Jerry Adams

BAX and BAK become killers without a BH3 trigger

Jerry M Adams

Journal article  |  2019  |  Cell Research

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2019  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams

Journal article  |  2019  |  Cell Death & Differentiation

Drugs targeting various pro-survival BCL-2 family members (''BH3 mimetics'') have efficacy in hemopoietic malignancies, but the no..

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams

Journal article  |  2019  |  Cell Reports

A Joint Odyssey into Cancer Genetics

Suzanne Cory, Jerry M Adams

Journal article  |  2019  |  Annual Review of Cancer Biology

The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Jerry M Adams, Suzanne Cory

Journal article  |  2018  |  Cell Death & Differentiation

Targeting BCL-2-like Proteins to Kill Cancer Cells

Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Journal article  |  2016  |  Trends in Cancer

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis

S Grabow, GL Kelly, ARD Delbridge, PN Kelly, P Bouillet, JM Adams, A Strasser

Journal article  |  2016  |  Cell Death & Disease

Functional antagonism between pro-apoptotic BIM and anti-apoptotic BCL-XL in MYC-induced lymphomagenesis

ARD Delbridge, S Grabow, P Bouillet, JM Adams, A Strasser

Journal article  |  2015  |  Oncogene

Donald Metcalf: The father of modern hematology

Jerry M Adams, Suzanne Cory

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E Czabotar, Brian J Smith, Jerry M Adams, Ruth M Kluck

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams, Peter M Colman, Peter E Czabotar

Journal article  |  2014  |  Archives of Biochemistry and Biophysics

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David CS Huang

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams

Journal article  |  2014  |  Nature Reviews Molecular Cell Biology

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman

Journal article  |  2013  |  Cell

Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice

PN Kelly, S Grabow, ARD Delbridge, JM Adams, A Strasser

Journal article  |  2013  |  Cell Death & Differentiation

Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer

Jerry M Adams

Journal article  |  2012  |  Journal of Clinical Investigation

Endogenous Bcl-x(L) is essential for Myc-driven lymphomagenesis in mice

Priscilla N Kelly, Stephanie Grabow, Alex RD Delbridge, Andreas Strasser, Jerry M Adams

Journal article  |  2011  |  Blood

Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

A Villunger, V Labi, P Bouillet, J Adams, A Strasser

Journal article  |  2011  |  Cell Death Differ.

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

Andreas Strasser, Suzanne Cory, Jerry M Adams

Journal article  |  2011  |  EMBO Journal

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

Edwina Naik, Lorraine A O'Reilly, Marie-Liesse Asselin-Labat, Delphine Merino, Ann Lin, Michele Cook, Leigh Coultas, Philippe Bouillet, Jerry M Adams, Andreas Strasser

Journal article  |  2011  |  Journal of Experimental Medicine

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

PN Kelly, MJ White, MW Goschnick, KA Fairfax, DM Tarlinton, SA Kinkel, P Bouillet, JM Adams, BT Kile, A Strasser

Journal article  |  2010  |  Cell Death & Differentiation

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Ewa M Michalak, Cassandra J Vandenberg, Alex RD Delbridge, Li Wu, Clare L Scott, Jerry M Adams, Andreas Strasser

Journal article  |  2010  |  Genes & Development

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their alpha 6 Helices

Grant Dewson, Tobias Kratina, Peter Czabotar, Catherine L Day, Jerry M Adams, Ruth M Kluck

Journal article  |  2009  |  Molecular Cell

Erratum: Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (18081-18087) DOI: 10.1073/pnas.0808691105)

JI Fletcher, S Meusburger, CJ Hawkins, DT Riglar, EF Lee, WD Fairlie, DCS Huang, JM Adams

Journal article  |  2009  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

Jamie I Fletchera, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David CS Huang, Jerry M Adams

Journal article  |  2008  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

EM Michalak, A Villunger, JM Adams, A Strasser

Journal article  |  2008  |  Cell Death Differ.

Is tumor growth sustained by rare cancer stem cells or dominant clones?

Jerry M Adams, Andreas Strasser

Journal article  |  2008  |  Cancer Res.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3 : Groove interactions

Grant Dewson, Tobias Kratina, Huiyan W Sim, Hamsa Puthalakath, Jerry M Adams, Peter M Colman, Ruth M Kluck

Journal article  |  2008  |  Molecular Cell

Role of "Cancer Stem Cells" and Cell Survival in Tumor Development and Maintenance

JM Adams, PN Kelly, A Dakic, S Carotta, SL Nutt, A Strasser

Journal article  |  2008  |  Cold Spring Harbor Laboratory - Symposia on Quantitative Biology

Response to comment on "tumor growth need not be driven by rare cancer stem cells"

Jerry M Adams, Priscilla N Kelly, Aleksandar Dakic, Stephen L Nutt, Andreas Strasser

Journal article  |  2007  |  Science

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

Jerry M Adams, Suzanne Cory

Journal article  |  2007  |  Current Opinion in Immunology

Tumor growth need not be driven by rare cancer stem cells

Priscilla N Kelly, Aleksandar Dakic, Jerry M Adams, Stephen L Nutt, Andreas Strasser

Journal article  |  2007  |  SCIENCE

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis

Leigh Coultas, Susanna Terzano, Tim Thomas, Anne Voss, Kate Reid, Edouard G Stanley, Clare L Scott, Philippe Bouillet, Perry Bartlett, Jonathan Ham, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  J. Cell Sci.

Endogenous bcl-2 is not required for the development of Eμ-myc-induced B-cell lymphoma

PN Kelly, H Puthalakath, JM Adams, A Strasser

Journal article  |  2007  |  Blood

Endogenous bcl-2 is not required for the development of E mu-myc-induced B-cell lymphoma

Priscilla N Kelly, Hamsa Puthalakath, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  Blood

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

Rachel T Uren, Grant Dewson, Lin Chen, Stephanie C Coyne, David CS Huang, Jerry M Adams, Ruth M Kluck

Journal article  |  2007  |  Journal of Cell Biology

The Bcl-2 apoptotic switch in cancer development and therapy

JM Adams, S Cory

Journal article  |  2007  |  Oncogene

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

Edwina Naik, Ewa M Michalak, Andreas Villunger, Jerry M Adams, Andreas Strasser

Journal article  |  2007  |  J. Cell Biol.

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

VS Marsden, T Kaufmann, LA O'Reilly, JM Adams, A Strasser

Journal article  |  2006  |  Blood

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo

M Erlacher, EM Michalak, PN Kelly, V Labi, H Niederegger, L Coultas, JM Adams, A Strasser, A Villunger

Journal article  |  2005  |  Blood

Life in the balance: how BH3-only proteins induce apoptosis

SN Willis, JM Adams

Journal article  |  2005  |  Current Opinion in Cell Biology

Concomitant loss of proapoptotic BH3-only bcl-2 antagonists Bik and Bim arrests spermatogenesis

L Coultas, P Bouillet, KL Loveland, S Meachem, H Perlman, JM Adams, A Strasser

Journal article  |  2005  |  EMBO J.

