Ricky Johnstone

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  The Journal of Immunology

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors

JP Hilton-Proctor, O Ilyichova, Z Zheng, IG Jennings, RW Johnstone, J Shortt, SJ Mountford, MJ Scanlon, PE Thompson

Journal article  |  2020  |  European Journal of Medicinal Chemistry

N-Methylpyrrolidone is one of several chemotypes that have been described as a mimetic of acetyl-lysine in the development of brom..

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matthias Geyer, Nathanael S Gray, Stephin J Vervoort, et al.

Journal article  |  2020  |  Science Advances

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition

JP Hilton-Proctor, O Ilyichova, Z Zheng, IG Jennings, RW Johnstone, J Shortt, SJ Mountford, MJ Scanlon, PE Thompson

Journal article  |  2019  |  Bioorganic & Medicinal Chemistry

N-Methylpyrrolidone is a solvent molecule which has been shown to compete with acetyl-lysine-containing peptides for binding to br..

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.

Darren C Phillips, Sha Jin, Gareth P Gregory, Qi Zhang, John Xue, Xiaoxian Zhao, Jun Chen, Yunsong Tong, Haichao Zhang, Morey Smith, Stephen K Tahir, Rick F Clark, Thomas D Penning, Jennifer R Devlin, Jake Shortt, Eric D Hsi, Daniel H Albert, Marina Konopleva, Ricky W Johnstone, Joel D Leverson, et al.

Journal article  |  2019  |  Leukemia

MCL-1 is one of the most frequently amplified genes in cancer, facilitating tumor initiation and maintenance and enabling resistan..

In vitro on-target and selectivity profiling of small-molecule inhibitors of the Myc/Max heterodimeric complex

Sang-Kyu Kim, Richard C Foitzik, Songhui Li, Andrew Vinson, Alex Shmaylov, Karen Jarvis, Susan James, Scott R Walker, Mark York, Benjamin Cao, Susan K Nilsson, Ricky W Johnstone

Conference Proceedings  |  2019  |  Protein-protein Interaction

Joseph F. Sambrook (1939-2019) obituary

Ashley Dunn, Ricky W Johnstone, Bruce Stillman

Journal article  |  2019  |  Nature Structural & Molecular Biology

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Madison J Kelly, Jessica Michie, Lizzy Pijpers, Ricky W Johnstone, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cell Reports

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

Mark D McKenzie, Margherita Ghisi, Ethan P Oxley, Steven Ngo, Luisa Cimmino, Cecile Esnault, Ruijie Liu, Jessica M Salmon, Charles C Bell, Nouraiz Ahmed, Michael Erlichster, Matthew T Witkowski, Grace J Liu, Michael Chopin, Aleksandar Dakic, Emilia Simankowicz, Giovanna Pomilio, Tina Vu, Pavle Krsmanovic, Shian Su, et al.

Journal article  |  2019  |  Cell Stem Cell

Enhancing antitumor immune responses with clinical BET bromodomain inhibitor RG6146

Simon J Hogg, Lisa Wellinger, Daniel Rohle, Ricky W Johnstone

Conference Proceedings  |  2019  |  Experimental and Molecular Therapeutics

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Madison J Kelly, Joan So, Amy J Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D Gearhart, Vivian J Bardwell, Ricky W Johnstone, Stephin J Vervoort, Lev M Kats

Journal article  |  2019  |  Nature Communications

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

Rare T-Cell Subtypes.

C van der Weyden, C McCormack, S Lade, RW Johnstone, HM Prince

Book Chapter  |  2019  |  Cancer Treatment and Research

There are a number of rare T-cell lymphoma subtypes that may be encountered in clinical practice. In recent years, improved immuno..

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E Tron, Matthew A Belmonte, Ammar Adam, Brian M Aquila, Lawrence H Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J Embrey, Eric Gangl, Francis D Gibbons, Gareth P Gregory, David Hargreaves, J Adam Hendricks, Jeffrey W Johannes, Ricky W Johnstone, Steven L Kazmirski, Jason G Kettle, Michelle L Lamb, Shannon M Matulis, Ajay K Nooka, et al.

Journal article  |  2018  |  Nature Communications

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, Hannah Huckstep, Jarrod Sandow, Ray C Bartolo, Nadia Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky W Johnstone, Alicia Oshlack, Melissa Davis, Paul G Ekert

Conference Proceedings  |  2018  |  Blood

BCOR Regulates Cell Fate Transition, Myeloid Differentiation and Leukaemogenesis

Lev M Kats, Madison J Kelly, Gareth Gregory, Ricky W Johnstone, Stephin J Vervoort

Conference Proceedings  |  2018  |  Blood

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Jonathan B Baell, David J Leaver, Stefan J Hermans, Gemma L Kelly, Margs S Brennan, Natalie L Downer, Nghi Nguyen, Johannes Wichmann, Helen M Mcrae, Yuqing Yang, Ben Cleary, H Rachel Lagiakos, Stephen Mieruszynski, Guido Pacini, Hannah K Vanyai, Maria I Bergamasco, Rose E May, Bethany K Davey, Kimberly J Morgan, Andrew J Sealey, et al.

Journal article  |  2018  |  Nature

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

Journal article  |  2018  |  Genes and Develpment

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer

Daniella Brasacchio, Rita A Busuttil, Tahereh Noori, Ricky W Johnstone, Alex Boussioutas, Joseph A Trapani

Journal article  |  2018  |  Cell Death & Disease

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

M Waibel, SJ Vervoort, IY Kong, S Heinzel, KM Ramsbottom, BP Martin, ED Hawkins, RW Johnstone

Journal article  |  2018  |  Leukemia

A Comprehensive Protocol Resource for Performing Pooled shRNA and CRISPR Screens

Leonie A Cluse, Iva Nikolic, Deborah Knight, Piyush B Madhamshettiwar, Jennii Luu, Karla J Cowley, Timothy Semple, Gisela Mir Arnau, Jake Shortt, Ricky W Johnstone, Kaylene J Simpson

Book Chapter  |  2018  |  Methods in Molecular Biology

DOCK8 Drives Src-Dependent NK Cell Effector Function

Conor J Kearney, Stephin J Vervoort, Kelly M Ramsbottom, Andrew J Freeman, Jessica Michie, Jane Peake, Jean-Laurent Casanova, Capucine Picard, Stuart G Tangye, Cindy S Ma, Ricky W Johnstone, Katrina L Randall, Jane Oliaro

Journal article  |  2017  |  The Journal of Immunology

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

Daniella Brasacchio, Amber E Alsop, Tahereh Noori, Mariam Lufti, Sweta Iyer, Kaylene J Simpson, Phillip I Bird, Ruth M Kluck, Ricky W Johnstone, Joseph A Trapani

Journal article  |  2017  |  Cell Death & Differentiation

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML

LM Kats, SJ Vervoort, R Cole, AJ Rogers, GP Gregory, E Vidacs, J Li, R Nagaraja, KE Yen, RW Johnstone

Journal article  |  2017  |  Leukemia

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors

Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2017  |  Cancer Research

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Clinical Cancer Research

HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia

P Mehdipour, F Santoro, OA Botrugno, M Romanenghi, C Pagliuca, GM Matthews, RW Johnstone, S Minucci

Journal article  |  2017  |  Leukemia

Genomic characterisation of E mu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Geoffrey M Matthews, Gareth P Gregory, Benjamin P Martin, Madison J Kelly, Izabela Todorovski, Maria A Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, et al.

Journal article  |  2017  |  Nature Communications

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

Journal article  |  2017  |  Journal of Clinical Investigation

A chemical probe toolbox for dissecting the cancer epigenome

Jake Shortt, Christopher J Ott, Ricky W Johnstone, James E Bradner

Journal article  |  2017  |  Nature Reviews Cancer

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Simon J Hogg, Stephin J Vervoort, Sumit Deswal, Christopher J Ott, Jason Li, Leonie A Cluse, Paul A Beavis, Phillip K Darcy, Benjamin P Martin, Andrew Spencer, Anna K Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E Bradner, Johannes Zuber, Jake Shortt, Ricky W Johnstone

Journal article  |  2017  |  Cell Reports

Durable clinical remission induced by romidepsin for chemotherapy-refractory peripheral T-cell lymphoma with central nervous system involvement

Kah-Lok Chan, Carrie van der Weyden, Christine Khoo, Stephen Lade, Piers Blombery, David Westerman, Amit Khot, Brian Melo, Ricky W Johnstone, H Miles Prince, Michael Dickinson

Journal article  |  2017  |  Leukemia & Lymphoma

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

John Silke, Ricky W Johnstone

Journal article  |  2016  |  Cold Spring Harbor Protocols

Cell death, one of the most fundamental biological processes, has not made it into the public consciousness in the same way that g..

How do tumor cells respond to HDAC inhibition?

Andrea Newbold, Katrina J Falkenberg, H Miles Prince, Ricky W Johnstone

Journal article  |  2016  |  The FEBS Journal

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

Edwin D Hawkins, Delfim Duarte, Olufolake Akinduro, Reema A Khorshed, Diana Passaro, Malgorzata Nowicka, Lenny Straszkowski, Mark K Scott, Steve Rothery, Nicola Ruivo, Katie Foster, Michaela Waibel, Ricky W Johnstone, Simon J Harrison, David A Westerman, Hang Quach, John Gribben, Mark D Robinson, Louise E Purton, Dominique Bonnet, et al.

Journal article  |  2016  |  Nature

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)

Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

BET Inhibition Induces Apoptosis in Aggressive B-Cell Lymphoma via Epigenetic Regulation of BCL-2 Family Members

Simon J Hogg, Andrea Newbold, Stephin J Vervoort, Leonie A Cluse, Benjamin P Martin, Gareth P Gregory, Marcus Lefebure, Eva Vidacs, Richard W Tothill, James E Bradner, Jake Shortt, Ricky W Johnstone

Journal article  |  2016  |  Molecular Cancer Therapeutics

Whole exome sequencing reveals activating JAK1 and STAT3 mutations in breast implant-associated anaplastic large cell lymphoma anaplastic large cell lymphoma

Piers Blombery, Ella R Thompson, Kate Jones, Gisela Mir Arnau, Stephen Lade, John F Markham, Jason Li, Anand Deva, Ricky W Johnstone, Amit Khot, H Miles Prince, David Westerman

Journal article  |  2016  |  Haematologica

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A Doyle, Andrea Newbold, Jessica E Bolden, Kirsten A Fairfax, Carolyn A de Graaf, Matthew Firth, Johannes Zuber, Ross A Dickins, Lynn M Corcoran, Mark A Dawson, Gabrielle T Belz, Ricky W Johnstone

Journal article  |  2016  |  Cancer Cell

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

Kelly Waldeck, Carleen Cullinane, Kerry Ardley, Jake Shortt, Ben Martin, Richard W Tothill, Jason Li, Ricky W Johnstone, Grant A McArthur, Rodney J Hicks, Paul J Wood

Journal article  |  2016  |  Int J Cancer

Commentary on: Biomarkers Provide Clues to Early Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large Cell Lymphoma

H Miles Prince, Ricky Johnstone

Journal article  |  2016  |  Aesthetic Surgery Journal

CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity

Samantha E Boyle, Clare G Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard J Young, Annie Wong, Robert Fuller, John Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A Henderson, Ricky W Johnstone, Anthony T Papenfuss, Mark Shackleton

Journal article  |  2016  |  Cancer Research

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Omer Gilan, Enid YN Lam, Isabelle Becher, Dave Lugo, Ester Cannizzaro, Gerard Joberty, Aoife Ward, Meike Wiese, Chun Yew Fong, Sarah Ftouni, Dean Tyler, Kym Stanley, Laura MacPherson, Chen-Fang Weng, Yih-Chih Chan, Margherita Ghisi, David Smil, Christopher Carpenter, Peter Brown, Neil Garton, et al.

Journal article  |  2016  |  Nature Structural & Molecular Biology

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity

KJ Falkenberg, A Newbold, CM Gould, J Luu, JA Trapani, GM Matthews, KJ Simpson, RW Johnstone

Journal article  |  2016  |  Cell Death & Differentiation

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw

Journal article  |  2016  |  Oncotarget

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.

Journal article  |  2016  |  Science Translational Medicine

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

AC West, BP Martin, DA Andrews, SJ Hogg, A Banerjee, G Grigoriadis, RW Johnstone, J Shortt

Journal article  |  2016  |  Oncogenesis

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Liz J Valente, Brandon J Aubrey, Marco J Herold, Gemma L Kelly, Lina Happo, Clare L Scott, Andrea Newbold, Ricky W Johnstone, David CS Huang, Lyubomir T Vassilev, Andreas Strasser

Journal article  |  2016  |  Cell Reports

The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia

Adele Baker, Gareth P Gregory, Inge Verbrugge, Lev Kats, Joshua J Hilton, Eva Vidacs, Erwin M Lee, Richard B Lock, Johannes Zuber, Jake Shortt, Ricky W Johnstone

Journal article  |  2016  |  Cancer Research

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani

Journal article  |  2016  |  FEBS Journal

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

Autophagy and AML-food for thought

N Lalaoui, R Johnstone, PG Ekert

Journal article  |  2016  |  Cell Death & Differentiation

Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.

Nicole L Messina, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2016  |  JAK-STAT

Interferons (IFNs) are a family of immunoregulatory cytokines with important roles in anti-viral and anti-tumor responses. Type I ..

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

Stephen Q Wong, Kelly Waldeck, Ismael A Vergara, Jan Schroeder, Jason Madore, James S Wilmott, Andrew J Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J Helen Leonard, George Hruby, Graham J Mann, John F Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, et al.

Journal article  |  2015  |  Cancer Res

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

Geoffrey M Matthews, Parinaz Mehdipour, Leonie A Cluse, Katrina J Falkenberg, Eric Wang, Mareike Roth, Fabio Santoro, Eva Videos, Kym Stanley, Colin M House, James R Rusche, Christopher R Vakoc, Johannes Zuber, Saverio Minucci, Ricky W Johnstone

Journal article  |  2015  |  Blood

BET inhibitor resistance emerges from leukaemia stem cells

Chun Yew Fong, Omer Gilan, Enid YN Lam, Alan F Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G Ramsay, Steven W Lane, Omar Abdel-Wahab, Tony Kouzarides, et al.

