James Holden

Star-Peptide Polymers are Multi-Drug-Resistant Gram-Positive Bacteria Killers

Wenyi Li, Sara Hadjigol, Alicia Rasines Mazo, James Holden, Jason Lenzo, Steven J Shirbin, Anders Barlow, Sadegh Shabani, Tao Huang, Eric C Reynolds, Greg G Qiao, Neil M O'Brien-Simpson

Journal article  |  2022  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum ..

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

Wenyi Li, Feng Lin, Andrew Hung, Anders Barlow, Marc-Antoine Sani, Rita Paolini, William Singleton, James Holden, Mohammed Akhter Hossain, Frances Separovic, Neil M O'Brien-Simpson, John D Wade

Journal article  |  2022  |  CHEMICAL SCIENCE

Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum a..

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers

Tamara Matthyssen, Wenyi Li, James A Holden, Jason C Lenzo, Sara Hadjigol, Neil M O'Brien-Simpson

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum antibacterial activity, and can modula..

The Potential of Calcium Phosphate Nanoparticles as Adjuvants and Vaccine Delivery Vehicles

Zhe Sun, Wenyi Li, Jason C Lenzo, James A Holden, Michael J McCullough, Andrea J O'Connor, Neil M O'Brien-Simpson

Journal article  |  2021  |  FRONTIERS IN MATERIALS

Vaccination is one of the most efficacious and cost-effective ways to protect people from infectious diseases and potentially canc..

Tumor Associated Macrophages: Origin, Recruitment, Phenotypic Diversity, and Targeting

Tetiana Hourani, James A Holden, Wenyi Li, Jason C Lenzo, Sara Hadjigol, Neil M O'Brien-Simpson

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

The tumor microenvironment (TME) is known to have a strong influence on tumorigenesis, with various components being involved in t..

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  ACS APPLIED MATERIALS & INTERFACES

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  JOURNAL OF CLINICAL PERIODONTOLOGY

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

Celogentin mimetics as inhibitors of tubulin polymerization

Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2020  |  JOURNAL OF PEPTIDE SCIENCE

Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether ..

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Tao Huang, James A Holden, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2019  |  Nanoscale

The overuse of antibiotics has induced the rapid development of antibiotic resistance in bacteria. As a result, antibiotic efficac..

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2018  |  ADVANCED HEALTHCARE MATERIALS

In this work, the effect of two key structural parameters, number of arms and arm length, of star-shaped "structurally nanoenginee..