Peter Crouch

Transdermal Application of Soluble CuII(atsm) Increases Brain and Spinal Cord Uptake Compared to Gavage with an Insoluble Suspension

Sara Nikseresht, James BW Hilton, Jeffrey R Liddell, Kai Kysenius, Ashley I Bush, Scott Ayton, HuiJing Koay, Paul S Donnelly, Peter J Crouch

Journal article  |  2022  |  NEUROSCIENCE

CuII(atsm) is a blood-brain barrier permeant copper(II) compound that is under investigation in human clinical trials for the trea..

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Jeffrey Molendijk, Ronnie Blazev, Richard J Mills, Yaan-Kit Ng, Kevin Watt, Daryn Chau, Paul Gregorevic, Peter J Crouch, James BW Hilton, Leszek Lisowski, Peixiang Zhang, Karen Reue, Aldons J Lusis, James E Hudson, David E James, Marcus M Seldin, Benjamin L Parker

Journal article  |  2022  |  ELIFE

Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle meta..

Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord.

Benjamin G Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr Abdeen, Veronica Cottam, Dominic J Hare, Melanie White, Jens Altvater, Jennifer A Fifita, Alison Hogan, Natalie Grima, Ian P Blair, Kai Kysenius, Peter J Crouch, Asuncion Carmona, Yann Rufin, Stéphane Claverol, Stijn Van Malderen, Gerald Falkenberg, et al.

Journal article  |  2022  |  Brain

Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in v..

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Francesca M Alves, Kai Kysenius, Marissa K Caldow, Justin P Hardee, Jin D Chung, Jennifer Trieu, Dominic J Hare, Peter J Crouch, Scott Ayton, Ashley Bush, Gordon S Lynch, Rene Koopman

Journal article  |  2022  |  JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

BACKGROUND: Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the ..

Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain

Shene Yi-Shiuan Chiou, Kai Kysenius, Yifan Huang, Mark David Habgood, Liam M Koehn, Fiona Qiu, Peter J Crouch, Swati Varshney, Katherine Ganio, Katarzyna Magdalena Dziegielewska, Norman Ruthven Saunders

Journal article  |  2021  |  FLUIDS AND BARRIERS OF THE CNS

BACKGROUND: Little is known about the extent of drug entry into developing brain, when administered to pregnant and lactating wome..

CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1(G93A) mice with a C57BL/6 background

Jeremy S Lum, Mikayla L Brown, Natalie E Farrawell, Luke McAlary, Diane Ly, Christen G Chisholm, Josh Snow, Kara L Vine, Tim Karl, Fabian Kreilaus, Lachlan E McInnes, Sara Nikseresht, Paul S Donnelly, Peter J Crouch, Justin J Yerbury

Journal article  |  2021  |  SCIENTIFIC REPORTS

The synthetic copper-containing compound, CuATSM, has emerged as one of the most promising drug candidates developed for the treat..

Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND

Phan H Truong, Peter J Crouch, James BW Hilton, Catriona A McLean, Roberto Cappai, Giuseppe D Ciccotosto

Journal article  |  2021  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle para..

Quantification of metallothionein-III in brain tissues using liquid chromatography tandem mass spectrometry

Adam P Gunn, Catriona A McLean, Peter J Crouch, Blaine R Roberts

Journal article  |  2021  |  ANALYTICAL BIOCHEMISTRY

Metallothioneins (MTs) are crucial for metal ion homeostasis in mammalian cells. Specialized mass spectrometry methods have been d..

Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer's Disease

Irina Belaya, Nina Kucharikova, Veronika Gorova, Kai Kysenius, Dominic J Hare, Peter J Crouch, Tarja Malm, Mustafa Atalay, Anthony R White, Jeffrey R Liddell, Katja M Kanninen

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulation of brain iron metabolism is one of the pathological features of aging and Alzheimer's disease (AD), a neurodegenerat..

An integrated mass spectrometry imaging and digital pathology workflow for objective detection of colorectal tumours by unique atomic signatures

Bence Paul, Kai Kysenius, James B Hilton, Michael WM Jones, Robert W Hutchinson, Daniel D Buchanan, Christophe Rosty, Fred Fryer, Ashley Bush, Janet M Hergt, Jon D Woodhead, David P Bishop, Philip A Doble, Michelle M Hill, Peter J Crouch, Dominic J Hare

Journal article  |  2021  |  CHEMICAL SCIENCE

Tumours are abnormal growths of cells that reproduce by redirecting essential nutrients and resources from surrounding tissue. Cha..