Guillaume Lessene

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy

Journal article  |  2019  |  Cell Reports

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Richard W Birkinshaw, Jia-nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David CS Huang, Peter M Colman, Peter E Czabotar

Journal article  |  2019  |  Nature Communications

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia

Donia M Moujalled, Giovanna Pomilio, Corina Ghiurau, Adam Ivey, Jessica Salmon, Sewa Rijal, Sarah Macraild, Lan Zhang, Tse-Chieh Teh, Ing-Soo Tiong, Ping Lan, Maia Chanrion, Audrey Claperon, Francesca Rocchetti, Adrien Zichi, Laurence Kraus-Berthier, Youzhen Wang, Ensar Hamovic, Erick Morris, Frederic Colland, et al.

Journal article  |  2019  |  Leukemia

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

Delphine Merino, Gemma L Kelly, Guillaume Lessene, Andrew H Wei, Andrew W Roberts, Andreas Strasser

Journal article  |  2018  |  Cancer Cell

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W Roberts, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S Brennan, Catherine Chang, Lin Tai, Guillaume Lessene, Andreas Strasser, Grant Dewson, Gemma L Kelly, Marco J Herold

Journal article  |  2018  |  Blood

Dual Inhibition of BCL-XL and MCL-1 is Required to Induce Tumour Regression in Lung Squamous Cell Carcinomas Sensitive to FGFR Inhibition

C Weeden, C Ah-Cann, A Holik, D Merino, G Lessene, M Asselin-Labat

Conference Proceedings  |  2018  |  Journal of Thoracic Oncology

Strategies, Setbacks, and Successes in the Synthesis of (-)-Spiroleucettadine

Richard A Lamb, Nigel T Lucas, Guillaume Lessene, Bill C Hawkins

Journal article  |  2018  |  The Journal of Organic Chemistry

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

Clare E Weeden, Casey Ah-Cann, Aliaksei Z Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene, Marie-Liesse Asselin-Labat

Journal article  |  2018  |  Oncogene

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy

Journal article  |  2018  |  Nature Communications

The Synthesis of (-)-Spiroleucettadine

Richard A Lamb, Guillaume Lessene, Bill C Hawkins

Journal article  |  2018  |  Synlett

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, et al.

Journal article  |  2018  |  Science

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, DM Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, PG Ekert, G Lessene, SP Glaser, DCS Huang, AW Roberts, MA Guthridge, AH Wei

Journal article  |  2018  |  Leukemia

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Czabotar

Journal article  |  2017  |  Molecular Cell

Total Synthesis of (-)-Spiroleucettadine

Richard A Lamb, Nicholas S Aberle, Nigel T Lucas, Guillaume Lessene, Bill C Hawkins

Journal article  |  2017  |  Angewandte Chemie International Edition

ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity toHDACInhibitors across Tumor Types

Anderly C Chueh, Janson WT Tse, Michael Dickinson, Paul Ioannidis, Laura Jenkins, Lars Togel, BeeShin Tan, Ian Luk, Mercedes Davalos-Salas, Rebecca Nightingale, Matthew R Thompson, Bryan RG Williams, Guillaume Lessene, Erinna F Lee, Walter D Fairlie, Amardeep S Dhillon, John M Mariadason

Journal article  |  2017  |  Clinical Cancer Research

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander, Stephanie Grabow

Journal article  |  2017  |  Cell Death & Disease

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Ashleigh R Poh, Christopher G Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L Putoczki, Robert JJ O'Donoghue, Matthias Ernst

Journal article  |  2017  |  Cancer Cell

Analysis of Ca2 mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

Rebecca J Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E Sleebs, Guillaume Lessene, Malcolm J McConville, Kelly L Rogers, Christopher J Tonkin

Journal article  |  2017  |  Cellular Microbiology

Close encounter of the covalent kind: Inhibiting MCL1's proapoptotic activity with covalent inhibitors

Guillaune Lessene

Journal article  |  2017  |  Cell Death Discovery

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM

Leona Rohrbeck, Jia-Nan Gong, Erinna F Lee, Andrew J Kueh, Andreas Behren, Lin Tai, Guillaume Lessene, David CS Huang, Walter D Fairlie, Andreas Strasser, Marco J Herold

Journal article  |  2016  |  Cell Death & Differentiation

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Gamier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker

Journal article  |  2016  |  eLife

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy, Zoltan Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaetane Le Toumelin-Braizat, Maia Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Marton C Sekei, Attila Paczal, Zoltan B Szabo, Szabolcs Sipos, Gabor Radics, Agnes Proszenyak, Balazs Balint, Levente Ondi, Gabor Blasko, et al.

Journal article  |  2016  |  Nature

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris D Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessene, Andrew Spencer, Marco J Herold, Andrew W Roberts, David CS Huang

Journal article  |  2016  |  Blood

Exploiting the Biginelli reaction: nitrogen-rich pyrimidine-based tercyclic alpha-helix mimetics

Zelong Lim, Peter J Duggan, Soo San Wan, Guillaume Lessene, Adam G Meyer, Kellie L Tuck

Journal article  |  2016  |  Tetrahedron

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Mary Speir, Kate E Lawlor, Stefan P Glaser, Gilu Abraham, Seong Chow, Adam Vogrin, Keith E Schulze, Ralf Schuelein, Lorraine A O'Reilly, Kylie Mason, Elizabeth L Hartland, Trevor Lithgow, Andreas Strasser, Guillaume Lessene, David CS Huang, James E Vince, Thomas Naderer

Journal article  |  2016  |  Nature Microbiology

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy

Journal article  |  2016  |  Cell Death & Disease

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

Boris Reljic, Stephanie Conos, Erinna F Lee, Jean-Marc Garnier, Li Dong, Guillaume Lessene, W Douglas Fairlie, David L Vaux, Lisa M Lindqvist

Journal article  |  2016  |  Autophagy

Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy

Duong Nhu, Guillaume Lessene, David CS Huang, Christopher J Burns

Journal article  |  2016  |  MedChemComm

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.

Journal article  |  2015  |  Nature Communications

Dual role of Src kinase in governing neuronal survival

M Iqbal Hossaina, Ashfaqul Hoquel, Guillaume Lessene, M Aizuddin Kamaruddin, Percy WY Chu, Ivan HW Ng, Sevgi Irtegun, Dominic CH Ng, Marie A Bogoyevitch, Antony W Burgess, Andrew F Hill, Heung-Chin Cheng

Journal article  |  2015  |  Brain Research

Targeting cell death pathways with small molecules: playing with life and death at the cellular level to treat diseases

Guillaume Lessene

Journal article  |  2015  |  Future Medicinal Chemistry

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Michael J White, Kate McArthur, Donald Metcalf, Rachael M Lane, John C Cambier, Marco J Herold, Mark F van Delft, Sammy Bedoui, Guillaume Lessene, Matthew E Ritchie, David CS Huang, Benjamin T Kile

Journal article  |  2014  |  Cell

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Discovery of a Potent and Selective BCL-X-L Inhibitor with in Vivo Activity

Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Chang H Park, Erwin R Boghaert, Nathaniel D Catron, Jun Chen, Peter M Colman, Peter E Czabotar, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Sarah G Hymowitz, Sha Jin, Russell A Judge, Michael FT Koehler, Peter J Kovar, Guillaume Lessene, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Simplified Silvestrol Analogues with Potent Cytotoxic Activity

Bill C Hawkins, Lisa M Lindqvist, Nhu Duong, Phillip P Sharp, David Segal, Andrew K Powell, Michael Campbell, Eileen Ryan, Jennifer M Chambers, Jonathan M White, Mark A Rizzacasa, Guillaume Lessene, David CS Huang, Christopher J Burns

Journal article  |  2014  |  ChemMedChem

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Danette Dudley, Paul Gibbons, Brad E Sleebs, Carl S Rye, George Nikolakopoulos, Chinh Bui, Sanji Kulasegaram, Wilhelmus JA Kersten, Brian J Smith, Peter E Czabotar, Peter M Colman, David CS Huang, Jonathan B Baell, Keith G Watson, Lisa Hasvold, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway

MJ Roy, A Vom, PE Czabotar, G Lessene

Journal article  |  2014  |  British Journal of Pharmacology

A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research - Eighteen Million Assays and Counting

Kurt Lackovic, Guillaume Lessene, Hendrik Falk, Karl-Johan Leuchowius, Jonathan Baell, Ian Street

Journal article  |  2014  |  Combinatorial Chemistry & High Throughput Screening

De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-X-L: Synthesis, Structural and Biochemical Characterization

Ryan M Brady, Amelia Vom, Michael J Roy, Nathan Toovey, Brian J Smith, Rebecca M Moss, Effie Hatzis, David CS Huang, John P Parisot, Hong Yang, Ian P Street, Peter M Colman, Peter E Czabotar, Jonathan B Baell, Guillaume Lessene

Journal article  |  2014  |  Journal of Medicinal Chemistry

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar

Journal article  |  2014  |  Biochemical Journal

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams

Journal article  |  2014  |  Nature Reviews Molecular Cell Biology

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic

Sofia Caria, Srishti Chugh, Nhu Duong, Guillaume Lessene, Marc Kvansakul

Journal article  |  2012  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

Synthesis of conformationally constrained benzoylureas as BH3-mimetics

Ryan M Brady, Effie Hatzis, Theresa Connor, Ian P Street, Jonathan B Baell, Guillaume Lessene

Journal article  |  2012  |  Organic & Biomolecular Chemistry

BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity.

