Ilia Voskoboinik

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  British Journal of Haematology

Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus

Jason Gummow, Makutiro G Masavuli, Zelalem A Mekonnen, Yanrui Li, Danushka K Wijesundara, Ashish C Shrestha, Ilia Voskoboinik, Eric J Gowans, Branka Grubor-Bauk

Journal article  |  2020  |  Vaccines

Despite direct acting antivirals (DAAs) curing >95% of individuals infected with hepatitis C (HCV), in order to achieve the World ..

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani

Journal article  |  2020  |  Blood

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica

Lipid order and charge protect killer T cells from accidental death

Jesse A Rudd-Schmidt, Adrian W Hodel, Tahereh Noori, Jamie A Lopez, Hyun-Jung Cho, Sandra Verschoor, Annette Ciccone, Joseph A Trapani, Bart W Hoogenboom, Ilia Voskoboinik

Journal article  |  2019  |  NATURE COMMUNICATIONS

Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTL..

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia, Bradley A Spicer, Ruby HP Law, Adrian W Hodel, Edward S Parsons, Susan M Ekkel, Paul J Conroy, Georg Ramm, Hariprasad Venugopal, Phillip Bird, Bart W Hoogenboom, Ilia Voskoboinik, Yann Gambin, Emma Sierecki, Michelle A Dunstone, James C Whisstock

Journal article  |  2019  |  Nature Communications

THE MANY FACES OF FAMILIAL HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

Ilia Voskoboinik, Paul Gray, Stephen Opat, Andrew Grigg, Anthony Jaworowski, Joseph Trapani

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Neonatal Cytomegalovirus Palatal Ulceration and Bocavirus Pneumonitis Associated With a Defect of Lymphocyte Cytotoxicity Caused by Mutations in UNC13D

Paul Edgar Gray, Bella Shadur, Susan Russell, Richard Mitchell, Kerri Gallagher, Kevin Thia, Pamela Palasanthiran, Ilia Voskoboinik

Journal article  |  2019  |  Journal of the Pediatric Infectious Diseases Society

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

Distinguishing perforin-mediated lysis and granzyme-dependent apoptosis

Jesse A Rudd-Schmidt, Joseph A Trapani, Ilia Voskoboinik

Book Chapter  |  2019  |  Methods in Enzymology

Perforin is an indispensable effector protein of primary cytotoxic lymphocytes (CTL or NK cells) that typically defend the host ag..

PORES FOR THOUGHT

Helena S Jang, Ilia Voskoboinik, Ian Kerridge, Jamma Li, Melanie Wong, Andrew Williams, Richard Fulton, Suran L Fernando

Conference Proceedings  |  2018  |  INTERNAL MEDICINE JOURNAL

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Amelia J Brennan, Ruby HP Law, Paul J Conroy, Tahereh Noori, Natalya Lukoyanova, Helen Saibil, Hideo Yagita, Annette Ciccone, Sandra Verschoor, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  Cell Death & Differentiation

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome

Stephen Opat, Anna C Hearps, Kevin Thia, Agnes Yuen, Ben Rogers, Mkunde Chachage, Gregory Moore, Jake Shortt, Georgina Ryland, Piers Blombery, Anthony P Schwarer, Tahereh Noori, Joseph A Trapani, Anthony Jaworowski, Ilia Voskoboinik

Journal article  |  2018  |  Blood

Perforin-A key (shaped) weapon in the immunological arsenal

Bradley A Spicer, Paul J Conroy, Ruby HP Law, Ilia Voskoboinik, James C Whisstock

Journal article  |  2017  |  Seminars in Cell & Developmental Biology

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

Imran G House, Colin M House, Amelia J Brennan, Omer Gilan, Mark A Dawson, James C Whisstock, Ruby HP Law, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2017  |  EMBO reports

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L Burr, Christina E Sparbier, Yih-Chih Chan, James C Williamson, Katherine Woods, Paul A Beavis, Enid YN Lam, Melissa A Henderson, Charles C Bell, Sabine Stolzenburg, Omer Gilan, Stuart Bloor, Tahereh Noori, David W Morgens, Michael C Bassik, Paul J Neeson, Andreas Behren, Phillip K Darcy, Sarah-Jane Dawson, Ilia Voskoboinik, et al.

