David Ascher

SAP domain forms a flexible part of DNA aperture in Ku70/80

Ales Hnizda, Petr Tesina, Thanh-Binh Nguyen, Zdenek Kukacka, Lukas Kater, Amanda Chaplin, Roland Beckmann, David B Ascher, Petr Novak, Tom L Blundell

Journal article  |  2021  |  The FEBS Journal

Nonhomologous end joining (NHEJ) is a DNA repair mechanism that religates double-strand DNA breaks to maintain genomic integrity d..

Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource (vol 52, pg 999, 2020)

Stephanie Portelli, Moshe Olshansky, Carlos HM Rodrigues, Elston N D'Souza, Yoochan Myung, Michael Silk, Azadeh Alavi, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  Nature Genetics

Mercury methylation by metabolically versatile and cosmopolitan marine bacteria

Heyu Lin, David B Ascher, Yoochan Myung, Carl H Lamborg, Steven J Hallam, Caitlin M Gionfriddo, Kathryn E Holt, John W Moreau

Journal article  |  2021  |  The ISME Journal: Multidisciplinary Journal of Microbial Ecology

Microbes transform aqueous mercury (Hg) into methylmercury (MeHg), a potent neurotoxin that accumulates in terrestrial and marine ..

Unveiling six potent and highly selective antileishmanial agents via the open source compound collection 'Pathogen Box' against antimony-sensitive and -resistant Leishmania braziliensis

Juliano A Souza Silva, Luiza G Tunes, Roney S Coimbra, David B Ascher, Douglas E Pires, Rubens L Monte-Neto

Journal article  |  2021  |  Biomedicine & Pharmacotherapy

Despite all efforts to provide new chemical entities to tackle leishmaniases, we are still dependent on a the limited drug arsenal..

Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis.

Edward Airey, Stephanie Portelli, Joicymara S Xavier, Yoo Chan Myung, Michael Silk, Malancha Karmakar, João PL Velloso, Carlos HM Rodrigues, Hardik H Parate, Anjali Garg, Raghad Al-Jarf, Lucy Barr, Juliana A Geraldo, Pâmela M Rezende, Douglas EV Pires, David B Ascher

Journal article  |  2021  |  Methods in molecular biology (Clifton, N.J.)

Mutations in protein-coding regions can lead to large biological changes and are associated with genetic conditions, including can..

Designing safe and potent herbicides with the cropCSM online resource

Douglas Pires, Keith Stubbs, Joshua Mylne, David Ascher

Journal article  |  2020

Herbicides have revolutionised weed management, increased crop yields and improved profitability allowing for an increase in world..

The impact of size and charge on the pulmonary phatmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats

Shadabul Haque, Colin W Pouton, Michelle P McIntosh, David B Ascher, David W Keizer, Michael R Whittaker, Lisa M Kaminskas

Journal article  |  2020  |  Nanomedicine Nanotechnology Biology and Medicine

Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inha..

ThermoMutDB: a thermodynamic database for missense mutations.

Joicymara S Xavier, Thanh-Binh Nguyen, Malancha Karmarkar, Stephanie Portelli, Pâmela M Rezende, João PL Velloso, David B Ascher, Douglas EV Pires

Journal article  |  2020  |  Nucleic Acids Research

Proteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on their fol..

Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.

Stephanie Portelli, Yoochan Myung, Nicholas Furnham, Sundeep Chaitanya Vedithi, Douglas EV Pires, David B Ascher

Journal article  |  2020  |  Scientific Reports

Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infecti..

DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations

Carlos HM Rodrigues, Douglas EV Pires, David B Ascher

Journal article  |  2020  |  Protein Science

Predicting the effect of missense variations on protein stability and dynamics is important for understanding their role in diseas..