Phillip Darcy

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Promising Immuno-Oncology Options for the Future: Cellular Therapies and Personalized Cancer Vaccines.

Benjamin J Solomon, Paul A Beavis, Philip K Darcy

Journal article  |  2020  |  American Society of Clinical Oncology Educational Book

A common pathway for an effective immune anticancer response involves recognition of tumor neoantigens and subsequent targeting of..

Cross-talk between tumors at anatomically distinct sites

Amanda J Oliver, Phillip K Darcy, Joseph A Trapani, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  The FEBS Journal

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

Imran G House, Peter Savas, Junyun Lai, Amanda XY Chen, Amanda J Oliver, Zhi L Teo, Kirsten L Todd, Melissa A Henderson, Lauren Giuffrida, Emma V Petley, Kevin Sek, Sherly Mardiana, Tuba N Gide, Camelia Quek, Richard A Scolyer, Georgina V Long, James S Wilmott, Sherene Loi, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4) correlate with the extent of tumor immune infil..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

Enterotoxins can support CAR T cells against solid tumors

Bianca von Scheidt, Minyu Wang, Amanda J Oliver, Jack D Chan, Metta K Jana, Aesha I Ali, Fiona Clow, John D Fraser, Kylie M Quinn, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

First-in-human phase I clinical trial of a combined immune modulatory approach using TetMYB vaccine and Anti-PD-1 antibody in patients with advanced solid cancer including colorectal or adenoid cystic carcinoma: The MYPHISMO study protocol (NCT03287427)

Toan Pham, Lloyd Pereira, Sara Roth, Laura Galletta, Emma Link, Tim Akhurst, Ben Solomon, Michael Michael, Phillip Darcy, Shienny Sampurno, Alexander Heriot, Robert Ramsay, Jayesh Desai

Journal article  |  2019  |  Contemporary Clinical Trials Communications

Background: MYB is a transcription factor that is overexpressed in colorectal cancer (CRC) and also a driver mutation in adenoid c..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Enhancing CAR T cell therapy by enabling their interaction with antigen-presenting cells

CY Slaney, P Wang, JD Chan, PK Darcy, MH Kershaw

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Novel vaccine targeting colonic adenoma: A pre-clinical model

Toan D Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Kasmira Wilson, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Conference Proceedings  |  2019  |  Clinical Research (Excluding Clinical Trials)

Supercharging adoptive T cell therapy to overcome solid tumor-induced immunosuppression

Sherly Mardiana, Benjamin J Solomon, Phillip K Darcy, Paul A Beavis

Journal article  |  2019  |  Science Translational Medicine

DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER

D Meyran, J Zhu, J Buttler, D Tantalo, M Neeson, P Ekert, M Kershaw, J Trapani, P Darcy, P Neeson

Conference Proceedings  |  2019  |  Cytotherapy

Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.

Scott Williams, Simon Keam, Heloise Halse, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phil Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Novel Vaccine Targeting Colonic Adenoma: a Pre-clinical Model

Toan Pham, Sandra Carpinteri, Shienny Sampurno, Lloyd Pereira, Sara Roth, Vignesh Narasimhan, Phillip Darcy, Jayesh Desai, Alexander G Heriot, Robert G Ramsay

Journal article  |  2019  |  Journal of Gastrointestinal Surgery

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

CAR T cells take centre stage

Paul A Beavis, Phillip K Darcy

Journal article  |  2019  |  Clinical & Translational Immunology

Tissue-specific tumor microenvironments influence responses to immunotherapies

Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan, Bianca von Scheidt, Paul A Beavis, Imran G House, Jonas RM Van Audernaerde, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  Clinical & Translational Immunology

Objectives: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..

Switching on the green light for chimeric antigen receptor T-cell therapy

Sherly Mardiana, Junyun Lai, Imran Geoffrey House, Paul Andrew Beavis, Phillip Kevin Darcy

Journal article  |  2019  |  Clinical & Translational Immunology

Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

Kevin Sek, Christina Molck, Gregory D Stewart, Lev Kats, Phillip K Darcy, Paul A Beavis

Journal article  |  2018  |  International Journal of Molecular Sciences

Tumor-Infiltrating Lymphocyte Function Predicts Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

Joseph Cherng Huei Kong, Glen Robert Guerra, Rosemary Magdalena Millen, Sara Roth, Huiling Xu, Paul Joseph Neeson, Phillip Kevin Darcy, Michael Henry Kershaw, Shienny Sampurno, Jordane Malaterre, David Shi Hao Liu, Duc Pham Toan, Vignesh Narasimhan, Minyu Wang, Yu-Kuan Huang, Kumar Visvanathan, Jacob McCormick, Andrew Craig Lynch, Satish Warrier, Michael Michael, et al.

Journal article  |  2018  |  JCO Precision Oncology

Natural killer cells and their therapeutic role in pancreatic cancer: A systematic review

Jonas RM Van Audenaerde, Geert Roeyen, Phillip K Darcy, Michael H Kershaw, M Peeters, Evelien LJ Smits

Journal article  |  2018  |  Pharmacology & Therapeutics

Dual PD-1 and CTLA-4 Checkpoint Blockade Promotes Antitumor Immune Responses through CD4( )Foxp3(-) Cell-Mediated Modulation of CD103( ) Dendritic Cells

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Alexander J Davenport, Emma V Petley, Imran G House, Junyun Lai, Kevin Sek, Nicole Milenkovski, Liza B John, Sherly Mardiana, Clare Y Slaney, Joseph A Trapani, Sherene Loi, Michael H Kershaw, Nicole M Haynes, Phillip K Darcy

Journal article  |  2018  |  Cancer Immunology Research

CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment

Clare Y Slaney, Pin Wang, Phillip K Darcy, Michael H Kershaw

Journal article  |  2018  |  Cancer Discovery

Multiplex immunohistochemistry accurately defines the immune context of metastatic melanoma

H Halse, AJ Colebatch, P Petrone, MA Henderson, JK Mills, H Snow, JA Westwood, S Sandhu, JM Raleigh, A Behren, J Cebon, PK Darcy, MH Kershaw, GA McArthur, DE Gyorki, PJ Neeson

Journal article  |  2018  |  Scientific Reports

Investigating the role of polarity protein, SCRIB, in hematopoiesis

Novita Novita, Alysha Dew, Chad Johnson, Carl R Walkley, Louise E Purton, Patrick O Humbert, Phillip K Darcy, Sarah L Ellis

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P Mintoff, Franco Caramia, Roberto Salgado, David J Byrne, Zhi L Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J Luen, Catherine Poliness, Sophie S Nightingale, Anita S Skandarajah, David E Gyorki, Chantel M Thornton, Paul A Beavis, Stephen B Fox, et al.

Journal article  |  2018  |  Nature Medicine

A multifunctional role for adjuvant anti-4-1BB therapy in augmenting antitumor responses by CAR T cells

Sherly Mardiana, Liza B John, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

Adoptive cell therapy for melanoma

J Mills, P Darcy, DE Gyorki

Book Chapter  |  2018

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  Frontiers in Immunology

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

Nicholas A Gherardin, Liyen Loh, Lorenztino Admojo, Alexander J Davenport, Kelden Richardson, Amy Rogers, Phillip K Darcy, Misty R Jenkins, H Miles Prince, Simon J Harrison, Hang Quach, David P Fairlie, Katherine Kedzierska, James McCluskey, Adam P Uldrich, Paul J Neeson, David S Ritchie, Dale I Godfrey

Journal article  |  2018  |  Scientific Reports

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

AJ Davenport, RS Cross, KA Watson, Y Liao, W Shi, HM Prince, PA Beavis, JA Trapani, MH Kershaw, DS Ritchie, PK Darcy, PJ Neeson, MR Jenkins

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Tissue-Dependent Tumor Microenvironments and Their impact on immunotherapy Responses

Amanda J Oliver, Peter KH Lau, Ashleigh S Unsworth, Sherene Loi, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2018  |  Frontiers in Immunology

IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma

Carrie Van Der Weyden, Martine Bagot, Paul Neeson, Phil K Darcy, H Miles Prince

Journal article  |  2018  |  Expert Opinion on Investigational Drugs

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Jennifer A Westwood, Sarah Ellis, Jill Danne, Chad Johnson, Viola Oorschot, Georg Ramm, David C Tscharke, Alexander J Davenport, James C Whisstock, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2017  |  Oncotarget

Combined CDK4/6 and PI3K alpha Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Zhi Ling Teo, Stephanie Versaci, Sathana Dushyanthen, Franco Caramia, Peter Savas, Chris P Mintoff, Magnus Zethoven, Balaji Virassamy, Stephen J Luen, Grant A McArthur, Wayne A Phillips, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  Cancer Research

Neoadjuvant Interferons: Critical for Effective PD-1-Based Immunotherapy in TNBC

Natasha K Brockwell, Katie L Owen, Damien Zanker, Alex Spurling, Jai Rautela, Hendrika M Duivenvoorden, Nikola Baschuk, Franco Caramia, Sherene Loi, Phillip K Darcy, Elgene Lim, Belinda S Parker

Journal article  |  2017  |  Cancer Immunology Research

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Sathana Dushyanthen, Zhi Ling Teo, Franco Caramia, Peter Savas, Christopher P Mintoff, Balaji Virassamy, Melissa A Henderson, Stephen J Luen, Mariam Mansour, Michael H Kershaw, Joseph A Trapani, Paul J Neeson, Roberto Salgado, Grant A McArthur, Justin M Balko, Paul A Beavis, Phillip K Darcy, Sherene Loi

Journal article  |  2017  |  Nature Communications

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells

Paul A Beavis, Kevin Sek, Phillip K Darcy

Journal article  |  2017  |  Molecular Therapy

A novel combination strategy for effectively targeting cancer stem-like cells

Paul A Beavis, Emma V Petley, Phillip K Darcy

Journal article  |  2017  |  Immunology & Cell Biology

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape

Leisha A Emens, Paolo A Ascierto, Phillip K Darcy, Sandra Demaria, Alexander MM Eggermont, William L Redmond, Barbara Seliger, Francesco M Marincola

Journal article  |  2017  |  European Journal of Cancer

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science translational medicine

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2( ) Tumors

Mikolaj Medon, Eva Vidacs, Stephin J Vervoort, Jason Li, Misty R Jenkins, Kelly M Ramsbottom, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, Peter W Atadja, Michael A Henderson, Ricky W Johnstone, Nicole M Haynes

Journal article  |  2017  |  Cancer Research

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y Slaney, Bianca von Scheidt, Alexander J Davenport, Paul A Beavis, Jennifer A Westwood, Sherly Mardiana, David C Tscharke, Sarah Ellis, H Miles Prince, Joseph A Trapani, Ricky W Johnstone, Mark J Smyth, Michele W Teng, Aesha Ali, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo, Paul Neeson, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Clinical Cancer Research

CAR T-cell therapy of solid tumors

Carmen SM Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw

Journal article  |  2017  |  Immunology and Cell Biology

Immunotherapy of cancer

Joseph A Trapani, Phillip K Darcy

Journal article  |  2017  |  Australian Family Physician

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

Sherly Mardiana, Liza B John, Melissa A Henderson, Clare Y Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J Davenport, Joseph A Trapani, Paul J Neeson, Sherene Loi, Nicole M Haynes, Michael H Kershaw, Paul A Beavis, Phillip K Darcy

Journal article  |  2017  |  Cancer Research

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Paul A Beavis, Melissa A Henderson, Lauren Giuffrida, Jane K Mills, Kevin Sek, Ryan S Cross, Alexander J Davenport, Liza B John, Sherly Mardiana, Clare Y Slaney, Ricky W Johnstone, Joseph A Trapani, John Stagg, Sherene Loi, Lev Kats, David Gyorki, Michael H Kershaw, Phillip K Darcy

Journal article  |  2017  |  Journal of Clinical Investigation

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Simon J Hogg, Stephin J Vervoort, Sumit Deswal, Christopher J Ott, Jason Li, Leonie A Cluse, Paul A Beavis, Phillip K Darcy, Benjamin P Martin, Andrew Spencer, Anna K Traunbauer, Irina Sadovnik, Karin Bauer, Peter Valent, James E Bradner, Johannes Zuber, Jake Shortt, Ricky W Johnstone

Journal article  |  2017  |  Cell Reports

Immunosuppressive activities of adenosine in cancer

Bertrand Allard, Paul A Beavis, Phillip K Darcy, John Stagg

Journal article  |  2016  |  Current Opinion in Pharmacology

Effects of IFN-gamma dependent immune therapies The double-edged sword of IFN-gamma-dependent immune-based therapies

Liza B John, Phillip K Darcy

Journal article  |  2016  |  Immunology & Cell Biology

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw

Journal article  |  2016  |  Oncotarget

Clinical relevance of host immunity in breast cancer: from TILs to the clinic

Peter Savas, Roberto Salgado, Carsten Denkert, Christos Sotiriou, Phillip K Darcy, Mark J Smyth, Sherene Loi

Journal article  |  2016  |  Nature Reviews Clinical Oncology

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

Sherene Loi, Sathana Dushyanthen, Paul A Beavis, Roberto Salgado, Carsten Denkert, Peter Savas, Susan Combs, David L Rimm, Jennifer M Giltnane, Monica V Estrada, Violeta Sanchez, Melinda E Sanders, Rebecca S Cook, Mark A Pilkinton, Simon A Mallal, Kai Wang, Vincent A Miller, Phil J Stephens, Roman Yelensky, Franco D Doimi, et al.

