Jerry Adams

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluck

Journal article  |  2020  |  Cell Death and Disease

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

BAX and BAK become killers without a BH3 trigger

Jerry M Adams

Journal article  |  2019  |  Cell Research

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams

Journal article  |  2019  |  Cell Death and Differentiation

Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the no..

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams

Journal article  |  2019  |  Cell Reports

Targeting Mcl-1 is a promising strategy to kill mantle cell lymphoma cells

Michael A Dengler, Charis E Teh, Marco J Herold, Andrew W Roberts, Jerry M Adams

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

A Joint Odyssey into Cancer Genetics

Suzanne Cory, Jerry M Adams

Journal article  |  2019  |  Annual Review of Cancer Biology

The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Jerry M Adams, Suzanne Cory

Journal article  |  2018  |  Cell Death and Differentiation

Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Journal article  |  2016  |  Trends in Cancer

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, A Strasser

Journal article  |  2016  |  Cell Death and Disease