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

WS Wu, S Heinrichs, D Xu, SP Garrison, GP Zambetti, JM Adams, AT Look

Journal article  |  2005  |  Cell

In response to DNA damage, the p53 tumor suppressor can elicit either apoptosis or cell-cycle arrest and repair, but how this crit..

Killing cancer cells by flipping the Bcl-2/Bax switch

S Cory, JM Adams

Journal article  |  2005  |  Cancer Cell

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(L), but not Bcl-2, until displaced by BH3-only proteins

SN Willis, L Chen, G Dewson, A Wei, E Naik, JI Fletcher, JM Adams, DCS Huang

Journal article  |  2005  |  Genes & Development

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy

TT Tan, K Degenhardt, DA Nelson, B Beaudoin, W Nieves-Neira, P Bouillet, A Villunger, JM Adams, E White

Journal article  |  2005  |  Cancer Cell

The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim

M Nikrad, T Johnson, H Puthalalath, L Coultas, J Adams, AS Kraft

Journal article  |  2005  |  Molecular Cancer Therapeutics

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, CL Day, JM Adams, DCS Huang

Journal article  |  2005  |  Molecular Cell

Subversion of the Bcl-2 life/death switch in cancer development and therapy

JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.

Journal article  |  2005  |  Cold Spring Harbor Symp. Quant. Biol.

PU. 1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain

WD Cook, BJ McCaw, C Herring, DL John, SJ Foote, SL Nutt, JM Adams

Journal article  |  2004  |  Blood

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

VS Marsden, PG Ekert, M Van Delft, DL Vaux, JM Adams, A Strasser

Journal article  |  2004  |  J. Cell Biol.

Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate

C Navarro, H Puthalakath, JM Adams, A Strasser, R Lehmann

Journal article  |  2004  |  Nature Cell Biol.

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

L Coultas, P Bouillet, EG Stanley, TC Brodnicki, JM Adams, A Strasser

Journal article  |  2004  |  Mol. Cell. Biol.

Loss of pro-apoptotic BH3-only Bcl-2 family member Bim does not protect mutant Lurcher mice from neurodegeneration

P Bouillet, M Robati, JM Adams, A Strasser

Journal article  |  2003  |  J. Neurosci. Res.

The Bcl-2 family: roles in cell survival and oncogenesis

S Cory, DCS Huang, JM Adams

Journal article  |  2003  |  Oncogene

p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa

A Villunger, EM Michalak, L Coultas, F Mullauer, G Bock, MJ Ausserlechner, JM Adams, A Strasser

Journal article  |  2003  |  Science

Ways of dying: multiple pathways to apoptosis

JM Adams

Journal article  |  2003  |  Genes & Development

Apoptosomes: engines for caspase activation

JM Adams, S Cory

Journal article  |  2002  |  Current Opinion in Cell Biology

Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

L Coultas, DCS Huang, JM Adams, A Strasser

Journal article  |  2002  |  CELL DEATH AND DIFFERENTIATION

Pro-apoptotic BH-3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

L Coultas, DCS Huang, JM Adams, A Strasser

Journal article  |  2002  |  Cell Death & Differentiation

The BCL2 family: Regulators of the cellular life-or-death switch

S Cory, JM Adams

Journal article  |  2002  |  Nature Reviews Cancer

Erratum: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes (Nature (2002) 415 (922-926))

P Bouillet, JF Purton, DI Godfrey, LC Zhang, L Coultas, H Puthalakath, M Pellegrini, S Cory, JM Adams, A Strasser

Journal article  |  2002  |  Nature

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist bim

P Bouillet, S Cory, LC Zhang, A Strasser, JM Adams

Journal article  |  2001  |  Dev. Cell

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

GV Putcha, KL Moulder, JP Golden, P Bouillet, JA Adams, A Strasser, EM Johnson

Journal article  |  2001  |  Neuron

Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

P Bouillet, LC Zhang, DCS Huang, GC Webb, CDK Bottema, P Shore, HJ Eyre, GR Sutherland, JM Adams

Journal article  |  2001  |  Mammalian Genome

Life-or-death decisions by the Bcl-2 protein family

JM Adams, S Cory

Journal article  |  2001  |  Trends in Biochemical Sciences

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

M Grossmann, LA O'Reilly, R Gugasyan, A Strasser, JM Adams, S Gerondakis

Journal article  |  2000  |  The EMBO Journal

Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes

A Villunger, LA O'Reilly, N Holler, J Adams, A Strasser

Journal article  |  2000  |  The Journal of Experimental Medicine

Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine

DM Pritchard, C Print, L O'Reilly, JM Adams, CS Potten, JA Hickman

Journal article  |  2000  |  Oncogene

The potential role of the bcl-2 relative bcl-w as a physiological regulator of apoptosis in intestinal epithelia has been investig..

Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation

G Vairo, TJ Soos, TM Upton, J Zalvide, JA DeCaprio, ME Ewen, A Koff, JM Adams

Journal article  |  2000  |  Molecular and Cellular Biology

Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cy..

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L)

G Hausmann, LA O'Reilly, R van Driel, JC Beaumont, A Strasser, JM Adams, DCS Huang

Journal article  |  2000  |  The Journal of Cell Biology

Gamma-radiation-induced growth arrest and apoptosis in p53-null lymphoma cells is accompanied by modest transcriptional changes in many genes.

R Ofir, LC Zhang, AP Kyne, V Houtzager, L O'Connor, JM Adams

Journal article  |  2000  |  DNA and Cell Biology

Damage to DNA produces cell cycle arrest, apoptosis, or both. The response in cells with p53 tumor suppressor function involves tr..

How, when, and why do lymphocytes die?

A Strasser, K Newton, LA O'Reilly, M Pellegrini, L O'Connor, H Puthalakath, L Cullen, L Tai, L Coultas, DCS Huang, A Villunger, P Bouillet, ML Bath, DL Vaux, S Cory, JM Adams, AW Harris

Journal article  |  2000  |  Immunologist

The role of Bim, a proapoptotic BH3-only member of the Bcl-2 family, in cell-death control

A Strasser, H Puthalakath, P Bouillet, DCS Huang, L O'Connor, L O'Reilly, L Cullen, S Cory, JM Adams

Conference Proceedings  |  2000  |  Annals of the New York Academy of Sciences

The role of the pro-apoptotic bcl-2 family member Bim in physiological cell death

P Bouillet, DCS Huang, LA O'Reilly, H Puthalakath, L O'Connor, S Cory, JM Adams, A Strasser

Conference Proceedings  |  2000  |  Annals of the New York Academy of Sciences

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

S Ogilvy, D Metcalf, CG Print, ML Bath, AW Harris, JM Adams

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Bcl-2, which can both reduce apoptosis and retard cell cycle entry, is thought to have important roles in hematopoiesis. To evalua..

Interference with gene expression induces rapid apoptosis in p53-null T lymphoma cells

R Ofir, LC Zhang, JM Adams

Journal article  |  1999  |  Cell Death & Differentiation

Two p53-null T lymphoma cell lines proved to be highly sensitive to inhibition of gene expression. With either actinomycin D or cy..

Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

P Bouillet, D Metcalf, DCS Huang, DM Tarlinton, TWH Kay, F Kontgen, JM Adams, A Strasser

Journal article  |  1999  |  Science

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

JM Adams, AW Harris, A Strasser, S Ogilvy, S Cory

Journal article  |  1999  |  Oncogene

Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment

S Ogilvy, D Metcalf, L Gibson, ML Bath, AW Harris, JM Adams

Journal article  |  1999  |  Blood

To develop a method for targeting expression of genes to the full hematopoietic system, we have used transgenic mice to explore th..

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

K Moriishi, DCS Huang, S Cory, JM Adams

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

SP Holmgreen, DCS Huang, JM Adams, S Cory

Journal article  |  1999  |  Cell Death & Differentiation

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

S Cory, DL Vaux, A Strasser, AW Harris, JM Adams

Conference Proceedings  |  1999  |  Cancer Research

The chromosome translocations typifying Burkitt's lymphoma and follicular lymphoma deregulate very different oncogenes, myc and bc..

Insights from Bcl-2 and Myc: Malignancy involves abrogation of apoptosis as well as sustained proliferation

S Cory, DL Vaux, A Strasser, AW Harris, JM Adams

Journal article  |  1999  |  Cancer Research

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins

JM Adams, DCS Huang, H Puthalakath, P Bouillet, G Vairo, K Moriishi, G Hausmann, L O'Reilly, K Newton, S Ogilvy, ML Bath, CG Print, AW Harris, A Strasser, S Cory

Conference Proceedings  |  1999  |  Cold Spring Harbor Symposia on Quantitative Biology

Retroviral transduction of enriched hematopoietic stem cells allows lifelong Bcl-2 expression in multiple lineages but does not perturb hematopoiesis

KM Innes, SJ Szilvassy, HE Davidson, L Gibson, JM Adams, S Cory

Journal article  |  1999  |  Experimental Hematology

Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant

CG Print, KL Loveland, L Gibson, T Meehan, A Stylianou, N Wreford, D De Kretser, D Metcalf, F Kontgen, JM Adams, S Cory

Conference Proceedings  |  1998  |  Proceedings of the National Academy of Sciences

The Bcl-2 protein family: Arbiters of cell survival

JM Adams, S Cory

Journal article  |  1998  |  Science

Matters of life and death: programmed cell death at Cold Spring Harbor

S Cory, JM Adams

Conference Proceedings  |  1998  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

DCS Huang, JM Adams, S Cory

Journal article  |  1998  |  The EMBO Journal

Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment

S Ogilvy, AG Elefanty, J Visvader, ML Bath, AW Harris, JM Adams

Journal article  |  1998  |  Blood

Bim: a novel member of the Bcl-2 family that promotes apoptosis

L O'Connor, A Strasser, LA O'Reilly, G Hausmann, JM Adams, S Cory, DCS Huang

Journal article  |  1998  |  The EMBO Journal

Regulation of cell survival by the bcl-2 gene family

S Cory, JM Adams, L Gibson, S Holmgreen, G Vairo, L O'Rcilly, DCS Huang, A Strasser

Journal article  |  1997  |  FASEB Journal

Whitehead Symposium on cancer.

JM Adams

Conference Proceedings  |  1997  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival

G Vairo, KM Innes, JM Adams

Journal article  |  1996  |  Oncogene

Myeloid maturation appears to require exit from the cell cycle and leads to activation of apoptosis in the differentiated cells. T..

Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research.

A Strasser, L O'Connor, DC Huang, LA O'Reilly, ML Stanley, ML Bath, JM Adams, S Cory, AW Harris

Journal article  |  1996  |  Behring Institute Mitteilungen

The protein product of the proto-oncogene bcl-2, originally discovered by virtue of its chromosomal translocation in human follicu..

bcl-w, a novel member of the bcl-2 family, promotes cell survival

L Gibson, SP Holmgreen, DCS Huang, O Bernand, NG Copeland, NA Jenkins, GR Sutherland, E Baker, JM Adams, S Cory

Journal article  |  1996  |  Oncogene

Hlx homeo box gene is essential for an inductive tissue interaction that drives expansion of embryonic liver and gut

B Hentsch, I Lyons, RL Li, L Hartley, TJ Lints, JM Adams, RP Harvey

Journal article  |  1996  |  Genes & Development

The divergent murine homeo box gene Hlx is expressed in restricted hematopoietic cell types and, during embryogenesis, prominently..

ABSENCE OF P53 ALLOWS DIRECT IMMORTALIZATION OF HEMATOPOIETIC-CELLS BY THE MYC AND RAF ONCOGENES

T METZ, AW HARRIS, JM ADAMS

Journal article  |  1995  |  Cell

The p53 tumor suppressor is implicated here as a crucial barrier to unlimited cell proliferation. Its role in transformation of he..

OVEREXPRESSED MAX IS NOT ONCOGENIC AND ATTENUATES MYC-INDUCED LYMPHOPROLIFERATION AND LYMPHOMAGENESIS IN TRANSGENIC MICE

GJ LINDEMAN, AW HARRIS, ML BATH, RN EISENMAN, JM ADAMS

Journal article  |  1995  |  Oncogene

PERTURBED DEVELOPMENT OF T-CELLS AND B-CELLS IN MICE EXPRESSING AN HLX HOMEOBOX TRANSGENE

JD ALLEN, AW HARRIS, ML BATH, A STRASSER, R SCOLLAY, JM ADAMS

Journal article  |  1995  |  Journal of Immunology

THE C-TERMINAL ZINC-FINGER OF GATA-1 OR GATA-2 IS SUFFICIENT TO INDUCE MEGAKARYOCYTIC DIFFERENTIATION OF AN EARLY MYELOID CELL-LINE

JE VISVADER, M CROSSLEY, J HILL, SH ORKIN, JM ADAMS

Journal article  |  1995  |  Molecular and Cellular Biology

Cyclin D1 as the putative bcl-1 oncogene.

AW Harris, SE Bodrug, BJ Warner, ML Bath, GJ Lindeman, JM Adams

Journal article  |  1995  |  Current Topics in Microbiology and Immunology

B-LYMPHOID TO GRANULOCYTIC SWITCH DURING HEMATOPOIESIS IN A TRANSGENIC MOUSE STRAIN

GJ LINDEMAN, JM ADAMS, S CORY, AW HARRIS

Journal article  |  1994  |  Immunity

CYCLIN D1 TRANSGENE IMPEDES LYMPHOCYTE MATURATION AND COLLABORATES IN LYMPHOMAGENESIS WITH THE MYC GENE

SE BODRUG, BJ WARNER, ML BATH, GJ LINDEMAN, AW HARRIS, JM ADAMS

Journal article  |  1994  |  The EMBO Journal

ENHANCED CELL-SURVIVAL AND TUMORIGENESIS

S CORY, A STRASSER, T JACKS, LM CORCORAN, T METZ, AW HARRIS, JM ADAMS

Conference Proceedings  |  1994  |  Cold Spring Harbor Symposia on Quantitative Biology

BMI-1 TRANSGENE INDUCES LYMPHOMAS AND COLLABORATES WITH MYC IN TUMORIGENESIS

Y HAUPT, ML BATH, AW HARRIS, JM ADAMS

Journal article  |  1993  |  Oncogene

The bmi-1 gene was discovered as a frequent target of Moloney virus insertion in virally accelerated B-lymphoid tumors of E mu-myc..

MOLONEY VIRUS INDUCTION OF T-CELL LYMPHOMAS IN A PLASMACYTOMAGENIC STRAIN OF E-MU-V-ABL TRANSGENIC MICE

Y HAUPT, AW HARRIS, JM ADAMS

Journal article  |  1993  |  International Journal of Cancer

MEGAKARYOCYTIC DIFFERENTIATION-INDUCED IN 416B MYELOID CELLS BY GATA-2 AND GATA-3 TRANSGENES OR 5-AZACYTIDINE IS TIGHTLY COUPLED TO GATA-1 EXPRESSION

J VISVADER, JM ADAMS

Journal article  |  1993  |  Blood

ENFORCED EXPRESSION OF HLX HOMEOBOX GENE PROMPTS MYELOID CELL MATURATION AND ALTERED ADHERENCE PROPERTIES OF T-CELLS

JD ALLEN, JM ADAMS

Journal article  |  1993  |  Blood

Within the hematopoietic compartment, the murine Hlx homeobox gene is expressed in myeloid cells, most prominently in macrophages ..

GATA-1 BUT NOT SCL INDUCES MEGAKARYOCYTIC DIFFERENTIATION IN AN EARLY MYELOID LINE

JE VISVADER, AG ELEFANTY, A STRASSER, JM ADAMS

Journal article  |  1992  |  The EMBO Journal

NUCLEOTIDE-SEQUENCE OF BUP, AN UPSTREAM GENE IN THE BMI-1 PROVIRAL INSERTION LOCUS

Y HAUPT, G BARRI, JM ADAMS

Journal article  |  1992  |  Molecular Biology Reports

The ability of Moloney murine leukemia virus to accelerate lymphomagenesis in E mu-myc transgenic mice is frequently associated wi..

RETROVIRAL INFECTION ACCELERATES T-LYMPHOMAGENESIS IN E-MU-N-RAS TRANSGENIC MICE BY ACTIVATING C-MYC OR N-MYC

Y HAUPT, AW HARRIS, JM ADAMS

Journal article  |  1992  |  Oncogene

Transgenic mice bearing a mutant, activated N-ras oncogene directed to express within hematopoietic cells by an immunoglobulin enh..

THE HEMATOPOIETICALLY EXPRESSED VAV PROTOONCOGENE SHARES HOMOLOGY WITH THE DBL GDP-GTP EXCHANGE FACTOR, THE BCR GENE AND A YEAST GENE (CDC24) INVOLVED IN CYTOSKELETAL ORGANIZATION

JM ADAMS, H HOUSTON, J ALLEN, T LINTS, R HARVEY

Journal article  |  1992  |  Oncogene

The vav proto-oncogene encodes a protein of unknown function that is rendered oncogenic by loss of a short N-terminal domain. A co..

ONCOGENE COOPERATION IN LEUKEMOGENESIS

JM ADAMS, S CORY

Journal article  |  1992  |  Cancer Surveys

TRANSGENIC MODELS OF TUMOR-DEVELOPMENT

JM ADAMS, S CORY

Journal article  |  1991  |  Science

ENFORCED BCL2 EXPRESSION IN B-LYMPHOID CELLS PROLONGS ANTIBODY-RESPONSES AND ELICITS AUTOIMMUNE-DISEASE

A STRASSER, S WHITTINGHAM, DL VAUX, ML BATH, JM ADAMS, S CORY, AW HARRIS

Journal article  |  1991  |  Proceedings of the National Academy of Sciences

NOVEL ZINC FINGER GENE IMPLICATED AS MYC COLLABORATOR BY RETROVIRALLY ACCELERATED LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE

Y HAUPT, WS ALEXANDER, G BARRI, SP KLINKEN, JM ADAMS

Journal article  |  1991  |  Cell

TRANSGENIC MODELS FOR HEMATOPOIETIC MALIGNANCIES

JM ADAMS, S CORY

Journal article  |  1991  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

NOVEL MURINE HOMEO BOX GENE ON CHROMOSOME-1 EXPRESSED IN SPECIFIC HEMATOPOIETIC LINEAGES AND DURING EMBRYOGENESIS

JD ALLEN, T LINTS, NA JENKINS, NG COPELAND, A STRASSER, RP HARVEY, JM ADAMS

Journal article  |  1991  |  Genes & Development

DIFFERENTIAL EXPRESSION OF THE LYL, SCL AND E2A HELIX-LOOP-HELIX GENES WITHIN THE HEMATOPOIETIC SYSTEM

J VISVADER, CG BEGLEY, JM ADAMS

Journal article  |  1991  |  Oncogene

HOMEOBOX GENE-EXPRESSION PLUS AUTOCRINE GROWTH-FACTOR PRODUCTION ELICITS MYELOID-LEUKEMIA

A PERKINS, K KONGSUWAN, J VISVADER, JM ADAMS, S CORY

Journal article  |  1990  |  Proceedings of the National Academy of Sciences

Growth control circuitry and the oncogene connection.

JM Adams

Conference Proceedings  |  1990  |  Cancer Cells

AN E-MU-V-ABL TRANSGENE ELICITS PLASMACYTOMAS IN CONCERT WITH AN ACTIVATED MYC GENE

H ROSENBAUM, AW HARRIS, ML BATH, J MCNEALL, E WEBB, JM ADAMS, S CORY

Journal article  |  1990  |  The EMBO Journal

THE TRANSGENIC WINDOW ON LYMPHOID MALIGNANCY

JM ADAMS, AW HARRIS, DL VAUX, WS ALEXANDER, H ROSENBAUM, SP KLINKEN, A STRASSER, ML BATH, J MCNEALL, S CORY

Journal article  |  1990  |  Princess Takamatsu symposia

ABNORMALITIES OF THE IMMUNE-SYSTEM INDUCED BY DYSREGULATED BCL-2 EXPRESSION IN TRANSGENIC MICE

A STRASSER, AW HARRIS, DL VAUX, E WEBB, ML BATH, JM ADAMS, S CORY

Conference Proceedings  |  1990  |  Current Topics in Microbiology and Immunology

LYMPHOID TUMORIGENESIS BY V-ABL AND BCR-V-ABL IN TRANSGENIC MICE

AW HARRIS, ML BATH, H ROSENBAUM, J MCNEALL, JM ADAMS, S CORY

Conference Proceedings  |  1990  |  Current Topics in Microbiology and Immunology

LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE DOES NOT REQUIRE TRANSGENE REARRANGEMENT OR MUTATION OF MYC EXON-1

E WEBB, G BARRI, S CORY, JM ADAMS

Journal article  |  1989  |  Molecular Biology and Medicine

A BCR-V-ABL ONCOGENE INDUCES LYMPHOMAS IN TRANSGENIC MICE

IK HARIHARAN, AW HARRIS, M CRAWFORD, H ABUD, E WEBB, S CORY, JM ADAMS

Journal article  |  1989  |  Molecular and Cellular Biology

LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE CAN INVOLVE RAS MUTATIONS

WS ALEXANDER, O BERNARD, S CORY, JM ADAMS

Journal article  |  1989  |  Oncogene

EXPRESSION OF HOX-2.4 HOMEOBOX GENE DIRECTED BY PROVIRAL INSERTION IN A MYELOID-LEUKEMIA

K KONGSUWAN, J ALLEN, JM ADAMS

Journal article  |  1989  |  Nucleic Acids Research

The presence of an altered Hox-2.4 gene in the WEHI3B murine myeloid leukemia suggests that homeobox genes may contribute to neopl..

N-MYC TRANSGENE PROMOTES B-LYMPHOID PROLIFERATION, ELICITS LYMPHOMAS AND REVEALS CROSS-REGULATION WITH C-MYC

H ROSENBAUM, E WEBB, JM ADAMS, S CORY, AW HARRIS

Journal article  |  1989  |  The EMBO Journal

ONCOGENE COOPERATION IN LYMPHOCYTE-TRANSFORMATION - MALIGNANT CONVERSION OF E-MU-MYC TRANSGENIC PRE-B CELLS-INVITRO IS ENHANCED BY V-H-RAS OR V-RAF BUT NOT V-ABL

WS ALEXANDER, JM ADAMS, S CORY

Journal article  |  1989  |  Molecular and Cellular Biology

LYMPHOID NEOPLASIA AND THE CONTROL OF HEMATOPOIETIC DIFFERENTIATION

JM ADAMS, AW HARRIS, WY LANGDON, SP KLINKEN, K KONGSUWAN, WS ALEXANDER, I HARIHARAN, D VAUX, H ROSENBAUM, M CRAWFORD, E WEBB, H ABUD, S CORY

Journal article  |  1989  |  Ciba Foundation symposium

ANALYSIS OF THE LEUKEMOGENIC PROPERTIES OF THE BCR-V-ABL AND GM-CSF GENES USING A NEW RETROVIRAL VECTOR

IK HARIHARAN, GR JOHNSON, TJ GONDA, D METCALF, JM ADAMS, S CORY

Journal article  |  1989  |  Current Topics in Microbiology and Immunology

Oncogene cooperation and B-lymphoid tumorigenesis in Emu-myc transgenic mice.

WS Alexander, O Bernard, WY Langdon, AW Harris, JM Adams, S Cory

Journal article  |  1989  |  Haematology and blood transfusion

IMMUNOGLOBULIN-JH REARRANGEMENT IN A T-CELL LINE REFLECTS FUSION TO THE DH LOCUS AT A SEQUENCE LACKING THE NONAMER RECOGNITION SIGNAL

S GERONDAKIS, O BERNARD, S CORY, JM ADAMS

Journal article  |  1988  |  Immunogenetics

BCL-2 GENE PROMOTES HEMATOPOIETIC-CELL SURVIVAL AND COOPERATES WITH C-MYC TO IMMORTALIZE PRE-B-CELLS

DL VAUX, S CORY, JM ADAMS

Journal article  |  1988  |  Nature

EXPRESSION OF MULTIPLE HOMEOBOX GENES WITHIN DIVERSE MAMMALIAN HEMATOPOIETIC LINEAGES

K KONGSUWAN, E WEBB, P HOUSIAUX, JM ADAMS

Journal article  |  1988  |  The EMBO Journal

Several mouse and human genes encoding the DNA-binding homeobox domain are implicated here in haematopoiesis, a differentiation pr..

HEMATOPOIETIC LINEAGE SWITCH - V-RAF ONCOGENE CONVERTS E-MU-MYC TRANSGENIC B-CELLS INTO MACROPHAGES

SP KLINKEN, WS ALEXANDER, JM ADAMS

Journal article  |  1988  |  Cell

Hemopoietic lineage commitment can be breached by concomitant expression of the c-myc and v-raf oncogenes. Switching to the myeloi..

THE E-MU-MYC TRANSGENIC MOUSE - A MODEL FOR HIGH-INCIDENCE SPONTANEOUS LYMPHOMA AND LEUKEMIA OF EARLY B-CELLS

AW HARRIS, CA PINKERT, M CRAWFORD, WY LANGDON, RL BRINSTER, JM ADAMS

Journal article  |  1988  |  The Journal of Experimental Medicine

Mice transgenic for a c-myc gene driven by the IgH enhancer (E mu-myc) were shown to almost invariably develop lymphomas, 90% succ..

bcr-abl oncogene renders myeloid cell line factor independent: potential autocrine mechanism in chronic myeloid leukemia.

IK Hariharan, JM Adams, S Cory

Journal article  |  1988  |  Oncogene Research

In chronic myeloid leukemia (CML), a chromosome translocation has fused the bcr gene to the c-abl oncogene, such that a chimeric b..

TRANSGENIC MICE AND ONCOGENESIS

S CORY, JM ADAMS

Journal article  |  1988  |  Annual Review of Immunology

IMMUNOLOGICAL COMPETENCE OF B-CELLS SUBJECTED TO CONSTITUTIVE C-MYC ONCOGENE EXPRESSION IN IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER MYC TRANSGENIC MICE

DL VAUX, JM ADAMS, WS ALEXANDER, BL PIKE

Journal article  |  1987  |  Journal of Immunology

GENERATION OF ALTERED TRANSCRIPTS BY RETROVIRAL INSERTION WITHIN THE C-MYB GENE IN 2 MURINE MONOCYTIC LEUKEMIAS

TJ GONDA, S CORY, P SOBIESZCZUK, D HOLTZMAN, JM ADAMS

Journal article  |  1987  |  Journal of Virology

EXPRESSION OF THE C-MYC ONCOGENE UNDER CONTROL OF AN IMMUNOGLOBULIN ENHANCER IN E-MU-MYC TRANSGENIC MICE

WS ALEXANDER, JW SCHRADER, JM ADAMS

Journal article  |  1987  |  Molecular and Cellular Biology

Transgenic mice bearing a cellular myc oncogene coupled to the immunoglobulin heavy-chain enhancer (E mu) exhibit perturbed B-lymp..

CDNA SEQUENCE FOR HUMAN-BCR, THE GENE THAT TRANSLOCATES TO THE ABL-ONCOGENE IN CHRONIC MYELOID-LEUKEMIA

IK HARIHARAN, JM ADAMS

Journal article  |  1987  |  The EMBO Journal

The hallmark of human chronic myeloid leukaemia is a 9;22 chromosome translocation that fuses most of the c-abl oncogene to the 5'..

The myc oncogene and lymphoid neoplasia: from translocations to transgenic mice.

S Cory, AW Harris, WY Langdon, WS Alexander, LM Corcoran, RD Palmiter, CA Pinkert, RL Brinster, JM Adams

Journal article  |  1987  |  Haematology and blood transfusion

CHROMOSOME-8 BREAKPOINT FAR 3' OF THE C-MYC ONCOGENE IN A BURKITTS-LYMPHOMA 2-8 VARIANT TRANSLOCATION IS EQUIVALENT TO THE MURINE PVT-1 LOCUS

M GRAHAM, JM ADAMS

Journal article  |  1986  |  The EMBO Journal

The 2;8 variant translocation of human Burkitt's lymphomas is closely related cytogenetically to the t(6;15) of murine plasmacytom..

THE C-MYC ONCOGENE PERTURBS LYMPHOCYTE-B DEVELOPMENT IN E-MU-MYC TRANSGENIC MICE

WY LANGDON, AW HARRIS, S CORY, JM ADAMS

Journal article  |  1986  |  Cell

THE INFLUENCE OF IMMUNOGLOBULIN GENES IN LYMPHOID ONCOGENESIS

JM ADAMS

Journal article  |  1986  |  BioEssays

PROVIRAL INTEGRATION SITE MIS-1 IN RAT THYMOMAS CORRESPONDS TO THE PVT-1 TRANSLOCATION BREAKPOINT IN MURINE PLASMACYTOMAS

L VILLENEUVE, E RASSART, P JOLICOEUR, M GRAHAM, JM ADAMS

Journal article  |  1986  |  Molecular and Cellular Biology

Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral..

C-MYC-INDUCED LYMPHOMAGENESIS IN TRANSGENIC MICE AND THE ROLE OF THE THE PVT-1 LOCUS IN LYMPHOID NEOPLASIA

JM ADAMS, AW HARRIS, WY LANGDON, CA PINKERT, RL BRINSTER, RD PALMITER, L CORCORAN, WS ALEXANDER, MW GRAHAM, S CORY

Journal article  |  1986  |  Current Topics in Microbiology and Immunology

Oncogenic intelligence: oncogene activation by fusion of chromosomes in leukaemia

JM Adams

Journal article  |  1985  |  Nature

Oncogene activation by fusion of chromosomes in leukaemia.

JM Adams

Journal article  |  1985  |  Nature

MURINE T-LYMPHOMAS WITH RETROVIRAL INSERTS IN THE CHROMOSOMAL-15 LOCUS FOR PLASMACYTOMA VARIANT TRANSLOCATIONS

M GRAHAM, JM ADAMS, S CORY

Journal article  |  1985  |  Nature

VARIANT (6-15) TRANSLOCATIONS IN MURINE PLASMACYTOMAS INVOLVE A CHROMOSOME-15 LOCUS AT LEAST 72 KB FROM THE C-MYC ONCOGENE

S CORY, M GRAHAM, E WEBB, L CORCORAN, JM ADAMS

Journal article  |  1985  |  The EMBO Journal

TRANSPOSITION OF THE IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER TO THE MYC ONCOGENE IN A MURINE PLASMACYTOMA

LM CORCORAN, S CORY, JM ADAMS

Journal article  |  1985  |  Cell

THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE

JM ADAMS, AW HARRIS, CA PINKERT, LM CORCORAN, WS ALEXANDER, S CORY, RD PALMITER, RL BRINSTER

Journal article  |  1985  |  Nature

MYC ONCOGENE ACTIVATION IN B-LYMPHOID AND T-LYMPHOID TUMORS

JM ADAMS, S CORY

Journal article  |  1985  |  Proceedings of the Royal Society of London. Series B. Biological Sciences

ACTIVATION OF IMMUNOGLOBULIN MU-GENE EXPRESSION INVOLVES STEPWISE DEMETHYLATION

S GERONDAKIS, A BOYD, O BERNARD, E WEBB, JM ADAMS

Journal article  |  1984  |  The EMBO Journal

VARIANT (6-15) TRANSLOCATION IN A MURINE PLASMACYTOMA OCCURS NEAR AN IMMUNOGLOBULIN KAPPA-GENE BUT FAR FROM THE MYC ONCOGENE

E WEBB, JM ADAMS, S CORY

Journal article  |  1984  |  Nature

TRANSLOCATION OF THE MYC CELLULAR ONCOGENE TO THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS IN MURINE PLASMACYTOMAS IS AN IMPRECISE RECIPROCAL EXCHANGE

S GERONDAKIS, S CORY, JM ADAMS

Journal article  |  1984  |  Cell

MURINE T-LYMPHOMAS IN WHICH THE CELLULAR MYC ONCOGENE HAS BEEN ACTIVATED BY RETROVIRAL INSERTION

LM CORCORAN, JM ADAMS, AR DUNN, S CORY

Journal article  |  1984  |  Cell

ACTIVATION OF THE C-MYC ONCOGENE IN B-LYMPHOID AND T-LYMPHOID TUMORS

S CORY, S GERONDAKIS, LM CORCORAN, O BERNARD, E WEBB, JM ADAMS

Journal article  |  1984  |  Current Topics in Microbiology and Immunology

ONCOGENES

JM ADAMS

Journal article  |  1984  |  Australian journal of biological sciences

Oncogenes

JM Adams

Journal article  |  1984  |  Australian Journal of Biological Sciences

A barrage of information is now emerging about one of the thorniest and most significant problems in biology: the nature of the ge..

Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas

JM Adams, S Gerondakis, E Webb, LM Corcoran, S Cory

Journal article  |  1983  |  Proceedings of the National Academy of Sciences of the United States of America

FUSION OF DNA REGION TO MURINE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS CORRESPONDS TO PLASMACYTOMA-ASSOCIATED CHROMOSOME-TRANSLOCATION

S CORY, JM ADAMS, SD GERONDAKIS, JFAP MILLER, J GAMBLE, F WIENER, J SPIRA, U FRANCKE

Journal article  |  1983  |  The EMBO Journal

INTERCHROMOSOMAL RECOMBINATION OF THE CELLULAR ONCOGENE C-MYC WITH THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS IN MURINE PLASMACYTOMAS IS A RECIPROCAL EXCHANGE

S CORY, S GERONDAKIS, JM ADAMS

Journal article  |  1983  |  The EMBO Journal

SEQUENCE OF THE MURINE AND HUMAN CELLULAR MYC ONCOGENES AND 2 MODES OF MYC TRANSCRIPTION RESULTING FROM CHROMOSOME-TRANSLOCATION IN B-LYMPHOID TUMORS

O BERNARD, S CORY, S GERONDAKIS, E WEBB, JM ADAMS

Journal article  |  1983  |  The EMBO Journal

CELLULAR MYC ONCOGENE IS ALTERED BY CHROMOSOME-TRANSLOCATION TO AN IMMUNOGLOBULIN LOCUS IN MURINE PLASMACYTOMAS AND IS REARRANGED SIMILARLY IN HUMAN BURKITT LYMPHOMAS

JM ADAMS, S GERONDAKIS, E WEBB, LM CORCORAN, S CORY

Journal article  |  1983  |  Proceedings of the National Academy of Sciences

A SEARCH FOR MESSENGER-RNA MOLECULES BEARING IMMUNOGLOBULIN VH NUCLEOTIDE-SEQUENCES IN T-CELLS

DJ KEMP, JM ADAMS, PL MOTTRAM, WR THOMAS, ID WALKER, JFAP MILLER

Journal article  |  1982  |  The Journal of Experimental Medicine

Expression of VH-coded mRNA molecules in T cells, antigen-specific T cell lines, or T cell hybridomas was not detected using four ..

MESSENGER-RNA FOR SURFACE-IMMUNOGLOBULIN GAMMA-CHAINS ENCODES A HIGHLY CONSERVED TRANSMEMBRANE SEQUENCE AND A 28-RESIDUE INTRACELLULAR DOMAIN

BM TYLER, AF COWMAN, SD GERONDAKIS, JM ADAMS, O BERNARD

Journal article  |  1982  |  Proceedings of the National Academy of Sciences

TRANSCRIPTIONALLY ACTIVE DNA REGION THAT REARRANGES FREQUENTLY IN MURINE LYMPHOID TUMORS

JM ADAMS, S GERONDAKIS, E WEBB, J MITCHELL, O BERNARD, S CORY

Journal article  |  1982  |  Proceedings of the National Academy of Sciences

Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes.

S Cory, BM Tyler, JM Adams

Journal article  |  1981  |  Journal of Molecular and Applied Genetics

To count V kappa genes homologous to particular V kappa nucleotide sequences, thereby permitting estimates for the total V kappa r..

PLASMACYTOMAS WITH MORE THAN ONE IMMUNOGLOBULIN KAPPA-MESSENGER RNA - IMPLICATIONS FOR ALLELIC EXCLUSION

O BERNARD, NM GOUGH, JM ADAMS

Journal article  |  1981  |  Proceedings of the National Academy of Sciences

Although only one allele of an immunoglobulin gene is thought to be expressed as a polypeptide by a given lymphocyte ("allelic exc..

GENERATION OF LONG MESSENGER-RNA FOR MEMBRANE IMMUNOGLOBULIN GAMMA-2A CHAINS BY DIFFERENTIAL SPLICING

BM TYLER, AF COWMAN, JM ADAMS, AW HARRIS

Journal article  |  1981  |  Nature

Organization of genes and spacers within the mouse immunoglobulin VH locus.

DJ Kemp, B Tyler, O Bernard, N Gough, S Gerondakis, JM Adams, S Cory

Journal article  |  1981  |  Journal of Molecular and Applied Genetics

The germline organization of mouse immunoglobulin VH genes has been investigated using cloned VH sequences. Hybridization studies ..

RECOMBINATION EVENTS NEAR THE IMMUNOGLOBULIN C-MU GENE JOIN VARIABLE AND CONSTANT REGION GENES, SWITCH HEAVY-CHAIN EXPRESSION, OR INACTIVATE THE LOCUS

S CORY, E WEBB, J GOUGH, JM ADAMS

Journal article  |  1981  |  Biochemistry

ORGANIZATION AND EXPRESSION OF MURINE IMMUNOGLOBULIN GENES

JM ADAMS, DJ KEMP, O BERNARD, N GOUGH, E WEBB, B TYLER, S GERONDAKIS, S CORY

Journal article  |  1981  |  Immunological Reviews

Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching.

BM Tyler, JM Adams

Journal article  |  1980  |  Nucleic Acids Research

We have used heteroduplex analysis to investigate the sequences surrounding the germline C gamma 1 and C gamma 3 genes, and to com..

ENRICHMENT OF SPECIFIC GENES FROM GENOMIC DNA OR FROM CLONE LIBRARY DNA, USING R-LOOPING

BM TYLER, JM ADAMS

Journal article  |  1980  |  Gene

We have developed a procedure for enriching DNA for specific sequences that is based on R-looping (Thomas et al., 1976). R-loops a..

THE ORGANIZATION AND EXPRESSION OF IMMUNOGLOBULIN GENES

JM ADAMS

Journal article  |  1980  |  Immunology Today

TRANSCRIPTS OF THE IMMUNOGLOBULIN-C-MU GENE VARY IN STRUCTURE AND SPLICING DURING LYMPHOID DEVELOPMENT

DJ KEMP, AW HARRIS, JM ADAMS

Journal article  |  1980  |  Proceedings of the National Academy of Sciences

Two classes of transcripts of the mouse immunoglobulin mu constant region (C mu) gene can be distinguished. Whereas B cells contai..

INTERVENING SEQUENCES DIVIDE THE GENE FOR THE CONSTANT REGION OF MOUSE IMMUNOGLOBULIN-MU CHAINS INTO SEGMENTS, EACH ENCODING A DOMAIN

NM GOUGH, DJ KEMP, BM TYLER, JM ADAMS, S CORY

Journal article  |  1980  |  Proceedings of the National Academy of Sciences

MOLECULAR-CLONING OF SEVEN MOUSE IMMUNOGLOBULIN KAPPA-CHAIN MESSENGER RIBONUCLEIC-ACIDS

NM GOUGH, EA WEBB, S CORY, JM ADAMS

Journal article  |  1980  |  Biochemistry

SOMATIC REARRANGEMENTS FORMING ACTIVE IMMUNOGLOBULIN MU-GENES IN B-LYMPHOID AND T-LYMPHOID CELL-LINES

S CORY, JM ADAMS, DJ KEMP

Journal article  |  1980  |  Proceedings of the National Academy of Sciences

DELETIONS IN THE CONSTANT REGION LOCUS CAN ACCOUNT FOR SWITCHES IN IMMUNOGLOBULIN HEAVY-CHAIN EXPRESSION

S CORY, J JACKSON, JM ADAMS

Journal article  |  1980  |  Nature

MOLECULAR-CLONING OF MOUSE IMMUNOGLOBULIN HEAVY-CHAIN MESSENGER RIBONUCLEIC-ACIDS CODING FOR MU, ALPHA, GAMMA-1, GAMMA-2A, AND GAMMA-3 CHAINS

JM ADAMS, NM GOUGH, EA WEBB, BM TYLER, J JACKSON, S CORY

Journal article  |  1980  |  Biochemistry

DELETIONS ARE ASSOCIATED WITH SOMATIC REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES

S CORY, JM ADAMS

Journal article  |  1980  |  Cell

CLONED EMBRYONIC DNA-SEQUENCES FLANKING THE MOUSE IMMUNOGLOBULIN C-GAMMA-3 AND C-GAMMA-1 GENES

JM ADAMS, E WEBB, S GERONDAKIS, S CORY

Journal article  |  1980  |  Nucleic Acids Research

EXPRESSION OF THE IMMUNOGLOBULIN-C-MU GENE IN MOUSE LYMPHOID-T AND LYMPHOID-B AND MYELOID CELL-LINES

DJ KEMP, AW HARRIS, S CORY, JM ADAMS

Journal article  |  1980  |  Proceedings of the National Academy of Sciences

CLONED PAIRS OF VARIABLE REGION GENES FOR IMMUNOGLOBULIN HEAVY-CHAINS ISOLATED FROM A CLONE LIBRARY OF THE ENTIRE MOUSE GENOME

DJ KEMP, S CORY, JM ADAMS

Journal article  |  1979  |  Proceedings of the National Academy of Sciences

IDENTICAL 3' NON-CODING SEQUENCES IN 5 MOUSE IG K-CHAIN MESSENGER-RNAS FAVOR A UNIQUE CK GENE

NM GOUGH, S CORY, JM ADAMS

Journal article  |  1979  |  Nature

IMMUNOPRECIPITATION OF SPECIFIC POLYSOMES USING STAPHYLOCOCCUS-AUREUS - PURIFICATION OF IMMUNOGLOBULIN KAPPA-CHAIN MESSENGER-RNA FROM MOUSE MYELOMA MPC11

NM GOUGH, JM ADAMS

Journal article  |  1978  |  Biochemistry

NON-CODING NUCLEOTIDE-SEQUENCE IN 3'-TERMINAL REGION OF A MOUSE IMMUNOGLOBULIN KAPPA-CHAIN MESSENGER-RNA DETERMINED BY ANALYSIS OF COMPLEMENTARY-DNA

OD BERNARD, J JACKSON, S CORY, JM ADAMS

Journal article  |  1977  |  Biochemistry

VERY LARGE REPEATING UNIT OF MOUSE DNA CONTAINING 18S, 28S AND 5.8S RIBOSOMAL-RNA GENES

S CORY, JM ADAMS

Journal article  |  1977  |  Cell

COMPARISON OF IMMUNOGLOBULIN-CHAINS MADE IN ASCITES EXTRACT AND RETICULOCYTE LYSATE PROGRAMMED WITH MESSENGER-RNA FROM 4 MOUSE MYELOMAS

BJ SCHMECKPEPER, S CORY, JM ADAMS

Journal article  |  1977  |  Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

SYNTHESIS OF COMPLEMENTARY RNA ON RNA TEMPLATES USING DNA-DEPENDENT RNA-POLYMERASE OF ESCHERICHIA-COLI

O BERNARD, S CORY, JM ADAMS

Journal article  |  1977  |  Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

MODIFIED NUCLEOSIDES AND 5'-END GROUPS IN PURIFIED MOUSE IMMUNOGLOBULIN LIGHT CHAIN MESSENGER-RNA AND RABBIT GLOBIN MESSENGER-RNA DETECTED BY BOROHYDRIDE LABELING

S CORY, C GENIN, JM ADAMS

Journal article  |  1976  |  Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

The modified 5′-terinal sequences in messenger RNA of mouse myeloma cells

S Cory, JM Adams

Journal article  |  1975  |  Journal of Molecular Biology

DETECTION OF A POSSIBLE PRECURSOR OF IMMUNOGLOBULIN LIGHT CHAIN IN MOPC 41A PLASMACYTOMA CELLS

BJ SCHMECKPEPER, JM ADAMS, AW HARRIS

Journal article  |  1975  |  FEBS Letters

MODIFIED 5'-TERMINI IN SMALL NUCLEAR RNAS OF MOUSE MYELOMA CELLS

S CORY, JM ADAMS

Journal article  |  1975  |  Molecular Biology Reports

MODIFIED NUCLEOSIDES AND BIZARRE 5'-TERMINI IN MOUSE MYELOMA MESSENGER-RNA

JM ADAMS, S CORY

Journal article  |  1975  |  Nature

MODIFIED 5'-TERMINAL SEQUENCES IN MESSENGER-RNA OF MOUSE MYELOMA CELLS

S CORY, JM ADAMS

Journal article  |  1975  |  Journal of Molecular Biology

TRANSLATION OF IMMUNOGLOBULIN MESSENGER-RNAS IN A WHEAT-GERM CELL-FREE SYSTEM

BJ SCHMECKPEPER, S CORY, JM ADAMS

Journal article  |  1974  |  Molecular Biology Reports

SEQUENCE OF 51 NUCLEOTIDES AT 3'-END OF R17 BACTERIOPHAGE RNA

S CORY, U RENSING, PF SPAHR, JM ADAMS

Journal article  |  1972  |  Journal of Molecular Biology

NUCLEOTIDE SEQUENCE FROM 5' END TO FIRST CISTRON OF R17 BACTERIOPHAGE RIBONUCLEIC-ACID

JM ADAMS, PF SPAHR, S CORY

Journal article  |  1972  |  Biochemistry

NUCLEOTIDE SEQUENCES OF FRAGMENTS OF R17 BACTERIOPHAGE RNA FROM REGION IMMEDIATELY PRECEDING COAT-PROTEIN CISTRON

JM ADAMS, PF SPAHR, S CORY

Journal article  |  1972  |  European Journal of Biochemistry

UNTRANSLATED NUCLEOTIDE SEQUENCE AT 5'-END OF R17 BACTERIOPHAGE RNA

JM ADAMS, S CORY

Journal article  |  1970  |  Nature

Nucleotide sequences from fragments of R17 bacterophage RNA.

JM Adams, PG Jeppesen, F Sanger, BG Barrell

Journal article  |  1969  |  Cold Spring Harbor Symposia on Quantitative Biology

NUCLEOTIDE SEQUENCE FROM COAT PROTEIN CISTRON OF R17 BACTERIOPHAGE RNA

JM ADAMS, PG JEPPESEN, F SANGER, BG BARRELL

Journal article  |  1969  |  Nature

ON RELEASE OF FORMYL GROUP FROM NASCENT PROTEIN

JM ADAMS

Journal article  |  1968  |  Journal of Molecular Biology

Protein synthesis directed by DNA phage messengers.

GN Gussin, MR Capecchi, JM Adams, JE Argetsinger, J Tooze, K Weber, JD Watson

Journal article  |  1966  |  Cold Spring Harbor Symposia on Quantitative Biology

N-FORMYLMETHIONYL-SRNA AS INITIATOR OF PROTEIN SYNTHESIS

JM ADAMS, MR CAPECCHI

Journal article  |  1966  |  Proceedings of the National Academy of Sciences