Richard Pearson

Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload

Chentao Ge, Hemiao Huang, Feiyan Huang, Tianxin Yang, Tengfei Zhang, Hongzhang Wu, Hanwei Zhou, Qi Chen, Yue Shi, Yanfang Sun, Liangjue Liu, Xi Wang, Richard B Pearson, Yihai Cao, Jian Kang, Caiyun Fu

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery, Ella R Thompson, Andrew Fellowes, Karen E Sheppard, Grant A McArthur, Richard B Pearson, Ross D Hannan, Gretchen Poortinga, Simon J Harrison

Journal article  |  2019  |  Cancer Discovery

RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and it..

A functional genetic screen defines the AKT-induced senescence signaling network.

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2019  |  Cell Death Differ

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers, Victoria W Wen, Shiloh MC Middlemiss, Brenna Osborne, Helen Forgham, MoonSun Jung, Mawar Karsa, Molly Clifton, Angelika Bongers, Jixuan Gao, Chelsea Mayoh, Newsha Raoufi-Rad, Eric P Kusnadi, Kate M Hannan, David A Scott, Alan Kwek, Bing Liu, Claudia Flemming, Daria A Chudakova, Ruby Pandher, et al.

Journal article  |  2019  |  Oncogene

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode

Journal article  |  2019  |  eLife

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen RD Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Journal article  |  2019  |  Communications Biology

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, Nadine Hein, Jun Chen, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, Thomas John Gonda, Richard B Pearson, Johan Flygare, Katherine M Hannan, Amee J George, Ross Hannan

Conference Proceedings  |  2018  |  Blood

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Mitchell G Lawrence, Daisuke Obinata, Shahneen Sandhu, Luke A Selth, Stephen Q Wong, Laura H Porter, Natalie Lister, David Pook, Carmel J Pezaro, David L Goode, Richard J Rebello, Ashlee K Clark, Melissa Papargiris, Jenna Van Gramberg, Adrienne R Hanson, Patricia Banks, Hong Wang, Birunthi Niranjan, Shivakumar Keerthikumar, Shelley Hedwards, et al.

Journal article  |  2018  |  European Urology

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  Nature Communications

Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer

Anna Trigos, Rick Pearson, Anthony Papenfuss, David Goode

Journal article  |  2018  |  eLife

Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unic..

The dual inhibition of RNA Pol I transcription and PIM kinase as a new therapeutic approach to treat advanced prostate cancer.

Richard Rebello, Eric Kusnadi, Donald P Cameron, Pearson Helen, Denis Drygin, Shahneen Sandhu, Gail Risbridger, Richard B Pearson, Ross D Hannan, Luc Furic

Conference Proceedings  |  2018  |  CANCER RESEARCH

Using the evolutionary ages of genes to understand hallmark features of cancer

David L Goode, Anna S Trigos, Anthony T Papenfuss, Richard B Pearson

Conference Proceedings  |  2018  |  Bioinformatics and Systems Biology

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane

Journal article  |  2018  |  Cell Death & Differentiation

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naive melanoma but not after the development of BRAF inhibitor resistance

Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Kelly Waldeck, Richard J Young, Natalie Brajanovski, Donald P Cameron, Rachael Walker, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Richard B Pearson, Rodney J Hicks, Grant A McArthur, Karen E Sheppard

Journal article  |  2018  |  International Journal of Cancer

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama, Elaine Sanij, Hsiao PJ Voon, Jinbae Son, Linda Hii, Jeremy D Henson, F Lyn Chan, Fiona TM Chang, Yumei Liu, Richard B Pearson, Paul Kalitsis, Jeffrey R Mann, Philippe Collas, Ross D Hannan, Lee H Wong

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

How the evolution of multicellularity set the stage for cancer

Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode

Journal article  |  2018  |  British Journal of Cancer

Cystathionine beta-Synthase in Physiology and Cancer

Haoran Zhu, Shaun Blake, Keefe T Chan, Richard B Pearson, Jian Kang

Journal article  |  2018  |  BioMed Research International

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors

Anna S Trigos, Richard B Pearson, Anthony T Papenfuss, David L Goode

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  Gene

A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson

Conference Proceedings  |  2017  |  Synthetic Lethality and Viability

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

George Au-Yeung, Franziska Lang, Walid J Azar, Chris Mitchell, Kate E Jarman, Kurt Lackovic, Diar Aziz, Carleen Cullinane, Richard B Pearson, Linda Mileshkin, Danny Rischin, Alison M Karst, Ronny Drapkin, Dariush Etemadmoghadam, David DL Bowtell

Journal article  |  2017  |  Clinical Cancer Research

Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

Richard J Rebello, Richard B Pearson, Ross D Hannan, Luc Furic

Journal article  |  2017  |  Genes

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M Hannan, Ross D Hannan, Keefe T Chan, Richard B Pearson, Elaine Sanij

Journal article  |  2017  |  International Journal of Molecular Sciences

The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer

Richard J Rebello, Eric Kusnadi, Donald P Cameron, Helen B Pearson, Analia Lesmana, Jennifer R Devlin, Denis Drygin, Ashlee K Clark, Laura Porter, John Pedersen, Shahneen Sandhu, Gail P Risbridger, Richard B Pearson, Ross D Hannan, Luc Furic

Journal article  |  2016  |  Clinical Cancer Research

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence

Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Jian Kang, Eric P Kusnadi, Allison J Ogden, Rodney J Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D Hannan, Katherine M Hannan, Richard B Pearson

Journal article  |  2016  |  Oncotarget

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Naomi C Mitchell, Elissaveta B Tchoubrieva, Arjun Chahal, Simone Woods, Amanda Lee, Jane I Lin, Linda Parsons, Katarzyna Jastrzebski, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  Cellular Signalling

The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Rachel Ramsdale, Robert N Jorissen, Frederic Z Li, Sheren Al-Obaidi, Teresa Ward, Karen E Sheppard, Patricia E Bukczynska, Richard J Young, Samantha E Boyle, Mark Shackleton, Gideon Bollag, Georgina V Long, Eugene Tulchinsky, Helen Rizos, Richard B Pearson, Grant A McArthur, Amardeep S Dhillon, Petranel T Ferrao

Journal article  |  2015  |  Science Signaling

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Simone J Woods, Katherine M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Sally J Davis, Karen E Sheppard, Michael S Anglesio, Joshy George, Nadia Traficante, Sian Fereday, Maria P Intermaggio, Usha Menon, Aleksandra Gentry-Maharaj, Jan Lubinski, Jacek Gronwald, Celeste Leigh Pearce, Malcolm C Pike, Anna Wu, Stefan Kommoss, Jacobus Pfisterer, Andreas du Bois, Felix Hilpert, Susan J Ramus, David DL Bowtell, et al.

Journal article  |  2015  |  Molecular Cancer Therapeutics

Unexpected role of CDK4 in a G2/M checkpoint

Karen E Sheppard, Richard B Pearson, Ross D Hannan

Journal article  |  2015  |  Cell Cycle

PR55 alpha-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity

O Gilan, J Diesch, M Amalia, K Jastrzebski, AC Chueh, NM Verrills, RB Pearson, JM Mariadason, E Tulchinsky, RD Hannan, AS Dhillon

Journal article  |  2015  |  Oncogene

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Eric P Kusnadi, Katherine M Hannan, Rodney J Hicks, Ross D Hannan, Richard B Pearson, Jian Kang

Journal article  |  2015  |  Gene

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

Elaine Sanij, Jeannine Diesch, Analia Lesmana, Gretchen Poortinga, Nadine Hein, Grace Lidgerwood, Donald P Cameron, Jason Ellul, Gregory J Goodall, Lee H Wong, Amardeep S Dhillon, Nourdine Hamdane, Lawrence I Rothblum, Richard B Pearson, Izhak Haviv, Tom Moss, Ross D Hannan

Journal article  |  2015  |  Genome Research

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Richard J Young, Kelly Waldeck, Claire Martin, Jung H Foo, Donald P Cameron, Laura Kirby, Hongdo Do, Catherine Mitchell, Carleen Cullinane, Wendy Liu, Stephen B Fox, Ken Dutton-Regester, Nicholas K Hayward, Nicholas Jene, Alexander Dobrovic, Richard B Pearson, James G Christensen, Sophia Randolph, Grant A McArthur, Karen E Sheppard

Journal article  |  2014  |  Pigment Cell & Melanoma Research

Targeting the nucleolus for cancer intervention

Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2014  |  Biochimica et Biophysica Acta-Molecular Basis of Disease

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Tiffany J Parmenter, Margarete Kleinschmidt, Kathryn M Kinross, Simon T Bond, Jason Li, Mohan R Kaadige, Aparna Rao, Karen E Sheppard, Willy Hugo, Gulietta M Pupo, Richard B Pearson, Sean L Mcgee, Georgina V Long, Richard A Scolyer, Helen Rizos, Roger S Lo, Carleen Cullinane, Donald E Ayer, Antoni Ribas, Ricky W Johnstone, et al.

Journal article  |  2014  |  Cancer Discov

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon

Journal article  |  2014  |  PLoS One

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  European Journal of Cancer

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

Journal article  |  2013  |  The FEBS Journal

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

BD Green, AM Jabbour, JJ Sandow, CD Riffkin, D Masouras, CP Daunt, M Salmanidis, G Brumatti, BA Hemmings, MA Guthridge, RB Pearson, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

Ross D Hannan, Denis Drygin, Richard B Pearson

Journal article  |  2013  |  Expert Opinion On Therapeutic Targets

Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Megan J Bywater, Richard B Pearson, Grant A McArthur, Ross D Hannan

Journal article  |  2013  |  Nature Reviews Cancer

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  Blood

Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer

Sally J Davis, Karen E Sheppard, Richard B Pearson, Ian G Campbell, Kylie L Gorringe, Kaylene J Simpson

Journal article  |  2013  |  Clinical Cancer Research

Dysregulation of RNA polymerase I transcription during disease

KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson

Journal article  |  2013  |  Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, et al.

Journal article  |  2013  |  PLoS Genetics

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

Journal article  |  2013  |  Cancer Discovery

AKT-independent PI3-K signaling in cancer - emerging role for SGK3.

Maressa A Bruhn, Richard B Pearson, Ross D Hannan, Karen E Sheppard

Journal article  |  2013  |  Cancer Management and Research

The phosphoinositide 3-kinase (PI3-K) signaling pathway plays an important role in a wide variety of fundamental cellular processe..

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

Meredith J Layton, Mirette Saad, Nicole L Church, Richard B Pearson, Christina A Mitchell, Wayne A Phillips

Journal article  |  2012  |  BMC Biochemistry

Too much or too little Harnessing senescence to control oncogene-driven cancer

Katherine M Hannan, Richard B Pearson

Journal article  |  2012  |  Cell Cycle

LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Prue A Cowin, Joshy George, Sian Fereday, Elizabeth Loehrer, Peter Van Loo, Carleen Cullinane, Dariush Etemadmoghadam, Sarah Ftouni, Laura Galletta, Michael S Anglesio, Joy Hendley, Leanne Bowes, Karen E Sheppard, Elizabeth L Christie, Richard B Pearson, Paul R Harnett, Viola Heinzelmann-Schwarz, Michael Friedlander, Orla McNally, Michael Quinn, et al.

Journal article  |  2012  |  Cancer Research

Targeting cancer with PI3K pathway inhibitors: who to aim at?

Kathryn M Kinross, Karen E Sheppard, Richard B Pearson, Wayne A Phillips

Journal article  |  2012  |  Translational Cancer Research

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bliesath, Mustapha Haddach, Michael K Schwaebe, David M Ryckman, William G Rice, Clemens Schmitt, Scott W Lowe, Ricky W Johnstone, et al.

Journal article  |  2012  |  Cancer Cell

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, RD Hannan, RB Pearson

Journal article  |  2012  |  Oncogene

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur, et al.

Journal article  |  2012  |  Journal of Clinical Investigation

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

Karen Sheppard, Kathryn M Kinross, Benjamin Solomon, Richard B Pearson, Wayne A Phillips

Journal article  |  2012  |  Critical Reviews in Oncogenesis

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating cell growth, proliferation, metabolism, s..

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone

Jane I Lin, Naomi C Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J Stewart, Steven J Marygold, Cherryl D Walker, George Thomas, Sally J Leevers, Richard B Pearson, Leonie M Quinn, Ross D Hannan

Journal article  |  2011  |  PLoS Genetics

Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis

Charbel Darido, Smitha R Georgy, Tomasz Wilanowski, Sebastian Dworkin, Alana Auden, Quan Zhao, Gerhard Rank, Seema Srivastava, Moira J Finlay, Anthony T Papenfuss, Pier Paolo Pandolfi, Richard B Pearson, Stephen M Jane

Journal article  |  2011  |  Cancer Cell

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  Science Signaling

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Katarzyna Jastrzebski, Katherine M Hannan, Colin M House, Sandy S-C Hung, Richard B Pearson, Ross D Hannan

Journal article  |  2011  |  Cellular Signaling

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

NA Veldhuis, MJ Kuiper, RCJ Dobson, RB Pearson, J Camakaris

Journal article  |  2011  |  Biometals

Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy

Nicola J Smith, Hsiu-Wen Chan, Hongwei Qian, Allison M Bourne, Katherine M Hannan, Fiona J Warner, Rebecca H Ritchie, Richard B Pearson, Ross D Hannan, Walter G Thomas

Journal article  |  2011  |  Hypertension

Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

Aslaug Helland, Michael S Anglesio, Joshy George, Prue A Cowin, Cameron N Johnstone, Colin M House, Karen E Sheppard, Dariush Etemadmoghadam, Nataliya Melnyk, Anil K Rustgi, Wayne A Phillips, Hilde Johnsen, Ruth Holm, Gunnar B Kristensen, Michael J Birrer, Richard B Pearson, Anne-Lise Borresen-Dale, David G Huntsman, Anna deFazio, Chad J Creighton, et al.

Journal article  |  2011  |  PLoS One

Signaling to the Ribosome in Cancer-It Is More Than Just mTORC1

Katherine M Hannan, Elaine Sanij, Nadine Hein, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  IUBMB Life

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.

Rachel S Lee, Colin M House, Briony E Cristiano, Ross D Hannan, Richard B Pearson, Katherine M Hannan

Journal article  |  2011  |  Enzyme Research

The AKT protooncogene mediates many cellular processes involved in normal development and disease states such as cancer. The three..

Second AKT: The rise of SGK in cancer signalling

Maressa A Bruhn, Richard B Pearson, Ross D Hannan, Karen E Sheppard

Journal article  |  2010  |  Growth Factors

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Anissa M Jabbour, Carmel P Daunt, Benjamin D Green, Sandra Vogel, Lavinia Gordon, Rachel S Lee, Natasha Silke, Richard B Pearson, Cassandra J Vandenberg, Priscilla N Kelly, Stephen L Nutt, Andreas Strasser, Christoph Borner, Paul G Ekert

Journal article  |  2010  |  Blood

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Nicholas A Veldhuis, Valentina A Valova, Ann P Gaeth, Nickless Palstra, Katherine M Hannan, Belinda J Michell, Leonard E Kelly, Ian Jennings, Bruce E Kemp, Richard B Pearson, Phillip J Robinson, James Camakaris

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

Class IA Phosphatidylinositol 3-Kinase Signaling in Non-small Cell Lung Cancer

Benjamin Solomon, Richard B Pearson

Journal article  |  2009  |  Journal of Thoracic Oncology

The multi-layered regulation of copper translocating P-type ATPases

Nicholas A Veldhuis, Ann P Gaeth, Richard B Pearson, Kipros Gabriel, James Camakaris

Journal article  |  2009  |  Biometals

UBF levels determine the number of active ribosomal RNA genes in mammals

Elaine Sanij, Gretchen Poortinga, Kerith Sharkey, Sandy Hung, Timothy P Holloway, Jaclyn Quin, Elysia Robb, Lee H Wong, Walter G Thomas, Victor Stefanovsky, Tom Moss, Lawrence Rothblum, Katherine M Hannan, Grant A McArthur, Richard B Pearson, Ross D Hannan

Journal article  |  2008  |  The Journal of Cell Biology

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Grant A McArthur

Journal article  |  2008  |  Blood

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Katarzyna Jastrzebski, Katherine M Hannan, Elissaveta B Tchoubrieva, Ross D Hannan, Richard B Pearson

Journal article  |  2007  |  Growth Factors

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition

Briony E Cristiano, Joanna C Chan, Katherine M Hannan, Nicole A Lundie, Nelly J Marmy-Conus, Ian G Campbell, Wayne A Phillips, Melissa Robbie, Ross D Hannan, Richard B Pearson

Journal article  |  2006  |  Cancer Research

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus

WA Phillips, SE Russell, ML Ciavarella, DYH Choong, KG Montgomery, K Smith, RB Pearson, RJS Thomas, IG Campbell

Journal article  |  2006  |  International Journal of Cancer

The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation

LM Ooms, CG Fedele, MV Astle, I Ivetac, V Cheung, RB Pearson, MJ Layton, A Forrai, HH Nandurkar, CA Mitchell

Journal article  |  2006  |  Molecular Biology of the Cell

Expression of stress response protein glucose regulated protein-78 mediated by c-Myb

RG Ramsay, D Ciznadija, T Mantamadiotis, R Anderson, R Pearson

Journal article  |  2005  |  International Journal of Biochemistry and Cell Biology

Mutation of the PIK3CA gene in ovarian and breast cancer

IG Campbell, SE Russell, DYH Choong, KG Montgomery, ML Ciavarella, CSF Hooi, BE Cristiano, RB Pearson, WA Phillips

Journal article  |  2004  |  Cancer Research

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, M Wall, Y Brandenburger, M Palatsides, RB Pearson, GA McArthur, RD Hannan

Journal article  |  2004  |  EMBO Journal

mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF

KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, L Rothblum, T Moss, G Poortinga, GA McArthur, RB Pearson, RD Hannan

Journal article  |  2003  |  Molecular and Cellular Biology

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

I Voskoboinik, R Fernando, N Veldhuis, KM Hannan, N Marmy-Conus, RB Pearson, J Camakaris

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex

KM Hannan, G Thomas, RB Pearson

Journal article  |  2003  |  Biochemical Journal

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson

Journal article  |  2002  |  Journal of Biological Chemistry

The synthetic peptide RPRAATF allows specific assay of akt activity in cell lysates

S Bozinovski, BE Cristiano, N Marmy-Conus, RB Pearson

Journal article  |  2002  |  Analytical Biochemistry

Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling

N Marmy-Conus, KM Hannan, RB Pearson

Journal article  |  2002  |  FEBS Letters

Phosphorylation of nuclear phospholipase C beta 1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I

AM Xu, PG Suh, N Marmy-Conus, RB Pearson, OY Seok, L Cocco, RS Gilmour

Journal article  |  2001  |  Molecular and Cellular Biology

STIM1: a novel phosphoprotein located at the cell surface

SSM Manji, NJ Parker, RT Williams, L van Stekelenburg, RB Pearson, M Dziadek, PJ Smith

Journal article  |  2000  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Insulin and insulin antagonists evoke phosphorylation of P20 at serine 157 and serine 16 respectively in rat skeletal muscle

Y Wang, AM Xu, RB Pearson, GJS Cooper

Journal article  |  1999  |  FEBS Letters

The Akt kinase signals directly to endothelial nitric oxide synthase

BJ Michell, JE Griffiths, KI Mitchelhill, I Rodriguez-Crespo, T Tiganis, S Bozinovski, PRO de Montellano, BE Kemp, RB Pearson

Journal article  |  1999  |  Current Biology

Dual posttranscriptional targets of retinoic acid-induced gene expression

SS Manji, RB Pearson, M Pardee, V Paspaliaris, A d'Apice, TL Martin, KW Ng

Journal article  |  1999  |  Journal of Cellular Biochemistry

Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

PB Dennis, N Pullen, RB Pearson, SC Kozma, G Thomas

Journal article  |  1998  |  Journal of Biological Chemistry

Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70(S6k)

NM Conus, BA Hemmings, RB Pearson

Journal article  |  1998  |  Journal of Biological Chemistry

Effects of wortmannin and rapamycin on CSF-1 mediated responses in macrophages

JA Hamilton, R Byrne, G Whitty, PK Vadiveloo, N Marmy, RB Pearson, E Christy, A Jaworowski

Journal article  |  1998  |  The International Journal of Biochemistry & Cell Biology

Dual requirement for a newly identified phosphorylation site in p70(s6k)

BA Moser, PB Dennis, N Pullen, RB Pearson, NA Williamson, REH Wettenhall, SC Kozma, G Thomas

Journal article  |  1997  |  Molecular and Cellular Biology

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70(S6k)

HBJ Jefferies, S Fumagalli, PB Dennis, C Reinhard, RB Pearson, G Thomas

Journal article  |  1997  |  The EMBO Journal

THE PRINCIPAL TARGET OF RAPAMYCIN-INDUCED P70(S6K) INACTIVATION IS A NOVEL PHOSPHORYLATION SITE WITHIN A CONSERVED HYDROPHOBIC DOMAIN

RB PEARSON, PB DENNIS, JW HAN, NA WILLIAMSON, SC KOZMA, REH WETTENHALL, G THOMAS

Journal article  |  1995  |  The EMBO Journal

RAPAMYCIN, WORTMANNIN, AND THE METHYLXANTHINE SQ20006 INACTIVATE P70(S6K) BY INDUCING DEPHOSPHORYLATION OF THE SAME SUBSET OF SITES

JW HAN, RB PEARSON, PB DENNIS, G THOMAS

Journal article  |  1995  |  Journal of Biological Chemistry

THE IMMUNOSUPPRESSANT RAPAMYCIN INDUCES INACTIVATION OF P70(S6K) THROUGH DEPHOSPHORYLATION OF A NOVEL SET OF SITES

S FERRARI, RB PEARSON, M SIEGMANN, SC KOZMA, G THOMAS

Journal article  |  1993  |  Journal of Biological Chemistry

ROLE OF THE PSEUDOSUBSTRATE SEQUENCE IN SMOOTH-MUSCLE MYOSIN LIGHT-CHAIN KINASE THERMAL-STABILITY

MC FAUX, RB PEARSON, KI MITCHELHILL, BE KEMP

Journal article  |  1993  |  Journal of Biological Chemistry

STRUCTURAL BASIS OF THE INTRASTERIC REGULATION OF MYOSIN LIGHT CHAIN KINASES

DR KNIGHTON, RB PEARSON, JM SOWADSKI, AR MEANS, LF TENEYCK, SS TAYLOR, BE KEMP

Journal article  |  1992  |  Science

PROTEOLYTIC CLEAVAGE SITES IN SMOOTH-MUSCLE MYOSIN-LIGHT-CHAIN KINASE AND THEIR RELATION TO STRUCTURAL AND REGULATORY DOMAINS

RB PEARSON, M ITO, NA MORRICE, AJ SMITH, R CONDRON, REH WETTENHALL, BE KEMP, DJ HARTSHORNE

Journal article  |  1991  |  European Journal of Biochemistry

INTRASTERIC REGULATION OF PROTEIN-KINASES AND PHOSPHATASES

BE KEMP, RB PEARSON

Journal article  |  1991  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DESIGN AND USE OF PEPTIDE-SUBSTRATES FOR PROTEIN-KINASES

BE KEMP, RB PEARSON

Journal article  |  1991  |  Methods in Enzymology

PROTEIN-KINASE PHOSPHORYLATION SITE SEQUENCES AND CONSENSUS SPECIFICITY MOTIFS - TABULATIONS

RB PEARSON, BE KEMP

Journal article  |  1991  |  Methods in Enzymology

PSEUDOSUBSTRATE-BASED PEPTIDE INHIBITORS

BE KEMP, RB PEARSON, CM HOUSE

Journal article  |  1991  |  Methods in Enzymology

THE SMOOTH-MUSCLE 132 KDA CYCLIC GMP-DEPENDENT PROTEIN-KINASE SUBSTRATE IS NOT MYOSIN LIGHT CHAIN KINASE OR CALDESMON

B SARCEVIC, PJ ROBINSON, RB PEARSON, BE KEMP

Journal article  |  1990  |  Biochemical Journal

PROTEIN-KINASE RECOGNITION SEQUENCE MOTIFS

BE KEMP, RB PEARSON

Journal article  |  1990  |  Trends in Biochemical Sciences

REGULATORY AND STRUCTURAL MOTIFS OF CHICKEN GIZZARD MYOSIN LIGHT CHAIN KINASE

NJ OLSON, RB PEARSON, DS NEEDLEMAN, MY HURWITZ, BE KEMP, AR MEANS

Journal article  |  1990  |  Proceedings of the National Academy of Sciences

REGULATION OF PROTEIN-KINASES BY PSEUDOSUBSTRATE PROTOTOPES

BE KEMP, RB PEARSON, C HOUSE, PJ ROBINSON, AR MEANS

Journal article  |  1989  |  Cellular Signalling

AUTO-REGULATION OF ENZYMES BY PSEUDOSUBSTRATE PROTOTOPES - MYOSIN LIGHT CHAIN KINASE

RB PEARSON, REH WETTENHALL, AR MEANS, DJ HARTSHORNE, BE KEMP

Journal article  |  1988  |  Science

HYDROXYAMINO ACID SPECIFICITY OF SMOOTH-MUSCLE MYOSIN LIGHT CHAIN KINASE

RB PEARSON, DM FLOYD, JT HUNT, VG LEE, BE KEMP

Journal article  |  1988  |  Archives of Biochemistry and Biophysics

THE CALMODULIN BINDING DOMAIN OF CHICKEN SMOOTH-MUSCLE MYOSIN LIGHT CHAIN KINASE CONTAINS A PSEUDOSUBSTRATE SEQUENCE

BE KEMP, RB PEARSON, V GUERRIERO, IC BAGCHI, AR MEANS

Journal article  |  1987  |  Journal of Biological Chemistry

CHEMICAL MODIFICATION OF LYSINE AND ARGININE RESIDUES IN THE MYOSIN REGULATORY LIGHT CHAIN INHIBITS PHOSPHORYLATION

RB PEARSON, BE KEMP

Journal article  |  1986  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

A POTENT SYNTHETIC PEPTIDE INHIBITOR OF THE CAMP-DEPENDENT PROTEIN-KINASE

HC CHENG, BE KEMP, RB PEARSON, AJ SMITH, L MISCONI, SM VANPATTEN, DA WALSH

Journal article  |  1986  |  Journal of Biological Chemistry

SMOOTH-MUSCLE MYOSIN KINASE REQUIRES RESIDUES ON THE COOH-TERMINAL SIDE OF THE PHOSPHORYLATION SITE - PEPTIDE INHIBITORS

RB PEARSON, LY MISCONI, BE KEMP

Journal article  |  1986  |  Journal of Biological Chemistry

Substrate specificity of a multifunctional calmodulin-dependent protein kinase

RB Pearson, JR Woodgett, P Cohen, BE Kemp

Journal article  |  1985  |  Journal of Biological Chemistry

SPATIAL REQUIREMENTS FOR LOCATION OF BASIC RESIDUES IN PEPTIDE-SUBSTRATES FOR SMOOTH-MUSCLE MYOSIN LIGHT CHAIN KINASE

BE KEMP, RB PEARSON

Journal article  |  1985  |  Journal of Biological Chemistry

SUBSTRATE-SPECIFICITY OF A MULTIFUNCTIONAL CALMODULIN-DEPENDENT PROTEIN-KINASE

BE KEMP, RB PEARSON, JR WOODGETT, P COHEN

Journal article  |  1985  |  Federation Proceedings

PHOSPHORYLATION SITE SEQUENCE OF SMOOTH-MUSCLE MYOSIN LIGHT CHAIN (MR=20000)

RB PEARSON, R JAKES, M JOHN, J KENDRICKJONES, BE KEMP

Journal article  |  1984  |  FEBS Letters

COMPARISON OF SUBSTRATE-SPECIFICITY OF MYOSIN KINASE AND CYCLIC AMP-DEPENDENT PROTEIN-KINASE

RB PEARSON, S FORREST, M DAVIS, TJ MARTIN, BE KEMP

Journal article  |  1984  |  Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Spatial requirements for location of basic residues in peptide substrates for myosin kinase

BE Kemp, RB Pearson

Journal article  |  1984  |  Federation Proceedings

THE INFLUENCE OF BASIC RESIDUES ON THE PHOSPHORYLATION OF SYNTHETIC PEPTIDES BY THE MYOSIN LIGHT CHAIN KINASE

BE KEMP, RB PEARSON, C HOUSE

Journal article  |  1983  |  FEDERATION PROCEEDINGS

Role of basic residues in the phosphorylation of synthetic peptides by myosin light chain kinase

BE Kemp, RB Pearson, C House

Journal article  |  1983  |  Proceedings of the National Academy of Sciences

PHOSPHORYLATION OF A SYNTHETIC HEPTADECAPEPTIDE BY SMOOTH-MUSCLE MYOSIN LIGHT CHAIN KINASE

BE KEMP, RB PEARSON, C HOUSE

Journal article  |  1982  |  Journal of Biological Chemistry

MYOSIN LIGHT CHAIN KINASE BINDING TO PLASTIC

RB PEARSON, C HOUSE, BE KEMP

Journal article  |  1982  |  FEBS Letters