Amanda Edgley

Inhibitory Effects of 3',4'-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts.

Jennifer C Fan Gaskin, Roy CK Kong, Manisha H Shah, Amanda J Edgley, Hitesh M Peshavariya, Elsa C Chan

Journal article  |  2022  |  Transl Vis Sci Technol

PURPOSE: Cytotoxic agents such as mitomycin C (MMC) are part of the mainstay treatment for limiting subconjunctival scarring follo..

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

Cindy Nguyen, Amanda J Edgley, Darren J Kelly, Andrew R Kompa

Journal article  |  2022  |  TOXINS

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardio..

NP202 treatment improves left ventricular systolic function and attenuates pathological remodelling following chronic myocardial infarction

Andrew R Kompa, Fay L Khong, Yuan Zhang, Cindy Nguyen, Amanda J Edgley, Owen L Woodman, Grant McLachlan, Darren J Kelly

Journal article  |  2021  |  LIFE SCIENCES

AIMS: Myocardial injury is a major contributor to left ventricular (LV) remodelling activating neurohormonal and inflammatory proc..

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

β-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat.

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  Clin Sci (Lond)

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat

James T Pearson, Hamish P Thambyah, Mark T Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P Ngo, Connie PC Ow, Takashi Sonobe, Yi Ching Chen, Amanda J Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai

Journal article  |  2021  |  CLINICAL SCIENCE

A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitro..

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF CARDIOLOGY

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

Journal article  |  2020  |  International Journal of Cardiology

BACKGROUND: Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain..

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Mark T Waddingham, Takashi Sonobe, Hirotsugu Tsuchimochi, Amanda J Edgley, Vijayakumar Sukumaran, Yi Ching Chen, Sarabjit S Hansra, Daryl O Schwenke, Keiji Umetani, Kohki Aoyama, Naoto Yagi, Darren J Kelly, Shahrooz Gaderih, Melissa Herwig, Detmar Kolijn, Andreas Muegge, Walter J Paulus, Takeshi Ogo, Mikiyasu Shirai, Nazha Hamdani, et al.

Journal article  |  2019  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocy..