profile icon
Prof

David Huang

Honorary
Medical Biology (W.E.H.I.)
Novel Anti-Cancer Therapies
science & technology
life sciences & biomedicine
apoptosis
animals
humans
mice
proto-oncogene proteins c-bcl-2
cell biology
David Huang's Profile Picture
Prof

David Huang

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Control of apoptotic cell death in cancer
David Huang's Profile Picture
Prof

David Huang

 

Research interest

The long-term goals of my laboratory are to understand how cancers arise and to develop better approaches for their diagnosis and treatment. Our focus is on the regulation of apoptosis by the Bcl-2 family.

In collaboration with other scientists at the institute, members of my laboratory are unravelling the mechanisms by which members of the Bcl-2 family determine whether a cell lives or dies.

Precisely how Bcl-2 restrains essential cell death mediators Bax and Bak is unclear and how Bax and Bak become activated to drive apoptosis is also uncertain. Elucidating the key steps in cell death signalling is essential for understanding how cell death is regulated physiologically.

We are actively translating the knowledge we have gained so far into efforts to target Bcl-2 or its pro-survival relatives for treating patients with cancers (e.g. leukaemias, lymphomas) and identifying potential mechanisms why such small molecule inhibitors might fail.

www.wehi.edu.au/people/david-huang

Scholarly Works

Displaying the 196 most recent scholarly works by David Huang.

News

Displaying the most recent news article by David Huang.

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)