James Holden

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  JOURNAL OF CLINICAL PERIODONTOLOGY

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

Celogentin mimetics as inhibitors of tubulin polymerization

Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2020  |  JOURNAL OF PEPTIDE SCIENCE

Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether ..

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Tao Huang, James A Holden, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2019  |  Nanoscale

The overuse of antibiotics has induced the rapid development of antibiotic resistance in bacteria. As a result, antibiotic efficac..

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2018  |  ADVANCED HEALTHCARE MATERIALS

In this work, the effect of two key structural parameters, number of arms and arm length, of star-shaped "structurally nanoenginee..

Designing antibiotic peptide polymer adjuvants for multidrug resistant bacteria

Neil O'Brien-Simpson, Shu Lam, Jason C Lenzo, James Holden, Greg Qiao, Eric Reynolds

Conference Proceedings  |  2018  |  JOURNAL OF PEPTIDE SCIENCE

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  PEPTIDE SCIENCE

To combat the serious issue of increasing global antibiotic resistance, new antimicrobial therapies are urgently required. As one ..

Antimicrobial activity of simplified mimics of celogentin C

Varsha J Thombare, James A Holden, Sreetama Pal, Eric C Reynolds, Amitabha Chattopadhyay, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2018  |  TETRAHEDRON

Linear and bicyclic analogues of the peptide natural product, celogentin C, have been prepared in which the sidechain–sidechain cr..

Biocompatibility and Osteogenic/Calcification Potential of Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride

Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF ENDODONTICS

INTRODUCTION: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and CPP-ACP with fluoride (CPP-ACFP) have been shown to ..

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2

James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca KH Orth, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  INFECTION AND IMMUNITY

Porphyromonas gulae is an anaerobic, Gram-negative coccobacillus that has been associated with periodontal disease in companion an..