David Huang

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins.

Leah Fitzsimmons, Rachel Cartlidge, Catherine Chang, Nenad Sejic, Laura CA Galbraith, Chathura D Suraweera, Deborah Croom-Carter, Grant Dewson, Rosemary J Tierney, Andrew I Bell, Clare Shannon-Lowe, Marco J Herold, Alan B Rickinson, Peter M Colman, David CS Huang, Andreas Strasser, Marc Kvansakul, Martin Rowe, Gemma L Kelly

Journal article  |  2019  |  Cell Death & Differentiation

Epstein-Barr virus (EBV), which is ubiquitous in the adult population, is causally associated with human malignancies. Like many i..

Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

V Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O'Connor, Chris D Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David CS Huang, Makoto T Hayashi, Anthony J Cesare

Journal article  |  2019  |  Nature Communications

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery, Richard W Birkinshaw, Tamia Nguyen, Jia-nan Gong, Ella R Thompson, Zhen Xu, David A Westerman, Peter E Czabotar, Michael Dickinson, David CS Huang, John F Seymour, Andrew W Roberts

Journal article  |  2019  |  British Journal of Haematology

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  Cell Death & Differentiation

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Richard W Birkinshaw, Jia-nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David CS Huang, Peter M Colman, Peter E Czabotar

Journal article  |  2019  |  Nature Communications

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M Moujalled, Giovanna Pomilio, Corina Ghiurau, Adam Ivey, Jessica Salmon, Sewa Rijal, Sarah Macraild, Lan Zhang, Tse-Chieh Teh, Ing-Soo Tiong, Ping Lan, Maia Chanrion, Audrey Claperon, Francesca Rocchetti, Adrien Zichi, Laurence Kraus-Berthier, Youzhen Wang, Ensar Hamovic, Erick Morris, Frederic Colland, et al.

Journal article  |  2019  |  Leukemia

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella R Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E Lew, Ian J Majewski, Daniel HD Gray, David A Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs

Huiqin Liu, Mengnan Sun, Zhengsheng Liu, Chao Kong, Weijian Kong, Junxiao Ye, Jianan Gong, David CS Huang, Feng Qian

Journal article  |  2019  |  Journal of Controlled Release

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Danny Chui, Douglas A Whittington, Xin Huang, Leszek Poppe, Alan C Cheng, Mario Cardozom, Jonathan Houze, Yunxiao Li, Brian Lucas, Nick A Paras, Xianghong Wang, Joshua P Taygerly, Marc Vimolratana, Manuel Zancanella, Liusheng Zhu, et al.

Journal article  |  2018  |  Cancer Discovery

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David Huang, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W Roberts, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  Nature Communications

IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos

Pasquale L Fedele, Simon N Willis, Yang Liao, Michael S Low, Jai Rautela, David H Segal, Jia-Nan Gong, Nicholas D Huntington, Wei Shi, David CS Huang, George Grigoriadis, Julie Tellier, Stephen L Nutt

Journal article  |  2018  |  Blood

CARM1-mediated methylation of protein arginine methyltransferase 5 represses human -globin gene expression in erythroleukemia cells

Min Nie, Yadong Wang, Chan Guo, Xinyu Li, Ying Wang, Yexuan Deng, Bing Yao, Tao Gui, Chi Ma, Ming Liu, Panxue Wang, Ruoyun Wang, Renxiang Tan, Ming Fang, Bing Chen, Yinghong He, David CS Huang, Junyi Ju, Quan Zhao

Journal article  |  2018  |  Journal of Biological Chemistry

Infection with flaviviruses requires BCLXL for cell survival

Tatsuya Suzuki, Toru Okamoto, Hiroshi Katoh, Yukari Sugiyama, Shinji Kusakabe, Makoto Tokunaga, Junki Hirano, Yuka Miyata, Takasuke Fukuhara, Masahito Ikawa, Takashi Satoh, Sachiyo Yoshio, Ryosuke Suzuki, Masayuki Saijo, David CS Huang, Tatsuya Kantor, Shizuo Akira, Yoshiharu Matsuura

Journal article  |  2018  |  PLOS Pathogens

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Esther JY Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J Majewski, Fan-Suo Geng, Jaber Firas, David CS Huang, Mark F van Delft, Joan K Heath

Journal article  |  2018  |  Stem Cell Reports

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, DM Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, PG Ekert, G Lessene, SP Glaser, DCS Huang, AW Roberts, MA Guthridge, AH Wei

Journal article  |  2018  |  Leukemia

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

Journal article  |  2017  |  ACS Medicinal Chemistry Letters

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, et al.

Journal article  |  2017  |  Nature Communications

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins

A Antignani, D Segal, N Simon, RJ Kreitman, D Huang, DJ FitzGerald

Journal article  |  2017  |  Oncogene

Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia

Kate McArthur, Akshay A D'Cruz, David Segal, Kurt Lackovic, Andrew F Wilks, Joanne A O'Donnell, Cameron J Nowell, Motti Gerlic, David CS Huang, Christopher J Burns, Ben A Croker

Journal article  |  2017  |  Oncotarget

Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia

Andrew W Roberts, Stephan Stilgenbauer, John F Seymour, David CS Huang

Journal article  |  2017  |  Clinical Cancer Research

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax

Mary Ann Anderson, Constantine Tam, Thomas E Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David CS Huang, John F Seymour, Andrew W Roberts

Journal article  |  2017  |  Blood

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath

Journal article  |  2017  |  Cell Death & Differentiation

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  Cell Death & Differentiation

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies Genome Editing Techniques and Their Therapeutic Applications

AW Roberts, DCS Huang

Journal article  |  2017  |  Clinical Pharmacology & Therapeutics

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai, Guillaume Lessene, David CS Huang, Walter D Fairlie, Andreas Strasser, Marco J Herold

Journal article  |  2016  |  Cell Death & Differentiation

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy, Zoltan Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaetane Le Toumelin-Braizat, Maia Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Marton C Sekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Gabor Radics, Agnes Proszenyak, Balazs Balint, Levente Ondi, Gabor Blasko, et al.

