James Holden

Celogentin mimetics as inhibitors of tubulin polymerization

Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2020  |  Journal of Peptide Science

Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether ..

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Tao Huang, James A Holden, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2019  |  Nanoscale

The overuse of antibiotics has induced the rapid development of antibiotic resistance in bacteria. As a result, antibiotic efficac..

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2018  |  Advanced Healthcare Materials

Designing antibiotic peptide polymer adjuvants for multidrug resistant bacteria

Neil O'Brien-Simpson, Shu Lam, Jason C Lenzo, James Holden, Greg Qiao, Eric Reynolds

Conference Proceedings  |  2018  |  JOURNAL OF PEPTIDE SCIENCE

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  PEPTIDE SCIENCE

Antimicrobial activity of simplified mimics of celogentin C

Varsha J Thombare, James A Holden, Sreetama Pal, Eric C Reynolds, Amitabha Chattopadhyay, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2018  |  Tetrahedron

Biocompatibility and Osteogenic/Calcification Potential of Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride

Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2018  |  Journal of Endodontics

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2

James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca KH Orth, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  Infection and Immunity

Outer Membrane Vesicles Prime and Activate Macrophage Inflammasomes and Cytokine Secretion In Vitro and In Vivo

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, William Singleton, Alexis Perez-Gonzalez, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  Frontiers in Immunology

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  npj Vaccines

Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers

Shu J Lam, Neil M O'Brien-Simpson, Namfon Pantarat, Adrian Sulistio, Edgar HH Wong, Yu-Yen Chen, Jason C Lenzo, James A Holden, Anton Blencowe, Eric C Reynolds, Greg G Qiao

Journal article  |  2016  |  Nature Microbiology

TARGETING AND KILLING MULTIDRUG-RESISTANT BACTERIA WITH POLYPEPTIDE STAR NANOPARTICLES

N O'Brien-Simpson, S Lam, N Pantarat, A Sulistio, E Wong, Y-Y Chen, J Lenzo, J Holden, A Blencowe, G Qiao, E Reynolds

Conference Proceedings  |  2016  |  JOURNAL OF PEPTIDE SCIENCE

Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis

R Lam, N O'Brien-Simpson, J Holden, J Lenzo, SB Fong, E Reynolds

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Porphyromonas gulae activates M1 macrophages via TLR2, TLR4 and NOD2

J Holden, J Lenzo, R Orth, NM O'Brien-Simpson, EC Reynolds

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis

Roselind S Lam, Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Shao B Fong, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Determination of Active Phagocytosis of Unopsonized Porphyromonas gingivalis by Macrophages and Neutrophils Using the pH-Sensitive Fluorescent Dye pHrodo

Jason C Lenzo, Neil M O'Brien-Simpson, Jessica Cecil, James A Holden, Eric C Reynolds

Journal article  |  2016  |  Infection and Immunity

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

Jessica D Cecil, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Yu-Yen Chen, William Singleton, Katelyn T Gause, Yan Yan, Frank Caruso, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors

Paul D Veith, Yu-Yen Chen, Dina Chen, Neil M O'Brien-Simpson, Jessica D Cecil, James A Holden, Jason C Lenzo, Eric C Reynolds

Journal article  |  2015  |  Journal of Proteome Research

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model

Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds

Journal article  |  2015  |  Immunology & Cell Biology

Porphyromonas gingivalis Lipopolysaccharide Weakly Activates M1 and M2 Polarized Mouse Macrophages but Induces Inflammatory Cytokines

James A Holden, Troy J Attard, Katrina M Laughton, Ashley Mansell, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2014  |  Infection and Immunity

Macrophage Depletion Abates Porphyromonas gingivalis-Induced Alveolar Bone Resorption in Mice

Roselind S Lam, Neil M O'Brien-Simpson, Jason C Lenzo, James A Holden, Gail C Brammar, Katrina A Walsh, Judith E McNaughtan, Dennis K Rowler, Nico Van Rooijen, Eric C Reynolds

Journal article  |  2014  |  Journal of Immunology

Porphyromonas gingivalis Outer Membrane Vesicles Exclusively Contain Outer Membrane and Periplasmic Proteins and Carry a Cargo Enriched with Virulence Factors

Paul D Veith, Yu-Yen Chen, Dhana G Gorasia, Dina Chen, Michelle D Glew, Neil M O'Brien-Simpson, Jessica D Cecil, James A Holden, Eric C Reynolds

Journal article  |  2014  |  Journal of Proteome Research

Porphyromonas gingivalis LPS induces cytokine secretion in macrophages without costimulatory marker expression

J Holden, NM O'Brien-Simpson, EC Reynolds

Journal article  |  2012  |  Immunology

The Multi-Copper-Ion Oxidase CueO of Salmonella enterica Serovar Typhimurium Is Required for Systemic Virulence

Maud ES Achard, Jai J Tree, James A Holden, Kim R Simpfendorfer, Odilia LC Wijburg, Richard A Strugnell, Mark A Schembri, Matthew J Sweet, Michael P Jennings, Alastair G McEwan

Journal article  |  2010  |  Infection and Immunity

Spatially resolved force spectroscopy of bacterial surfaces using force-volume imaging

Fabien Gaboriaud, Bhargava S Parcha, Michelle L Gee, James A Holden, Richard A Strugnell

Journal article  |  2008  |  Colloids and Surfaces B: Biointerfaces

An evaluation of the immunogenicity and protective responses to Brachyspira hyodysenteriae recombinant SmpB vaccination

James Holden, Peter J Coloe, Peter M Smooker

Journal article  |  2008  |  Veterinary Microbiology

Gamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar typhimurium

Jason D Price, Kim R Simpfendorfer, Radhakrishnam R Mantena, James Holden, William R Heath, Nico van Rooijen, Richard A Strugnell, Odilia LC Wijburg

Journal article  |  2007  |  Infection and Immunity

Bacterial surface properties of Shewanella spp. as probed by force spectroscopy and microelectrophoresis

Etienne Daguel, Jerome FL Duval, Michelle L Gee, James A Holden, Richard Strugnell, Fabien Gaboriaud

Journal article  |  2007  |  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

SmpB: A novel outer membrane protein present in some Brachyspira hyodysenteriae strains

James Holden, George Moutafis, Taghrid Istivan, Peter J Coloe, Peter M Smooker

Journal article  |  2006  |  Veterinary Microbiology