Lab focus: Genetic basis of cancer and cell death control
Impaired cell death is now recognised as an important step towards cancer, and a major barrier to effective anti-cancer therapy. Our team's discoveries on apoptosis have galvanised the search for drugs that directly engage the cell’s apoptotic machinery, as a new way to treat cancer.
One such drug has been approved for an aggressive form of leukaemia and is under trial for many other malignancies.
One major goal of our research is to determine how drugs that promote cell death can be used most effectively to improve cancer treatment. We also aim to clarify further how apoptosis is controlled and how the control goes awry in cancer.
Our primary focus is better understanding of cell death mechanisms, which should expedite the search for better ways to control cell death to improve therapy.
Find out more about Jerry Adams' experience
Jerry Adams' highlights
Jerry Adams' selected work
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell ly..
By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein a..
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Alloster..
Displaying the 219 most recent scholarly works by Jerry Adams.
Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams
Journal article | 2019 | Oncogene
Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..
By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737
Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams
Journal article | 2019 | Cell Death & Differentiation
Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the no..
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association
Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams
Journal article | 2019 | Cell Reports
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E Czabotar, Brian J Smith, Jerry M Adams, Ruth M Kluck
Journal article | 2014 | Proceedings of the National Academy of Sciences
NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS
Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams, Peter M Colman, Peter E Czabotar
Journal article | 2014 | Archives of Biochemistry and Biophysics
Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David CS Huang
Journal article | 2014 | Proceedings of the National Academy of Sciences of the United States of America
Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L
Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.
Journal article | 2013 | Journal of Medicinal Chemistry
Structure-guided design of a selective BCL-X-L inhibitor
Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.
Journal article | 2013 | Nature Chemical Biology
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman
Journal article | 2013 | Cell
Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells
Edwina Naik, Lorraine A O'Reilly, Marie-Liesse Asselin-Labat, Delphine Merino, Ann Lin, Michele Cook, Leigh Coultas, Philippe Bouillet, Jerry M Adams, Andreas Strasser
Journal article | 2011 | Journal of Experimental Medicine
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
PN Kelly, MJ White, MW Goschnick, KA Fairfax, DM Tarlinton, SA Kinkel, P Bouillet, JM Adams, BT Kile, A Strasser
Journal article | 2010 | Cell Death & Differentiation
Erratum: Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (18081-18087) DOI: 10.1073/pnas.0808691105)
JI Fletcher, S Meusburger, CJ Hawkins, DT Riglar, EF Lee, WD Fairlie, DCS Huang, JM Adams
Journal article | 2009 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
Jamie I Fletchera, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David CS Huang, Jerry M Adams
Journal article | 2008 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis
Leigh Coultas, Susanna Terzano, Tim Thomas, Anne Voss, Kate Reid, Edouard G Stanley, Clare L Scott, Philippe Bouillet, Perry Bartlett, Jonathan Ham, Jerry M Adams, Andreas Strasser
Journal article | 2007 | J. Cell Sci.
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
WS Wu, S Heinrichs, D Xu, SP Garrison, GP Zambetti, JM Adams, AT Look
Journal article | 2005 | Cell
In response to DNA damage, the p53 tumor suppressor can elicit either apoptosis or cell-cycle arrest and repair, but how this crit..
Subversion of the Bcl-2 life/death switch in cancer development and therapy
JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.
Journal article | 2005 | Cold Spring Harbor Symp. Quant. Biol.
Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine
DM Pritchard, C Print, L O'Reilly, JM Adams, CS Potten, JA Hickman
Journal article | 2000 | Oncogene
The potential role of the bcl-2 relative bcl-w as a physiological regulator of apoptosis in intestinal epithelia has been investig..
Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation
G Vairo, TJ Soos, TM Upton, J Zalvide, JA DeCaprio, ME Ewen, A Koff, JM Adams
Journal article | 2000 | Molecular and Cellular Biology
Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cy..
Gamma-radiation-induced growth arrest and apoptosis in p53-null lymphoma cells is accompanied by modest transcriptional changes in many genes.
R Ofir, LC Zhang, AP Kyne, V Houtzager, L O'Connor, JM Adams
Journal article | 2000 | DNA and Cell Biology
Damage to DNA produces cell cycle arrest, apoptosis, or both. The response in cells with p53 tumor suppressor function involves tr..
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
S Ogilvy, D Metcalf, CG Print, ML Bath, AW Harris, JM Adams
Journal article | 1999 | Proceedings of the National Academy of Sciences
Bcl-2, which can both reduce apoptosis and retard cell cycle entry, is thought to have important roles in hematopoiesis. To evalua..
Interference with gene expression induces rapid apoptosis in p53-null T lymphoma cells
R Ofir, LC Zhang, JM Adams
Journal article | 1999 | Cell Death & Differentiation
Two p53-null T lymphoma cell lines proved to be highly sensitive to inhibition of gene expression. With either actinomycin D or cy..
Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment
S Ogilvy, D Metcalf, L Gibson, ML Bath, AW Harris, JM Adams
Journal article | 1999 | Blood
To develop a method for targeting expression of genes to the full hematopoietic system, we have used transgenic mice to explore th..
Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.
S Cory, DL Vaux, A Strasser, AW Harris, JM Adams
Conference Proceedings | 1999 | Cancer Research
The chromosome translocations typifying Burkitt's lymphoma and follicular lymphoma deregulate very different oncogenes, myc and bc..
Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins
JM Adams, DCS Huang, H Puthalakath, P Bouillet, G Vairo, K Moriishi, G Hausmann, L O'Reilly, K Newton, S Ogilvy, ML Bath, CG Print, AW Harris, A Strasser, S Cory
Conference Proceedings | 1999 | Cold Spring Harbor Symposia on Quantitative Biology
Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research.
A Strasser, L O'Connor, DC Huang, LA O'Reilly, ML Stanley, ML Bath, JM Adams, S Cory, AW Harris
Journal article | 1996 | Behring Institute Mitteilungen
The protein product of the proto-oncogene bcl-2, originally discovered by virtue of its chromosomal translocation in human follicu..
Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut
B Hentsch, I Lyons, RL Li, L Hartley, TJ Lints, JM Adams, RP Harvey
Journal article | 1996 | Genes & Development
The divergent murine homeo box gene Hlx is expressed in restricted hematopoietic cell types and, during embryogenesis, prominently..
Enforced expression of Hlx homeobox gene prompts myeloid cell maturation and altered adherence properties of T cells.
JD Allen, JM Adams
Journal article | 1993 | Blood
Within the hematopoietic compartment, the murine Hlx homeobox gene is expressed in myeloid cells, most prominently in macrophages ..
RETROVIRAL INFECTION ACCELERATES T-LYMPHOMAGENESIS IN E-MU-N-RAS TRANSGENIC MICE BY ACTIVATING C-MYC OR N-MYC
Y HAUPT, AW HARRIS, JM ADAMS
Journal article | 1992 | Oncogene
Transgenic mice bearing a mutant, activated N-ras oncogene directed to express within hematopoietic cells by an immunoglobulin enh..
THE HEMATOPOIETICALLY EXPRESSED VAV PROTOONCOGENE SHARES HOMOLOGY WITH THE DBL GDP-GTP EXCHANGE FACTOR, THE BCR GENE AND A YEAST GENE (CDC24) INVOLVED IN CYTOSKELETAL ORGANIZATION
JM ADAMS, H HOUSTON, J ALLEN, T LINTS, R HARVEY
Journal article | 1992 | Oncogene
The vav proto-oncogene encodes a protein of unknown function that is rendered oncogenic by loss of a short N-terminal domain. A co..
EXPRESSION OF HOX-2.4 HOMEOBOX GENE DIRECTED BY PROVIRAL INSERTION IN A MYELOID-LEUKEMIA
K KONGSUWAN, J ALLEN, JM ADAMS
Journal article | 1989 | Nucleic Acids Research
The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neopl..
EXPRESSION OF MULTIPLE HOMEOBOX GENES WITHIN DIVERSE MAMMALIAN HEMATOPOIETIC LINEAGES
K KONGSUWAN, E WEBB, P HOUSIAUX, JM ADAMS
Journal article | 1988 | The EMBO Journal
Several mouse and human genes encoding the DNA-binding homeobox domain are implicated here in haematopoiesis, a differentiation pr..
THE E-MU-MYC TRANSGENIC MOUSE - A MODEL FOR HIGH-INCIDENCE SPONTANEOUS LYMPHOMA AND LEUKEMIA OF EARLY B-CELLS
AW HARRIS, CA PINKERT, M CRAWFORD, WY LANGDON, RL BRINSTER, JM ADAMS
Journal article | 1988 | The Journal of Experimental Medicine
Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariably develop lymphomas, 90% succ..
bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.