Genevieve Evin, Guillaume Lessene, Simon Wilkins

Journal article  |  2011  |  Recent Patents on CNS Drug Discovery

Current drug development for the treatment of Alzheimer's Disease is principally based on the amyloid cascade theory, and aims to ..

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Brad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, W Douglas Fairlie, John A Flygare, David CS Huang, Wilhelmus JA Kersten, Michael FT Koehler, Guillaume Lessene, Kym Lowes, John P Parisot, Brian J Smith, Morey L Smith, Andrew J Souers, Ian P Street, Hong Yang, Jonathan B Baell

Journal article  |  2011  |  Journal of Medicinal Chemistry

Benzoylureas as removable cis amide inducers: synthesis of cyclic amides via ring closing metathesis (RCM)

Ryan M Brady, Yelena Khakham, Guillaume Lessene, Jonathan B Baell

Journal article  |  2011  |  Org. Biomol. Chem.

Synthesis of Azide-Alkyne Fragments for "Click" Chemical Applications. Part 2. Formation of Oligomers from Orthogonally Protected Chiral Trialkylsilylhomopropargyl Azides and Homopropargyl Alcohols

Oliver D Montagnat, Guillaume Lessene, Andrew B Hughes

Journal article  |  2010  |  The Journal of Organic Chemistry

Bcl-2 Family Proteins as Therapeutic Targets

Peter E Czabotar, Guillaume Lessene

Journal article  |  2010  |  Current Pharmaceutical Design

Synthesis of Azide-alkyne Fragments for 'Click' Chemical Applications. Formation of Chiral 1,4-Disubstituted-(beta-alkyl)-gamma-1,2,3-triazole Scaffolds from Orthogonally Protected Chiral beta-Alkyl-trialkylsilyl-gamma-pentynyl Azides and Chiral beta-Alkyl-gamma-pentynyl-alcohols

Oliver D Montagnat, Guillaume Lessene, Andrew B Hughes

Journal article  |  2010  |  Australian Journal of Chemistry

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Erinna F Lee, Peter E Czabotar, Hong Yang, Brad E Sleebs, Guillaume Lessene, Peter M Colman, Brian J Smith, W Douglas Fairlie

Journal article  |  2009  |  Journal of Biological Chemistry

Characterization of the Two Fundamental Conformations of Benzoylureas and Elucidation of the Factors That Facilitate Their Conformational Interchange

Guillaume Lessene, Brian J Smith, Robert W Gable, Jonathan B Baell

Journal article  |  2009  |  The Journal of Organic Chemistry

BCL-2 family antagonists for cancer therapy

Guillaume Lessene, Peter E Czabotar, Peter M Colman

Journal article  |  2008  |  Nature Reviews Drug Discovery

Synthesis of azide-alkyne fragments for 'click' chemical applications formation of oligomers from orthogonally protected trialkylsilyl-propargyl azides and propargyl alcohols

Oliver D Montagnat, Guillaume Lessene, Andrew B Hughes

Journal article  |  2006  |  Tetrahedron Letters

A concise total synthesis of naamidine A

NS Aberle, G Lessene, KG Watson

Journal article  |  2006  |  Organic Letters

Advances in the Negishi coupling

G Lessene

Journal article  |  2004  |  Australian Journal of Chemistry

Diazonamide synthesis studies: use of Negishi coupling to fashion diazonamide-related biaryls with defined axial chirality.

Ken S Feldman, Kyle J Eastman, Guillaume Lessene

Journal article  |  2002  |  Organic Letters

The syntheses of a bis indole and an indole salicylate with the required axial chirality for diazonamide A are reported. Atropsele..

Selective electrochemical synthesis and reactivity of functional benzylic fluorosilylsynthons

P Clavel, G Lessene, C Biran, M Bordeau, N Roques, S Trévin, D de Montauzon

Journal article  |  2001  |  Journal of Fluorine Chemistry

Towards the electroreduction of very weak acids

G Lessene, M Bordeau, C Biran, D De Montauzon, J Gerval

Journal article  |  2000  |  Journal of Electroanalytical Chemistry

Magnesium bis(diisopropylamide), a useful reagent for regio- and stereoselective synthesis of kinetic silyl enol ethers

G Lessène, R Tripoli, P Cazeau, C Biran, M Bordeau

Journal article  |  1999  |  Tetrahedron Letters