar, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Sarah G Hymowitz, Sha Jin, Russell A Judge, Michael FT Koehler, Peter J Kovar, Guillaume Lessene, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Jason M Brouwer, Dana Westphal, Grant Dewson, Adeline Y Robin, Rachel T Uren, Ray Bartolo, Geoff V Thompson, Peter M Colman, Ruth M Kluck, Peter E Czabotar

Journal article  |  2014  |  Molecular Cell

Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1L

Stephanie Campbell, John Thibault, Ninad Mehta, Peter M Colman, Michele Barry, Marc Kvansakul

Journal article  |  2014  |  Journal of Virology

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Danette Dudley, Paul Gibbons, Brad E Sleebs, Carl S Rye, George Nikolakopoulos, Chinh Bui, Sanji Kulasegaram, Wilhelmus JA Kersten, Brian J Smith, Peter E Czabotar, Peter M Colman, David CS Huang, Jonathan B Baell, Keith G Watson, Lisa Hasvold, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams, Peter M Colman, Peter E Czabotar

Journal article  |  2014  |  Archives of Biochemistry and Biophysics

De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-X-L: Synthesis, Structural and Biochemical Characterization

Ryan M Brady, Amelia Vom, Michael J Roy, Nathan Toovey, Brian J Smith, Rebecca M Moss, Effie Hatzis, David CS Huang, John P Parisot, Hong Yang, Ian P Street, Peter M Colman, Peter E Czabotar, Jonathan B Baell, Guillaume Lessene

Journal article  |  2014  |  Journal of Medicinal Chemistry

Crystallography and New Medicines: Examples from Influenza and Cell Death

Peter M Colman

Journal article  |  2014  |  Australian Journal of Chemistry

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman

Journal article  |  2013  |  Cell

Early days in drug discovery by crystallography - personal recollections

Peter M Colman

Journal article  |  2013  |  Acta Crystallographica Section A Foundations of Crystallography

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

Toru Okamoto, Stephanie Campbell, Ninad Mehta, John Thibault, Peter M Colman, Michele Barry, David CS Huang, Marc Kvansakul

Journal article  |  2012  |  Journal of Virology

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

Jian-Guo Zhang, Peter E Czabotar, Antonia N Policheni, Irina Caminschi, Soo San Wan, Susie Kitsoulis, Kirsteen M Tullett, Adeline Y Robin, Rajini Brammananth, Mark F van Delft, Jinhua Lu, Lorraine A O'Reilly, Emma C Josefsson, Benjamin T Kile, Wei Jin Chin, Justine D Mintern, Maya A Olshina, Wilson Wong, Jake Baum, Mark D Wright, et al.

Journal article  |  2012  |  Immunity

Evaluation of Diverse alpha/beta-Backbone Patterns for Functional alpha-Helix Mimicry: Analogues of the Bim BH3 Domain

Melissa D Boersma, Holly S Haase, Kimberly J Peterson-Kaufman, Erinna F Lee, Oliver B Clarke, Peter M Colman, Brian J Smith, W Seth Horne, W Douglas Fairlie, Samuel H Gellman

Journal article  |  2012  |  Journal of the American Chemical Society

Structural Basis of Bcl-x(L) Recognition by a BH3-Mimetic alpha/beta-Peptide Generated by Sequence-Based Design

Erinna F Lee, Brian J Smith, W Seth Horne, Kelsey N Mayer, Marco Evangelista, Peter M Colman, Samuel H Gellman, W Douglas Fairlie

Journal article  |  2011  |  ChemBioChem

Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis

Peter E Czabotar, Erinna F Lee, Geoff V Thompson, Ahmad Z Wardak, W Douglas Fairlie, Peter M Colman

Journal article  |  2011  |  Journal of Biological Chemistry

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

Marc Kvansakul, Andrew H Wei, Jamie I Fletcher, Simon N Willis, Lin Chen, Andrew W Roberts, David CS Huang, Peter M Colman

Journal article  |  2010  |  PLOS PATHOGENS

Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1.

Stephanie Campbell, Bart Hazes, Marc Kvansakul, Peter Colman, Michele Barry

Journal article  |  2010  |  Journal of Biological Chemistry

The Bcl-2 family regulates induction of apoptosis at the mitochondria. Essential to this regulation are the interactions between B..

Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins

Erinna F Lee, Anna Fedorova, Kerry Zobel, Michelle J Boyle, Hong Yang, Matthew A Perugini, Peter M Colman, David CS Huang, Kurt Deshayes, W Douglas Fairlie

Journal article  |  2009  |  Journal of Biological Chemistry

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Erinna F Lee, Peter E Czabotar, Hong Yang, Brad E Sleebs, Guillaume Lessene, Peter M Colman, Brian J Smith, W Douglas Fairlie

Journal article  |  2009  |  Journal of Biological Chemistry

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

Anthony N Hodder, Robyn L Malby, Oliver B Clarke, W Douglas Fairlie, Peter M Colman, Brendan S Crabb, Brian J Smith

Journal article  |  2009  |  Journal of Molecular Biology

Bax activation by Bim?

PE Czabotar, PM Colman, DCS Huang

Journal article  |  2009  |  Cell Death Differ.

New Antivirals and Drug Resistance

Peter M Colman

Journal article  |  2009  |  Annual Review of Biochemistry

High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)

Erinna F Lee, Jack D Sadowsky, Brian J Smith, Peter E Czabotar, Kimberly J Peterson-Kaufman, Peter M Colman, Samuel H Gellman, W Douglas Fairlie

Journal article  |  2009  |  Angewandte Chemie International Edition

BCL-2 family antagonists for cancer therapy

Guillaume Lessene, Peter E Czabotar, Peter M Colman

Journal article  |  2008  |  Nature Reviews Drug Discovery

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency

EF Lee, L Chen, H Yang, PM Colman, DCS Huang, WD Fairlie

Journal article  |  2008  |  Cell Death Differ.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3 : Groove interactions

Grant Dewson, Tobias Kratina, Huiyan W Sim, Hamsa Puthalakath, Jerry M Adams, Peter M Colman, Ruth M Kluck

Journal article  |  2008  |  Molecular Cell

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Erinna F Lee, Peter E Czabotar, Mark F Van Delft, Ewa M Michalak, Michelle J Boyle, Simon N Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M Colman, David CS Huang, W Douglas Fairlie

Journal article  |  2008  |  Journal of Cell Biology

Crystal structure of ABT-737 complexed with Bcl-x(L): implications for selectivity of antagonists of the Bcl-2 family

EF Lee, PE Czabotar, BJ Smith, K Deshayes, K Zobel, PM Colman, WD Fairlie

Journal article  |  2007  |  Cell Death & Differentiation

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E Czabotar, Erinna F Lee, Mark F van Delft, Catherine L Day, Brian J Smith, David CS Huang, W Douglas Fairlie, Mark G Hinds, Peter M Colman

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

A structural viral mimic of prosurvival Bcl-2: A pivotal role for sequestering proapoptotic Bax and Bak

Marc Kvansakul, Mark F van Delft, Erinna F Lee, Jacqueline M Gulbis, W Douglas Fairlie, David CS Huang, Peter M Colman

Journal article  |  2007  |  Molecular Cell

Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms

Lukasz Kedzierski, Robyn L Malby, Brian J Smith, Matthew A Perugini, Anthony N Hodder, Thomas Ilg, Peter M Colman, Emanuela Handman

Journal article  |  2006  |  Journal of Molecular Biology

CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13

WD Fairlie, MA Perugini, M Kvansakul, L Chen, DCS Huang, PM Colman

Journal article  |  2006  |  Cell Death & Differentiation

Zanamivir: an influenza virus neuraminidase inhibitor.

PM Colman

Journal article  |  2005  |  Expert Review of Anti-infective Therapy

Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Relenza, an oral..

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, CL Day, JM Adams, DCS Huang

Journal article  |  2005  |  Molecular Cell

Subversion of the Bcl-2 life/death switch in cancer development and therapy

JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.

Journal article  |  2005  |  Cold Spring Harbor Symp. Quant. Biol.

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III

MC Lawrence, NA Borg, VA Streltsov, PA Pilling, VC Epa, JN Varghese, JL McKimm-Breschkin, PM Colman

Journal article  |  2004  |  Journal of Molecular Biology

Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.

Jennifer L McKimm-Breschkin, Peter M Colman, Betty Jin, Guy Y Krippner, Mandy McDonald, Phillip A Reece, Simon P Tucker, Lynne Waddington, Keith G Watson, Wen-Yang Wu

Journal article  |  2003  |  Angewandte Chemie International Edition

The structural biology of type I viral membrane fusion

PM Colman, MC Lawrence

Journal article  |  2003  |  Nature Reviews Molecular Cell Biology

Specificity and promiscuity in protein-ligand and protein-protein interactions

PM Colman, BJ Smith

Journal article  |  2003  |  Australian Journal of Chemistry

The trypanosomal trans-sialidase: Two catalytic functions associated with one catalytic site

PM Colman, BJ Smith

Journal article  |  2002  |  Structure

Structural studies of the resistance of influenza virus neuramindase to inhibitors

BJ Smith, JL McKimm-Breshkin, M McDonald, RT Fernley, JN Varghese, PM Colman

Journal article  |  2002  |  Journal of Medicinal Chemistry

Neuraminidase inhibitors as antivirals

PM Colman

Conference Proceedings  |  2002  |  Vaccine

Modelling the structure of the fusion protein from human respiratory syncytial virus

BJ Smith, MC Lawrence, PM Colman

Journal article  |  2002  |  Protein Engineering, Design and Selection

Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus.

L Chen, PM Colman, LJ Cosgrove, MC Lawrence, LJ Lawrence, PA Tulloch, JJ Gorman

Journal article  |  2001  |  Virology

We have recently reported the X-ray crystal structure of a fragment of the fusion protein (F) of Newcastle disease virus (NDV). Th..

Analysis of inhibitor binding in influenza virus neuraminidase.

BJ Smith, PM Colman, M Von Itzstein, B Danylec, JN Varghese

Journal article  |  2001  |  Protein Science

2,3-didehydro-2-deoxy-N:-acetylneuraminic acid (DANA) is a transition state analog inhibitor of influenza virus neuraminidase (NA)..

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.

PG Wyatt, BA Coomber, DN Evans, TI Jack, HE Fulton, AJ Wonacott, P Colman, J Varghese

Journal article  |  2001  |  Bioorganic & Medicinal Chemistry Letters

SAR investigations of the 4- and 5-positions of a series of 4-amino-4H-pyran-2-carboxylic acid 6-carboxamides are reported. Potent..

The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.

L Chen, JJ Gorman, J McKimm-Breschkin, LJ Lawrence, PA Tulloch, BJ Smith, PM Colman, MC Lawrence

Journal article  |  2001  |  Structure

BACKGROUND: Membrane fusion within the Paramyxoviridae family of viruses is mediated by a surface glycoprotein termed the "F", or ..

Shape and electrostatic complementarity at viral antigen-antibody complexes.

VC Epa, PM Colman

Book  |  2001  |  Current Topics in Microbiology and Immunology

Neuraminidase inhibitors: progress in the management of influenza.

M Woodhead, D Lavanchy, S Johnston, P Colman, D Fleming

Journal article  |  2000  |  International Journal of Clinical Practice

Influenza is a serious respiratory illness and represents a significant clinical burden. As well as being debilitating, influenza ..

A novel approach to antiviral therapy for influenza.

PM Colman

Conference Proceedings  |  1999  |  Journal of Antimicrobial Chemotherapy

The influenza glycoprotein, neuraminidase, destroys sialic acid-containing receptors on the surface of infected cells and on proge..

Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase.

A Sahasrabudhe, L Lawrence, VC Epa, JN Varghese, PM Colman, JL McKimm-Breschkin

Journal article  |  1998  |  Virology

We have previously reported the isolation and characterization of an influenza virus variant with decreased sensitivity to the neu..

Three-dimensional structures of single-chain Fv-neuraminidase complexes.

RL Malby, AJ McCoy, AA Kortt, PJ Hudson, PM Colman

Journal article  |  1998  |  Journal of Molecular Biology

The structure of the complex between a recombinant single-chain Fv construct of antibody NC10 with a five-residue peptide linker b..

Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.

JN Varghese, PW Smith, SL Sollis, TJ Blick, A Sahasrabudhe, JL McKimm-Breschkin, PM Colman

Journal article  |  1998  |  Structure

BACKGROUND: Inhibitors of the influenza virus neuraminidase have been shown to be effective antiviral agents in humans. Several st..

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

NR Taylor, A Cleasby, O Singh, T Skarzynski, AJ Wonacott, PW Smith, SL Sollis, PD Howes, PC Cherry, R Bethell, P Colman, J Varghese

Journal article  |  1998  |  Journal of Medicinal Chemistry

The first paper in this series (see previous article) described structure-activity studies of carboxamide analogues of zanamivir b..

Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.

JL McKimm-Breschkin, A Sahasrabudhe, TJ Blick, M McDonald, PM Colman, GJ Hart, RC Bethell, JN Varghese

Journal article  |  1998  |  Journal of Virology

The influenza virus neuraminidase (NA)-specific inhibitor zanamivir (4-guanidino-Neu5Ac2en) is effective in humans when administer..

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.

JN Varghese, PM Colman, A van Donkelaar, TJ Blick, A Sahasrabudhe, JL McKimm-Breschkin

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza vir..

Virus versus antibody.

PM Colman

Journal article  |  1997  |  Structure

Variation in the proteins produced by animal viruses allows the virus to reinfect the same host, but is constrained by the require..

Electrostatic complementarity at protein/protein interfaces.

AJ McCoy, V Chandana Epa, PM Colman

Journal article  |  1997  |  Journal of Molecular Biology

Calculation of the electrostatic potential of protein-protein complexes has led to the general assertion that protein-protein inte..

Novel inhibitors of influenza sialidases related to GG167. Structure-activity, crystallographic and molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

PW Smith, SL Sollis, PD Howes, PC Cherry, KN Cobley, H Taylor, AR Whittington, J Scicinski, RC Bethell, N Taylor, T Skarzynski, A Cleasby, O Singh, A Wonacott, J Varghese, P Colman

Journal article  |  1996  |  Bioorganic & Medicinal Chemistry Letters

Chapter 6 The antigen-antibody complex: Structure and recognition

PM Colman

Journal article  |  1996  |  Principles of Medical Biology

Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme.

JL McKimm-Breschkin, M McDonald, TJ Blick, PM Colman

Journal article  |  1996  |  Virology

We previously isolated a variant of the influenza virus NWS/G70C, with a decreased sensitivity to the neuraminidase-specific inhib..

Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions.

M von Itzstein, P Colman

Journal article  |  1996  |  Current Opinion in Structural Biology

Our understanding of carbohydrate-protein interactions has significantly advanced over the past two years. In particular, a health..

Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the Neuraminidase-Specific inhibitor 4-guanidino-Neu5Ac2en

TJ Blick, T Tiong, A Sahasrabudhe, JN Varghese, PM Colman, GJ Hart, RC Bethell, JL McKimm-Breschkin

Journal article  |  1995  |  Virology

Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.

JN Varghese, VC Epa, PM Colman

Journal article  |  1995  |  Protein Science

The three-dimensional X-ray structure of a complex of the potent neuraminidase inhibitor 4-guanidino-Neu5Ac2en and influenza virus..

Design and antiviral properties of influenza virus neuraminidase inhibitors

PM Colman

Journal article  |  1995  |  Pure and Applied Chemistry

Structure-based drug design.

PM Colman

Journal article  |  1994  |  Current Opinion in Structural Biology

There are now many successful examples of the design of new ligands based on knowledge of target protein structures. In most cases..

Influenza virus neuraminidase: structure, antibodies, and inhibitors.

PM Colman

Journal article  |  1994  |  Protein Science

The determination of the 3-dimensional structure of the influenza virus neuraminidase in 1983 has served as a platform for underst..

THE STRUCTURE OF A COMPLEX BETWEEN THE NC10 ANTIBODY AND INFLUENZA-VIRUS NEURAMINIDASE AND COMPARISON WITH THE OVERLAPPING BINDING-SITE OF THE NC41 ANTIBODY

RL MALBY, WR TULIP, VR HARLEY, JL MCKIMMBRESCHKIN, WG LAVER, RG WEBSTER, PM COLMAN

Journal article  |  1994  |  Structure

Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.

MC Lawrence, T Izard, M Beuchat, RJ Blagrove, PM Colman

Journal article  |  1994  |  Journal of Molecular Biology

The refinement to 2.2 A resolution of the three-dimensional structure of the seed storage protein phaseolin from the French bean (..

THE 3-DIMENSIONAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM ESCHERICHIA-COLI

T IZARD, MC LAWRENCE, RL MALBY, GG LILLEY, PM COLMAN

Journal article  |  1994  |  Structure

RECOMBINANT ANTI-SIALIDASE SINGLE-CHAIN VARIABLE FRAGMENT ANTIBODY - CHARACTERIZATION, FORMATION OF DIMER AND HIGHER-MOLECULAR-MASS MULTIMERS AND THE SOLUTION OF THE CRYSTAL-STRUCTURE OF THE SINGLE-CHAIN VARIABLE FRAGMENT SIALIDASE COMPLEX

AA KORTT, RL MALBY, JB CALDWELL, LC GRUEN, N IVANCIC, MC LAWRENCE, GJ HOWLETT, RG WEBSTER, PJ HUDSON, PM COLMAN

Journal article  |  1994  |  European Journal of Biochemistry

Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities.

JN Varghese, TP Garrett, PM Colman, L Chen, PB Høj, GB Fincher

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

The three-dimensional structures of (1-->3)-beta-glucanase (EC 3.2.1.39) isoenzyme GII and (1-->3,1-->4)-beta-glucanase (EC 3.2.1...

Effects of amino acid sequence changes on antibody-antigen interactions.

PM Colman

Journal article  |  1994  |  Research in Immunology

Shape complementarity at protein/protein interfaces

MC Lawrence, PM Colman

Journal article  |  1993  |  Journal of Molecular Biology

Rational design of potent sialidase-based inhibitors of influenza virus replication.

M von Itzstein, WY Wu, GB Kok, MS Pegg, JC Dyason, B Jin, T Van Phan, ML Smythe, HF White, SW Oliver

Journal article  |  1993  |  Nature

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effectiv..

Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase.

PM Colman, PA Hoyne, MC Lawrence

Journal article  |  1993  |  Journal of Virology

A model is proposed for the three-dimensional structure of the paramyxovirus hemagglutinin-neuraminidase (HN) protein. The model i..

RECOMBINANT ANTINEURAMINIDASE SINGLE-CHAIN ANTIBODY - EXPRESSION, CHARACTERIZATION, AND CRYSTALLIZATION IN COMPLEX WITH ANTIGEN

RL MALBY, JB CALDWELL, LC GRUEN, VR HARLEY, N IVANCIC, AA KORTT, GG LILLEY, BE POWER, RG WEBSTER, PM COLMAN, PJ HUDSON

Journal article  |  1993  |  Proteins: Structure, Function, and Genetics

From X-ray Crystallography to Cure of Flu?

M Von Itzstein, WY Wu, GB Kok, MS Pegg, JC Dyason, B Jin, TV Phan, ML Smythe, HF White, SW Oliver, PM Colman, JN Varghese, DM Ryan, JM Woods, RC Bethell, VJ Hotham, JM Cameron, CR Penn

Journal article  |  1993  |  Trends in Glycoscience and Glycotechnology

CRYSTAL-STRUCTURE OF THE COMPLEX BETWEEN A SINGLE CHAIN ANTIBODY AND NEURAMINIDASE - A BASIS FOR RATIONAL PROTEIN ENGINEERING

RL MALBY, MC LAWRENCE, WR TULIP, VR HARLEY, RG WEBSTER, PJ HUDSON, PM COLMAN

Journal article  |  1993  |  Protein Engineering, Design and Selection

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.

JN Varghese, JL McKimm-Breschkin, JB Caldwell, AA Kortt, PM Colman

Journal article  |  1992  |  Proteins: Structure, Function, and Genetics

Crystallographic studies of neuraminidase-sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Thre..

CRYSTAL-STRUCTURES OF 2 MUTANT NEURAMINIDASE ANTIBODY COMPLEXES WITH AMINO-ACID SUBSTITUTIONS IN THE INTERFACE

WR TULIP, JN VARGHESE, RG WEBSTER, WG LAVER, PM COLMAN

Journal article  |  1992  |  Journal of Molecular Biology

REFINED CRYSTAL-STRUCTURE OF THE INFLUENZA VIRUS-N9 NEURAMINIDASE NC41 FAB COMPLEX

WR TULIP, JN VARGHESE, WG LAVER, RG WEBSTER, PM COLMAN

Journal article  |  1992  |  Journal of Molecular Biology

Structural basis of antigenic variation: studies of influenza virus neuraminidase.

PM Colman

Journal article  |  1992  |  Immunology and Cell Biology

Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution.

JN Varghese, PM Colman

Journal article  |  1991  |  Journal of Molecular Biology

An atomic model of the tetrameric surface glycoprotein neuraminidase of influenza virus A/Tokyo/3/67 has been built and refined ba..

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.

WR Tulip, JN Varghese, AT Baker, A van Donkelaar, WG Laver, RG Webster, PM Colman

Journal article  |  1991  |  Journal of Molecular Biology

The crystal structure of the N9 subtype neuraminidase of influenza virus was refined by simulated annealing and conventional techn..

Antigen-antigen receptor interactions. Current Opinion in Structural Biology 1991, 1:232-236

PM Colman

Journal article  |  1991  |  Current Opinion in Structural Biology

Influenza and antibody binding

J Varghese, W Tulip, P Colman

Journal article  |  1990  |  Today's Life Science

The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.

MC Lawrence, E Suzuki, JN Varghese, PC Davis, A Van Donkelaar, PA Tulloch, PM Colman

Journal article  |  1990  |  The EMBO Journal

The polypeptides of the trimeric seed storage protein phaseolin comprise two structurally similar units each made up of a beta-bar..

Conformations of immunoglobulin hypervariable regions.

C Chothia, AM Lesk, A Tramontano, M Levitt, SJ Smith-Gill, G Air, S Sheriff, EA Padlan, D Davies, WR Tulip

Journal article  |  1989  |  Nature

On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire..

Three-dimensional structures of influenza virus neuraminidase-antibody complexes.

PM Colman, WR Tulip, JN Varghese, PA Tulloch, AT Baker, WG Laver, GM Air, RG Webster

Journal article  |  1989  |  Philosophical Transactions of the Royal Society of London. B, Biological Sciences

X-ray diffraction analysis of crystals of a monoclonal Fab fragment NC41 bound to a viral antigen, influenza virus neuraminidase, ..

Crystal structures of neuraminidase-antibody complexes.

WR Tulip, JN Varghese, RG Webster, GM Air, WG Laver, PM Colman

Conference Proceedings  |  1989  |  Cold Spring Harbor Symposia on Quantitative Biology

Antigenic properties of influenza neuraminidases

GM Air, RG Webster, WG Laver, PM Colman

Conference Proceedings  |  1988  |  Virus Research

Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.

JN Varghese, RG Webster, WG Laver, PM Colman

Journal article  |  1988  |  Journal of Molecular Biology

The three-dimensional structure of the membrane glycoprotein neuraminidase of an escape mutant of the influenza virus strain A/Tok..

Structure of antibody-antigen complexes: implications for immune recognition.

PM Colman

Journal article  |  1988  |  Advances in Immunology

Distribution of sequence differences in influenza N9 neuraminidase of tern and whale viruses and crystallization of the whale neuraminidase complexed with antibodies.

GM Air, RG Webster, PM Colman, WG Laver

Journal article  |  1987  |  Virology

Neuraminidase genes from A/tern/Australia/G70C/75 (H11N9) and A/whale/Maine/1/84 (H13N9) influenza viruses have been sequenced. Se..

Antigenic structure and variation in an influenza virus N9 neuraminidase.

RG Webster, GM Air, DW Metzger, PM Colman, JN Varghese, AT Baker, WG Laver

Journal article  |  1987  |  Journal of Virology

We previously determined, by X-ray crystallography, the three-dimensional structure of a complex between influenza virus N9 neuram..

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.

PM Colman, WG Laver, JN Varghese, AT Baker, PA Tulloch, GM Air, RG Webster

Journal article  |  1987  |  Nature

The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexibl..

Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus.

AT Baker, JN Varghese, WG Laver, GM Air, PM Colman

Journal article  |  1987  |  Proteins: Structure, Function, and Genetics

Neuraminidases from different subtypes of influenza virus are characterized by the absence of serological cross-reactivity and an ..

How antibodies recognize virus proteins

PM Colman, GM Air, RG Webster, JN Varghese, AT Baker, MR Lentz, PA Tulloch, WG Laver

Journal article  |  1987  |  Immunology Today

Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens.

WG Laver, RG Webster, PM Colman

Journal article  |  1987  |  Virology

We describe here, for the first time, crystals of antibodies bound to a viral antigen which diffract X-rays to beyond 3 A. Crystal..

Electron and X-ray diffraction studies of influenza neuraminidase complexed with monoclonal antibodies.

PA Tulloch, PM Colman, PC Davis, WG Laver, RG Webster, GM Air

Journal article  |  1986  |  Journal of Molecular Biology

Complexes of influenza virus neuraminidase both with antigen-binding (Fab) fragments and with whole monoclonal antibody molecules ..

Gene and protein sequence of an influenza neuraminidase with hemagglutinin activity.

GM Air, LR Ritchie, WG Laver, PM Colman

Journal article  |  1985  |  Virology

An influenza virus neuraminidase (NA) of the N9 subtype also has hemagglutinin (HA) activity (W. G. Laver, P. M. Colman, R. G. Web..

Structure and diversity of influenza virus neuraminidase.

PM Colman, CW Ward

Journal article  |  1985  |  Current Topics in Microbiology and Immunology

Influenza virus neuraminidase with hemagglutinin activity.

WG Laver, PM Colman, RG Webster, VS Hinshaw, GM Air

Journal article  |  1984  |  Virology

Isolated intact influenza virus neuraminidase (NA) molecules of the N9 subtype have been found to possess hemagglutinin (HA) activ..

Three-dimensional structure of the Mcg IgG1 immunoglobulin.

SS Rajan, KR Ely, EE Abola, MK Wood, PM Colman, RJ Athay, AB Edmundson

Journal article  |  1983  |  Molecular Immunology

The three-dimensional structure of an IgG1(lambda) immunoglobulin from a patient (Mcg) with amyloidosis was determined at 6.5-A re..

Physicochemical and structural studies of phaseolin from French bean seed

RJ Blagrove, PM Colman, GG Lilley, A Van Donkelaar, E Suzuki

Journal article  |  1983  |  Plant Foods for Human Nutrition

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution.

JN Varghese, WG Laver, PM Colman

Journal article  |  1983  |  Nature

The influenza virus neuraminidase glycoprotein is a tetramer with a box-shaped head, 100 X 100 X 60 A, attached to a slender stalk..

Structure of the catalytic and antigenic sites in influenza virus neuraminidase.

PM Colman, JN Varghese, WG Laver

Journal article  |  1983  |  Nature

The catalytic sites of influenza virus neuraminidase are located on the upper corners of the box-shaped tetramer that forms the he..

The disulphide bonds of an Asian influenza virus neuraminidase.

CW Ward, PM Colman, WG Laver

Journal article  |  1983  |  FEBS Letters

The arrangement of the disulphide bonds in the pronase-released neuraminidase heads of the Asian influenza virus A/Tokyo/3/67 have..

Crystallization of phaseolin from Phaseolus vulgaris.

E Suzuki, A Van Donkelaar, JN Varghese, GG Lilley, RJ Blagrove, PM Colman

Journal article  |  1983  |  Journal of Biological Chemistry

Three different types of crystals were grown from phaseolin, the major storage body protein from French bean. Type I crystals are ..

Crystal structure of soybean ferric leghaemoglobin α nicotinate at a resolution of 3.3 Å

DL Ollis, CA Appleby, PM Colman, AE Cutten, J Mitchell Guss, MP Venkatappa, HC Freeman

Journal article  |  1983  |  Australian Journal of Chemistry

The crystal structure of soybean ferric leghaemoglobin a nicotinate has been solved at 3.3 � resolution by the multiple isomorphou..

Crystalline monoclonal fab fragment with specificity towards an influenza virus neuraminidase.

PM Colman, KH Gough, GG Lilley, RJ Blagrove, RG Webster, WG Laver

Journal article  |  1981  |  Journal of Molecular Biology

Particle and crystal symmetry of Erysimum latent virus.

PM Colman, PA Tulloch, DD Shukla, KH Gough

Journal article  |  1980  |  Journal of Molecular Biology

The structure of cucurbitin: subunit symmetry and organization in situ.

PM Colman, E Suzuki, A Van Donkelaar

Journal article  |  1980  |  European Journal of Biochemistry

The low-resolution (2 nm) subunit symmetry of cucurbitin, the crystalline seed storage globulin of cucurbits, has been determined ..

X-ray crystal structure analysis of plastocyanin at 2.7 Å resolution

PM Colman, HC Freeman, JM Guss, M Murata, VA Norris, JAM Ramshaw, MP Venkatappa

Journal article  |  1978  |  Nature

Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule.

M Matsushima, M Marquart, TA Jones, PM Colman, K Bartels, R Huber

Journal article  |  1978  |  Journal of Molecular Biology

Mobile Fc region in the Zie IgG2 cryoglobulin: comparison of crystals of the F(ab')2 fragment and the intact immunoglobulin.

KR Ely, PM Colman, EE Abola, AC Hess, DS Peabody, DM Parr, GE Connell, CA Laschinger, AB Edmundson

Journal article  |  1978  |  Biochemistry

Crystal and molecular structure of the dimer of variable domains of the Bence-Jones protein ROY.

PM Colman, HJ Schramm, JM Guss

Journal article  |  1977  |  Journal of Molecular Biology

Preliminary crystallographic data for a basic copper-containing protein from cucumber seedlings.

PM Colman, HC Freeman, JM Guss, M Murata, VA Norris, JA Ramshaw, MP Venkatappa, LE Vickery

Journal article  |  1977  |  Journal of Molecular Biology

Preliminary crystallographic data for a copper-containing protein, plastocyanin.

GV Chapman, PM Colman, HC Freeman, JM Guss, M Murata, VA Norris, JA Ramshaw, MP Venkatappa

Journal article  |  1977  |  Journal of Molecular Biology

Preliminary crystallographic data for a copper-containing protein, plastocyanin

GV Chapman, PM Colman, HC Freeman, JM Guss, M Mitsuo, VA Norris, JAM Ramshaw, MP Venkatappa

Journal article  |  1977  |  Journal of Molecular Biology

Crystallographic structure studies of an IgG molecule and an Fc fragment.

R Huber, J Deisenhofer, PM Colman, M Matsushima, W Palm

Journal article  |  1976  |  Nature

The crystal structures of a human IgG antibody molecule Kol and a human Fc fragment have been determined at 4-A and 3.4-A resoluti..

Crystallographic structural studies of a human Fc fragment. II. A complete model based on a Fourier map at 3.5 A resolution.

J Deisenhofer, PM Colman, O Epp, R Huber

Journal article  |  1976  |  Hoppe-Seyler´s Zeitschrift für physiologische Chemie

The crystal structure analysis of a human Fc fragment was pursued to 3.5 A resolution and a complete model was built and refined i..

Proceedings: X-ray diffraction analysis of immunoglobulin structure.

R Huber, J Deisenhofer, PM Colman, O Epp, H Fehlhammer, W Palm

Journal article  |  1976  |  Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

Subunit symmetry of tetrameric phosphorylase a.

K Bartels, PM Colman

Journal article  |  1976  |  Biophysics of Structure and Mechanism

Native crystallographic data of tetrameric phosphorylase a crystals, space group P21, have been collected photographically to 3 A ..

Crystallographic structural studies of a human Fc-fragment. I. An electron-density map at 4 A resolution and a partial model.

J Deisenhofer, PM Colman, R Huber, H Haupt, G Schwick

Journal article  |  1976  |  Hoppe-Seyler´s Zeitschrift für physiologische Chemie

The crystal structure of a human Fc fragment was analysed at 4 A resolution. A partial interpretation of the electron-density map ..

Structure of the human antibody molecule Kol (immunoglobulin G1): an electron density map at 5 A resolution.

PM Colman, J Deisenhofer, R Huber

Journal article  |  1976  |  Journal of Molecular Biology

The use of rotation and translation functions in the interpretation of low resolution electron density maps.

PM Colman, H Fehlhammer

Journal article  |  1976  |  Journal of Molecular Biology

The structure determination of the variable portion of the Bence-Jones protein Au.

H Fehlhammer, M Schiffer, O Epp, PM Colman, EE Lattman, P Schwager, W Steigemann, HJ Schramm

Journal article  |  1975  |  Biophysics of Structure and Mechanism

The structure of a pi-type Bence-Jones protein variable fragment Au has been determined by molecular replacement methods using the..

X-ray studies on antibody fragments.

PM Colman, O Epp, H Fehlhammer, W Bode, M Schiffer, EE Lattman, TA Jones, W Palm

Journal article  |  1974  |  FEBS Letters

Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI.

O Epp, P Colman, H Fehlhammer, W Bode, M Schiffer, R Huber, W Palm

Journal article  |  1974  |  European Journal of Biochemistry

Letter: Preliminary x-ray data from well-ordered crystals of a human immunoglobulin G molecule.

W Palm, PM Colman

Journal article  |  1974  |  Journal of Molecular Biology

Nonerystallographic symmetry and the sampling theorem

PM Colman

Journal article  |  1974  |  Zeitschrift für Kristallographie - Crystalline Materials

AbstractWhen the asymmetric unit of a crystal structure expresses some noncrystallographic symmetry it is often found that these l..

A computer controlled film scanner for x-ray crystallography

BW Matthews, CE Klopfenstein, PM Colman

Journal article  |  1972  |  Journal of Physics E: Scientific Instruments

The structure of thermolysin: an electron density map at 2-3 A resolution.

PM Colman, JN Jansonius, BW Matthews

Journal article  |  1972  |  Journal of Molecular Biology

Three-dimensional structure of thermolysin.

BW Matthews, JN Jansonius, PM Colman, BP Schoenborn, D Dupourque

Journal article  |  1972  |  Nature New Biology

Structure of thermolysin.

BW Matthews, PM Colman, JN Jansonius, K Titani, KA Walsh, H Neurath

Journal article  |  1972  |  Nature New Biology

Rare earths as isomorphous calcium replacements for protein crystallography.

PM Colman, LH Weaver, BW Matthews

Journal article  |  1972  |  Biochemical and Biophysical Research Communications

Symmetry, molecular weight and crystallographic data for sweet potato -amylase.

PM Colman, BW Matthews

Journal article  |  1971  |  Journal of Molecular Biology