James Holden

Multifunctional Antimicrobial Polypeptide-Selenium Nanoparticles Combat Drug-Resistant Bacteria

Tao Huang, James A Holden, Eric C Reynolds, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2020  |  ACS Applied Materials & Interfaces

Antibiotic-resistant bacteria are a severe threat to human health. The World Health Organization's Global Antimicrobial Surveillan..

Peripheral memory T-cell profile is modified in patients undergoing periodontal management

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson

Journal article  |  2020  |  Journal Of Clinical Periodontology

AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells i..

Celogentin mimetics as inhibitors of tubulin polymerization

Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2020  |  Journal of Peptide Science

Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether ..

Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Tao Huang, James A Holden, Daniel E Heath, Neil M O'Brien-Simpson, Andrea J O'Connor

Journal article  |  2019  |  Nanoscale

The overuse of antibiotics has induced the rapid development of antibiotic resistance in bacteria. As a result, antibiotic efficac..

Architectural Effects of Star-Shaped "Structurally Nanoengineered Antimicrobial Peptide Polymers" (SNAPPs) on Their Biological Activity

Steven J Shirbin, Ignacio Insua, James A Holden, Jason C Lenzo, Eric C Reynolds, Neil M O'Brien-Simpson, Greg G Qiao

Journal article  |  2018  |  Advanced Healthcare Materials

Designing antibiotic peptide polymer adjuvants for multidrug resistant bacteria

Neil O'Brien-Simpson, Shu Lam, Jason C Lenzo, James Holden, Greg Qiao, Eric Reynolds

Conference Proceedings  |  2018  |  JOURNAL OF PEPTIDE SCIENCE

Covalent conjugation of cationic antimicrobial peptides with a beta-lactam antibiotic core

Wenyi Li, Neil M O'Brien-Simpson, James A Holden, Laszlo Otvos, Eric C Reynolds, Frances Separovic, Mohammed Akhter Hossain, John D Wade

Journal article  |  2018  |  PEPTIDE SCIENCE

Antimicrobial activity of simplified mimics of celogentin C

Varsha J Thombare, James A Holden, Sreetama Pal, Eric C Reynolds, Amitabha Chattopadhyay, Neil M O'Brien-Simpson, Craig A Hutton

Journal article  |  2018  |  Tetrahedron

Biocompatibility and Osteogenic/Calcification Potential of Casein Phosphopeptide-amorphous Calcium Phosphate Fluoride

Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF ENDODONTICS

Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2

James A Holden, Neil M O'Brien-Simpson, Jason C Lenzo, Rebecca KH Orth, Ashley Mansell, Eric C Reynolds

Journal article  |  2017  |  INFECTION AND IMMUNITY