Toby Phesse

Mesenchymal niche-derived Neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium

jacqueline Donoghue, Thierry Jarde

Journal article  |  2020  |  Cell Stem Cell

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key component of organoid growth media y..

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  CANCERS

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar, Arfon G Powell, Elizabeth Vincan, Toby J Phesse

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeosta..

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan

Journal article  |  2019  |  CANCER RESEARCH

A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of lig..

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Dustin J Flanagan, Chloe R Austin, Elizabeth Vincan, Toby J Phesse

Journal article  |  2018  |  GENES

Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is crit..

Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells

Renate HM Schwab, Nancy Amin, Dustin J Flanagan, Timothy M Johanson, Toby J Phesse, Elizabeth Vincan

Journal article  |  2018  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Metastasis underlies most colorectal cancer mortality. Cancer cells spread through the body as single cells or small c..

The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy

Elizabeth Vincan, Renate HM Schwab, Dustin J Flanagan, Jean M Moselen, Bang M Tran, Nick Barker, Toby J Phesse

Journal article  |  2018  |  WNT SIGNALING IN HEALTH AND DISEASE

The Wnt pathway is at the heart of organoid technology, which is set to revolutionize the cancer field. We can now predetermine a ..

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

Journal article  |  2017  |  BRITISH JOURNAL OF PHARMACOLOGY

UNLABELLED: Gastric cancer persists as a frequent and deadly disease that claims over 700 000 lives annually. Gastric cancer is a ..

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Toby J Phesse, Victoria Marsh Durban, Owen J Sansom

Journal article  |  2017  |  CARCINOGENESIS

Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. A..

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo

Dustin J Flanagan, Nick Barker, Cameron Nowell, Hans Clevers, Matthias Ernst, Toby J Phesse, Elizabeth Vincan

Journal article  |  2017  |  DISEASE MODELS & MECHANISMS

The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of ..