Journal article  |  2015  |  Nature

Errata: Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia (Blood (2011) 117, 13 (3658-3668))

MJ Bishton, SJ Harrison, BP Martin

Journal article  |  2015  |  Blood

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo

GP Gregory, SJ Hogg, LM Kats, E Vidacs, AJ Baker, O Gilan, M Lefebure, BP Martin, MA Dawson, RW Johnstone, J Shortt

Journal article  |  2015  |  Leukemia

Manipulation of B-cell responses with histone deacetylase inhibitors

Michaela Waibel, Ailsa J Christiansen, Margaret L Hibbs, Jake Shortt, Sarah A Jones, Ian Simpson, Amanda Light, Kristy O'Donnell, Eric F Morand, David M Tarlinton, Ricky W Johnstone, Edwin D Hawkins

Journal article  |  2015  |  Nature Communications

Combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia

Jessica M Salmon, Michael Bots, Eva Vidacs, Kym L Stanley, Peter Atadja, Johannes Zuber, Ricky W Johnstone

Journal article  |  2015  |  Clinical Epigenetics

Letter to the Editor, "BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction"

SJ Hogg, RW Johnstone, J Shortt

Journal article  |  2015  |  Journal of Dental Research

Aml: Deacetylases

M Ghisi, RW Johnstone

Book Chapter  |  2015

The role of p21(waf1/cip1) and p27(Kip1) in HDACi-mediated tumor cell death and cell cycle arrest in the E mu-myc model of B-cell lymphoma

A Newbold, JM Salmon, BP Martin, K Stanley, RW Johnstone

Journal article  |  2014  |  Oncogene

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

Julian H Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J Cameron, Miranda Z Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H Prince, Jennifer F Hoy, Nicolas Chomont, Remi Fromentin, Francesco A Procopio, Joumana Zeidan, Sarah Palmer, et al.

Journal article  |  2014  |  PLoS Pathogens

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

Katrina J Falkenberg, Ricky W Johnstone

Journal article  |  2014  |  Nature Reviews Drug Discovery

The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling

Inge Verbrugge, Alessia Gasparini, Nicole M Haynes, Jim Hagekyriakou, Mara Galli, Trina J Stewart, Scott I Abrams, Hideo Yagita, Marcel Verheij, Ricky W Johnstone, Jannie Borst, Jacques Neefjes

Journal article  |  2014  |  Radiation Research

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers

Jennifer A Westwood, Geoffrey M Matthews, Jake Shortt, David Faulkner, Hollie J Pegram, Connie PM Duong, Marta Chesi, P Leif Bergsagel, Leslie L Sharp, Richard D Huhn, Phillip K Darcy, Ricky W Johnstone, Michael H Kershaw

Journal article  |  2014  |  Leukemia Research

Rational combination therapies targeting survival signaling in aggressive B-cell leukemia/lymphoma

Michaela Waibel, Gareth Gregory, Jake Shortt, Ricky W Johnstone

Journal article  |  2014  |  Current Opinion in Hematology

Id2 represses E2A-mediated activation of IL-10 expression in T cells

Frederick Masson, Margherita Ghisi, Joanna R Groom, Axel Kallies, Cyril Seillet, Ricky W Johnstone, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2014  |  Blood

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

D Brasacchio, T Noori, C House, AJ Brennan, KJ Simpson, O Susanto, PI Bird, RW Johnstone, JA Trapani

Journal article  |  2014  |  Cell Death & Differentiation

The Drug Vehicle and Solvent N-Methylpyrrolidone Is an Immunomodulator and Antimyeloma Compound

Jake Shortt, Andy K Hsu, Benjamin P Martin, Karen Doggett, Geoffrey M Matthews, Maria A Doyle, Jason Ellul, Tina E Jockel, Daniel M Andrews, Simon J Hogg, Andrea Reitsma, David Faulkner, P Leif Bergsagel, Marta Chesi, Joan K Heath, William A Denny, Philip E Thompson, Paul J Neeson, David S Ritchie, Grant A McArthur, et al.

Journal article  |  2014  |  Cell Reports

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads

Jan Schroeder, Arthur Hsu, Samantha E Boyle, Geoff Macintyre, Marek Cmero, Richard W Tothill, Ricky W Johnstone, Mark Shackleton, Anthony T Papenfuss

Journal article  |  2014  |  Bioinformatics

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Tiffany J Parmenter, Margarete Kleinschmidt, Kathryn M Kinross, Simon T Bond, Jason Li, Mohan R Kaadige, Aparna Rao, Karen E Sheppard, Willy Hugo, Gulietta M Pupo, Richard B Pearson, Sean L Mcgee, Georgina V Long, Richard A Scolyer, Helen Rizos, Roger S Lo, Carleen Cullinane, Donald E Ayer, Antoni Ribas, Ricky W Johnstone, et al.

Journal article  |  2014  |  Cancer Discov

Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas

Shoukat Afshar-Sterle, Dimitra Zotos, Nicholas J Bernard, Anna K Scherger, Lisa Roedling, Amber E Alsop, Jennifer Walker, Frederick Masson, Gabrielle T Belz, Lynn M Corcoran, Lorraine A O'Reilly, Andreas Strasser, Mark J Smyth, Ricky Johnstone, David M Tarlinton, Stephen L Nutt, Axel Kallies

Journal article  |  2014  |  Nature Medicine

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

Michael Bots, Inge Verbrugge, Benjamin P Martin, Jessica M Salmon, Margherita Ghisi, Adele Baker, Kym Stanley, Jake Shortt, Gert J Ossenkoppele, Johannes Zuber, Amy R Rappaport, Peter Atadja, Scott W Lowe, Ricky W Johnstone

Journal article  |  2014  |  Blood

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells

Toshihiko Tanno, Yiting Lim, Qiuju Wang, Marta Chesi, P Leif Bergsagel, Geoff Matthews, Ricky W Johnstone, Nilanjan Ghosh, Ivan Borrello, Carol Ann Huff, William Matsui

Journal article  |  2014  |  Blood

Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia

Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell

Journal article  |  2014  |  PLoS ONE

From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma

Jonathan D Licht, Jake Shortt, Ricky Johnstone

Journal article  |  2014  |  Cancer Cell

The anticancer effects of HDAC inhibitors require the immune system

Alison C West, Mark J Smyth, Ricky W Johnstone

Journal article  |  2014  |  OncoImmunology

Genome-wide functional genomic and transcriptomic analyses for genes regulating sensitivity to vorinostat

Katrina J Falkenberg, Cathryn M Gould, Ricky W Johnstone, Kaylene J Simpson

Journal article  |  2014  |  Scientific Data

New and emerging HDAC inhibitors for cancer treatment

Alison C West, Ricky W Johnstone

Journal article  |  2014  |  Journal of Clinical Investigation

An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

Alison C West, Stephen R Mattarollo, Jake Shortt, Leonie A Cluse, Ailsa J Christiansen, Mark J Smyth, Ricky W Johnstone

Journal article  |  2013  |  Cancer Research

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  European Journal of Cancer

Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities

Andrea Newbold, Geoffrey M Matthews, Michael Bots, Leonie A Cluse, Christopher JP Clarke, Kellie-Marie Banks, Carleen Cullinane, Jessica E Bolden, Ailsa J Christiansen, Ross A Dickins, Claudia Miccolo, Susanna Chiocca, Astrid M Kral, Nicole D Ozerova, Thomas A Miller, Joey L Methot, Victoria M Richon, J Paul Secrist, Saverio Minucci, Ricky W Johnstone

Journal article  |  2013  |  Molecular Cancer Therapeutics

Combined Targeting of JAK2 and Bcl-2/Bcl-xL to Cure Mutant JAK2-Driven Malignancies and Overcome Acquired Resistance to JAK2 Inhibitors

Michaela Waibel, Vanessa S Solomon, Deborah A Knight, Rachael A Ralli, Sang-Kyu Kim, Kellie-Marie Banks, Eva Vidacs, Clemence Virely, Keith CS Sia, Lauryn S Bracken, Racquel Collins-Underwood, Christina Drenberg, Laura B Ramsey, Sara C Meyer, Megumi Takiguchi, Ross A Dickins, Ross Levine, Jacques Ghysdael, Mark A Dawson, Richard B Lock, et al.

Journal article  |  2013  |  Cell Reports

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

Journal article  |  2013  |  The FEBS Journal

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2 '-Deoxycytidine in Solid Tumor Cells

Sascha Venturelli, Alexander Berger, Timo Weiland, Frank Essmann, Michaela Waibel, Tina Nuebling, Sabine Haecker, Martin Schenk, Klaus Schulze-Osthoff, Helmut R Salih, Simone Fulda, Bence Sipos, Ricky W Johnstone, Ulrich M Lauer, Michael Bitzer

Journal article  |  2013  |  Molecular Cancer Therapeutics

Modulation of antitumour immune responses by intratumoural Stat1 expression

Nicole L Messina, Kellie M Banks, Eva Vidacs, Ben P Martin, Fennella Long, Ailsa J Christiansen, Mark J Smyth, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2013  |  Immunology and Cell Biology

Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy

J Shortt, AK Hsu, RW Johnstone

Journal article  |  2013  |  Oncogene

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

GM Matthews, M Lefebure, MA Doyle, J Shortt, J Ellul, M Chesi, K-M Banks, E Vidacs, D Faulkner, P Atadja, PL Bergsagel, RW Johnstone

Journal article  |  2013  |  Cell Death & Disease

Histone deacetylase inhibitors reduce glycoprotein VI expression and platelet responses to collagen related peptide

Mark J Bishton, Elizabeth E Gardiner, Simon J Harrison, H Miles Prince, Ricky W Johnstone

Journal article  |  2013  |  Thrombosis Research

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

Fabio Santoro, Oronza A Botrugno, Roberto Dal Zuffo, Isabella Pallavicini, Geoffrey M Matthews, Leonie Cluse, Iros Barozzi, Silvia Senese, Lorenzo Fornasari, Simona Moretti, Lucia Altucci, Pier Giuseppe Pelicci, Susanna Chiocca, Ricky W Johnstone, Saverio Minucci

Journal article  |  2013  |  Blood

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  Blood

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses

JE Bolden, W Shi, K Jankowski, C-Y Kan, L Cluse, BP Martin, KL MacKenzie, GK Smyth, RW Johnstone

Journal article  |  2013  |  Cell Death & Disease

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

Journal article  |  2013  |  Cancer Discovery

Enhancing the antitumor effects of radiotherapy with combinations of immunostimulatory antibodies

Inge Verbrugge, Mara Galli, Mark J Smyth, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2012  |  OncoImmunology

Oncogenes in Cell Survival and Cell Death

Jake Shortt, Ricky W Johnstone

Journal article  |  2012  |  Cold Spring Harbor Perspectives in Biology

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

Stephen R Mattarollo, Alison C West, Kim Steegh, Helene Duret, Christophe Paget, Ben Martin, Geoffrey M Matthews, Jake Shortt, Marta Chesi, P Leif Bergsagel, Michael Bots, Johannes Zuber, Scott W Lowe, Ricky W Johnstone, Mark J Smyth

Journal article  |  2012  |  Blood

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax (R))

Simon J Harrison, Mark Bishton, Susan E Bates, Steven Grant, Richard L Piekarz, Ricky W Johnstone, Yun Dai, Becki Lee, Maria E Araujo, H Miles Prince

Journal article  |  2012  |  Epigenomics

PIDDosome-independent tumor suppression by Caspase-2

C Manzl, L Peintner, G Krumschnabel, F Bock, V Labi, M Drach, A Newbold, R Johnstone, Andreas Villunger

Journal article  |  2012  |  Cell Death & Differentiation

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

LM Lindqvist, I Vikstroem, JM Chambers, K McArthur, M Ann Anderson, KJ Henley, L Happo, L Cluse, RW Johnstone, AW Roberts, BT Kile, BA Croker, CJ Burns, MA Rizzacasa, A Strasser, DCS Huang

Journal article  |  2012  |  Cell Death & Disease

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors

A Newbold, SJ Vervoort, BP Martin, M Bots, RW Johnstone

Journal article  |  2012  |  Cell Death & Disease

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  Blood

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

Marta Chesi, Geoffrey M Matthews, Victoria M Garbitt, Stephen E Palmer, Jake Shortt, Marcus Lefebure, A Keith Stewart, Ricky W Johnstone, P Leif Bergsagel

Journal article  |  2012  |  Blood

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bliesath, Mustapha Haddach, Michael K Schwaebe, David M Ryckman, William G Rice, Clemens Schmitt, Scott W Lowe, Ricky W Johnstone, et al.

Journal article  |  2012  |  Cancer Cell

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

Inge Verbrugge, Jim Hagekyriakou, Leslie L Sharp, Mara Galli, Alison West, Nicole M McLaughlin, Helene Duret, Hideo Yagita, Ricky W Johnstone, Mark J Smyth, Nicole M Haynes

Journal article  |  2012  |  Cancer Research

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

VR Sutton, K Sedelies, G Dewson, ME Christensen, PI Bird, RW Johnstone, RM Kluck, JA Trapani, NJ Waterhouse

Journal article  |  2012  |  Cell Death & Disease

Cell death research, on an island girt by sea.

ME Christensen, WW-L Wong, M Waibel, RW Johnstone, NJ Waterhouse

Journal article  |  2012  |  Cell Death & Differentiation

Histone deacetylase inhibitors are unable to synergize with ABT-737 in killing primary chronic lymphocytic leukaemia cells in vitro

R Ralli, KM Banks, AP Wiegmans, D Carney, JF Seymour, RW Johnstone, AE Alsop

Journal article  |  2012  |  Leukemia

The combination of histone deacetylase inhibitors with immune-stimulating antibodies has potent anti-cancer effects

Alison C West, Ailsa J Christiansen, Mark J Smyth, Ricky W Johnstone

Journal article  |  2012  |  OncoImmunology

Structures of the HIN Domain: DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Tengchuan Jin, Andrew Perry, Jiansheng Jiang, Patrick Smith, James A Curry, Leonie Unterholzner, Zhaozhao Jiang, Gabor Horvath, Vijay A Rathinam, Ricky W Johnstone, Veit Hornung, Eicke Latz, Andrew G Bowie, Katherine A Fitzgerald, T Sam Xiao

Journal article  |  2012  |  Immunity

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

PT Ferrao, EP Bukczynska, RW Johnstone, GA McArthur

Journal article  |  2012  |  Oncogene

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

Daniel J Gough, Nicole L Messina, Christopher JP Clarke, Ricky W Johnstone, David E Levy

Journal article  |  2012  |  Immunity

Regulating the TRAIL of Destruction: How A20 Protects Glioblastomas from TRAIL-Mediated Death

Inge Verbrugge, Ricky W Johnstone

Journal article  |  2012  |  Cancer Discovery

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur, et al.