IK Hariharan, JM Adams, S Cory
Journal article | 1988 | Oncogene Research
In chronic myeloid leukemia (CML), a chromosome translocation has fused the bcr gene to the c-abl oncogene, such that a chimeric b..
EXPRESSION OF THE C-MYC ONCOGENE UNDER CONTROL OF AN IMMUNOGLOBULIN ENHANCER IN E-MU-MYC TRANSGENIC MICE
WS ALEXANDER, JW SCHRADER, JM ADAMS
Journal article | 1987 | Molecular and Cellular Biology
Transgenic mice bearing a cellular myc oncogene coupled to the immunoglobulin heavy-chain enhancer (E mu) exhibit perturbed B-lymp..
CDNA SEQUENCE FOR HUMAN-BCR, THE GENE THAT TRANSLOCATES TO THE ABL-ONCOGENE IN CHRONIC MYELOID-LEUKEMIA
IK HARIHARAN, JM ADAMS
Journal article | 1987 | The EMBO Journal
The hallmark of human chronic myeloid leukaemia is a 9;22 chromosome translocation that fuses most of the c-abl oncogene to the 5'..
CHROMOSOME-8 BREAKPOINT FAR 3' OF THE C-MYC ONCOGENE IN A BURKITTS-LYMPHOMA 2-8 VARIANT TRANSLOCATION IS EQUIVALENT TO THE MURINE PVT-1 LOCUS
M GRAHAM, JM ADAMS
Journal article | 1986 | The EMBO Journal
The 2;8 variant translocation of human Burkitt's lymphomas is closely related cytogenetically to the t(6;15) of murine plasmacytom..
Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.
L Villeneuve, E Rassart, P Jolicoeur, M Graham, JM Adams
Journal article | 1986 | Molecular and Cellular Biology
Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral..
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas
JM Adams, S Gerondakis, E Webb, LM Corcoran, S Cory
Journal article | 1983 | Proceedings of the National Academy of Sciences of the United States of America
A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS
DJ KEMP, JM ADAMS, PL MOTTRAM, WR THOMAS, ID WALKER, JFAP MILLER
Journal article | 1982 | The Journal of Experimental Medicine
Expression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four ..
Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes.
S Cory, BM Tyler, JM Adams
Journal article | 1981 | Journal of Molecular and Applied Genetics
To count V kappa genes homologous to particular V kappa nucleotide sequences, thereby permitting estimates for the total V kappa r..
PLASMACYTOMAS WITH MORE THAN ONE IMMUNOGLOBULIN KAPPA-MESSENGER RNA - IMPLICATIONS FOR ALLELIC EXCLUSION
O BERNARD, NM GOUGH, JM ADAMS
Journal article | 1981 | Proceedings of the National Academy of Sciences
Although only one allele of an immunoglobulin gene is thought to be expressed as a polypeptide by a given lymphocyte ("allelic exc..
Organization of genes and spacers within the mouse immunoglobulin VH locus.
DJ Kemp, B Tyler, O Bernard, N Gough, S Gerondakis, JM Adams, S Cory
Journal article | 1981 | Journal of Molecular and Applied Genetics
The germline organization of mouse immunoglobulin VH genes has been investigated using cloned VH sequences. Hybridization studies ..
Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching.
BM Tyler, JM Adams
Journal article | 1980 | Nucleic Acids Research
We have used heteroduplex analysis to investigate the sequences surrounding the germline C gamma 1 and C gamma 3 genes, and to com..
TRANSCRIPTS OF THE IMMUNOGLOBULIN-C-MU GENE VARY IN STRUCTURE AND SPLICING DURING LYMPHOID DEVELOPMENT
DJ KEMP, AW HARRIS, JM ADAMS
Journal article | 1980 | Proceedings of the National Academy of Sciences
Two classes of transcripts of the mouse immunoglobulin mu constant region (C mu) gene can be distinguished. Whereas B cells contai..
Honours, Awards and Fellowships
FAACR - Fellow of the Academy of the American Association for Cancer Research
FRS - Fellow of the Royal Society
FAA - Fellow of the Australian Academy of Science