Lachlan Thompson

Hemispheric cortical atrophy and chronic microglial activation following mild focal ischemic stroke in adult male rats.

Charlotte M Ermine, Jess Nithianantharajah, Katrina O'Brien, Jessica A Kauhausen, Stefano Frausin, Alexander Oman, Mark W Parsons, Vanessa H Brait, Amy Brodtmann, Lachlan H Thompson

Journal article  |  2021  |  J Neurosci Res

Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this researc..

Histological characterization and quantification of newborn cells in the adult rodent brain.

Charlotte M Ermine, Carolina A Chavez, Lachlan H Thompson

Journal article  |  2021  |  STAR Protoc

This protocol describes the identification and characterization of newborn cells generated in the rodent brain after injury throug..

Tissue Programmed Hydrogels Functionalized with GDNF Improve Human Neural Grafts in Parkinson's Disease

Cameron PJ Hunt, Vanessa Penna, Carlos W Gantner, Niamh Moriarty, Yi Wang, Stephanie Franks, Charlotte M Ermine, Isabelle R de Luzy, Chiara Pavan, Benjamin M Long, Richard J Williams, Lachlan H Thompson, David R Nisbet, Clare L Parish

Journal article  |  2021  |  ADVANCED FUNCTIONAL MATERIALS

The survival and synaptic integration of transplanted dopaminergic (DA) progenitors are essential for ameliorating motor symptoms ..

Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

Isabelle R de Luzy, Kevin CL Law, Niamh Moriarty, Cameron PJ Hunt, Jennifer C Durnall, Lachlan H Thompson, Andras Nagy, Clare L Parish

Journal article  |  2021  |  NATURE COMMUNICATIONS

Despite advancements in human pluripotent stem cells (hPSCs) differentiation protocols to generate appropriate neuronal progenitor..

Longitudinal hippocampal volumetric changes in mice following brain infarction

Vanessa H Brait, David K Wright, Mohsen Nategh, Alexander Oman, Warda T Syeda, Charlotte M Ermine, Katrina R O'Brien, Emilio Werden, Leonid Churilov, Leigh A Johnston, Lachlan H Thompson, Jess Nithianantharajah, Katherine A Jackman, Amy Brodtmann

Journal article  |  2021  |  SCIENTIFIC REPORTS

Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cogniti..

FGF-MAPK signaling regulates human deep-layer corticogenesis

Carlos W Gantner, Cameron PJ Hunt, Jonathan C Niclis, Vanessa Penna, Stuart J McDougall, Lachlan H Thompson, Clare L Parish

Journal article  |  2021  |  STEM CELL REPORTS

Despite heterogeneity across the six layers of the mammalian cortex, all excitatory neurons are generated from a single founder po..

Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury

Brett J Kagan, Charlotte M Ermine, Stefano Frausin, Clare L Parish, Jess Nithianantharajah, Lachlan H Thompson

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neonatal arterial ischemic stroke is one of the more severe birth complications. The injury can result in extensive neurological d..

Embryonic stem cells go from bench to bedside for Parkinson's disease

Clare L Parish, Lachlan H Thompson

Journal article  |  2021  |  CELL REPORTS MEDICINE

Stem-cell-derived transplants may soon be a promising treatment option for Parkinson's disease. In preparation for clinical trial,..

In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia

Serena Viventi, Stefano Frausin, Sara E Howden, Shiang Y Lim, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Kwaku Dad Abu-Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori

Journal article  |  2021  |  STEM CELLS TRANSLATIONAL MEDICINE

Friedreich ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of dorsal root ganglia (DRG) sensory neur..

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions.

Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  STAR Protoc

Here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (v..