Dr Amanda Edgley obtained her PhD from Monash University in 2001, after which she undertook a post-doctoral position at AstraZeneca Pharmaceuticals in Sweden, as part of an NHMRC Industry Fellowship. Dr Edgley currently holds a joint position as a senior research fellow in the Biomedical Translational Research Group and as Academic Co-ordinator of Research Training at Eastern Hill Academic Precinct.
Her current research interests focus on developing and evaluating novel compounds for the treatment of pathological inflammation and fibrosis in diabetic and non-diabetic kidney, heart and eye disease. Inflammation and fibrosis underlie the decline in organ function in many cardiovascular conditions. Dr Edgley has over 17 years’ experience in the field of integrative cardiovascular physiology and pharmacology, with technical expertise in vivo analysis of vascular, cardiac and renal function. Dr Edgley has also used synchrotron radiation microangiography techniques to study aspects of coronary microvascular function in health and disease and has utilised synchrotron short angle x-ray scattering (SAXS) to investigate regulation of myocardial cross bridge function in disease.
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Amanda Edgley's highlights
FEATURED Journal article
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes modelRead more
Amanda Edgley's selected work
The Effect Of Certa Next Generation Antifibrotic Compounds On Collagen Synthesis And Cellu..
Uremic toxin induced endothelial dysfunction can be restored by inhibition of the aryl hyd..
Oral administration of the novel small molecule drug OCX063 protects against inflammation ..
Displaying the 13 most recent projects by Amanda Edgley.
Internal Research Grant
Displaying the 49 most recent scholarly works by Amanda Edgley.
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model
Mark T Waddingham, Takashi Sonobe, Hirotsugu Tsuchimochi, Amanda J Edgley, Vijayakumar Sukumaran, Yi Ching Chen, Sarabjit S Hansra, Daryl O Schwenke, Keiji Umetani, Kohki Aoyama, Naoto Yagi, Darren J Kelly, Shahrooz Gaderih, Melissa Herwig, Detmar Kolijn, Andreas Muegge, Walter J Paulus, Takeshi Ogo, Mikiyasu Shirai, Nazha Hamdani, et al.
Journal article | 2019 | Journal of Molecular and Cellular Cardiology
Coronary microvessel endothelial dysfunction and nitric oxide (NO) depletion contribute to elevated passive tension of cardiomyocy..
Oral administration of the novel small molecule drug OCX063 protects against inflammation and vascular pathology in a rat diabetic retinopathy (DR) model
Roy Chze Khai Kong, Amanda Edgley, Elsa Chan, Alison J Cox, Sylwia Glowacka, Michelle Papadimitriou, Fay Lin Khong, Darren Kelly
Conference Proceedings | 2019 | INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model
Claire L Curl, Vennetia R Danes, James R Bell, Antonia JA Raaijmakers, Wendy TK Ip, Chanchal Chandramouli, Tristan W Harding, Enzo R Porrello, Jeffrey R Erickson, Fadi J Charchar, Andrew R Kompa, Amanda J Edgley, David J Crossman, Christian Soeller, Kimberley M Mellor, Jonathan M Kalman, StephenB Harrap, Lea MD Delbridge
Journal article | 2018 | Journal of the American Heart Association
Changes in titin phosphorylation and PKG activity underlie diastolic dysfunction at the cross-bridge level in the early stages of type 2 diabetes
MT Waddingham, N Hamdani, AJ Edgley, H Tsuchimochi, T Sonobe, DJ Kelly, N Yagi, WJ Paulus, M Shirai, JT Pearson
Conference Proceedings | 2018 | EUROPEAN JOURNAL OF HEART FAILURE
Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model
James T Pearson, Misa Yoshimoto, Yi Ching Chen, Rohullah Sultani, Amanda J Edgley, Hajime Nakaoka, Makoto Nishida, Keiji Umetani, Mark T Waddingham, Hui-Ling Jin, Yuan Zhang, Darren J Kelly, Daryl O Schwenke, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Issei Komuro, Shizuya Yamashita, Mikiyasu Shirai
Journal article | 2017 | Scientific Reports
Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet
H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
Conference Proceedings | 2017 | EUROPEAN HEART JOURNAL
Effect of insulin resistance on compound 21 mediated coronary microvascular dilation in female rats in vivo
JT Pearson, P Meagher, H Tsuchimochi, AJ Edgley, M Yoshimoto, MT Waddingham, YC Chen, KM Mirabito Colafella, LM Hilliard, K Umetani, RE Widdop, M Shirai, KM Denton