Journal article  |  2016  |  Nature

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J Herold, Andrew W Roberts, David CS Huang

Journal article  |  2016  |  Blood

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

Seong Lin Khaw, Santi Suryani, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Raushan T Kurmasheva, Catherine A Billups, Stephen W Erickson, Yuelong Guo, Peter J Houghton, Malcolm A Smith, Hernan Carol, Andrew W Roberts, David CS Huang, Richard B Lock

Journal article  |  2016  |  Blood

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Ingela B Vikstrom, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, JH Marco Jansen, Jeanette HW Leusen, Andreas Strasser, David CS Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton

Journal article  |  2016  |  Cell Death & Disease

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

Z Xu, PP Sharp, Y Yao, D Segal, CH Ang, SL Khaw, BJ Aubrey, J Gong, GL Kelly, MJ Herold, A Strasser, AW Roberts, WS Alexander, CJ Burns, DCS Huang, SP Glaser

Journal article  |  2016  |  Leukemia

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism

Mary Ann Anderson, Jing Deng, John F Seymour, Constantine Tam, Su Young Kim, Joshua Fein, Lijian Yu, Jennifer R Brown, David Westerman, Eric G Si, Ian J Majewski, David Segal, Sari L Heitner Enschede, David CS Huang, Matthew S Davids, Anthony Letai, Andrew W Roberts

Journal article  |  2016  |  Blood

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Sweta Iyer, Khatira Anwari, Amber E Alsop, Wai Shan Yuen, David CS Huang, John Carroll, Nicholas A Smith, Brian J Smith, Grant Dewson, Ruth M Kluck

Journal article  |  2016  |  Nature Communications

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  Cell Reports

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Mary Speir, Kate E Lawlor, Stefan P Glaser, Gilu Abraham, Seong Chow, Adam Vogrin, Keith E Schulze, Ralf Schuelein, Lorraine A O'Reilly, Kylie Mason, Elizabeth L Hartland, Trevor Lithgow, Andreas Strasser, Guillaume Lessene, David CS Huang, James E Vince, Thomas Naderer

Journal article  |  2016  |  Nature Microbiology

Current challenges and novel treatment strategies in double hit lymphomas

Mary Ann Anderson, Alpha Tsui, Meaghan Wall, David CS Huang, Andrew W Roberts

Journal article  |  2016  |  Therapeutic Advances in Hematology

The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia

Tun Kiat Ko, Hui San Chin, Charles TH Chuah, John WJ Huang, King-Pan Ng, Seong Lin Khaw, David CS Huang, S Tiong Ong

Journal article  |  2016  |  Oncotarget

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy

Journal article  |  2016  |  Cell Death & Disease

Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy

Duong Nhu, Guillaume Lessene, David CS Huang, Christopher J Burns

Journal article  |  2016  |  MedChemComm

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

Christina B Woelwer, Luke B Pase, Helen B Pearson, Nathan J Goedde, Kurt Lackovic, David CS Huang, Sarah M Russell, Patrick O Humbert

Journal article  |  2015  |  PLOS ONE

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma

Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang A Shelat, Cathryn M Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Asa Karlstroem, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW Zannettino, Chris Burns, David CS Huang, Michael A Dyer, Kaylene J Simpson, Carl R Walkley

Journal article  |  2015  |  Clinical Cancer Research

BCL2 inhibition in double hit lymphoma

Mary Ann Anderson, David CS Huang, Andrew W Roberts

Journal article  |  2015  |  Leukemia & Lymphoma

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Emma M Carrington, Jian-Guo Zhang, Robyn M Sutherland, Ingela B Vikstrom, Jamie L Brady, Priscilla Soo, David Vremec, Cody Allison, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Stephanie Grabow, Eleonora Ottina, Marco J Herold, Marc Pellegrini, David CS Huang, David M Tarlinton, Andreas Strasser, Andrew M Lew, Yifan Zhan

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Joel D Leverson, Darren C Phillips, Michael J Mitten, Erwin R Boghaert, Dolores Diaz, Stephen K Tahir, Lisa D Belmont, Paul Nimmer, Yu Xiao, Xiaoju Max Ma, Kym N Lowes, Peter Kovar, Jun Chen, Sha Jin, Morey Smith, John Xue, Haichao Zhang, Anatol Oleksijew, Terrance J Magoc, Kedar S Vaidya, et al.

Journal article  |  2015  |  Science Translational Medicine

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.

Journal article  |  2015  |  Nature Communications

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production

Yifan Zhan, Emma M Carrington, Hyun-Ja Ko, Ingela B Vikstrom, Shereen Oon, Jian-Guo Zhang, David Vremec, Jamie L Brady, Philippe Bouillet, Li Wu, David CS Huang, Ian P Wicks, Eric F Morand, Andreas Strasser, Andrew M Lew

Journal article  |  2015  |  Arthritis & Rheumatology

A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo

EF Lee, M Takiguchi, A Pettikiriarachchi, M Evangelista, DCS Huang, RA Dickins, WD Fairlie

Journal article  |  2015  |  Cell Death & Disease

Autoreactive T cells induce necrosis and not BCL-2-regulated or death receptor-mediated apoptosis or RIPK3-dependent necroptosis of transplanted islets in a mouse model of type 1 diabetes

Yuxing Zhao, Nicholas A Scott, Stacey Fynch, Lorraine Elkerbout, W Wei-Lynn Wong, Kylie D Mason, Andreas Strasser, David C Huang, Thomas WH Kay, Helen E Thomas

Journal article  |  2015  |  Diabetologia

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Michael J White, Kate McArthur, Donald Metcalf, Rachael M Lane, John C Cambier, Marco J Herold, Mark F van Delft, Sammy Bedoui, Guillaume Lessene, Matthew E Ritchie, David CS Huang, Benjamin T Kile

Journal article  |  2014  |  Cell

Effects of Tamoxifen and oestrogen on histology and radiographic density in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers

GL Chew, CW Huo, D Huang, T Blick, P Hill, J Cawson, H Frazer, MC Southey, JL Hopper, K Britt, MA Henderson, I Haviv, EW Thompson

Journal article  |  2014  |  Breast Cancer Research and Treatment

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

Bill C Hawkins, Lisa M Lindqvist, Nhu Duong, Phillip P Sharp, David Segal, Andrew K Powell, Michael Campbell, Eileen Ryan, Jennifer M Chambers, Jonathan M White, Mark A Rizzacasa, Guillaume Lessene, David CS Huang, Christopher J Burns

Journal article  |  2014  |  ChemMedChem

Targeting BCL2 for the Treatment of Lymphoid Malignancies

Mary Ann Anderson, David Huang, Andrew Roberts

Journal article  |  2014  |  Seminars in Hematology

A Biosensor of Src Family Kinase Conformation by Exposable Tetracysteine Useful for Cell-Based Screening

Sevgi Irtegun, Rebecca Wood, Kurt Lackovic, Joerg Schweiggert, Yasmin M Ramdzan, David CS Huang, Terrence D Mulhern, Danny M Hatters

Journal article  |  2014  |  ACS Chemical Biology

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

Lisa M Lindqvist, Melanie Heinlein, David CS Huang, David L Vaux

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199

SL Khaw, D Merino, MA Anderson, SP Glaser, P Bouillet, AW Roberts, DCS Huang

Journal article  |  2014  |  Leukemia

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Danette Dudley, Paul Gibbons, Brad E Sleebs, Carl S Rye, George Nikolakopoulos, Chinh Bui, Sanji Kulasegaram, Wilhelmus JA Kersten, Brian J Smith, Peter E Czabotar, Peter M Colman, David CS Huang, Jonathan B Baell, Keith G Watson, Lisa Hasvold, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

Toru Okamoto, David Segal, Kerry Zobel, Anna Fedorova, Hong Yang, Wayne J Fairbrother, David CS Huang, Brian J Smith, Kurt Deshayes, Peter E Czabotar

Journal article  |  2014  |  ACS Chemical Biology

De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-X-L: Synthesis, Structural and Biochemical Characterization

Ryan M Brady, Amelia Vom, Michael J Roy, Nathan Toovey, Brian J Smith, Rebecca M Moss, Effie Hatzis, David CS Huang, John P Parisot, Hong Yang, Ian P Street, Peter M Colman, Peter E Czabotar, Jonathan B Baell, Guillaume Lessene

Journal article  |  2014  |  Journal of Medicinal Chemistry

Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David CS Huang

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

Gemma L Kelly, Stephanie Grabow, Stefan P Glaser, Leah Fitzsimmons, Brandon J Aubrey, Toru Okamoto, Liz J Valente, Mikara Robati, Lin Tai, W Douglas Fairlie, Erinna F Lee, Mikael S Lindstrom, Klas G Wiman, David CS Huang, Philippe Bouillet, Martin Rowe, Alan B Rickinson, Marco J Herold, Andreas Strasser

Journal article  |  2014  |  Genes & Development

Evaluation of functional groups as acetyl-lysine mimetics for BET bromodomain inhibition

Phillip P Sharp, Jean-Marc Garnier, David CS Huang, Christopher J Burns

Journal article  |  2014  |  Med. Chem. Commun.

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A Powell, Francois Vergez, David H Segal, Nhu-Y N Nguyen, Adele Baker, Tse-Chieh Teh, Emma F Barry, Jean-Emmanuel Sarry, Erwin M Lee, Tracy L Nero, Anissa M Jabbour, Giovanna Pomilio, Benjamin D Green, Stephane Manenti, Stefan P Glaser, Michael W Parker, Angel F Lopez, Paul G Ekert, Richard B Lock, et al.

Journal article  |  2013  |  Blood

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Dynamic changes in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers during various murine peripartum states and over time

GL Chew, D Huang, CW Huo, T Blick, P Hill, J Cawson, H Frazer, MD Southey, JL Hopper, MA Henderson, I Haviv, EW Thompson

Journal article  |  2013  |  Breast Cancer Research and Treatment

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia

Mary Ann Anderson, David CS Huang, Andrew W Roberts

Journal article  |  2013  |  Leukemia and Lymphoma

Stabilizing the Pro-Apoptotic Bim BH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Toru Okamoto, Kerry Zobel, Anna Fedorova, Clifford Quan, Hong Yang, Wayne J Fairbrother, David CS Huang, Brian J Smith, Kurt Deshayes, Peter E Czabotar

Conference Proceedings  |  2013  |  BIOPOLYMERS

Synthesis of Biotinylated Episilvestrol: Highly Selective Targeting of the Translation Factors eIF4AI/II

Jennifer M Chambers, Lisa M Lindqvist, Andrew Webb, David CS Huang, G Paul Savage, Mark A Rizzacasa

Journal article  |  2013  |  Organic Letters

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

MCMV-mediated Inhibition of the Pro-apoptotic Bak Protein Is Required for Optimal In Vivo Replication

Peter Fleming, Marc Kvansakul, Valentina Voigt, Benjamin T Kile, Ruth M Kluck, David CS Huang, Mariapia A Degli-Esposti, Christopher E Andoniou

Journal article  |  2013  |  PLoS Pathogens

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Toru Okamoto, Kerry Zobel, Anna Fedorova, Clifford Quan, Hong Yang, Wayne J Fairbrother, David CS Huang, Brian J Smith, Kurt Deshayes, Peter E Czabotar

Journal article  |  2013  |  ACS Chemical Biology

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J Souers, Joel D Leverson, Erwin R Boghaert, Scott L Ackler, Nathaniel D Catron, Jun Chen, Brian D Dayton, Hong Ding, Sari H Enschede, Wayne J Fairbrother, David CS Huang, Sarah G Hymowitz, Sha Jin, Seong Lin Khaw, Peter J Kovar, Lloyd T Lam, Jackie Lee, Heather L Maecker, Kennan C Marsh, Kylie D Mason, et al.

Journal article  |  2013  |  Nature Medicine

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman

Journal article  |  2013  |  Cell

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Megumi Takiguchi, Lukas E Dow, Julia E Prier, Catherine L Carmichael, Benjamin T Kile, Stephen J Turner, Scott W Lowe, David CS Huang, Ross A Dickins

Journal article  |  2013  |  PLoS One

Sheeppox Virus SPPV14 Encodes a Bcl-2-Like Cell Death Inhibitor That Counters a Distinct Set of Mammalian Proapoptotic Proteins

Toru Okamoto, Stephanie Campbell, Ninad Mehta, John Thibault, Peter M Colman, Michele Barry, David CS Huang, Marc Kvansakul

Journal article  |  2012  |  Journal of Virology

Synthesis and biological evaluation of a potent salicylihalamide A lactam analogue

Dan Balan, Christopher J Burns, Nicholas G Fisk, Helmut Huegel, David CS Huang, David Segal, Charlotte White, Joerg Wagler, Mark A Rizzacasa

Journal article  |  2012  |  Organic & Biomolecular Chemistry

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

Journal article  |  2012  |  Cell Death & Disease

A Cluster of Interferon-gamma-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

Masahiro Yamamoto, Megumi Okuyama, Ji Su Ma, Taishi Kimura, Naganori Kamiyama, Hiroyuki Saiga, Jun Ohshima, Miwa Sasai, Hisako Kayama, Toru Okamoto, David CS Huang, Dominique Soldati-Favre, Kyoji Horie, Junji Takeda, Kiyoshi Takeda

Journal article  |  2012  |  Immunity

Total Synthesis of 2 ''',5 '''-Diepisilvestrol and Its C1 ''' Epimer: Key Structure Activity Relationships at C1 ''' and C2 '''

Jennifer M Chambers, David CS Huang, Lisa M Lindqvist, G Paul Savage, Jonathan M White, Mark A Rizzacasa

Journal article  |  2012  |  Journal of Natural Products

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Delphine Merino, Seong L Khaw, Stefan P Glaser, Daniel J Anderson, Lisa D Belmont, Chihunt Wong, Peng Yue, Mikara Robati, Belinda Phipson, Walter D Fairlie, Erinna F Lee, Kirsteen J Campbell, Cassandra J Vandenberg, Suzanne Cory, Andrew W Roberts, Mary JC Ludlam, David CS Huang, Philippe Bouillet

Journal article  |  2012  |  Blood

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Michael J White, Simone M Schoenwaelder, Emma C Josefsson, Kate E Jarman, Katya J Henley, Chloe James, Marlyse A Debrincat, Shaun P Jackson, David CS Huang, Benjamin T Kile

Journal article  |  2012  |  Blood

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

Jian-Guo Zhang, Peter E Czabotar, Antonia N Policheni, Irina Caminschi, Soo San Wan, Susie Kitsoulis, Kirsteen M Tullett, Adeline Y Robin, Rajini Brammananth, Mark F van Delft, Jinhua Lu, Lorraine A O'Reilly, Emma C Josefsson, Benjamin T Kile, Wei Jin Chin, Justine D Mintern, Maya A Olshina, Wilson Wong, Jake Baum, Mark D Wright, et al.

Journal article  |  2012  |  Immunity

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Andrew W Roberts, John F Seymour, Jennifer R Brown, William G Wierda, Thomas J Kipps, Seong Lin Khaw, Dennis A Carney, Simon Z He, David CS Huang, Hao Xiong, Yue Cui, Todd A Busman, Evelyn M McKeegan, Andrew P Krivoshik, Sari H Enschede, Rod Humerickhouse

Journal article  |  2012  |  Journal of Clinical Oncology

Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737

Keryn M Lucas, Nethia Mohana-Kumaran, Diana Lau, Xu Dong Zhang, Peter Hersey, David C Huang, Wolfgang Weninger, Nikolas K Haass, John D Allen

Journal article  |  2012  |  Clinical Cancer Research

Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies

Seong Lin Khaw, David CS Huang, Andrew W Roberts

Journal article  |  2011  |  Pathology

Evaluation of the Bcl-2 family antagonist ABT-737 in collagen-induced arthritis

Kate E Lawlor, Scott D Smith, Annemarie van Nieuwenhuijze, David CS Huang, Ian P Wicks

Journal article  |  2011  |  Journal of Leukocyte Biology

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Emma C Josefsson, Chloe James, Katya J Henley, Marlyse A Debrincat, Kelly L Rogers, Mark R Dowling, Michael J White, Elizabeth A Kruse, Rachael M Lane, Sarah Ellis, Paquita Nurden, Kylie D Mason, Lorraine A O'Reilly, Andrew W Roberts, Donald Metcalf, David CS Huang, Benjamin T Kile

Journal article  |  2011  |  Journal of Experimental Medicine

Bcl-x(L)-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Simone M Schoenwaelder, Kate E Jarman, Elizabeth E Gardiner, My Hua, Jianlin Qiao, Michael J White, Emma C Josefsson, Imala Alwis, Akiko Ono, Abbey Willcox, Robert K Andrews, Kylie D Mason, Hatem H Salem, David CS Huang, Benjamin T Kile, Andrew W Roberts, Shaun P Jackson

Journal article  |  2011  |  Blood

Erratum: Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 (Nature (2011) 471 (110-114))

IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, E Helgason, JA Ernst, M Eby, J Liu, LD Belmont, JS Kaminker, KM Orourke, K Pujara, PB Kohli, AR Johnson, ML Chiu, JR Lill, PK Jackson, WJ Fairbrother, et al.

