Eric Joo

Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status.

Romy Walker, Peter Georgeson, Khalid Mahmood, Jihoon E Joo, Enes Makalic, Mark Clendenning, Julia Como, Susan Preston, Sharelle Joseland, Bernard J Pope, Ryan A Hutchinson, Kais Kasem, Michael D Walsh, Finlay A Macrae, Aung K Win, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, et al.

Journal article  |  2023  |  J Mol Diagn

Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. Tumor features, individually and in c..

Heritable methylation marks associated with prostate cancer risk.

James G Dowty, Chenglong Yu, Mahnaz Hosseinpour, Jihoon Eric Joo, Ee Ming Wong, Tu Nguyen-Dumont, Joseph Rosenbluh, Graham G Giles, Roger L Milne, Robert J MacInnis, Pierre-Antoine Dugué, Melissa C Southey

Journal article  |  2023  |  Fam Cancer

DNA methylation marks that are inherited from parents to offspring are known to play a role in cancer risk and could explain part ..

Body Mass Index, sex, non-steroidal anti-inflammatory drug medications, smoking and alcohol are differentially associated with World Health Organisation criteria and colorectal cancer risk in people with Serrated Polyposis Syndrome: an Australian case-control study.

Emma Anthony, Jeanette C Reece, Elasma Milanzi, Jihoon E Joo, Sharelle Joseland, Mark Clendenning, Amanda Whelan, Susan Parry, Julie Arnold, Varnika Vijay, Nathan Atkinson, John L Hopper, Aung K Win, Mark A Jenkins, Finlay A Macrae, Ingrid M Winship, Christophe Rosty, Daniel D Buchanan, undefined Australasian Coloretal Cancer Family Registry, undefined Family Cancer Clinics of Australia, et al.

Journal article  |  2022  |  BMC Gastroenterol

OBJECTIVE: The unknown aetiology of Serrated Polyposis Syndrome (SPS) impedes risk prediction and prevention. We investigated risk..

Germline mutations in WNK2 could be associated with serrated polyposis syndrome

Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K Sommer, Isabel Spier, Iris BAW te Paske, Yasmijn J van Herwaarden, Antoni Castells, et al.

Journal article  |  2022  |  JOURNAL OF MEDICAL GENETICS

BACKGROUND: Patients with serrated polyposis syndrome (SPS) have multiple and/or large serrated colonic polyps and higher risk for..

Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon E Joo, Enes Makalic, Daniel F Schmidt, Daniel D Buchanan, Gianluca Severi, John L Hopper, Dallas R English, Graham G Giles, Roger L Milne, Melissa C Southey, Pierre-Antoine Dugue

Journal article  |  2022  |  EPIGENETICS

Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether ..

Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Peter Georgeson, Tabitha A Harrison, Bernard J Pope, Syed H Zaidi, Conghui Qu, Robert S Steinfelder, Yi Lin, Jihoon E Joo, Khalid Mahmood, Mark Clendenning, Romy Walker, Efrat L Amitay, Sonja Berndt, Hermann Brenner, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Kimberly F Doheny, David A Drew, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorecta..

Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality

Chenglong Yu, Allison M Hodge, Ee Ming Wong, Jihoon Eric Joo, Enes Makalic, Daniel Schmidt, Daniel D Buchanan, John L Hopper, Graham G Giles, Melissa C Southey, Pierre-Antoine Dugue

Journal article  |  2021  |  CELLS

Genetic variants in FOXO3 are associated with longevity. Here, we assessed whether blood DNA methylation at FOXO3 was associated w..

Smoking Methylation Marks for Prediction of Urothelial Cancer Risk

Chenglong Yu, Kristina M Jordahl, Julie K Bassett, Jihoon Eric Joo, Ee Ming Wong, Maree T Brinkman, Daniel F Schmidt, Damien M Bolton, Enes Makalic, Theodore M Brasky, Aladdin H Shadyab, Lesley F Tinker, Anthony Longano, John L Hopper, Dallas R English, Roger L Milne, Parveen Bhatti, Melissa C Southey, Graham G Giles, Pierre-Antoine Dugue

Journal article  |  2021  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: Self-reported information may not accurately capture smoking exposure. We aimed to evaluate whether smoking-associated..

Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer

James M Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson, Khalid Mahmood, Romy Walker, Julia Como, Jihoon E Joo, Susan Preston, Ryan A Hutchinson, Bernard J Pope, Andrew Metz, Catherine Beard, Rebecca Purvis, Julie Arnold, Varnika Vijay, Galina Konycheva, Nathan Atkinson, Susan Parry, Mark A Jenkins, et al.

Journal article  |  2021  |  FAMILIAL CANCER

Germline loss-of-function variants in AXIN2 are associated with oligodontia and ectodermal dysplasia. The association between colo..

Transcriptomic Remodelling of Fetal Endothelial Cells During Establishment of Inflammatory Memory

Elisa Weiss, Amanda Vlahos, Bowon Kim, Sachintha Wijegunasekara, Dhanya Shanmuganathan, Thomas Aitken, Ji-Hoon E Joo, Samira Imran, Rebecca Shepherd, Jeffrey M Craig, Mark Green, Ursula Hiden, Boris Novakovic, Richard Saffery

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Inflammatory memory involves the molecular and cellular 'reprogramming' of innate immune cells following exogenous stimuli, leadin..