Eric Ji-Hoon Joo

Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers.

Peter Georgeson, Bernard J Pope, Christophe Rosty, Mark Clendenning, Khalid Mahmood, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Susan Preston, Julia Como, Sharelle Joseland, Aung Ko Win, Finlay A Macrae, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, Darren R Brenner, Steve Gallinger, et al.

Journal article  |  2021  |  Gut

OBJECTIVE: Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH un..

Smoking methylation marks for prediction of urothelial cancer risk.

Chenglong Yu, Kristina M Jordahl, Julie K Bassett, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Daniel F Schmidt, Damien M Bolton, Enes Makalic, Theodore M Brasky, Aladdin H Shadyab, Lesley F Tinker, Anthony Longano, John L Hopper, Dallas R English, Roger L Milne, Parveen Bhatti, Melissa C Southey, Graham G Giles, Pierre-Antoine Dugué

Journal article  |  2021  |  Cancer Epidemiol Biomarkers Prev

BACKGROUND: Self-reported information may not accurately capture smoking exposure. We aimed to evaluate whether smoking-associated..

Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

Pierre-antoine Dugue, Allison Hodge, Ee Ming Wong, Eric Joo, Chol-Hee Jung, John Hopper, Dallas English, Graham Giles, Roger Milne, Melissa Southey

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

BACKGROUND: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldo..

DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer

Jihoon E Joo, Mark Clendenning, Ee Ming Wong, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Ingrid M Winship, Susan G Preston, Aung Ko Win, Pierre-Antoine Dugue, Harindra Jayasekara, Dallas English, Finlay A Macrae, John L Hopper, Mark A Jenkins, Roger L Milne, Graham G Giles, Melissa C Southey, Daniel D Buchanan

Journal article  |  2021  |  CANCERS

We investigated aberrant DNA methylation (DNAm) changes and the contribution of ageing-associated methylomic drift and age acceler..

Epigenetic Drift Association with Cancer Risk and Survival, and Modification by Sex

Chenglong Yu, Ee Ming Wong, Jihoon Eric Joo, Allison M Hodge, Enes Makalic, Daniel Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Melissa C Southey, Pierre-Antoine Dugue

Journal article  |  2021  |  CANCERS

To investigate age- and sex-specific DNA methylation alterations related to cancer risk and survival, we used matched case-control..

Germline and Tumor Sequencing as a Diagnostic Tool To Resolve Suspected Lynch Syndrome

Bernard J Pope, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Harindra Jayasekara, Sharelle Joseland, Julia Como, Susan Preston, Amanda B Spurdle, Finlay A Macrae, Aung K Win, John L Hopper, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan

Journal article  |  2021  |  JOURNAL OF MOLECULAR DIAGNOSTICS

Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or so..

VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association

Pierre-Antoine Dugue, Chenglong Yu, Timothy McKay, Ee Ming Wong, Jihoon Eric Joo, Helen Tsimiklis, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, John L Hopper, Graham G Giles, Roger L Milne, Jason A Steen, James G Dowty, Tu Nguyen-Dumont, Melissa C Southey

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associa..

DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case-control Study

James A Chamberlain, Pierre-Antoine Dugue, Julie K Bassett, Roger L Milne, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Geoffrey W Stuart, Alex Boussioutas, Melissa C Southey, Graham G Giles, Hazel Mitchell, Dallas R English, Allison M Hodge

Journal article  |  2021  |  CANCER PREVENTION RESEARCH

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We co..

Biological Aging Measures Based on Blood DNA Methylation and Risk of Cancer: A Prospective Study

Pierre-Antoine Dugue, Julie K Bassett, Ee Ming Wong, JiHoon E Joo, Shuai Li, Chenglong Yu, Daniel F Schmidt, Enes Makalic, Nicole Wong Doo, Daniel D Buchanan, Allison M Hodge, Dallas R English, John L Hopper, Graham G Giles, Melissa C Southey, Roger L Milne

Journal article  |  2021  |  JNCI CANCER SPECTRUM

Background: We previously investigated the association between 5 "first-generation" measures of epigenetic aging and cancer risk i..

Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer

Medha Suman, Pierre-Antoine Dugue, Ee Ming Wong, JiHoon Eric Joo, John L Hopper, Tu Nguyen-Dumont, Graham G Giles, Roger L Milne, Catriona McLean, Melissa C Southey

Journal article  |  2021  |  CLINICAL EPIGENETICS

BACKGROUND: Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognos..