Ilia Voskoboinik

Lipid specificity of the immune effector perforin.

Adrian W Hodel, Jesse A Rudd-Schmidt, Joseph A Trapani, Ilia Voskoboinik, Bart W Hoogenboom

Journal article  |  2021  |  Faraday Discuss

Perforin is a pore forming protein used by cytotoxic T lymphocytes to remove cancerous or virus-infected cells during the immune r..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

The killer's armour: Physical membrane properties protect cytotoxic lymphocytes from accidental death

Adrian Hodel, Jesse Rudd-Schmidt, Ilia Voskoboinik, Bart Hoogenboom

Conference Proceedings  |  2021  |  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Dilemmas in the diagnosis and pathogenesis of atypical late-onset familial haemophagocytic lymphohistiocytosis

Adrian Minson, Ilia Voskoboinik, Andrew Grigg

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: A congenital loss of cytotoxic lymphocyte activity leads to a potentially fatal immune dysregulation, familial haemoph..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Ilia Voskoboinik, Paul Ekert, Rajeev Rudraraju, Sharon Lewin, Joseph Trapani

Journal article  |  2020

ABSTRACT Mutation-driven evolution of SARS coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultane..

Words of Advice: choosing the right lab for your post-doctoral fellowship

Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  FEBS JOURNAL

For most researchers, the time they spend as a postdoc stands out as one of challenge, but also enormous personal and professional..

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus

Vivien R Sutton, Christopher Andoniou, Michael G Leeming, Colin M House, Sally Watt, Sandra Verschoor, Annette Ciccone, Ilia Voskoboinik, Mariapia Degli-Esposti, Joseph A Trapani

Journal article  |  2020  |  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the p..

Recovery of natural killer cell cytotoxicity in a p.A91V perforin homozygous patient following severe haemophagocytic lymphohistiocytosis

Helena S Jang, Thijs WH Flinsenberg, Paul Lacaze, Kevin YT Thia, Tahereh Noori, Suran L Fernando, Ian Kerridge, Moeen Riaz, John J McNeil, Piers A Blombery, Joseph A Trapani, Ilia Voskoboinik

Journal article  |  2020  |  BRITISH JOURNAL OF HAEMATOLOGY

Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus

Jason Gummow, Makutiro G Masavuli, Zelalem A Mekonnen, Yanrui Li, Danushka K Wijesundara, Ashish C Shrestha, Ilia Voskoboinik, Eric J Gowans, Branka Grubor-Bauk

Journal article  |  2020  |  VACCINES

Despite direct acting antivirals (DAAs) curing >95% of individuals infected with hepatitis C (HCV), in order to achieve the World ..

Prevalence and disease predisposition of p.A91V perforin in an aged population of European ancestry

Ilia Voskoboinik, Paul Lacaze, Helena Sung-In Jang, Thijs Flinsenberg, Suran L Fernando, Ian Kerridge, Moeen Riaz, Robert Sebra, Kevin Thia, Taherah Noori, Eric E Schadt, John J McNeil, Joseph A Trapani

Journal article  |  2020  |  BLOOD

In a population-based analysis including a large database restricted to patients over age 70, the authors demonstrate that the A91..