Journal article  |  2017  |  Nature

Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner

Danushka K Wijesundara, Wenbo Yu, Ben JC Quah, Preethi Eldi, John D Hayball, Kerrilyn R Diener, Ilia Voskoboinik, Eric J Gowans, Branka Grubor-Bauk

Journal article  |  2017  |  Scientific Reports

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D

Paul Edgar Gray, Bella Shadur, Susan Russell, Richard Mitchell, Michael Buckley, Kerri Gallagher, Ian Andrews, Kevin Thia, Joseph A Trapani, Edwin Philip Kirk, Ilia Voskoboinik

Journal article  |  2017  |  Frontiers in Immunology

Real-time visualization of perforin nanopore assembly

Carl Leung, Adrian W Hodel, Amelia J Brennan, Natalya Lukoyanova, Sharon Tran, Colin M House, Stephanie C Kondos, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik, Helen R Saibil, Bart W Hoogenboom

Journal article  |  2017  |  Nature Nanotechnology

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Vivien R Sutton, Amelia J Brennan, Sarah Ellis, Jill Danne, Kevin Thia, Misty R Jenkins, Ilia Voskoboinik, Gunnar Pejler, Ricky W Johnstone, Daniel M Andrews, Joseph A Trapani

Journal article  |  2016  |  FEBS Journal

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

Mohammed S Chaudhry, Kimberly C Gilmour, Imran G House, Mark Layton, Nicki Panoskaltsis, Mamta Sohal, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2016  |  OncoImmunology

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing

Conor J Kearney, Kelly M Ramsbottom, Ilia Voskoboinik, Phillip K Darcy, Jane Oliaro

Journal article  |  2016  |  OncoImmunology

Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs

B Grubor-Bauk, W Yu, D Wijesundara, J Gummow, T Garrod, AJ Brennan, I Voskoboinik, EJ Gowans

Journal article  |  2016  |  Gene Therapy

Structural Basis for Ca2 -mediated Interaction of the Perforin C2 Domain with Lipid Membranes

Hiromasa Yagi, Paul J Conroy, Eleanor WW Leung, Ruby HP Law, Joseph A Trapani, Ilia Voskoboinik, James C Whisstock, Raymond S Norton

Journal article  |  2015  |  Journal of Biological Chemistry

A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice

Jason Gummow, Yanrui Li, Wenbo Yu, Tamsin Garrod, Danushka Wijesundara, Amelia J Brennan, Ranajoy Mullick, Ilia Voskoboinik, Branka Grubor-Bauk, Eric J Gowans

Journal article  |  2015  |  Journal of Virology

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Imran G House, Kevin Thia, Amelia J Brennan, Richard Tothill, Alexander Dobrovic, Wei Z Yeh, Richard Saffery, Zac Chatterton, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2015  |  Immunology & Cell Biology

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis

Magdalena Hagn, Archana Panikkar, Corey Smith, Henry H Balfour, Rajiv Khanna, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  Clinical & Translational Immunology

Perforin and granzymes: function, dysfunction and human pathology

Ilia Voskoboinik, James C Whisstock, Joseph A Trapani

Journal article  |  2015  |  Nature Reviews Immunology

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

Misty R Jenkins, Jesse A Rudd-Schmidt, Jamie A Lopez, Kelly M Ramsbottom, Stuart I Mannering, Daniel M Andrews, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2015  |  JOURNAL OF EXPERIMENTAL MEDICINE

Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin

Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby HP Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda AK Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone

Journal article  |  2015  |  PLOS Biology

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker consequences?

