James Murphy

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Teresa Sadras, Fatimah BB Jalud, Hansen JJ Kosasih, Christopher RR Horne, Lauren MM Brown, Sam El-Kamand, Charles EE de Bock, Lachlan McAloney, Ashley PP Ng, Nadia MM Davidson, Louise EA Ludlow, Alicia Oshlack, Mark JJ Cowley, Seong LL Khaw, James MM Murphy, Paul GG Ekert

Journal article  |  2023  |  LEUKEMIA

From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

Christopher R Gardner, Katherine A Davies, Ying Zhang, Martin Brzozowski, Peter E Czabotar, James M Murphy, Guillaume Lessene

Journal article  |  2023  |  JOURNAL OF MEDICINAL CHEMISTRY

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an inflammatory phenotype. This process..

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

Emma C Tovey C Crutchfield, Sarah E Garnish, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie SN Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, Andre L Samson, James M Murphy, Joanne M Hildebrand

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and ..

The web of death: the expanding complexity of necroptotic signaling

Christopher R Horne, Andre L Samson, James M Murphy

Journal article  |  2023  |  TRENDS IN CELL BIOLOGY

The past decade has seen the emergence of the necroptosis programmed cell death pathway as an important contributor to the pathoph..

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1 beta release in X-linked inhibitor of apoptosis (XIAP) deficiency

Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, et al.

Journal article  |  2023  |  EMBO JOURNAL

Genetic lesions in X-linked inhibitor of apoptosis (XIAP) pre-dispose humans to cell death-associated inflammatory diseases, altho..

Role of necroptosis in kidney health and disease

Benedikt Kolbrink, Friedrich A von Samson-Himmelstjerna, James M Murphy, Stefan Krautwald

Journal article  |  2023  |  NATURE REVIEWS NEPHROLOGY

Cell death, particularly that of tubule epithelial cells, contributes critically to the pathophysiology of kidney disease. A body ..

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

Nanobodies identify an activated state of the TRIB2 pseudokinase

Sam A Jamieson, Michael Pudjihartono, Christopher R Horne, Juan Salamanca Viloria, Jessica L Dunlop, Hamish D McMillan, Robert C Day, Karen Keeshan, James M Murphy, Peter D Mace

Journal article  |  2022  |  STRUCTURE

Tribbles proteins (TRIB1-3) are pseudokinases that recruit substrates to the COP1 ubiquitin ligase. TRIB2 was the first Tribbles o..

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M Bader, Simon P Preston, Katie Saliba, Adam Lipszyc, Zoe L Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M Murphy, Cody C Allison, Marc Pellegrini, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including infla..

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

Daniel Frank, Sarah E Garnish, Jarrod J Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A Cobbold, Simon R Scutts, Marcel Doerflinger, Holly Anderton, Kate E Lawlor, Najoua Lalaoui, Andrew J Kueh, Vik Ven Eng, Rebecca L Ambrose, Marco J Herold, Andre L Samson, Rebecca Feltham, et al.

Journal article  |  2022  |  ISCIENCE

Pathogen recognition and TNF receptors signal via receptor interacting serine/threonine kinase-3 (RIPK3) to cause cell death, incl..