David Ascher

Definition of the immune evasion-replication interface of rabies virus P protein.

Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley

Journal article  |  2021  |  PLoS Pathog

Rabies virus phosphoprotein (P protein) is a multifunctional protein that plays key roles in replication as the polymerase cofacto..

mmCSM-PPI: predicting the effects of multiple point mutations on protein-protein interactions.

Carlos HM Rodrigues, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  Nucleic Acids Res

Protein-protein interactions play a crucial role in all cellular functions and biological processes and mutations leading to their..

MTR3D: identifying regions within protein tertiary structures under purifying selection.

Michael Silk, Douglas EV Pires, Carlos HM Rodrigues, Elston N D'Souza, Moshe Olshansky, Natalie Thorne, David B Ascher

Journal article  |  2021  |  Nucleic Acids Res

The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome s..

pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties.

Raghad Al-Jarf, Alex GC de Sá, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  J Chem Inf Model

The development of new, effective, and safe drugs to treat cancer remains a challenging and time-consuming task due to limited hit..

The mutation G133D on Leishmania guyanensis AQP1 is highly destabilizing as revealed by molecular modeling and hypo-osmotic shock assay.

Luiza G Tunes, David B Ascher, Douglas V Pires, Rubens L Monte-Neto

Journal article  |  2021  |  Biochim Biophys Acta Biomembr

The Leishmania aquaglyceroporin 1 (AQP1) plays an important role in osmoregulation and antimony (Sb) uptake, being determinant for..

SAP domain forms a flexible part of DNA aperture in Ku70/80

Ales Hnizda, Petr Tesina, Thanh-Binh Nguyen, Zdenek Kukacka, Lukas Kater, Amanda Chaplin, Roland Beckmann, David B Ascher, Petr Novak, Tom L Blundell

Journal article  |  2021  |  FEBS JOURNAL

Nonhomologous end joining (NHEJ) is a DNA repair mechanism that religates double-strand DNA breaks to maintain genomic integrity d..

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource (vol 52, pg 999, 2020)

Stephanie Portelli, Moshe Olshansky, Carlos HM Rodrigues, Elston N D'Souza, Yoochan Myung, Michael Silk, Azadeh Alavi, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  NATURE GENETICS

A Correction to this paper has been published: https://doi.org/10.1038/s41588-020-00775-x.

Mercury methylation by metabolically versatile and cosmopolitan marine bacteria

Heyu Lin, David B Ascher, Yoochan Myung, Carl H Lamborg, Steven J Hallam, Caitlin M Gionfriddo, Kathryn E Holt, John W Moreau

Journal article  |  2021  |  ISME JOURNAL

Microbes transform aqueous mercury (Hg) into methylmercury (MeHg), a potent neurotoxin that accumulates in terrestrial and marine ..

Unveiling six potent and highly selective antileishmanial agents via the open source compound collection 'Pathogen Box' against antimony-sensitive and -resistant Leishmania braziliensis

Juliano A Souza Silva, Luiza G Tunes, Roney S Coimbra, David B Ascher, Douglas E Pires, Rubens L Monte-Neto

Journal article  |  2021  |  BIOMEDICINE & PHARMACOTHERAPY

Despite all efforts to provide new chemical entities to tackle leishmaniases, we are still dependent on a the limited drug arsenal..

Distinguishing between PTEN clinical phenotypes through mutation analysis.

Stephanie Portelli, Lucy Barr, Alex GC de Sá, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  Comput Struct Biotechnol J

Phosphate and tensin homolog on chromosome ten (PTEN) germline mutations are associated with an overarching condition known as PTE..