Journal article  |  2012  |  Journal of Clinical Investigation

Intrinsic and Extrinsic Apoptotic Pathway Signaling as Determinants of Histone Deacetylase Inhibitor Antitumor Activity

Geoffrey M Matthews, Andrea Newbold, Ricky W Johnstone

Book Chapter  |  2012  |  Advances in Cancer Research

A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma

Simon J Harrison, Hang Quach, Emma Link, John F Seymour, David S Ritchie, Sam Ruell, Joanne Dean, Henry Januszewicz, Ricky Johnstone, Paul Neeson, Michael Dickinson, Jean Nichols, H Miles Prince

Journal article  |  2011  |  Blood

Promises and challenges of anticancer drugs that target the epigenome

Inge Verbrugge, Ricky W Johnstone, Michael Bots

Journal article  |  2011  |  Epigenomics

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  Science Signaling

In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a Kras(G12D);Pten Deletion Mouse Model of Ovarian Cancer

Kathryn M Kinross, Daniel V Brown, Margarete Kleinschmidt, Susan Jackson, James Christensen, Carleen Cullinane, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur

Journal article  |  2011  |  Molecular Cancer Therapeutics

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

Kate L Burbury, Mark J Bishton, Ricky W Johnstone, Michael J Dickinson, Jeffrey Szer, H Miles Prince

Journal article  |  2011  |  Annals of Hematology

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

Ben P Martin, Ailsa J Frew, Michael Bots, Stephen Fox, Fenella Long, Kazuyoshi Takeda, Hideo Yagita, Peter Atadja, Mark J Smyth, Ricky W Johnstone

Journal article  |  2011  |  International Journal of Cancer

Deciphering the Molecular Events Necessary for Synergistic Tumor Cell Apoptosis Mediated by the Histone Deacetylase Inhibitor Vorinostat and the BH3 Mimetic ABT-737

Adrian P Wiegmans, Amber E Alsop, Michael Bots, Leonie A Cluse, Steven P Williams, Kellie-Marie Banks, Rachael Ralli, Clare L Scott, Anna Frenzel, Andreas Villunger, Ricky W Johnstone

Journal article  |  2011  |  Cancer Research

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

Mark J Bishton, Simon J Harrison, Benjamin P Martin, Nicole McLaughlin, Chloe James, Emma C Josefsson, Katya J Henley, Benjamin T Kile, H Miles Prince, Ricky W Johnstone

Journal article  |  2011  |  Blood

Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies

Ailsa J Christiansen, Alison West, Kellie-Marie Banks, Nicole M Haynes, Michele W Teng, Mark J Smyth, Ricky W Johnstone

Journal article  |  2011  |  Proceedings of the National Academy of Sciences of the United States of America

SnapShot: Extrinsic Apoptosis Pathways

Inge Verbrugge, Ricky W Johnstone, Mark J Smyth

Journal article  |  2010  |  Cell

Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect

Michael Dickinson, Ricky W Johnstone, H Miles Prince

Journal article  |  2010  |  Investigational New Drugs

Functional imaging in the age of targeted therapeutics for haematological cancers

J Shortt, A Newbold, RW Johnstone

Journal article  |  2010  |  ANZ Nuclear Medicine

Overview of Histone Deacetylase Inhibitors in Haematological Malignancies.

Mark J Bishton, Ricky W Johnstone, Michael Dickinson, Simon Harrison, H Miles Prince

Journal article  |  2010  |  Pharmaceuticals

Histone deacetylase inhibitors (HDACi) can induce hyperacetylation of both histone and non-histone target resulting in epigenetic ..

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.

Journal article  |  2010  |  Journal of Immunology

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

Daniel J Gough, Nicole L Messina, Linda Hii, Jodee A Gould, Kanaga Sabapathy, Ashley PS Robertson, Joseph A Trapani, David E Levy, Paul J Hertzog, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2010  |  PLoS Biology

Inducible Activation of IFI 16 Results in Suppression of Telomerase Activity, Growth Suppression and Induction of Cellular Senescence

Christopher JP Clarke, Linda L Hii, Jessica E Bolden, Ricky W Johnstone

Journal article  |  2010  |  Journal of Cellular Biochemistry

Enhancing the apoptotic and therapeutic effects of HDAC inhibitors

Ailsa J Frew, Ricky W Johnstone, Jessica E Bolden

Journal article  |  2009  |  Cancer Letters

The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

Leigh Ellis, Michael Bots, Ralph K Lindemann, Jessica E Bolden, Andrea Newbold, Leonie A Cluse, Clare L Scott, Andreas Strasser, Peter Atadja, Scott W Lowe, Ricky W Johnstone

Journal article  |  2009  |  Blood

Rational Combinations Using HDAC Inhibitors

Michael Bots, Ricky W Johnstone

Journal article  |  2009  |  Clinical Cancer Research

Epigenetics in cancer: Targeting chromatin modifications

Leigh Ellis, Peter W Atadja, Ricky W Johnstone

Journal article  |  2009  |  Molecular Cancer Therapeutics

Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors

H Miles Prince, Mark J Bishton, Ricky W Johnstone

Journal article  |  2009  |  Future Oncology

Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors

Kate F Whitecross, Amber E Alsop, Leonie A Cluse, Adrian Wiegmans, Kellie-Marie Banks, Claudia Coomans, Melissa J Peart, Andrea Newbold, Ralph K Lindemann, Ricky W Johnstone

Journal article  |  2009  |  Blood

Perforin-mediated suppression of B-cell lymphoma

Paul Bolitho, Shayna EA Street, Jennifer A Westwood, Winfried Edelmann, Duncan MacGregor, Paul Waring, William K Murray, Dale I Godfrey, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors

Elizabeth M Algar, Andrea Muscat, Vinod Dagar, Christian Rickert, CW Chow, Jaclyn A Biegel, Paul G Ekert, Richard Saffery, Jeff Craig, Ricky W Johnstone, David M Ashley

Journal article  |  2009  |  PLoS One

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

EM Algar, A Muscat, V Dagar, C Rickert, CW Chow, JA Biegel, PG Ekert, R Saffery, J Craig, RW Johnstone, DM Ashley

Journal article  |  2009  |  PLoS ONE

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

John Stagg, Janelle Sharkey, Sandra Pommey, Richard Young, Kazuyoshi Takeda, Hideo Yagita, Ricky W Johnstone, Mark J Smyth

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

The TRAIL apoptotic pathway in cancer onset, progression and therapy

Ricky W Johnstone, Ailsa J Frew, Mark J Smyth

Journal article  |  2008  |  Nature Reviews Cancer

IFN-gamma signaling-Does it mean JAK-STAT?

Daniel J Gough, David E Levy, Ricky W Johnstone, Christopher J Clarke

Journal article  |  2008  |  Cytokine & Growth Factor Reviews

The partial rescue of impaired interferon-gamma signalling in type I interferon receptor deficient cells by re-expression of STAT1

Nicole L Messina, Daniel J Gough, Linda Hii, Ricky Johnstone, Chris Clarke, Peter MacCallum

Conference Proceedings  |  2008  |  Cytokine

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

Ailsa J Frew, Ralph K Lindemann, Ben P Martin, Christopher JP Clarke, Janelle Sharkey, Desiree A Anthony, Kellie-Marie Banks, Nicole M Haynes, Pradnya Gangatirkar, Kym Stanley, Jessica E Bolden, Kazuyoshi Takeda, Hideo Yagita, J Paul Secrist, Mark J Smyth, Ricky W Johnstone

Journal article  |  2008  |  Proceedings of the National Academy of Sciences of the United States of America

Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma

Leigh Ellis, Yan Pan, Gordon K Smyth, Daniel J George, Chris McCormack, Roxanne Williams-Truax, Monica Mita, Joachim Beck, Howard Burris, Gail Ryan, Peter Atadja, Dale Butterfoss, Margaret Dugan, Kenneth Culver, Ricky W Johnstone, H Miles Prince

Journal article  |  2008  |  Clinical Cancer Research

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin

Andrea Newbold, Ralph K Lindemann, Leonie A Cluse, Kate F Whitecross, Anthony E Dear, Ricky W Johnstone

Journal article  |  2008  |  Molecular Cancer Therapeutics

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

KA Sedelies, A Ciccone, CJP Clarke, J Oliaro, VR Sutton, FL Scott, J Silke, O Susanto, DR Green, RW Johnstone, PI Bird, JA Trapani, NJ Waterhouse

Journal article  |  2008  |  Cell Death & Differentiation

Cloning and characterisation of IFi206: A new murine HIN-200 family member

Louise E Ludlow, Linda L Hii, Janine Thorpe, Andrea Newbold, Kellie M Tainton, Joseph A Trapani, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2008  |  Journal of Cellular Biochemistry

Histone deacetylase inhibitors in lymphoma and solid malignancies

Walid Rasheed, Mark Bishton, Ricky W Johnstone, H Miles Prince

Journal article  |  2008  |  Expert Review of Anticancer Therapy

The role of p202 in regulating hematopoietic cell proliferation and differentiation (Journal of Interferon and Cytokine Research 28, 1, (5-11))

LE Ludlow, LE Purton, K Klarmann, DJ Gough, LL Hii, JA Trapani, JR Keller, CJP Clarke, RW Johnstone

Journal article  |  2008  |  Journal of Interferon & Cytokine Research

The role of p202 in regulating hematopoietic cell proliferation and differentiation

Louise E Ludlow, Louise E Purton, Kim Klarmann, Daniel J Gough, Linda L Hii, Joseph A Trapani, Jonathan R Keller, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2008  |  Journal of Interferon and Cytokine Research

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

Mai Nguyen, Richard C Marcellus, Anne Roulston, Mark Watson, Lucile Serfass, SR Murthy Madiraju, Daniel Goulet, Jean Viallet, Laurent Belec, Xavier Billot, Stephane Acoca, Enrico Purisima, Adrian Wiegmans, Leonie Cluse, Ricky W Johnstone, Pierre Beauparlant, Gordon C Shore

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

From cancer immunosurveillance to cancer immunotherapy

John Stagg, Ricky W Johnstone, Mark J Smyth

Journal article  |  2007  |  Immunological Reviews

Not safe enough fixing transportation security

RW Johnstone

Journal article  |  2007  |  Issues in Science and Technology

Epigenetic targets in hematological malignancies: Combination therapies with HDACis and demethylating agents

Mark Bishton, Melita Kenealy, Ricky Johnstone, Walid Rasheed, H Miles Prince

Journal article  |  2007  |  Expert Review of Anticancer Therapy

Response: Does bid play a role in the DNA damage response?

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Damien Arnoult, Andreas Strasser

Journal article  |  2007  |  Cell

The constitutive secretion of type I interferon is necessary for maintenance of STAT1 expression and cross-talk between type I and IIIFN

Daniel J Gough, Jodee A Gould, Paul J Hertzog, Nicole Messina, Kanaga Sabapathy, Joseph A Trapani, Christophe JP Clarke, Ricky W Johnstone

Conference Proceedings  |  2007  |  Cytokine

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

RK Lindemann, A Newbold, KF Whitecross, LA Cluse, AJ Frew, L Ellis, S Williams, AP Wiegmans, AE Dear, CL Scott, M Pellegrini, A Wei, VM Richon, Paul A Marks, SW Lowe, MJ Smyth, RW Johnstone

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

Histone deacetylase inhibitors in cancer therapy

Walid K Rasheed, Ricky W Johnstone, H Miles Prince

Journal article  |  2007  |  Expert Opinion on Investigational Drugs

The BH3-only protein bid is dispensable for DNA darnage- and replicative stress-induced apoptosis or cell-cycle arrest

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Andreas Strasser

Journal article  |  2007  |  Cell

A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes

Daniel J Gough, Kanaga Sabapathy, Enoch Yi-No Ko, Helen A Arthur, Robert D Schreiber, Joseph A Trapani, Christopher JP Clarke, Ricky W Johnstone

Journal article  |  2007  |  Journal of Biological Chemistry

Anticancer activities of histone deacetylase inhibitors

Jessica E Bolden, Melissa J Peart, Ricky W Johnstone

Journal article  |  2006  |  Nature Reviews Drug Discovery

Defining the apoptotic pathways underlying histone deacetylase inhibitor-mediated tumor therapy

Ralph K Lindemann, Andrea Newbold, Kate Whitecross, Anthony E Dear, Clare L Scott, Andrew Wei, Victoria Richon, Scott W Lowe, Ricky W Johnstone

Conference Proceedings  |  2006  |  European Journal of Cancer Supplements

Functional dissociation of Delta Psi m and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

NJ Waterhouse, KA Sedelies, VR Sutton, MJ Pinkoski, KY Thia, R Johnstone, PI Bird, DR Green, JA Trapani

Journal article  |  2006  |  Cell Death & Differentiation

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

EK Baker, RW Johnstone, JR Zalcberg, A El-Osta

Journal article  |  2005  |  Oncogene

The HIN-200 family: More than interferon-inducible genes?

LEA Ludlow, RW Johnstone, CJP Clarke

Journal article  |  2005  |  Experimental Cell Research

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

MJ Peart, GK Smyth, RK van Laar, DD Bowtell, VM Richon, PA Marks, AJ Holloway, RW Johnstone

Journal article  |  2005  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A central role for bid in granzyme B-induced apoptosis

NJ Waterhouse, KA Sedelies, KA Browne, ME Wowk, A Newbold, VR Sutton, CJP Clarke, J Oliaro, RK Lindemann, PI Bird, RW Johnstone, JA Trapani

Journal article  |  2005  |  Journal of Biological Chemistry

Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2

KS Cresswell, CJP Clarke, JT Jackson, PK Darcy, JA Trapani, RW Johnstone

Journal article  |  2005  |  Biochemical and Biophysical Research Communications

The multidrug resistance gene mdr1a influences resistance to ectromelia virus infection by mechanisms other than conventional immunity

DM Xu, M Regner, D Smith, J Ruby, R Johnstone, A Mullbacher

Journal article  |  2004  |  Immunology and Cell Biology

Histone deacetylase inhibitors specifically kill nonproliferating tumour cells

A Burgess, A Ruefli, H Beamish, R Warrener, N Saunders, R Johnstone, B Gabrielli

Journal article  |  2004  |  Oncogene

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux

KM Tainton, MJ Smyth, JT Jackson, JE Tanner, L Cerruti, SM Jane, PK Darcy, RW Johnstone

Journal article  |  2004  |  Cell Death & Differentiation

Suberanilohydroxamic acid aton pharma

RW Johnstone

Journal article  |  2004  |  IDrugs : the investigational drugs journal

Histone-deacetylase inhibitors for the treatment of cancer

RK Lindemann, B Gabrielli, RW Johnstone

Journal article  |  2004  |  Cell Cycle

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

JA Aglipay, SW Lee, S Okada, N Fujiuchi, T Ohtsuka, JC Kwak, Y Wang, RW Johnstone, CX Deng, J Qin, T Ouchi

Journal article  |  2003  |  Oncogene

Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif

GA Darnell, TM Antalis, RW Johnstone, BW Stringer, SM Ogbourne, D Harrich, A Suhrbier

Journal article  |  2003  |  Molecular and Cellular Biology

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors

MJ Peart, KM Tainton, AA Ruefli, AE Dear, KA Sedelies, LA O'Reilly, NJ Waterhouse, JA Trapani, RW Johnstone

Journal article  |  2003  |  Cancer Research

Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

H Xin, J Curry, RW Johnstone, BJ Nickoloff, D Choubey

Journal article  |  2003  |  Oncogene

A role for P-glycoprotein in regulating cell growth and survival

AA Ruefli, RW Johnstone

Journal article  |  2003  |  Clinical and Applied Immunology Reviews

Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?

RW Johnstone, JD Licht

Journal article  |  2003  |  Cancer Cell

Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16

CJP Clarke, V Apostolidis, LLP Hii, DJ Gough, JA Trapani, RW Johnstone

Journal article  |  2003  |  Journal of Cellular Biochemistry

Expression of IFI 16 in epithelial cells and lymphoid tissues

W Wei, CJP Clarke, GR Somers, KS Cresswell, KA Loveland, JA Trapani, RW Johnstone

Journal article  |  2003  |  Histochemistry and Cell Biology

Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia

R Crazzolara, K Johrer, RW Johnstone, R Greil, R Kofler, B Meister, D Bernhard

Journal article  |  2002  |  British Journal of Haematology

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation

A Ruefli, KM Tainton, PK Darcy, MJ Smyth, RW Johnstone

Journal article  |  2002  |  Cell Death & Differentiation

Deamidation of Bcl-X-L: A new twist in a genotoxic murder mystery

RW Johnstone

Journal article  |  2002  |  Molecular Cell

Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells

AA Ruefli, D Bernhard, KM Tainton, R Kofler, MJ Smyth, RW Johnstone

Journal article  |  2002  |  International Journal of Cancer

Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer

RW Johnstone

Journal article  |  2002  |  Nature Reviews Drug Discovery

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis

AL Greenway, DA McPhee, K Allen, R Johnstone, G Holloway, J Mills, A Azad, S Sankovich, P Lambert

Journal article  |  2002  |  Journal of Virology

Apoptosis: A link between cancer genetics and chemotherapy

RW Johnstone, AA Ruefli, SW Lowe

Journal article  |  2002  |  Cell

P-glycoprotein as a general antiapoptotic protein

AA RUEFLI, MJ SMYTH, RW JOHNSTONE

Book Chapter  |  2002

Identifying Molecular Targets Mediating the Anticancer Activity of Histone Deacetylase Inhibitors: A Work in Progress

BG Gabrielli, RW Johnstone, NA Saunders

Journal article  |  2002  |  Current Cancer Drug Targets

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

AA Ruefli, MJ Ausserlechner, D Bernhard, VR Sutton, KM Tainton, R Kofler, MJ Smyth, RW Johnstone

Journal article  |  2001  |  Proceedings of the National Academy of Sciences of the United States of America

Mechanisms of interferon mediated anti-viral resistance.

CJ Clarke, JA Trapani, RW Johnstone

Journal article  |  2001  |  Current Drug Target - Immune, Endocrine & Metabolic Disorders

Interferons (IFNs) are an important part of immune responses and are believed to protect the host from viral and bacterial pathoge..

P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins

RW Johnstone, KM Tainton, AA Ruefli, CJ Froelich, L Cerruti, SM Jane, MJ Smyth

Journal article  |  2001  |  Journal of Biological Chemistry

Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies

AA Ruefli, JE Davis, VR Sutton, JA Trapani, MJ Smyth, RW Johnstone

Journal article  |  2001  |  Drug Development Research

Functional analysis of the leukemia protein ELL: Evidence for a role in the regulation of cell growth and survival

RW Johnstone, M Gerber, T Landewe, A Tollefson, WS Wold, A Shilatifard

Journal article  |  2001  |  Molecular and Cellular Biology

Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16

LJ Briggs, RW Johnstone, RM Elliot, CY Xiao, M Dawson, JA Trapani, DA Jans

Journal article  |  2001  |  Biochemical Journal

Novel properties of the protein kinase CK2-site-regulated nuclear-localization sequence of the interferon-induced nuclear factor IFI 16

LJ Briggs, RW Johnstone, RM Elliot, CY Xiao, M Dawson, JA Trapani, DA Jans

Journal article  |  2001  |  Biochemical Journal

Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis

KA Browne, RW Johnstone, DA Jans, JA Trapani

Journal article  |  2000  |  Journal of Biological Chemistry

Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16

RW Johnstone, W Wei, A Greenway, JA Trapani

Journal article  |  2000  |  Oncogene

Regulators and effectors of the interferon response

RW Johnstone

Journal article  |  2000  |  Today's Life Science

Initiation of apoptosis by granzyme B requires direct cleavage of Bid, but not direct granzyme B-mediated caspase activation

VR Sutton, JE Davis, M Cancilla, RW Johnstone, AA Ruefli, K Sedelies, KA Browne, JA Trapani

Journal article  |  2000  |  Journal of Experimental Medicine

Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3

T Miller, K Williams, RW Johnstone, A Shilatifard

Journal article  |  2000  |  Journal of Biological Chemistry

Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine

KM Tainton, AA Ruefli, MJ Smyth, RW Johnstone

Journal article  |  2000  |  Biochemical and Biophysical Research Communications

Role of TNF in lymphocyte-mediated cytotoxicity

MJ Smyth, RW Johnstone

Journal article  |  2000  |  Microscopy Research and Technique

A role for P-glycoprotein in regulating cell death

RW Johnstone, AA Ruefli, KM Tainton, MJ Smyth

Journal article  |  2000  |  Leukemia & Lymphoma

HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance

AA Ruefli, MJ Smyth, RW Johnstone

Journal article  |  2000  |  Blood

Multiple physiological functions for multidrug transporter P-glycoprotein?

RW Johnstone, AA Ruefli, MJ Smyth

Journal article  |  2000  |  Trends in Biochemical Sciences

Transcription and growth regulatory functions of the HIN-200 family of proteins

RW Johnstone, JA Trapani

Journal article  |  1999  |  Molecular and Cellular Biology

Structural organization, tissue expression, and chromosomal localization of Ciao 1, a functional modulator of the Wilms' tumor suppressor, WT1

RW Johnstone, N Tommerup, C Hansen, H Vissing, Y Shi

Journal article  |  1999  |  Immunogenetics

Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice

MJ Smyth, RW Johnstone, E Cretney, NM Haynes, JD Sedgwick, H Korner, LD Poulton, AG Baxter

Journal article  |  1999  |  Journal of Immunology

P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death

RW Johnstone, E Cretney, MJ Smyth

Journal article  |  1999  |  Blood

P-glycoprotein: More than a drug pump?

RW Johnstone, AA Ruefli, MJ Smyth

Journal article  |  1999  |  Today's Life Science

Mapping of the human PAWR (par-4) gene to chromosome 12q21

RW Johnstone, N Tommerup, C Hansen, H Vissing, Y Shi

Journal article  |  1998  |  Genomics

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

MJ Dawson, NJ Elwood, RW Johnstone, JA Trapani

Journal article  |  1998  |  Journal of Leukocyte Biology

Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing

RW Johnstone, MH Kershaw, JA Trapani

Journal article  |  1998  |  Biochemistry

The human interferon-inducible protein, IFI 16, is a repressor of transcription

RW Johnstone, JA Kerry, JA Trapani

Journal article  |  1998  |  Journal of Biological Chemistry

Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8( ) cytotoxic T lymphocytes

MJ Smyth, E Krasovskis, RW Johnstone

Journal article  |  1998  |  Journal of Virology

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

MJ Smyth, E Krasovskis, VR Sutton, RW Johnstone

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

RW Johnstone, J Wang, N Tommerup, H Vissing, T Roberts, Y Shi

Journal article  |  1998  |  Journal of Biological Chemistry

The question begs - what is the role of P-glycoprotein in normal physiology?

