Lachlan Thompson

In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia

Serena Viventi, Stefano Frausin, Sara E Howden, Shiang Y Lim, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Kwaku Dad Abu-Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori

Journal article  |  2021  |  Stem Cells Translational Medicine

Friedreich ataxia (FRDA) is an autosomal recessive disease characterized by degeneration of dorsal root ganglia (DRG) sensory neur..

An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions.

Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  STAR Protoc

Here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (v..

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis

Charlotte M Ermine, Jordan L Wright, Davor Stanic, Clare L Parish, Lachlan H Thompson

Journal article  |  2020  |  iScience

Ischemic damage to the adult rodent forebrain has been widely used as a model system to study injury-induced neurogenesis, resulti..

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

Carlos W Gantner, Isabelle R de Luzy, Jessica A Kauhausen, Niamh Moriarty, Jonathan C Niclis, Christopher R Bye, Vanessa Penna, Cameron PJ Hunt, Charlotte M Ermine, Colin W Pouton, Deniz Kirik, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  Cell Stem Cell

Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating followin..

Unprecedented Potential for Neural Drug Discovery Based on Self-Organizing hiPSC Platforms

Agustin Cota-Coronado, Jennifer C Durnall, Nestor Fabian Diaz, Lachlan H Thompson, N Emmanuel Diaz-Martinez

Journal article  |  2020  |  Molecules

Human induced pluripotent stem cells (hiPSCs) have transformed conventional drug discovery pathways in recent years. In particular..

Novel pluripotent stem cell lines for enriched grafting in Parkinson's disease

Agustin Cota-Coronado, Lachlan H Thompson, N Emmanuel Diaz-Martinez

Journal article  |  2020  |  Neural Regeneration Research

Long-Term Motor Deficit and Diffuse Cortical Atrophy Following Focal Cortical Ischemia in Athymic Rats

Charlotte M Ermine, Fahad Somaa, Ting-Yi Wang, Brett J Kagan, Clare L Parish, Lachlan H Thompson

Journal article  |  2019  |  Frontiers in Cellular Neuroscience

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

Isabelle R de Luzy, Jonathan C Niclis, Carlos W Gantner, Jessica A Kauhausen, Cameron PJ Hunt, Charlotte Ermine, Colin W Pouton, Lachlan H Thompson, Clare L Parish

Journal article  |  2019  |  Journal of Neuroscience

Human pluripotent stem cells (hPSCs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic (vm..

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain

Christopher R Bye, Vanessa Penna, Isabelle R de Luzy, Carlos W Gantner, Cameron PJ Hunt, Lachlan H Thompson, Clare L Parish

Journal article  |  2019  |  Stem Cell Reports

Human pluripotent stem cells are a valuable resource for transplantation, yet our ability to profile xenografts is largely limited..

Evolution of brain volume and hippocampal neurogenesis over 12 months after focal ischemia in adult rats

Charlotte Ermine, Warda Syeda, David Wright, Jessica Kauhausen, Stefano Frausin, Vanessa Brait, Katrina O'Brien, Jessica Nithianantharajah, Emilio Werden, Leigh Johnston, Amy Brodtmann, Lachlan Thompson

Conference Proceedings  |  2019  |  INTERNATIONAL JOURNAL OF STROKE