Ilia Voskoboinik

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  British Journal of Haematology

Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus

Jason Gummow, Makutiro G Masavuli, Zelalem A Mekonnen, Yanrui Li, Danushka K Wijesundara, Ashish C Shrestha, Ilia Voskoboinik, Eric J Gowans, Branka Grubor-Bauk

Journal article  |  2020  |  Vaccines

Despite direct acting antivirals (DAAs) curing >95% of individuals infected with hepatitis C (HCV), in order to achieve the World ..

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani

Journal article  |  2020  |  Blood

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica: the hematology journal

Lipid order and charge protect killer T cells from accidental death

Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik

Journal article  |  2019  |  NATURE COMMUNICATIONS

Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A Spicer, Ruby HP Law, Adrian W Hodel, Edward S Parsons, Susan M Ekkel, Paul J Conroy, Georg Ramm, Hariprasad Venugopal, Phillip Bird, Bart W Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A Dunstone, James C Whisstock

Journal article  |  2019  |  Nature Communications

THE MANY FACES OF FAMILIAL HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Ilia Voskoboinik, Paul Gray, Stephen Opat, Andrew Grigg, Anthony Jaworowski, Joseph Trapani

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY