James McCluskey

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G Nelson, Bronte Ennis, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M Lew, Daniel G Pellicci, James McCluskey, Yifan Zhan, et al.

Journal article  |  2023  |  CELL DEATH & DISEASE

Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell de..

Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

Caroline L Ashley, Brian P McSharry, Hamish EG McWilliam, Richard J Stanton, Ceri A Fielding, Rommel A Mathias, David P Fairlie, James McCluskey, Jose A Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

INTRODUCTION: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to presen..

Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I-related protein 1 MR1

Carl JH Wang, Wael Awad, Ligong Liu, Jeffrey YW Mak, Natacha Veerapen, Patricia T Illing, Anthony W Purcell, Sidonia BG Eckle, James McCluskey, Gurdyal S Besra, David P Fairlie, Jamie Rossjohn, Jerome Le Nours

Journal article  |  2022  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The Major Histocompatibility Complex class I-related protein 1 (MR1) presents small molecule metabolites, drugs, and drug-like mol..

The establishment of a cytomegalovirus -specific CD8( ) T-cell threshold by kinetic modeling for the prediction of post-hemopoietic stem cell transplant reactivation

Jing Zhang, Jinpeng Cao, Runhui Zheng, Mengqiu Yu, Zhengfang Lin, Caixia Wang, James McCluskey, Ji Yang, Zhenjun Chen, Alexandra J Corbett, Pengxing Cao, Wenjian Mo, Zhongfang Wang

Journal article  |  2022  |  ISCIENCE

The dynamic interaction between the CMV virus and host immune response remains obscure, thus hindering the diagnosis and therapeut..

The role of mucosal-associated invariant T cells in visceral leishmaniasis

Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antonio Pascoal-Xavier, Agata Lopes Ribeiro, Victoria Hellena Silva Pereira, Troi Pediongco, Marcio Sobreira da Silva Araujo, Andrea Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitoria Assumpcao Mourao, Flavia Alves Campos, Marineide Borges, Mariangela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are restricted by MR1 and are known to protect against bacterial and viral infections...

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection

Huimeng Wang, Adam G Nelson, Bingjie Wang, Zhe Zhao, Xin Yi Lim, Mai Shi, Lucy J Meehan, Xiaoxiao Jia, Katherine Kedzierska, Bronwyn S Meehan, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Jeffrey YW Mak, David P Fairlie, James McCluskey, Zhongfang Wang, Alexandra J Corbett, Zhenjun Chen

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infec..

Dual TCR-alpha Expression on Mucosal-Associated Invariant T Cells as a Potential Confounder of TCR Interpretation

Sara Suliman, Lars Kjer-Nielsen, Sarah K Iwany, Kattya Lopez Tamara, Liyen Loh, Ludivine Grzelak, Katherine Kedzierska, Tonatiuh A Ocampo, Alexandra J Corbett, James McCluskey, Jamie Rossjohn, Segundo R Leon, Roger Calderon, Leonid Lecca-Garcia, Megan B Murray, D Branch Moody, Ildiko Van Rhijn

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are highly abundant in human blood and tissues. Most MAIT..

Differential location of NKT and MAIT cells within lymphoid tissue

Darryl N Johnson, Zheng Ruan, Emma Petley, Sapna Devi, Lauren E Holz, Adam P Uldrich, Jeffrey YW Mak, Jyh Liang Hor, Scott N Mueller, James McCluskey, David P Fairlie, Phillip K Darcy, Paul A Beavis, William R Heath, Dale Godfrey

Journal article  |  2022  |  SCIENTIFIC REPORTS

Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant α..

Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..