Joseph A Trapani, Ilia Voskoboinik, Misty R Jenkins

Journal article  |  2015  |  OncoImmunology

A Method for Detecting Intracellular Perforin in Mouse Lymphocytes

Amelia J Brennan, Imran G House, Jane Oliaro, Kelly M Ramsbottom, Magdalena Hagn, Hideo Yagita, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2014  |  The Journal of Immunology

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives

I Voskoboinik, K Thia, JA Trapani

Journal article  |  2014  |  Internal Medicine Journal

Defining the interaction of perforin with calcium and the phospholipid membrane

Daouda AK Traore, Amelia J Brennan, Ruby HP Law, Con Dogovski, Matthew A Perugini, Natalya Lukoyanova, Eleanor WW Leung, Raymond S Norton, Jamie A Lopez, Kylie A Browne, Hideo Yagita, Gordon J Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A Trapani, James C Whisstock, Ilia Voskoboinik

Journal article  |  2013  |  BIOCHEMICAL JOURNAL

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

Julie A Spicer, Gersande Lena, Dani M Lyons, Kristiina M Huttunen, Christian K Miller, Patrick D O'Connor, Matthew Bull, Nuala Helsby, Stephen MF Jamieson, William A Denny, Annette Ciccone, Kylie A Browne, Jamie A Lopez, Jesse Rudd-Schmidt, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2013  |  Journal of Medicinal Chemistry

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

O Susanto, SE Stewart, I Voskoboinik, D Brasacchio, M Hagn, S Ellis, S Asquith, KA Sedelies, PI Bird, NJ Waterhouse, JA Trapani

Journal article  |  2013  |  Cell Death & Differentiation

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

Jamie A Lopez, Misty R Jenkins, Jesse A Rudd-Schmidt, Amelia J Brennan, Jillian C Danne, Stuart I Mannering, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  JOURNAL OF IMMUNOLOGY

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Jamie A Lopez, Olivia Susanto, Misty R Jenkins, Natalya Lukoyanova, Vivien R Sutton, Ruby HP Law, Angus Johnston, Catherina H Bird, Phillip I Bird, James C Whisstock, Joseph A Trapani, Helen R Saibil, Ilia Voskoboinik

Journal article  |  2013  |  BLOOD

Human perforin mutations and susceptibility to multiple primary cancers

Joseph A Trapani, Kevin YT Thia, Miles Andrews, Ian D Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G Campbell, Wayne A Phillips, Ilia Voskoboinik, Jonathan S Cebon

Journal article  |  2013  |  ONCOIMMUNOLOGY

Surprisingly variable "dangers, toils, and snares" faced by humans and mice

Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2013  |  BLOOD

Perforinopatly: a spectrum of human immune disease caused by defective perforin delivery or function

Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2013  |  FRONTIERS IN IMMUNOLOGY

Deciphering the syntax of cytotoxic lymphocyte degranulation

Jamie A Lopez, Ilia Voskoboinik

Journal article  |  2013  |  European Journal of Immunology

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Jamie A Lopez, Amelia J Brennan, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2012  |  Trends in Immunology (formerly Immunology Today)

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin

Jenny Chia, Kevin Thia, Amelia J Brennan, Margaret Little, Bronwyn Williams, Jamie A Lopez, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2012  |  BLOOD

Molecular study of the perforin gene in familial hematological malignancies

Rim El Abed, Violaine Bourdon, Ilia Voskoboinik, Halima Omri, Yosra Ben Youssef, Mohamed Adnene Laatiri, Laetitia Huiart, Francois Eisinger, Laetitia Rabayrol, Marc Frenay, Paul Gesta, Liliane Demange, Helene Dreyfus, Valerie Bonadona, Catherine Dugast, Helene Zattara, Laurence Faivre, Monia Zaier, Saloua Yacoub Jemni, Testsuro Noguchi, et al.

Journal article  |  2011  |  Hereditary Cancer in Clinical Practice

Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes

Amelia J Brennan, Jenny Chia, Kylie A Browne, Annette Ciccone, Sarah Ellis, Jamie A Lopez, Olivia Susanto, Sandra Verschoor, Hideo Yagita, James C Whisstock, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2011  |  Immunity

Cytotoxic granules house potent proapoptotic toxins critical for antiviral responses and immune homeostasis

K Baran, I Voskoboinik, NJ Waterhouse, VR Sutton, JA Trapani

Book Chapter  |  2011

The structural basis for membrane binding and pore formation by lymphocyte perforin

Ruby HP Law, Natalya Lukoyanova, Ilia Voskoboinik, Tom T Caradoc-Davies, Katherine Baran, Michelle A Dunstone, Michael E D'Angelo, Elena V Orlova, Fasseli Coulibaly, Sandra Verschoor, Kylie A Browne, Annette Ciccone, Michael J Kuiper, Phillip I Bird, Joseph A Trapani, Helen R Saibil, James C Whisstock

Journal article  |  2010  |  Nature

The structure and function of mammalian membrane-attack complex/perforin-like proteins

SC Kondos, T Hatfaludi, I Voskoboinik, JA Trapani, RHP Law, JC Whisstock, MA Dunstone

Journal article  |  2010  |  Tissue Antigens

Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik, Michelle A Dunstone, Katherine Baran, James C Whisstock, Joseph A Trapani

Journal article  |  2010  |  Immunological Reviews

Perforin deficiency and susceptibility to cancer

AJ Brennan, J Chia, JA Trapani, I Voskoboinik

Journal article  |  2010  |  Cell Death & Differentiation

The battlefield of perforin/granzyme cell death pathways

Sabine Hoves, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2010  |  Journal of Leukocyte Biology

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

Jenny Chia, Kim Pin Yeo, James C Whisstock, Michelle A Dunstone, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

Katherine Baran, Michelle Dunstone, Jenny Chia, Annette Ciccone, Kylie A Browne, Christopher JP Clarke, Natalya Lukoyanova, Helen Saibil, James C Whisstock, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2009  |  Immunity

The MACPF/CDC family of pore-forming toxins

Carlos J Rosado, Stephanie Kondos, Tara E Bull, Michael J Kuiper, Ruby HP Law, Ashley M Buckle, Ilia Voskoboinik, Phillip I Bird, Joseph A Trapani, James C Whisstock, Michelle A Dunstone

Journal article  |  2008  |  Cellular Immunology

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules

Vivien R Sutton, Nigel J Waterhouse, Katherine Baran, Kylie Browne, Ilia Voskoboinik, Joseph A Trapani

Journal article  |  2008  |  Methods

A common fold mediates vertebrate defense and bacterial attack

Carlos J Rosado, Ashley M Buckle, Ruby HP Law, Rebecca E Butcher, Wan-Ting Kan, Catherina H Bird, Kheng Ung, Kylie A Browne, Katherine Baran, Tanya A Bashtannyk-Puhalovich, Noel G Faux, Wilson Wong, Corrine J Porter, Robert N Pike, Andrew M Ellisdon, Mary C Pearce, Stephen P Bottomley, Jonas Emsley, A Ian Smith, Jamie Rossjohn, et al.

Journal article  |  2007  |  Science

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

Ilia Voskoboinik, Vivien R Sutton, Annette Ciccone, Colin M House, Jenny Chia, Phillip K Darcy, Hideo Yagita, Joseph A Trapani

Journal article  |  2007  |  Immunobiology

Apoptosis induced by the lymphocyte effector molecule perforin

Paul Bolitho, Ilia Voskoboinik, Joseph A Trapani, Mark J Smyth

Journal article  |  2007  |  Current Opinion in Immunology

The complex issue of regulating perforin expression

Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2007  |  Trends in Immunology (formerly Immunology Today)

Purification and membrane reconstitution of catalytically active Menkes copper-transporting P-type ATPase (MNK; ATP7A)

Ya Hui Hung, Meredith J Layton, Ilia Voskoboinik, Julian FB Mercer, James Camakaris

Journal article  |  2007  |  Biochemical Journal

Perforin-mediated target-cell death and immune homeostasis

Ilia Voskoboinik, Mark J Smyth, Joseph A Trapani

Journal article  |  2006  |  Nature Reviews Immunology

Unravelling the mysteries of Perforin

I Voskoboinik, JA Trapani

Journal article  |  2006  |  KLINISCHE PADIATRIE

Addressing the mysteries of perforin function

I Voskoboinik, JA Trapani

Journal article  |  2006  |  Immunology & Cell Biology

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis

I Voskoboinik, MC Thia, JA Trapani

Journal article  |  2005  |  Blood

Immune surveillance of lymphoma in humans?

MJ Smyth, I Voskoboinik, JA Trapani

Journal article  |  2005  |  Blood

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain

I Voskoboinik, MC Thia, J Fletcher, A Ciccone, K Browne, MJ Smyth, JA Trapani

Journal article  |  2005  |  Journal of Biological Chemistry

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells

M Greenough, L Pase, I Voskoboinik, MJ Petris, AW O'Brien, J Camakaris

Journal article  |  2004  |  American Journal of Physiology - Cell Physiology

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

I Voskoboinik, MC Thia, A De Bono, K Browne, E Cretney, JT Jackson, PK Darcy, SM Jane, MJ Smyth, JA Trapani

Journal article  |  2004  |  Journal of Experimental Medicine

Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool

L Pase, I Voskoboinik, M Greenough, J Camakaris

Journal article  |  2004  |  Biochemical Journal

P-type pumps:copper pump

I VOSKOBOINIK, J CAMAKARIS

Book Chapter  |  2004

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

I Voskoboinik, R Fernando, N Veldhuis, KM Hannan, N Marmy-Conus, RB Pearson, J Camakaris

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Mutational analysis of the Menkes copper P-type ATPase (ATP7A)

I Voskoboinik, J Mar, J Camakaris

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate

MJ Petris, I Voskoboinik, M Cater, K Smith, BE Kim, RM Llanos, D Strausak, J Camakaris, JFB Mercer

Journal article  |  2002  |  Journal of Biological Chemistry

Menkes copper-translocating P-type ATPase (ATP7A): Biochemical and cell biology properties, and role in Menkes disease

I Voskoboinik, J Camakaris

Journal article  |  2002  |  Journal of Bioenergetics and Biomembranes

Understanding the mechanism and function of copper P-type ATPases

I Voskoboinik, J Camakaris, JFB Mercer

Book Chapter  |  2002  |  Advances in Protein Chemistry

The regulation of catalytic activity of the menkes copper-translocating P-type ATPase - Role of high affinity copper-binding sites

I Voskoboinik, J Mar, D Strausak, J Camakaris

Journal article  |  2001  |  Journal of Biological Chemistry

Functional studies on the Wilson copper P-type ATPase and toxic milk mouse mutant

I Voskoboinik, M Greenough, S La Fontaine, JFB Mercer, J Camakaris

Journal article  |  2001  |  Biochemical and Biophysical Research Communications

Molecular mechanisms of copper homeostasis

J Camakaris, I Voskoboinik, JF Mercer

Journal article  |  1999  |  Biochemical and Biophysical Research Communications

Functional analysis of the N-terminal CXXC metal-binding motifs in the human menkes copper-transporting p-type ATPase expressed in cultured mammalian cells

N Voskoboinik, D Strausak, M Greenough, H Brooks, M Petris, S Smith, JF Mercer, J Camakaris

Journal article  |  1999  |  Journal of Biological Chemistry

The copper transporting p-type ATPase of Menkes disease

J Camakaris, I Voskoboinik, J Mercer, C Lane, R Parton, M Petris, D Strausak

Journal article  |  1999  |  JOURNAL OF INORGANIC BIOCHEMISTRY

ATP-dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells

I Voskoboinik, H Brooks, S Smith, P Shen, J Camakaris

Journal article  |  1998  |  FEBS Letters

Peroxisome proliferator nafenopin potentiated cytotoxicity and genotoxicity of cyclophosphamide in the liver and bone marrow cells

I Voskoboinik, R Drew, JT Ahokas

Journal article  |  1997  |  Chemico-Biological Interactions

Differential effect of peroxisome proliferators on rat glutathione S-transferase isoenzymes

I Voskoboinik, R Drew, JT Ahokas

Journal article  |  1996  |  Toxicology Letters