Richard Pearson

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

Katherine M Hannan, Priscilla Soo, Mei S Wong, Justine K Lee, Nadine Hein, Perlita Poh, Kira D Wysoke, Tobias D Williams, Christian Montellese, Lorey K Smith, Sheren J Al-Obaidi, Lorena Nunez-Villacis, Megan Pavy, Jin-Shu He, Kate M Parsons, Karagh E Loring, Tess Morrison, Jeannine Diesch, Gaetan Burgio, Rita Ferreira, et al.

Journal article  |  2022  |  CELL REPORTS

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal..

Cystathionine-beta-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang

Journal article  |  2022  |  ELIFE

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts..

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF(V600) melanoma

Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately ..

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  NATURE CELL BIOLOGY

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologo..

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

Jian Kang, Natalie Brajanovski, Keefe T Chan, Jiachen Xuan, Richard B Pearson, Elaine Sanij

Journal article  |  2021  |  SIGNAL TRANSDUCTION AND TARGETED THERAPY

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal pro..

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

Ana Domostegui, Suresh Peddigari, Carol A Mercer, Flavia Iannizzotto, Marta L Rodriguez, Marta Garcia-Cajide, Virginia Amador, Sarah T Diepstraten, Gemma L Kelly, Ramon Salazar, Sara C Kozma, Eric P Kusnadi, Jian Kang, Antonio Gentilella, Richard B Pearson, George Thomas, Joffrey Pelletier

Journal article  |  2021  |  BLOOD

MYC-driven B-cell lymphomas are addicted to increased levels of ribosome biogenesis (RiBi), offering the potential for therapeutic..

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine RC Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij, Richard B Pearson, Keefe T Chan

Journal article  |  2020  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcino..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  EMBO JOURNAL

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer

Jiachen Xuan, Richard B Pearson, Elaine Sanij

Journal article  |  2020  |  MOLECULAR & CELLULAR ONCOLOGY

Acquired drug resistance leads to poor clinical outcome in high grade serous ovarian cancer (HGSOC). We have demonstrated the effi..