Journal article  |  2011  |  Nature

Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

Sandro Prato, Justine D Mintern, Mireille H Lahoud, David C Huang, Jose A Villadangos

Journal article  |  2011  |  Immunology and Cell Biology

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Brad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, W Douglas Fairlie, John A Flygare, David CS Huang, Wilhelmus JA Kersten, Michael FT Koehler, Guillaume Lessene, Kym Lowes, John P Parisot, Brian J Smith, Morey L Smith, Andrew J Souers, Ian P Street, Hong Yang, Jonathan B Baell

Journal article  |  2011  |  Journal of Medicinal Chemistry

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J Anderson, Elizabeth Helgason, James A Ernst, Mike Eby, Jinfeng Liu, Lisa D Belmont, Josh S Kaminker, Karen M O'Rourke, Kanan Pujara, Pawan Bir Kohli, Adam R Johnson, Mark L Chiu, Jennie R Lill, Peter K Jackson, Wayne J Fairbrother, et al.

Journal article  |  2011  |  Nature

Deerpox Virus Encodes an Inhibitor of Apoptosis That Regulates Bak and Bax

Logan Banadyga, Sing-Chi Lam, Toru Okamoto, Marc Kvansakul, David C Huang, Michele Barry

Journal article  |  2011  |  Journal of Virology

Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim

Diane Moujalled, Ross Weston, Holly Anderton, Robert Ninnis, Pranay Goel, Andrew Coley, David CS Huang, Li Wu, Andreas Strasser, Hamsa Puthalakath

Journal article  |  2011  |  EMBO Rep.

Transgenic, inducible RNAi in megakaryocytes and platelets in mice

M Takiguchi, C James, EC Josefsson, CL Carmichael, PK Premsrirut, SW Lowe, JR Hamilton, DCS Huang, BT Kile, RA Dickins

Journal article  |  2010  |  Journal of Thrombosis and Haemostasis

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

Marc Kvansakul, Andrew H Wei, Jamie I Fletcher, Simon N Willis, Lin Chen, Andrew W Roberts, David CS Huang, Peter M Colman

Journal article  |  2010  |  PLOS PATHOGENS

The BH3-Mimetic ABT-737 Induces Mast Cell Apoptosis In Vitro and In Vivo: Potential for Therapeutics

Mats Karlberg, Maria Ekoff, David CS Huang, Paula Mustonen, Ilkka T Harvima, Gunnar Nilsson

Journal article  |  2010  |  J. Immunol.

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

Emma M Carrington, Ingela B Vikstrom, Amanda Light, Robyn M Sutherland, Sarah L Londrigan, Kylie D Mason, David CS Huang, Andrew M Lew, David M Tarlinton

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases

MF van Delft, DP Smith, MH Lahoud, DCS Huang, JM Adams

Journal article  |  2010  |  Cell Death & Differentiation

Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis

M Karlberg, M Ekoff, V Labi, A Strasser, D Huang, G Nilsson

Journal article  |  2010  |  Cell Death Dis.

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax

Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David CS Huang, Philippe Bouillet, Janette Allison, Thomas WH Kay, Andreas Strasser, Helen E Thomas

Journal article  |  2010  |  Diabetes

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Martin Schwickart, XiaoDong Huang, Jennie R Lill, Jinfeng Liu, Ronald Ferrando, Dorothy M French, Heather Maecker, Karen O'Rourke, Fernando Bazan, Jeffrey Eastham-Anderson, Peng Yue, David Dornan, David CS Huang, Vishva M Dixit

Journal article  |  2010  |  Nature

Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins

Erinna F Lee, Anna Fedorova, Kerry Zobel, Michelle J Boyle, Hong Yang, Matthew A Perugini, Peter M Colman, David CS Huang, Kurt Deshayes, W Douglas Fairlie

Journal article  |  2009  |  Journal of Biological Chemistry

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia

KD Mason, SL Khaw, KC Rayeroux, E Chew, EF Lee, WD Fairlie, AP Grigg, JF Seymour, J Szer, DCS Huang, AW Roberts

Journal article  |  2009  |  Leukemia

Bax activation by Bim?

PE Czabotar, PM Colman, DCS Huang

Journal article  |  2009  |  Cell Death Differ.

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J Jost, Stephanie Grabow, Daniel Gray, Mark D McKenzie, Ueli Nachbur, David CS Huang, Philippe Bouillet, Helen E Thomas, Christoph Borner, John Silke, Andreas Strasser, Thomas Kaufmann

Journal article  |  2009  |  Nature

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Simone M Schoenwaelder, Yuping Yuan, Emma C Josefsson, Michael J White, Yu Yao, Kylie D Mason, Lorraine A O'Reilly, Katya J Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W Roberts, David CS Huang, Hatem H Salem, Benjamin T Kile, Shaun P Jackson

Journal article  |  2009  |  Blood

MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

Lorraine A O'Reilly, Elizabeth A Kruse, Hamsa Puthalakath, Priscilla N Kelly, Thomas Kaufmann, David CS Huang, Andreas Strasser

Journal article  |  2009  |  Journal of Immunology

Erratum: Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (18081-18087) DOI: 10.1073/pnas.0808691105)

JI Fletcher, S Meusburger, CJ Hawkins, DT Riglar, EF Lee, WD Fairlie, DCS Huang, JM Adams

Journal article  |  2009  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virally mediated inhibition of Bax in leukocytes promotes dissemination of murine cytomegalovirus

M Manzur, P Fleming, DCS Huang, MA Degli-Esposti, CE Andoniou

Journal article  |  2009  |  Cell Death Differ.

beta TrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

Elinor Dehan, Florian Bassermann, Daniele Guardavaccaro, Gaia Vasiliver-Shamis, Michael Cohen, Kym N Lowes, Michael Dustin, David CS Huang, Jack Taunton, Michele Pagano

Journal article  |  2009  |  Mol. Cell

BH3-mimetics - the solution to chemoresistance?

Seong L Khaw, David CS Huang, Andrew W Roberts

Journal article  |  2009  |  Leuk. Lymphoma

BH3-only proteins and their roles in programmed cell death

M Giam, DCS Huang, P Bouillet

Journal article  |  2008  |  Oncogene

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

Jamie I Fletchera, Sarina Meusburger, Christine J Hawkins, David T Riglar, Erinna F Lee, W Douglas Fairlie, David CS Huang, Jerry M Adams

Journal article  |  2008  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

Kylie D Mason, Cassandra J Vandenberg, Clare L Scott, Andrew H Wei, Suzanne Cory, David CS Huang, Andrew W Roberts

Journal article  |  2008  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency

EF Lee, L Chen, H Yang, PM Colman, DCS Huang, WD Fairlie

Journal article  |  2008  |  Cell Death Differ.

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

M Kvansakul, H Yang, WD Fairlie, PE Czabotar, SF Fischer, MA Perugini, DCS Huang, PM Colman

Journal article  |  2008  |  Cell Death & Differentiation

Erratum: Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis (Cell Death and Differentiation (2006) vol. 13 (109-118) 10.1038/sj.cdd.4401718)

SF Fischer, H Ludwig, J Holzapfel, M Kvansakul, L Chen, DCS Huang, G Sutter, M Knese, G Häcker

Journal article  |  2008  |  Cell Death & Differentiation

Proapoptotic BH3-only protein bid is essential for death receptor-induced apoptosis of pancreatic beta-cells

Mark D McKenzie, Emma M Carrington, Thomas Kaufmann, Andreas Strasser, David CS Huang, Thomas WH Kay, Janette Allison, Helen E Thomas

Journal article  |  2008  |  Diabetes

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Erinna F Lee, Peter E Czabotar, Mark F Van Delft, Ewa M Michalak, Michelle J Boyle, Simon N Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M Colman, David CS Huang, W Douglas Fairlie

Journal article  |  2008  |  Journal of Cell Biology

Controlling the cell death mediators Bax and Bak - Puzzles and conundrums

Jamie I Fletcher, David CS Huang

Journal article  |  2008  |  Cell Cycle

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

Mark S Cragg, Junya Kuroda, Hamsa Puthalakath, David CS Huang, Andreas Strasser

Journal article  |  2007  |  PLoS Med.

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis, Noboru Motoyama, David CS Huang, Stephen L Nutt, David M Tarlinton, Andreas Strasser

Journal article  |  2007  |  NATURE IMMUNOLOGY

Response: Does bid play a role in the DNA damage response?

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Damien Arnoult, Andreas Strasser

Journal article  |  2007  |  Cell

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak

Rachel T Uren, Grant Dewson, Lin Chen, Stephanie C Coyne, David CS Huang, Jerry M Adams, Ruth M Kluck

Journal article  |  2007  |  Journal of Cell Biology

The BH3-only protein bid is dispensable for DNA darnage- and replicative stress-induced apoptosis or cell-cycle arrest

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Andreas Strasser

Journal article  |  2007  |  Cell

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E Czabotar, Erinna F Lee, Mark F van Delft, Catherine L Day, Brian J Smith, David CS Huang, W Douglas Fairlie, Mark G Hinds, Peter M Colman

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

A structural viral mimic of prosurvival Bcl-2: A pivotal role for sequestering proapoptotic Bax and Bak

Marc Kvansakul, Mark F van Delft, Erinna F Lee, Jacqueline M Gulbis, W Douglas Fairlie, David CS Huang, Peter M Colman

Journal article  |  2007  |  Molecular Cell

(alpha/beta alpha)-Peptide antagonists of BH3 Domain/Bcl-x(L) recognition: Toward general strategies for foldamer-based inhibition of protein-protein interactions

Jack D Sadowsky, W Douglas Fairlie, Erik B Hadley, Hee-Seung Lee, Naoki Umezawa, Zaneta Nikolovska-Coleska, Shaomeng Wang, David CS Huang, York Tomita, Samuel H Gellman

Journal article  |  2007  |  Journal of the American Chemical Society

Erratum: Bim and Bad mediate imatinib-induced killing of Bcr/Abl leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (Proceedings of the National Academy of Sciences of the United States of America (October 3, 2006) 40, 103 (14907-14912) DOI: 10.1073/pnas.0606176103)

J Kuroda, H Puthalakath, MS Cragg, PN Kelly, P Bouillet, DCS Huang, S Kimura, OG Ottmann, BJ Druker, A Villunger, AW Roberts, A Strasser

Journal article  |  2006  |  Proceedings of the National Academy of Sciences

"Bim and Bad mediate imatinib-induced killing of Bcr/Abl( ) leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic" (vol 103, pg 14907, 2006)

Junya Kuroda, Hamsa Puthalakath, Mark S Cragg, Priscilla N Kelly, Philippe Bouillet, David CS Huang, Shinya Kimura, Oliver G Ottmann, Brian J Druker, Andreas Villunger, Andrew W Roberts, Andreas Strasser

Journal article  |  2006  |  Proc. Natl. Acad. Sci. U. S. A.

BH3-only proteins: orchestrating cell death

JI Fletcher, DCS Huang

Journal article  |  2006  |  Cell Death & Differentiation

How the Bcl-2 family of proteins interact to regulate apoptosis

MF van Delft, DC Huang

Journal article  |  2006  |  Cell Research

Modified vaccinia virus Ankara protein F1L is a novel BH3-domain-binding protein and acts together with the early viral protein E3L to block virus-associated apoptosis

SF Fischer, H Ludwig, J Holzapfel, M Kvansakul, L Chen, DCS Huang, G Sutter, M Knese, G Hacker

Journal article  |  2006  |  Cell Death & Differentiation

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

J Silke, T Kratina, D Chu, PG Ekert, CL Day, M Pakusch, DCS Huang, DL Vaux

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

M Pellegrini, S Bath, VS Marsden, DCS Huang, D Metcalf, AW Harris, A Strasser

Journal article  |  2005  |  Blood

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x(L), but not Bcl-2, until displaced by BH3-only proteins

SN Willis, L Chen, G Dewson, A Wei, E Naik, JI Fletcher, JM Adams, DCS Huang

Journal article  |  2005  |  Genes & Development

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands

CL Day, L Chen, SJ Richardson, PJ Harrison, DCS Huang, MG Hinds

Journal article  |  2005  |  Journal of Biological Chemistry

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, CL Day, JM Adams, DCS Huang

Journal article  |  2005  |  Molecular Cell

Subversion of the Bcl-2 life/death switch in cancer development and therapy

JM Adams, DCS Huang, A Strasser, S Willis, L Chen, A Wei, M Van Delft, JI Fletcher, H Puthalakath, J Kuroda, EM Michalak, PN Kelly, P Bouillet, A Villunger, L O'Reilly, ML Bath, DP Smith, A Egle, AW Harris, M Hinds, et al.

Journal article  |  2005  |  Cold Spring Harbor Symp. Quant. Biol.

Nuclear localization of FADD protein.

S Frisch

Journal article  |  2004  |  Cell Death Differ.

Nuclear localisation of FADD - rebuttal

L O'Reilly, S Crawford, DCS Huang, A Strasser

Journal article  |  2004  |  Cell Death & Differentiation

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes

LA O'Reilly, U Divisekera, K Newton, K Scalzo, T Kataoka, H Puthalakath, M Ito, DCS Huang, A Strasser

Journal article  |  2004  |  Cell Death Differ.

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

CL Day, H Puthalakath, G Skea, A Strasser, I Barsukov, LY Lian, DCS Huang, MG Hinds

Journal article  |  2004  |  Biochem. J.

The Bcl-2 family: roles in cell survival and oncogenesis

S Cory, DCS Huang, JM Adams

Journal article  |  2003  |  Oncogene

The Bcl-2-regulated apoptotic pathway

S Willis, CL Day, MG Hinds, DCS Huang

Journal article  |  2003  |  Journal of Cell Science

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

MG Hinds, M Lackmann, GL Skea, PJ Harrison, DCS Huang, CL Day

Journal article  |  2003  |  The EMBO Journal

Pro-apoptotic BH3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

L Coultas, DCS Huang, JM Adams, A Strasser

Journal article  |  2002  |  CELL DEATH AND DIFFERENTIATION

Pro-apoptotic BH-3-only Bcl-2 family members in vertebrate model organisms suitable for genetic experimentation

L Coultas, DCS Huang, JM Adams, A Strasser

Journal article  |  2002  |  Cell Death & Differentiation

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

JB Baell, DCS Huang

Journal article  |  2002  |  Biochemical Pharmacology

Direct addition of BimL to mitochondria does not lead to cytochrome c release

O Terradillos, S Montessuit, DCS Huang, JC Martinou

Journal article  |  2002  |  FEBS Letters

Rapid selection against truncation mutants in yeast reverse two-hybrid screens

H Puthalakath, A Strasser, DCS Huang

Journal article  |  2001  |  BioTechniques

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

LA O'Reilly, C Print, G Hausmann, K Morlishi, S Cory, DCS Huang, A Strasser

Journal article  |  2001  |  Cell Death Differ.

Gene structure, alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

P Bouillet, LC Zhang, DCS Huang, GC Webb, CDK Bottema, P Shore, HJ Eyre, GR Sutherland, JM Adams

Journal article  |  2001  |  Mammalian Genome

BH3-Only proteins - Essential initiators of apoptotic cell death

DCS Huang, A Strasser

Journal article  |  2000  |  Cell

Bcl-2 does not inhibit cell death induced by the physiological Fas ligand: implications for the existence of type I and type II cells

DCS Huang, J Tschopp, A Strasser

Journal article  |  2000  |  Cell Death & Differentiation

Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD

A Villunger, DCS Huang, N Holler, J Tschopp, A Strasser

Journal article  |  2000  |  The Journal of Immunology

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

LA O'Reilly, L Cullen, J Visvader, GJ Lindeman, C Print, ML Bath, DCS Huang, A Strasser

Journal article  |  2000  |  The American Journal of Pathology

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L)

G Hausmann, LA O'Reilly, R van Driel, JC Beaumont, A Strasser, JM Adams, DCS Huang

Journal article  |  2000  |  The Journal of Cell Biology

Apoptosis and cell division - Commentary

L O'Connor, DCS Huang, LA O'Reilly, A Strasser

Journal article  |  2000  |  Current Opinion in Cell Biology

Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery

PA Colussi, LM Quinn, DCS Huang, M Coombe, SH Read, H Richardson, S Kumar

Journal article  |  2000  |  The Journal of Cell Biology

How, when, and why do lymphocytes die?

A Strasser, K Newton, LA O'Reilly, M Pellegrini, L O'Connor, H Puthalakath, L Cullen, L Tai, L Coultas, DCS Huang, A Villunger, P Bouillet, ML Bath, DL Vaux, S Cory, JM Adams, AW Harris

Journal article  |  2000  |  Immunologist

The role of Bim, a proapoptotic BH3-only member of the Bcl-2 family, in cell-death control

A Strasser, H Puthalakath, P Bouillet, DCS Huang, L O'Connor, L O'Reilly, L Cullen, S Cory, JM Adams

Conference Proceedings  |  2000  |  Annals of the New York Academy of Sciences

The role of the pro-apoptotic bcl-2 family member Bim in physiological cell death

P Bouillet, DCS Huang, LA O'Reilly, H Puthalakath, L O'Connor, S Cory, JM Adams, A Strasser

Conference Proceedings  |  2000  |  Annals of the New York Academy of Sciences

Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction

J Allison, H Thomas, D Beck, JL Brady, AM Lew, A Elefanty, H Kosaka, TW Kay, DCS Huang, A Strasser

Journal article  |  2000  |  International Immunology

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

DCS Huang, M Hahne, M Schroeter, K Frei, A Fontana, A Villunger, K Newton, J Tschopp, A Strasser

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

P Bouillet, D Metcalf, DCS Huang, DM Tarlinton, TWH Kay, F Kontgen, JM Adams, A Strasser

Journal article  |  1999  |  Science

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

K Moriishi, DCS Huang, S Cory, JM Adams

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF

M Grell, G Zimmermann, E Gottfried, CM Chen, U Grunwald, DCS Huang, YHW Lee, H Durkop, H Engelmann, P Scheurich, H Wajant, A Strasser

Journal article  |  1999  |  The EMBO Journal

Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members

SP Holmgreen, DCS Huang, JM Adams, S Cory

Journal article  |  1999  |  Cell Death & Differentiation

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

H Puthalakath, DCS Huang, LA O'Reilly, SM King, A Strasser

Journal article  |  1999  |  Molecular Cell

Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins

JM Adams, DCS Huang, H Puthalakath, P Bouillet, G Vairo, K Moriishi, G Hausmann, L O'Reilly, K Newton, S Ogilvy, ML Bath, CG Print, AW Harris, A Strasser, S Cory

Conference Proceedings  |  1999  |  Cold Spring Harbor Symposia on Quantitative Biology

Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins

LA O'Reilly, L Cullen, K Moriishi, L O'Connor, DCS Huang, A Strasser

Journal article  |  1998  |  BioTechniques

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

DCS Huang, JM Adams, S Cory

Journal article  |  1998  |  The EMBO Journal

Bim: a novel member of the Bcl-2 family that promotes apoptosis

L O'Connor, A Strasser, LA O'Reilly, G Hausmann, JM Adams, S Cory, DCS Huang

Journal article  |  1998  |  The EMBO Journal

Regulation of cell survival by the bcl-2 gene family

S Cory, JM Adams, L Gibson, S Holmgreen, G Vairo, L O'Rcilly, DCS Huang, A Strasser

Journal article  |  1997  |  FASEB Journal

The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy

A Strasser, DCS Huang, DL Vaux

Journal article  |  1997  |  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

DCS Huang, LA OReilly, A Strasser, S Cory

Journal article  |  1997  |  The EMBO Journal

Bcl-2, Bcl-x(L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

DCS Huang, S Cory, A Strasser

Journal article  |  1997  |  Oncogene

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

LA OReilly, DCS Huang, A Strasser

Journal article  |  1996  |  The EMBO Journal

Lessons from bcl-2 transgenic mice for immunology, cancer biology and cell death research.

A Strasser, L O'Connor, DC Huang, LA O'Reilly, ML Stanley, ML Bath, JM Adams, S Cory, AW Harris

Journal article  |  1996  |  Behring Institute Mitteilungen

The protein product of the proto-oncogene bcl-2, originally discovered by virtue of its chromosomal translocation in human follicu..

bcl-w, a novel member of the bcl-2 family, promotes cell survival

L Gibson, SP Holmgreen, DCS Huang, O Bernand, NG Copeland, NA Jenkins, GR Sutherland, E Baker, JM Adams, S Cory

Journal article  |  1996  |  Oncogene

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

A Strasser, AW Harris, DCS Huang, PH Krammer, S Cory

Journal article  |  1995  |  The EMBO Journal

PLASMA MEMBRANE-TARGETED RAS GTPASE-ACTIVATING PROTEIN IS A POTENT SUPPRESSOR OF P21(RAS) FUNCTION

DCS HUANG, CJ MARSHALL, JF HANCOCK

Journal article  |  1993  |  Molecular and Cellular Biology

EFFECTS OF ANTI-TNF MONOCLONAL-ANTIBODY INFUSION IN PATIENTS WITH HAIRY-CELL LEUKEMIA

D HUANG, JE REITTIE, S STEPHENS, AV HOFFBRAND, MK BRENNER

Journal article  |  1992  |  British Journal of Haematology

REGRESSION OF INTRACEREBRAL LESIONS IN T-PROLYMPHOCYTIC LEUKEMIA TREATED WITH INTRAVENOUS DEOXYCOFORMYCIN

F BRITOBABAPULLE, D HUANG, P LAVENDER, D GALTON, D CATOVSKY

Journal article  |  1988  |  European Journal of Haematology