Journal article  |  2016  |  Clinical cancer research : an official journal of the American Association for Cancer Research

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, David Gyorki, Paul J Neeson, Phillip K Darcy

Journal article  |  2016  |  Seminars in Immunology

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer

Rosemary Millen, Jordane Malaterre, Ryan S Cross, Sandra Carpinteri, Jayesh Desai, Ben Tran, Phillip Darcy, Peter Gibbs, Oliver Sieber, Nikolajs Zeps, Paul Waring, Stephen Fox, Lloyd Pereira, Robert G Ramsay

Journal article  |  2016  |  OncoImmunology

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Conor J Kearney, Kelly M Ramsbottom, Ilia Voskoboinik, Phillip K Darcy, Jane Oliaro

Journal article  |  2016  |  OncoImmunology

Releasing the Brake on Oncolytic Viral Therapy

Clare Y Slaney, Phillip K Darcy

Journal article  |  2015  |  Clinical Cancer Research

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice

Carmen SM Yong, Jennifer A Westwood, Jan Schroeder, Anthony T Papenfuss, Bianca von Scheidt, Maria Moeller, Christel Devaud, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  PLOS ONE

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

Connie PM Duong, Carmen SM Yong, Michael H Kershaw, Clare Y Slaney, Phillip K Darcy

Journal article  |  2015  |  Molecular Immunology

Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene

Carmen SM Yong, Janelle Sharkey, Belinda Duscio, Ben Venville, Wei-Zen Wei, Richard F Jones, Clare Y Slaney, Gisela Mir Arnau, Anthony T Papenfuss, Jan Schroeder, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  PLOS ONE

Relevance of tumor-infiltrating lymphocytes in breast cancer

Sathana Dushyanthen, Paul A Beavis, Peter Savas, Zhi Ling Teo, Chenhao Zhou, Mariam Mansour, Phillip K Darcy, Sherene Loi

Journal article  |  2015  |  BMC Medicine

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses

Paul A Beavis, Nicole Milenkovski, Melissa A Henderson, Liza B John, Bertrand Allard, Sherene Loi, Michael H Kershaw, John Stagg, Phillip K Darcy

Journal article  |  2015  |  Cancer Immunology Research

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

Alexander J Davenport, Misty R Jenkins, Ryan S Cross, Carmen S Yong, H Miles Prince, David S Ritchie, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  Cancer Immunology Research

Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein

Ryan S Cross, Jordane Malaterre, Alexander J Davenport, Sandra Carpinteri, Robin L Anderson, Phillip K Darcy, Robert G Ramsay

Journal article  |  2015  |  Clinical & Translational Immunology

CD73: A potential biomarker for anti-PD-1 therapy

Paul A Beavis, Clare Y Slaney, Nicole Milenkovski, Melissa A Henderson, Sherene Loi, John Stagg, Michael H Kershaw, Phillip K Darcy

Journal article  |  2015  |  OncoImmunology

Adoptive immunotherapy: a new era for the treatment of cancer

Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  Immunotherapy

Cross-talk between tumors can affect responses to therapy

Christel Devaud, Liza B John, Jennifer A Westwood, Carmen SM Yong, Paul A Beavis, Reto A Schwendener, Phillip K Darcy, Michael H Kershaw

Journal article  |  2015  |  OncoImmunology

The Role of the Immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor Immunity

Conor J Kearney, Amelia J Brennan, Phillip K Darcy, Jane Oliaro

Journal article  |  2015  |  Critical Reviews in Immunology

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

Paul A Beavis, Clare Y Slaney, Michael H Kershaw, Paul J Neeson, Phillip K Darcy

Journal article  |  2015  |  Immunotherapy

CAR-T cells are serial killers

Alexander J Davenport, Misty R Jenkins, David S Ritchie, H Miles Prince, Joseph A Trapani, Michael H Kershaw, Phillip K Darcy, Paul J Neeson

Journal article  |  2015  |  OncoImmunology

Trafficking of T Cells into Tumors

Clare Y Slaney, Michael H Kershaw, Phillip K Darcy

Journal article  |  2014  |  Cancer Research

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors

Christel Devaud, Jennifer A Westwood, Michele WL Teng, Liza B John, Carmen SM Yong, Connie PM Duong, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  OncoImmunology

Foxp3 Expression in Macrophages Associated with RENCA Tumors in Mice

Christel Devaud, Carmen SM Yong, Liza B John, Jennifer A Westwood, Connie PM Duong, Colin M House, Delphine Denoyer, Jason Li, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  PLoS ONE

Foxp3 expression in T regulatory cells and other cell lineages

Christel Devaud, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  Cancer Immunology, Immunotherapy

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers

Jennifer A Westwood, Geoffrey M Matthews, Jake Shortt, David Faulkner, Hollie J Pegram, Connie PM Duong, Marta Chesi, P Leif Bergsagel, Leslie L Sharp, Richard D Huhn, Phillip K Darcy, Ricky W Johnstone, Michael H Kershaw

Journal article  |  2014  |  Leukemia Research

The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy

Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  OncoImmunology

Routes of Delivery for CpG and Anti-CD137 for the Treatment of Orthotopic Kidney Tumors in Mice

Jennifer A Westwood, Titaina CU Potdevin Hunnam, Hollie J Pegram, Rodney J Hicks, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  PLoS ONE

Clinical application of genetically modified T cells in cancer therapy.

Michael H Kershaw, Jennifer A Westwood, Clare Y Slaney, Phillip K Darcy

Journal article  |  2014  |  Clinical & Translational Immunology

Immunotherapies are emerging as highly promising approaches for the treatment of cancer. In these approaches, a variety of materia..

Manipulating immune cells for adoptive immunotherapy of cancer

Phillip K Darcy, Paul Neeson, Carmen SM Yong, Michael H Kershaw

Journal article  |  2014  |  Current Opinion in Immunology

Tumour immunology: New frontiers in cancer immunotherapy

Phillip K Darcy, David S Ritchie

Journal article  |  2014  |  Current Opinion in Immunology

Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor

Liza B John, Tess M Chee, David E Gilham, Phillip K Darcy

Journal article  |  2014  |  Methods in Molecular Biology

Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy

Christel Devaud, Jennifer A Westwood, Liza B John, Jacqueline K Flynn, Sophie Paquet-Fifield, Connie PM Duong, Carmen SM Yong, Hollie J Pegram, Steven A Stacker, Marc G Achen, Trina J Stewart, Linda A Snyder, Michele WL Teng, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2014  |  Molecular Therapy

A(2A) blockade enhances anti-metastatic immune responses

Paul A Beavis, Nicole Milenkovski, John Stagg, Mark J Smyth, Phillip K Darcy

Journal article  |  2013  |  OncoImmunology

Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia

David S Ritchie, Paul J Neeson, Amit Khot, Stefan Peinert, Tsin Tai, Kellie Tainton, Karen Chen, Mandy Shin, Dominic M Wall, Dirk Hoenemann, Peter Gambell, David A Westerman, Javier Haurat, Jennifer A Westwood, Andrew M Scott, Lucy Kravets, Michael Dickinson, Joseph A Trapani, Mark J Smyth, Phillip K Darcy, et al.

Journal article  |  2013  |  Molecular Therapy

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B John, Christel Devaud, Connie PM Duong, Carmen S Yong, Paul A Beavis, Nicole M Haynes, Melvyn T Chow, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2013  |  Clinical Cancer Research

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

Liza B John, Michael H Kershaw, Phillip K Darcy

Journal article  |  2013  |  OncoImmunology

Blockade of A(2A) receptors potently suppresses the metastasis of CD73( ) tumors

Paul A Beavis, Upulie Divisekera, Christophe Paget, Melvyn T Chow, Liza B John, Christel Devaud, Karen Dwyer, John Stagg, Mark J Smyth, Phillip K Darcy

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment

Michael H Kershaw, Christel Devaud, Liza B John, Jennifer A Westwood, Phillip K Darcy

Journal article  |  2013  |  OncoImmunology

Gene-engineered T cells for cancer therapy

Michael H Kershaw, Jennifer A Westwood, Phillip K Darcy

Journal article  |  2013  |  Nature Reviews Cancer

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

Christel Devaud, Liza B John, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  OncoImmunology

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

Sherene Loi, Sandra Pommey, Benjamin Haibe-Kains, Paul A Beavis, Phillip K Darcy, Mark J Smyth, John Stagg

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor

Melissa A Henderson, Carmen SM Yong, Connie PM Duong, Alexander J Davenport, Liza B John, Christel Devaud, Paul Neeson, Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  Immunotherapy

Engineering T Cell Function Using Chimeric Antigen Receptors Identified Using a DNA Library Approach

Connie PM Duong, Jennifer A Westwood, Carmen SM Yong, Amanda Murphy, Christel Devaud, Liza B John, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  PLoS One

Environmental enrichment does not impact on tumor growth in mice.

Jennifer A Westwood, Phillip K Darcy, Michael H Kershaw

Journal article  |  2013  |  F1000Research

The effect of environmental enrichment (EE) on a variety of physiologic and disease processes has been studied in laboratory mice...

Using electroporation to determine function of a chimeric antigen receptor in T cell and macrophage cell lines

CSM Yong, CPM Duong, C Devaud, LB John, PK Darcy, MH Kershaw

Journal article  |  2013  |  The Open Gene Therapy Journal

Evoking durable anti-cancer responses with blocking antibodies to PD-1 and PD-L1

Mara Galli, Phillip K Darcy, Nicole M Haynes

Journal article  |  2012  |  Translational Cancer Research

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies

Jose I Quetglas, Liza B John, Michael H Kershaw, Luis Alvarez-Vallina, Ignacio Melero, Phillip K Darcy, Cristian Smerdou

Journal article  |  2012  |  OncoImmunology

CD73: a potent suppressor of antitumor immune responses

Paul A Beavis, John Stagg, Phillip K Darcy, Mark J Smyth

Journal article  |  2012  |  Trends in Immunology (formerly Immunology Today)

CD73-Deficient Mice Are Resistant to Carcinogenesis

John Stagg, Paul A Beavis, Upulie Divisekera, Mira CP Liu, Andreas Moeller, Phillip K Darcy, Mark J Smyth

Journal article  |  2012  |  Cancer Research

Oncolytic Virus and Anti-4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

Liza B John, Linda J Howland, Jacqueline K Flynn, Alison C West, Christel Devaud, Connie P Duong, Trina J Stewart, Jenny A Westwood, Z Sheng Guo, David L Bartlett, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2012  |  Cancer Research

Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

Michele WL Teng, Phillip K Darcy, Mark J Smyth

Journal article  |  2011  |  Cancer Cell

Autoimmunity associated with immunotherapy of cancer

Sally M Amos, Connie PM Duong, Jennifer A Westwood, David S Ritchie, Richard P Junghans, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Blood

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

Sally M Amos, Hollie J Pegram, Jennifer A Westwood, Liza B John, Christel Devaud, Chris J Clarke, Nicholas P Restifo, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Cancer Immunology, Immunotherapy

CD73-Deficient Mice Have Increased Antitumor Immunity and Are Resistant to Experimental Metastasis

John Stagg, Upulie Divisekera, Helene Duret, Tim Sparwasser, Michele WL Teng, Phillip K Darcy, Mark J Smyth

Journal article  |  2011  |  Cancer Research

Activating and inhibitory receptors of natural killer cells

Hollie J Pegram, Daniel M Andrews, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Immunology and Cell Biology

Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer

Connie PM Duong, Jennifer A Westwood, Linda J Berry, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Immunotherapy

Alloreactive natural killer cells in hematopoietic stem cell transplantation

Hollie J Pegram, David S Ritchie, Mark J Smyth, Andres Wiernik, H Miles Prince, Phillip K Darcy, Michael H Kershaw

Journal article  |  2011  |  Leukemia Research

Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity

Leanne XJ Wang, Jennifer A Westwood, Maria Moeller, Connie PM Duong, Wei-Zen Wei, Jordane Malaterre, Joseph A Trapani, Paul Neeson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Research

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8( ) T cells with effector and central memory-like phenotype

P Neeson, A Shin, KM Tainton, P Guru, HM Prince, SJ Harrison, S Peinert, MJ Smyth, JA Trapani, MH Kershaw, PK Darcy, DS Ritchie

Journal article  |  2010  |  Gene Therapy

Characterizing the anti-tumor function of adoptively transferred NK cells in vivo

Hollie J Pegram, Nicole M Haynes, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2010  |  Cancer Immunology, Immunotherapy

CD11c( ) Dendritic Cells and B Cells Contribute to the Tumoricidal Activity of Anti-DR5 Antibody Therapy in Established Tumors

Nicole M Haynes, Edwin D Hawkins, Ming Li, Nicole M McLaughlin, Guenther J Haemmerling, Reto Schwendener, Astar Winoto, Allen Wensky, Hideo Yagita, Kazuyoshi Takeda, Michael H Kershaw, Phillip K Darcy, Mark J Smyth

Journal article  |  2010  |  Journal of Immunology

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen

S Peinert, HM Prince, PM Guru, MH Kershaw, MJ Smyth, JA Trapani, P Gambell, S Harrison, AM Scott, FE Smyth, PK Darcy, K Tainton, P Neeson, DS Ritchie, D Hoenemann

Journal article  |  2010  |  Gene Therapy

Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

Jennifer A Westwood, Phillip K Darcy, Preethi Mayura Guru, Janelle Sharkey, Hollie J Pegram, Sally M Amos, Mark J Smyth, Michael H Kershaw

Journal article  |  2010  |  Journal of Translational Medicine

Enhancing adoptive immunotherapy of cancer

Jennifer A Westwood, Linda J Berry, Leanne XJ Wang, Connie PM Duong, Hollie J Pegram, Phillip K Darcy, Michael H Kershaw

Journal article  |  2010  |  Expert Opinion on Biological Therapy

Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion

Michele WL Teng, Jeremy B Swann, Bianca von Scheidt, Janelle Sharkey, Nadeen Zerafa, Nicole McLaughlin, Tomoyuki Yamaguchi, Shimon Sakaguchi, Phillip K Darcy, Mark J Smyth

Journal article  |  2010  |  Cancer Research

Generation of Chimeric T-Cell Receptor Transgenes and Their Efficient Transfer in Primary Mouse T Lymphocytes

Linda J Howland, Nicole M Haynes, Phillip K Darcy

Journal article  |  2010  |  Methods in Molecular Biology

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice

Jennifer A Westwood, Nicole M Haynes, Janelle Sharkey, Nicole McLaughlin, Hollie J Pegram, Reto A Schwendener, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Clinical Cancer Research

Bcl-2 over-expression and genetic manipulation of T cells provides tumor specificity and enhanced resistance to apoptosis in vitro

HJ Pegram, PK Darcy, MH Kershaw

Journal article  |  2009  |  The Open Gene Therapy Journal

Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells

LJ Berry, M Moeller, PK Darcy

Journal article  |  2009  |  Tissue Antigens

Genetic modification of natural killer cells for adoptive cellular immunotherapy

Hollie J Pegram, Michael H Kershaw, Phillip K Darcy

Journal article  |  2009  |  Immunotherapy

The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve as a Target for Genetically Redirected T cells Despite the Presence of Soluble Antigen in Serum

Jennifer A Westwood, William K Murray, Melanie Trivett, Nicole M Haynes, Benjamin Solomon, Linda Mileshkin, David Ball, Michael Michael, Angela Burman, Preethi Mayura-Guru, Joseph A Trapani, Stefan Peinert, Dirk Honemann, H Miles Prince, Andrew M Scott, Mark J Smyth, Phillip K Darcy, Michael H Kershaw

Journal article  |  2009  |  Journal of Immunotherapy

cAMP Response Element Binding Protein Is Required for Mouse Neural Progenitor Cell Survival and Expansion

Sebastian Dworkin, Jordane Malaterre, Frederic Hollande, Phillip K Darcy, Robert G Ramsay, Theo Mantamadiotis

Journal article  |  2009  |  Stem Cells

Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer

Benjamin B Williams, Meg Wall, Rebecca Yu Miao, Brenda Williams, Ivan Bertoncello, Michael H Kershaw, Theo Mantamadiotis, Michelle Haber, Murray D Norris, Anand Gautam, Phillip K Darcy, Robert G Ramsay

Journal article  |  2008  |  Cancer Immunology, Immunotherapy

Adoptive transfer of gene-modified primary NK cells can specifically inhibit tumor progression in vivo

Hollie J Pegram, Jacob T Jackson, Mark J Smyth, Michael H Kershaw, Phillip K Darcy

Journal article  |  2008  |  Journal of Immunology

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

JA Westwood, WK Murray, M Trivett, A Shin, P Neeson, DP MacGregor, NM Haynes, JA Trapani, P Mayura-Guru, S Fox, S Peinert, D Honemann, HM Prince, D Ritchie, AM Scott, FE Smyth, MJ Smyth, PK Darcy, MH Kershaw

Journal article  |  2008  |  Gene Therapy

IL-21 priming enhances T-cell immunotherapy

Phillip K Darcy

Journal article  |  2008  |  Blood

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4( ) T helper-1 and CD8( ) T cells

Maria Moeller, Michael H Kershaw, Rachel Cameron, Jennifer A Westwood, Joseph A Trapani, Mark J Smyth, Phillip K Darcy

Journal article  |  2007  |  Cancer Research

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Ilia Voskoboinik, Vivien R Sutton, Annette Ciccone, Colin M House, Jenny Chia, Phillip K Darcy, Hideo Yagita, Joseph A Trapani

Journal article  |  2007  |  Immunobiology

Antitumor activity of dual-specific T cells and influenza virus

A Murphy, JA Westwood, LE Brown, MWL Teng, M Moeller, Y Xu, MJ Smyth, P Hwu, PK Darcy, MH Kershaw

Journal article  |  2007  |  Cancer Gene Therapy

Adoptive transfer of chimeric Fc(epsilon)RI gene-modified human T cells for cancer immunotherapy

Michele WL Teng, Michael H Kershaw, Jacob T Jackson, Mark J Smyth, Phillip K Darcy

Journal article  |  2006  |  Human Gene Therapy

Supernatural T cells: Genetic modification of T cells for cancer therapy

MH Kershaw, MWL Teng, MJ Smyth, PK Darcy

Journal article  |  2005  |  Nature Reviews Immunology

T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner

MWL Teng, MH Kershaw, Y Hayakawa, L Cerutti, SM Jane, PK Darcy, MJ Smyth

Journal article  |  2005  |  Journal of Biological Chemistry

Adoptive transfer of gene-engineered CD4( ) helper T cells induces potent primary and secondary tumor rejection

M Moeller, NM Haynes, MH Kershaw, JT Jackson, MWL Teng, SE Street, L Cerutti, SM Jane, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2005  |  Blood

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation

MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell

Journal article  |  2005  |  Immunity

Gene modification strategies to induce tumor immunity

A Murphy, JA Westwood, MWL Teng, M Moeller, PK Darcy, MH Kershaw

Journal article  |  2005  |  Immunity

Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth

E Vincan, PK Darcy, MJ Smyth, EW Thompson, RJS Thomas, WA Phillips, RG Ramsay

Journal article  |  2005  |  Differentiation

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS

RG Ramsay, D Ciznadija, C Sicurella, N Reyes, K Mitchelhill, PK Darcy, G D'Abaco, T Mantamadiotis

Journal article  |  2005  |  DNA and Cell Biology

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

I Voskoboinik, MC Thia, A De Bono, K Browne, E Cretney, JT Jackson, PK Darcy, SM Jane, MJ Smyth, JA Trapani

Journal article  |  2004  |  Journal of Experimental Medicine

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux

KM Tainton, MJ Smyth, JT Jackson, JE Tanner, L Cerruti, SM Jane, PK Darcy, RW Johnstone

Journal article  |  2004  |  Cell Death & Differentiation

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

MH Kershaw, JT Jackson, NM Haynes, MWL Teng, M Moeller, Y Hayakawa, SE Street, R Cameron, JE Tanner, JA Trapani, MJ Smyth, PK Darcy

Journal article  |  2004  |  Journal of Immunology

Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes

MWL Teng, MH Kershaw, M Moeller, MJ Smyth, PK Darcy

Journal article  |  2004  |  Human Gene Therapy

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

M Moeller, NM Haynes, JA Trapani, MWL Teng, JT Jackson, JE Tanner, L Cerutti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2004  |  Cancer Gene Therapy

Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-Deficient tumor cells from natural killer cell-mediated rejection in vivo

A Tajima, T Tanaka, T Ebata, K Takeda, A Kawasaki, JM Kelly, PK Darcy, RE Vance, DH Raulet, K Kinoshita, K Okumura, MJ Smyth, H Yagita

Journal article  |  2003  |  Journal of Immunology

Cutting edge: Tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin

Y Hayakawa, JM Kelly, JA Westwood, PK Darcy, A Diefenbach, D Raulet, MJ Smyth

Journal article  |  2002  |  Journal of Immunology

Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Journal of Immunology

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

NM Haynes, JA Trapani, MWL Teng, JT Jackson, L Cerruti, SM Jane, MH Kershaw, MJ Smyth, PK Darcy

Journal article  |  2002  |  Gene Therapy

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation

A Ruefli, KM Tainton, PK Darcy, MJ Smyth, RW Johnstone

Journal article  |  2002  |  Cell Death & Differentiation

A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo

JM Kelly, K Takeda, PK Darcy, H Yagita, MJ Smyth

Journal article  |  2002  |  Journal of Immunology

Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection

JM Kelly, PK Darcy, JL Markby, DI Godfrey, K Takedo, H Yagita, MJ Smyth

Journal article  |  2002  |  Nature Immunology

Optimizing DNA Vaccines Against Nuclear Oncogenes

Sandra Carpinteri

Journal article  |  ImmunoGastroenterology