Conference Proceedings | 2017 | EUROPEAN HEART JOURNAL
Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats
Yi Ching Chen, Tadakatsu Inagaki, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Amanda J Edgley, Keiji Umetani, Yuan Zhang, Darren J Kelly, Misa Yoshimoto, Hisashi Nagai, Roger G Evans, Ichiro Kuwahira, Mikiyasu Shirai, James T Pearson
Journal article | 2016 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension
Mark T Waddingham, Amanda J Edgley, Alberto Astolfo, Tadakatsu Inagaki, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Hirotsugu Tsuchimochi, Naoto Yagi, Darren J Kelly, Mikiyasu Shirai, James T Pearson
Journal article | 2015 | Cardiovascular Diabetology
A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction
Yuan Zhang, Maros Elsik, Amanda J Edgley, Alison J Cox, Andrew R Kompa, Bing Wang, Christina Yan Ru Tan, Fay L Khong, David I Stapleton, Steven Zammit, Spencer J Williams, Richard E Gilbert, Henry Krum, Darren J Kelly
Journal article | 2013 | International Journal of Cardiology
Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation
James T Pearson, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Mandar Joshi, Mark T Waddingham, Yutaka Fujii, Daryl O Schwenke, Hirotsugu Tsuchimochi, Misa Yoshimoto, Keiji Umetani, Darren J Kelly, Mikiyasu Shirai
Journal article | 2013 | Cardiovascular Diabetology
Myosin Heads Are Displaced from Actin Filaments in the In Situ Beating Rat Heart in Early Diabetes
Mathew J Jenkins, James T Pearson, Daryl O Schwenke, Amanda J Edgley, Takashi Sonobe, Yutaka Fujii, Hatsue Ishibashi-Ueda, Darren J Kelly, Naoto Yagi, Mikiyasu Shirai
Journal article | 2013 | Biophysical Journal
FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
Yuan Zhang, Amanda J Edgley, Alison J Cox, Andrew K Powell, Bing Wang, Andrew R Kompa, David I Stapleton, Steven C Zammit, Spencer J Williams, Henry Krum, Richard E Gilbert, Darren J Kelly
Journal article | 2012 | European Journal of Heart Failure
Dynamic Synchrotron Imaging of Diabetic Rat Coronary Microcirculation In Vivo
Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Keiji Umetani, Daryl O Schwenke, Yutaka Fujii, Russell D Brown, Darren J Kelly, Mikiyasu Shirai, James T Pearson
Journal article | 2012 | Arteriosclerosis Thrombosis and Vascular Biology
Benefits of Synchrotron Microangiography for Dynamic Studies of Smooth Muscle and Endothelial Roles in the Pathophysiology of Vascular Disease
James T Pearson, Daryl O Schwenke, Mathew J Jenkins, Amanda J Edgley, Takashi Sonobe, Hatsue Ishibashi-Ueda, Keiji Umetani, Gabriela A Eppel, Roger G Evans, Yasuhiko Okura, Mikiyasu Shirai
Conference Proceedings | 2010 | AIP Conference Proceedings
Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease
Darren J Kelly, Amanda J Edgley, Yuan Zhang, Kerri Thai, Sih Min Tan, Alison J Cox, Andrew Advani, Kim A Connelly, Catharine I Whiteside, Richard E Gilbert
Journal article | 2009 | Nephrology, Dialysis, Transplantation
SYNCHROTRON-BASED ANGIOGRAPHY FOR INVESTIGATION OF THE REGULATION OF VASOMOTOR FUNCTION IN THE MICROCIRCULATION IN VIVO
Mikiyasu Shirai, Daryl O Schwenke, Gabriela A Eppel, Roger G Evans, Amanda J Edgley, Hirotsugu Tsuchimochi, Keiji Umetani, James T Pearson
Journal article | 2009 | Clinical and Experimental Pharmacology and Physiology
In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes
Amanda J Edgley, Marianne Tare, Roger G Evans, Con Skordilis, Helena C Parkington
Journal article | 2008 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Reduced stress- and cold-induced increase in energy expenditure in interleukin-6-deficient mice
Ingrid Wernstedt, Amanda Edgley, Anna Berndtsson, Jenny Faldt, Goran Bergstrom, Ville Wallenius, John-Olov Jansson
Journal article | 2006 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes
ND Oakes, P Thalen, E Aasum, A Edgley, T Larsen, SM Furler, B Ljung, D Severson
Journal article | 2006 | American Journal of Physiology - Endocrinology and Metabolism
Angiotensin II infused intrarenally causes preglomerular vascular changes and hypertension.
KM Stevenson, AJ Edgley, G Bergström, K Worthy, MM Kett, WP Anderson
Journal article | 2000 | Hypertension
The effects on the renal vasculature and on arterial blood pressure of chronic infusion of low doses of angiotensin II (Ang II) in..