Peter Colman

An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration.

Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S Chahal, Jiamin Zhao, Peter M Colman, Leonie M Quinn, Jacqueline M Gulbis

Journal article  |  2022  |  Sci Rep

Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer's Disease. ..

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the alpha 1-alpha 2 loop in BAK activation

Adeline Y Robin, Michelle S Miller, Sweta Iyer, Melissa X Shi, Ahmad Z Wardak, Daisy Lio, Nicholas A Smith, Brian J Smith, Richard W Birkinshaw, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Pro-apoptotic BAK and BAX are activated by BH3-only proteins to permeabilise the outer mitochondrial membrane. The antibody 7D10 a..

The Bak core dimer focuses triacylglycerides in the membrane

Nicholas A Smith, Ahmad Z Wardak, Angus D Cowan, Peter M Colman, Peter E Czabotar, Brian J Smith

Journal article  |  2022  |  BIOPHYSICAL JOURNAL

Apoptosis, the intrinsic programmed cell death process, is mediated by the Bcl-2 family members Bak and Bax. Activation via format..

Ion currents through Kir potassium channels are gated by anionic lipids

Ruitao Jin, Sitong He, Katrina A Black, Oliver B Clarke, Di Wu, Jani R Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M Colman, Carol Robinson, Derek Laver, Brian J Smith, Jacqueline M Gulbis

Journal article  |  2022  |  NATURE COMMUNICATIONS

Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textb..

Structure of detergent-activated BAK dimers derived from the inert monomer

Richard W Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S Luo, Jason M Brouwer, Michelle S Miller, Adeline Y Robin, Rachel T Uren, Grant Dewson, Ruth M Kluck, Peter M Colman, Peter E Czabotar

Journal article  |  2021  |  MOLECULAR CELL

A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of..

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X-L and BCL-2

Michael J Roy, Amelia Vom, Toru Okamoto, Brian J Smith, Richard W Birkinshaw, Hong Yang, Houda Abdo, Christine A White, David Segal, David CS Huang, Jonathan B Baell, Peter M Colman, Peter E Czabotar, Guillaume Lessene

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-XL, and MCL-1) is an important target for the developm..

Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2

William Nguyen, Erinna F Lee, Marco Evangelista, Mihwa Lee, Tiffany J Harris, Peter M Colman, Nicholas A Smith, Luke B Williams, Kate E Jarman, Kym N Lowes, Cecile Haeberli, Jennifer Keiser, Brian J Smith, W Douglas Fairlie, Brad E Sleebs

Journal article  |  2021  |  ACS INFECTIOUS DISEASES

Limited therapeutic options are available for the treatment of human schistosomiasis caused by the parasitic Schistosoma flatworm...

BAK core dimers bind lipids and can be bridged by them

Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of t..

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura CA Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David CS Huang, Andreas Strasser, Marc Kvansakul, Martin Rowe, Gemma L Kelly

Journal article  |  2020  |  CELL DEATH AND DIFFERENTIATION

Epstein-Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  NATURE CHEMICAL BIOLOGY

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..