RW Johnstone, MJ Smyth

Journal article  |  1998  |  Drug Resistance Updates

IFI 16 is a represser of transcription that interacts with cellular transcriptional modulators

RW Johnstone, JA Trapani

Journal article  |  1997  |  FASEB Journal

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

KL DeYoung, ME Ray, YA Su, SL Anzick, RW Johnstone, JA Trapani, PS Meltzer, JM Trent

Journal article  |  1997  |  Oncogene

Expression and function of the leucine zipper protein par-4 in apoptosis

SF Sells, SS Han, S Muthukkumar, N Maddiwar, R Johnstone, E Boghaert, D Gillis, GH Liu, P Nair, S Monnig, P Collini, MP Mattson, VP Sukhatme, SG Zimmer, DP Wood, JW McRoberts, Y Shi, VM Rangnekar

Journal article  |  1997  |  Molecular and Cellular Biology

A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

RW Johnstone, RH See, SF Sells, J Wang, S Muthukkumar, C Englert, DA Haber, JD Licht, SP Sugrue, T Roberts, VM Rangnekar, Y Shi

Journal article  |  1996  |  Molecular and Cellular Biology

COORDINATE FUNCTIONS OF MULTIPLE COMPLEMENT REGULATING MOLECULES, CD46, CD55, AND CD59

BE LOVELAND, K SZOKOLAI, RW JOHNSTONE, IFC MCKENZIE

Conference Proceedings  |  1994  |  Transplantation Proceedings

TISSUE-SPECIFIC EXPRESSION OF CD46 PROTEIN ISOFORMS DUE TO PRODUCTION OF RNA SPLICE VARIANTS

RW JOHNSTONE, S RUSSELL, BE LOVELAND, IFC MCKENZIE

Conference Proceedings  |  1994  |  Transplantation Proceedings

POLYMORPHIC EXPRESSION OF CD46 PROTEIN ISOFORMS DUE TO TISSUE-SPECIFIC RNA SPLICING

RW JOHNSTONE, SM RUSSELL, BE LOVELAND, IFC MCKENZIE

Journal article  |  1993  |  Molecular Immunology

IDENTIFICATION AND QUANTIFICATION OF COMPLEMENT REGULATOR CD46 ON NORMAL HUMAN TISSUES

RW JOHNSTONE, BE LOVELAND, IFC MCKENZIE

Journal article  |  1993  |  Immunology

CD46 (MCP) CONFERS PROTECTION FROM LYSIS BY XENOGENEIC ANTIBODIES

BE LOVELAND, RW JOHNSTONE, SM RUSSELL, BR THORLEY, IFC MCKENZIE

Conference Proceedings  |  1993  |  Transplantation Proceedings

Different membrane cofactor protein (CD46) isoforms protect transfected cells against antibody and complement mediated lysis.

BE Loveland, RW Johnstone, SM Russell, BR Thorley, IF McKenzie

Journal article  |  1993  |  Transplant Immunology

The need for organ transplantation, especially of kidneys, exceeds the availability of human donors and the possibility of xenotra..

TISSUE-SPECIFIC EXPRESSION OF CD46 ISOFORMS

RW JOHNSTONE, SM RUSSELL, BE LOVELAND, N JAYASURIYA, IFC MCKENZIE

Conference Proceedings  |  1992  |  Transplantation Proceedings

FUNCTIONAL-CHARACTERIZATION OF ALTERNATIVELY SPLICED CD46 CYTOPLASMIC TAILS

SM RUSSELL, BE LOVELAND, RW JOHNSTONE, BR THORLEY, IFC MCKENZIE

Conference Proceedings  |  1992  |  Transplantation Proceedings

STRONG ASSOCIATIONS BETWEEN RFLP AND PROTEIN POLYMORPHISMS FOR CD46

AN WILTON, RW JOHNSTONE, IFC MCKENZIE, DFJ PURCELL

Journal article  |  1992  |  Immunogenetics

THE MOLECULAR-BASIS OF CD46 POLYMORPHIC EXPRESSION AND DEMONSTRATION OF A PROTECTIVE ROLE AGAINST LYSIS BY XENOSERA

B LOVELAND, S RUSSELL, D PURCELL, R JOHNSTONE, B THORLEY, R SPARROW, I MCKENZIE

Conference Proceedings  |  1992  |  Transplantation Proceedings

MOLECULAR CHARACTERIZATION OF THE POLYMORPHIC EXPRESSION OF CD46 - A CELL-SURFACE MOLECULE PROTECTING CELLS FROM COMPLEMENT ATTACK

SM RUSSELL, RW JOHNSTONE, A WILTON, RL SPARROW, IFC MCKENZIE, DFJ PURCELL

Conference Proceedings  |  1992  |  Transplantation Proceedings

HUMAN ASTROCYTES EXPRESS MEMBRANE COFACTOR PROTEIN (CD46), A REGULATOR OF COMPLEMENT ACTIVATION

DL GORDON, TA SADLON, SL WESSELINGH, SM RUSSELL, RW JOHNSTONE, DFJ PURCELL

Journal article  |  1992  |  Journal of Neuroimmunology

IDENTIFICATION OF 4 DIFFERENT CD46 (MCP) MOLECULES WITH ANTIPEPTIDE ANTIBODIES

DFJ PURCELL, RW JOHNSTONE, IFC MCKENZIE

Journal article  |  1991  |  Biochemical and Biophysical Research Communications

TUMOR-LOCALIZATION BY COMBINATIONS OF MONOCLONAL-ANTIBODIES IN A NEW HUMAN COLON-CARCINOMA CELL-LINE (LIM1899)

SM ANDREW, JG TEH, RW JOHNSTONE, SM RUSSELL, RH WHITEHEAD, IFC MCKENZIE, GA PIETERSZ

Journal article  |  1990  |  Cancer Research

COMPARISON OF INVITRO-CELL BINDING CHARACTERISTICS OF 4 MONOCLONAL-ANTIBODIES AND THEIR INDIVIDUAL TUMOR-LOCALIZATION PROPERTIES IN MICE

SM ANDREW, RW JOHNSTONE, SM RUSSELL, IFC MCKENZIE, GA PIETERSZ

Journal article  |  1990  |  Cancer Research

THE EFFECT OF TEMPERATURE ON THE BINDING-KINETICS AND EQUILIBRIUM-CONSTANTS OF MONOCLONAL-ANTIBODIES TO CELL-SURFACE ANTIGENS

RW JOHNSTONE, SM ANDREW, MP HOGARTH, GA PIETERSZ, IFC MCKENZIE

Journal article  |  1990  |  Molecular Immunology

Efficient CRISPR/Cas9 gene ablation in uncultured naïve mouse T cells for in vivo studies

Simone Nüssing, Imran G House, Conor J Kearney, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article

AbstractCRISPR/Cas9 technologies have revolutionised our understanding of gene function in complex biological settings, including ..