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Prof

Jerry Adams

Honorary
Medical Biology (W.E.H.I.)
Molecular Biology
Drug Discovery
science & technology
life sciences & biomedicine
animals
mice
biochemistry & molecular biology
cell biology
apoptosis
Jerry Adams's Profile Picture
Prof

Jerry Adams

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Genetic basis of cancer and cell death control
Jerry Adams's Profile Picture
Prof

Jerry Adams

 
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Jerry's  Short Profile
 

www.wehi.edu.au/people/jerry-adams

Lab focus: Genetic basis of cancer and cell death control

Impaired cell death is now recognised as an important step towards cancer, and a major barrier to effective anti-cancer therapy. Our team's discoveries on apoptosis have galvanised the search for drugs that directly engage the cell’s apoptotic machinery, as a new way to treat cancer.

One such drug has been approved for an aggressive form of leukaemia and is under trial for many other malignancies.

One major goal of our research is to determine how drugs that promote cell death can be used most effectively to improve cancer treatment. We also aim to clarify further how apoptosis is controlled and how the control goes awry in cancer.

Our primary focus is better understanding of cell death mechanisms, which should expedite the search for better ways to control cell death to improve therapy.

Scholarly Works

Displaying the 10 most recent scholarly works by Jerry Adams.

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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target

Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams, Grant Dewson, Ruth M Kluck

Journal article  |  2020  |  Cell Death and Disease

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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

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BAX and BAK become killers without a BH3 trigger

Jerry M Adams

Journal article  |  2019  |  Cell Research

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By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams

Journal article  |  2019  |  Cell Death & Differentiation

Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the no..

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BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams

Journal article  |  2019  |  Cell Reports

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Targeting Mcl-1 is a promising strategy to kill mantle cell lymphoma cells

Michael A Dengler, Charis E Teh, Marco J Herold, Andrew W Roberts, Jerry M Adams

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

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A Joint Odyssey into Cancer Genetics

Suzanne Cory, Jerry M Adams

Journal article  |  2019  |  Annual Review of Cancer Biology

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The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Jerry M Adams, Suzanne Cory

Journal article  |  2018  |  Cell Death & Differentiation

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Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Journal article  |  2016  |  Trends in Cancer

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Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, A Strasser

Journal article  |  2016  |  Cell Death & Disease

221

Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Clinical Health (organs, Diseases and Abnormal Conditions)
Oncology and Carcinogenesis
Expanding Knowledge
Cardiovascular Medicine and Haematology
Medical Biochemistry and Metabolomics

News

Displaying the 1 most recent news article by Jerry Adams.

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Exposing the Achilles’ Heel of a major cancer gene

Cassandra Vandenberg, Jerry Adams, Suzanne Cory

February 20, 2020

1

News Articles

Honours, Awards and Fellowships

2014

Macfarlane Burnet Lecture and Medal, Australian Academy of Science
2014

FAACR - Fellow of the Academy of the American Association for Cancer Research

2004

FRS - Fellow of the Royal Society

1986

FAA - Fellow of the Australian Academy of Science

4

Awards

Credentials

Positions

Positions

Honorary

Medical Biology (W.E.H.I.)

Education

Education

Bachelor of Science

Institution not known

Doctor of Philosophy

Harvard University

Links

Links