Lachlan Thompson

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis.

Charlotte M Ermine, Jordan L Wright, Davor Stanic, Clare L Parish, Lachlan H Thompson

Journal article  |  2020  |  iScience

Ischemic damage to the adult rodent forebrain has been widely used as a model system to study injury-induced neurogenesis, resulti..

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

Carlos W Gantner, Isabelle R de Luzy, Jessica A Kauhausen, Niamh Moriarty, Jonathan C Niclis, Christopher R Bye, Vanessa Penna, Cameron PJ Hunt, Charlotte M Ermine, Colin W Pouton, Deniz Kirik, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  Cell Stem Cell

Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating followin..

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms

Agustin Cota-Coronado, Jennifer C Durnall, Nestor Fabian Diaz, Lachlan H Thompson, N Emmanuel Diaz-Martinez

Journal article  |  2020  |  Molecules

Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular..

Novel pluripotent stem cell lines for enriched grafting in Parkinson's disease

Agustin Cota-Coronado, Lachlan H Thompson, N Emmanuel Diaz-Martinez

Journal article  |  2020  |  Neural Regeneration Research

Long-Term Motor Deficit and Diffuse Cortical Atrophy Following Focal Cortical Ischemia in Athymic Rats

Charlotte M Ermine, Fahad Somaa, Ting-Yi Wang, Brett J Kagan, Clare L Parish, Lachlan H Thompson

Journal article  |  2019  |  Frontiers in Cellular Neuroscience

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

Isabelle R de Luzy, Jonathan C Niclis, Carlos W Gantner, Jessica A Kauhausen, Cameron PJ Hunt, Charlotte Ermine, Colin W Pouton, Lachlan H Thompson, Clare L Parish

Journal article  |  2019  |  The Journal of Neuroscience

Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic (vm..

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain

Christopher R Bye, Vanessa Penna, Isabelle R de Luzy, Carlos W Gantner, Cameron PJ Hunt, Lachlan H Thompson, Clare L Parish

Journal article  |  2019  |  Stem Cell Reports

Human pluripotent stem cells are a valuable resource for transplantation, yet our ability to profile xenografts is largely limited..

Evolution of brain volume and hippocampal neurogenesis over 12 months after focal ischemia in adult rats

Charlotte Ermine, Warda Syeda, David Wright, Jessica Kauhausen, Stefano Frausin, Vanessa Brait, Katrina O'Brien, Jessica Nithianantharajah, Emilio Werden, Leigh Johnston, Amy Brodtmann, Lachlan Thompson

Conference Proceedings  |  2019  |  INTERNATIONAL JOURNAL OF STROKE

Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins

Christopher R Bye, Valeria Rytova, Walaa F Alsanie, Clare L Parish, Lachlan H Thompson

Journal article  |  2019  |  The Journal of Neuroscience

The growth of axons corresponding to different neuronal subtypes is governed by unique expression profiles of molecules on the gro..

Local Injection of Endothelin-1 in the Early Neonatal Rat Brain Models Ischemic Damage Associated with Motor Impairment and Diffuse Loss in Brain Volume

Jordan L Wright, Hannah X Chu, Brett J Kagan, Charlotte M Ermine, Jessica A Kauhausen, Clare L Parish, Christopher G Sobey, Lachlan H Thompson

Journal article  |  2018  |  Neuroscience

Shear Containment of BDNF within Molecular Hydrogels Promotes Human Stem Cell Engraftment and Pos infarc ion Remodeling in Stroke

DR Nisbet, TY Wang, KF Bruggeman, JC Niclis, FA Somaa, V Penna, CPJ Hunt, Y Wang, JA Kauhausen, RJ Williams, LH Thompson, CL Parish

Journal article  |  2018  |  Advanced Biosystems

Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis

Charlotte M Ermine, Jordan L Wright, Stefano Frausin, Jessica A Kauhausen, Clare L Parish, Davor Stanic, Lachlan H Thompson

Journal article  |  2018  |  Hippocampus

BIOMATERIALS SUPPORT THE INTEGRATION OF HUMAN EMBRYONIC STEM CELL-DERIVED CORTICAL GRAFTS TO PROMOTE FUNCTIONAL REPAIR IN A MODEL OF FOCAL ISCHEMIA

FA Somaa, TY Wang, JC Niclis, KF Bruggman, JA Kauhausen, H Guo, S McDougall, RJ Williams, DR Nisbet, LH Thompson, CL Parish

Conference Proceedings  |  2018  |  JOURNAL OF GENE MEDICINE

COMPARISON OF THERAPEUTIC EFFICACY OF NEURAL PROGENITORS TO UMBILICAL CORD STEM CELLS IN A RODENT MODEL OF NEONATAL BRAIN DAMAGE

Brett J Kagan, Laura J Tatnell, Jennifer Durnall, Pei Tian, Ngaire Elwood, Clare L Parish, Lachlan H Thompson

Conference Proceedings  |  2018  |  JOURNAL OF GENE MEDICINE

Specification of murine ground state pluripotent stem cells to regional neuronal populations

Walaa F Alsanie, Jonathan C Niclis, Cameron P Hunt, Isabelle R De Luzy, Vanessa Penna, Christopher R Bye, Colin W Pouton, John Haynes, Jaber Firas, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  Scientific Reports

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

Jonathan C Niclis, Carlos W Gantner, Cameron PJ Hunt, Jessica A Kauhausen, Jennifer C Durnall, John M Haynes, Colin W Pouton, Clare L Parish, Lachlan H Thompson

Journal article  |  2017  |  Stem Cell Reports

Homophilic binding of the neural cell adhesion molecule CHL1 regulates development of ventral midbrain dopaminergic pathways

WF Alsanie, V Penna, M Schachner, LH Thompson, CL Parish

Journal article  |  2017  |  Scientific Reports

Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke

Fahad A Somaa, Ting-Yi Wang, Jonathan C Niclis, Kiara F Bruggeman, Jessica A Kauhausen, Haoyao Guo, Stuart McDougall, Richard J Williams, David R Nisbet, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  Cell Reports

Long-Distance Axonal Growth and Protracted Functional Maturation of Neurons Derived from Human Induced Pluripotent Stem Cells After Intracerebral Transplantation

Jonathan C Niclis, Christopher Turner, Jennifer Durnall, Stuart McDougal, Jessica A Kauhausen, Bryan Leaw, Mirella Dottori, Clare L Parish, Lachlan H Thompson

Journal article  |  2017  |  STEM CELLS Translational Medicine

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents

Jonathan C Niclis, Carlos W Gantner, Walaa F Alsanie, Stuart J McDougall, Chris R Bye, Andrew G Elefanty, Edouard G Stanley, John M Haynes, Colin W Pouton, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  STEM CELLS Translational Medicine

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

Jonathan C Niclis, Carlos W Gantner, Walaa F Alsanie, Stuart J McDougall, Chris R Bye, Andrew G Elefanty, Edouard G Stanley, John M Haynes, Colin W Pouton, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  Stem Cells Transl Med

Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain d..

Over-Expression of Meteorin Drives Gliogenesis Following Striatal Injury

Jordan L Wright, Charlotte M Ermine, Jesper R Jorgensen, Clare L Parish, Lachlan H Thompson

Journal article  |  2016  |  Frontiers in Cellular Neuroscience

Combined immunohistochemical and retrograde tracing reveals little evidence of innervation of the rat dentate gyrus by midbrain dopamine neurons

CM Ermine, JL Wright, CL Parish, D Stanic, LH Thompson

Journal article  |  2016  |  Frontiers in Biology

Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

Roger A Barker, Malin Parmar, Agnete Kirkeby, Anders Bjorklund, Lachlan Thompson, Patrik Brundin

Journal article  |  2016  |  Journal of Parkinson's Disease

Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice

Jessica A Kauhausen, Lachlan H Thompson, Clare L Parish

Journal article  |  2015  |  Molecular and Cellular Neuroscience

Reconstruction of brain circuitry by neural transplants generated from pluripotent stem cells

Lachlan H Thompson, Anders Bjorklund

Journal article  |  2015  |  Neurobiology of Disease

Meningeal cells influence midbrain development and the engraftment of dopamine progenitors in Parkinsonian mice

Fahad A Somaa, Christopher R Bye, Lachlan H Thompson, Clare L Parish

Journal article  |  2015  |  Experimental Neurology

Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors

Chris R Bye, Marie E Jonsson, Anders Bjorklund, Clare L Parish, Lachlan H Thompson

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease

Helene Hall, Stefanie Reyes, Natalie Landeck, Chris Bye, Giampiero Leanza, Kay Double, Lachlan Thompson, Glenda Halliday, Deniz Kirik

Journal article  |  2014  |  Brain

Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain

Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori

Journal article  |  2014  |  PLoS One

Differential Dopamine Receptor Occupancy Underlies L-DOPA-Induced Dyskinesia in a Rat Model of Parkinson's Disease

Gurdal Sahin, Lachlan H Thompson, Sonia Lavisse, Merve Ozgur, Latifa Rbah-Vidal, Frederic Dolle, Philippe Hantraye, Deniz Kirik

Journal article  |  2014  |  PLoS One

Modulating Wnt signaling to improve cell replacement therapy for Parkinsons disease

Clare L Parish, Lachlan H Thompson

Journal article  |  2014  |  Journal of Molecular Cell Biology

Developing stem cell-based therapies for neural repair

Clare L Parish, Lachlan H Thompson

Journal article  |  2013  |  Frontiers in Cellular Neuroscience

Cell intrinsic and extrinsic factors contribute to enhance the integration of neural transplants in Parkinsonian mice

CR Bye, JA Kauhausen, LH Thompson, CL Parish

Conference Proceedings  |  2013  |  JOURNAL OF NEUROCHEMISTRY

Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease

Stefanie Reyes, Yuhong Fu, Kay L Double, Veronica Cottam, Lachlan H Thompson, Deniz Kirik, George Paxinos, Charles Watson, Helen M Cooper, Glenda M Halliday

Journal article  |  2013  |  NEUROBIOLOGY OF AGING

Transplantation of Fetal Midbrain Dopamine Progenitors into a Rodent Model of Parkinson's Disease

Lachlan H Thompson, Clare L Parish

Journal article  |  2013  |  Methods in Molecular Biology

Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice

Jessica Kauhausen, Lachlan H Thompson, Clare L Parish

Journal article  |  2013  |  JOURNAL OF PHYSIOLOGY-LONDON

Generation of striatal projection neurons extends into the neonatal period in the rat brain

Jordan Wright, Davor Stanic, Lachlan H Thompson

Journal article  |  2013  |  JOURNAL OF PHYSIOLOGY-LONDON

Glycogen Synthase Kinase 3 beta and Activin/Nodal Inhibition in Human Embryonic Stem Cells Induces a Pre-Neuroepithelial State That Is Required for Specification to a Floor Plate Cell Lineage

Mark Denham, Chris Bye, Jessie Leung, Brock J Conley, Lachlan H Thompson, Mirella Dottori

Journal article  |  2012  |  STEM CELLS

GIRK2 Expression in Dopamine Neurons of the Substantia Nigra and Ventral Tegmental Area

Stefanie Reyes, Yuhong Fu, Kay Double, Lachlan Thompson, Deniz Kirik, George Paxinos, Glenda M Halliday

Journal article  |  2012  |  Journal of Comparative Neurology

Birth dating of midbrain dopamine neurons identifies A9 enriched tissue for transplantation into Parkinsonian mice

Christopher R Bye, Lachlan H Thompson, Clare L Parish

Journal article  |  2012  |  EXPERIMENTAL NEUROLOGY

Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation

Mark Denham, Clare L Parish, Bryan Leaw, Jordan Wright, Christopher A Reid, Steven Petrou, Mirella Dottori, Lachlan H Thompson

Journal article  |  2012  |  FRONTIERS IN CELLULAR NEUROSCIENCE

Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Jesper Roland Jorgensen, Anette Fransson, Lone Fjord-Larsen, Lachlan H Thompson, Jeffrey P Houchins, Nuno Andrade, Malene Torp, Nisse Kalkkinen, Elisabet Andersson, Olle Lindvall, Mats Ulfendahl, Soren Brunak, Teit E Johansen, Lars U Wahlberg

Journal article  |  2012  |  Experimental Neurology

Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation

Lachlan Thompson, Anders Bjorklund

Journal article  |  2012  |  Progress in Brain Research

Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model

Jesper Roland Jorgensen, Dwaine F Emerich, Chris Thanos, Lachlan H Thompson, Malene Torp, Briannan Bintz, Lone Fjord-Larsen, Teit E Johansen, Lars U Wahlberg

Journal article  |  2011  |  Neurobiology of Disease

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells (vol 106, pg 7613, 2009)

Stina Friling, Elisabet Andersson, Lachlan H Thompson, Marie E Joensson, Josephine B Hebsgaard, Evanthia Nanou, Zhanna Alekseenko, Ulrika Marklund, Susanna Kjellander, Nikolaos Volakakis, Outi Hovatta, Abdeljabbar El Manira, Anders Bjoerklund, Thomas Perlmann, Johan Ericson

Journal article  |  2010  |  Proceedings of the National Academy of Sciences

Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells

Mark Denham, Lachlan H Thompson, Jessie Leung, Alice Pebay, Anders Bjorklund, Mirella Dottori

Journal article  |  2010  |  Stem Cells

The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease

Shane Grealish, Marie E Jonsson, Meng Li, Deniz Kirik, Anders Bjorklund, Lachlan H Thompson

Journal article  |  2010  |  Brain

Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis

Marie E Jonsson, Yuichi Ono, Anders Bjorklund, Lachlan H Thompson

Journal article  |  2009  |  Experimental Neurology

Characterization of Meteorin-An Evolutionary Conserved Neurotrophic Factor

Jesper Roland Jorgensen, Lachlan Thompson, Lone Fjord-Larsen, Christina Krabbe, Malene Torp, Nisse Kalkkinen, Claus Hansen, Lars Wahlberg

Journal article  |  2009  |  Journal of Molecular Neuroscience

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

Lachlan H Thompson, Shane Grealish, Deniz Kirik, Anders Bjorklund

Journal article  |  2009  |  European Journal of Neuroscience

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

Stina Friling, Elisabet Andersson, Lachlan H Thompson, Marie E Jonssonc, Josephine B Hebsgaard, Evanthia Nanou, Zhanna Alekseenko, Ulrika Marklund, Susanna Kjellander, Nikolaos Volakakis, Outi Hovatta, Abdeljabbar El Manira, Anders Bjorklund, Thomas Perlmann, Johan Ericson

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain

L THOMPSON, S Grealish, D Kirik, A Bjorklund

Journal article  |  2009  |  European Journal of Neuroscience

Transgenic reporter mice as tools for studies of transplantability and connectivity of dopamine neuron precursors in fetal tissue grafts

Lachlan H Thompson, Anders Bjorklund

Journal article  |  2009  |  Progress in Brain Research

Embryonic dopaminergic precursors can be isolated at different states of differentiation and function upon grafting into an animal model of Parkinson's disease

ME Jonsson, M Parmar, LH Thompson, A Bjorklund

Conference Proceedings  |  2008  |  International Journal of Developmental Neuroscience

Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain

Lachlan H Thompson, Deniz Kirik, Anders Bjorklund

Journal article  |  2008  |  Experimental Neurology

In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway

Dwain K Irvin, Deniz Kirik, Anders Bjoerklund, Lachlan H Thompson

Journal article  |  2008  |  Neurobiology of Disease

Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon

LH Thompson, E Andersson, JB Jensen, P Barraud, F Guillemot, M Parmar, A Bjorklund

Journal article  |  2006  |  Experimental Neurology

Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse

P Barraud, L Thompson, D Kirik, A Bjorklund, M Parmar

Journal article  |  2005  |  European Journal of Neuroscience

Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections (vol 25, pg 6467, 2005)

L Thompson, P Barraud, E Andersson, D Kirik, AB Bjorklund

Journal article  |  2005  |  JOURNAL OF NEUROSCIENCE

Erratum: Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections (Journal of Neuroscience (July 6, 2005) (6467-6477))

L Thompson, P Barraud, E Andersson, D Kirik, A Björklund

Journal article  |  2005  |  Journal of Neuroscience

Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections

L Thompson, P Barraud, E Andersson, D Kirik, A Bjorklund

Journal article  |  2005  |  Journal of Neuroscience

Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts

AT Sorensen, L Thompson, D Kirik, A Bjorklund, O Lindvall, M Kokaia

Journal article  |  2005  |  European Journal of Neuroscience

Gene marking of human neural stem/precursor cells using green fluorescent proteins

B Navarro-Galve, A Villa, C Bueno, L Thompson, J Johansen, A Martinez-Serrano

Journal article  |  2005  |  The Journal of Gene Medicine

Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator

J Jakobsson, N Rosenqvist, L Thompson, P Barraud, C Lundberg

Journal article  |  2004  |  Experimental Cell Research