My lab studies the protein-protein interactions that underpin signal transduction. Much of our work is focused on understanding the molecular mechanisms by which protein kinases and their relatives, pseudokinases, regulate cell signalling.
Long considered the poor cousins of conventional protein kinases owing to their lack of catalytic activity, pseudokinases have emerged over the past decade as crucial components of signalling pathways across the kingdoms of life.
To date there have been few detailed studies of members of the mammalian ‘pseudokinome’, but already it is evident that this protein family exhibits functional diversity consistent with their diverse evolutionary origins.
My lab has focused on the pseudokinase, MLKL, the most terminal (known) effector in the necroptosis cell death pathway. Detailed knowledge of MLKL activation, regulation and downstream activity has set the scene for therapeutic targeting of MLKL. This work provides a template for developing a detailed understanding of how the remaining ~50 uncharacterised pseudokinases modulate cell signalling.
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Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death us..
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating..
Displaying the 123 most recent scholarly works by James Murphy.
Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS
Taide Wang, Nirma D Perera, Mathew DF Chiam, Brittany Cuic, Nayomi Wanniarachchillage, Doris Tomas, Andre L Samson, Wayne Cawthorne, Eric N Valor, James M Murphy, Bradley J Turner
Journal article | 2020 | Cell Death & Differentiation
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regu..
Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies
Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe PC Smith, Andrew I Webb, Peter E Czabotar, Shohei Koide, James M Murphy
Journal article | 2020 | Proceedings of the National Academy of Sciences
The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosph..
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases
Sarah J Trevelyan, Jodi L Brewster, Abigail E Burgess, Jennifer M Crowther, Antonia L Cadell, Benjamin L Parker, David R Croucher, Renwick CJ Dobson, James M Murphy, Peter D Mace
Journal article | 2020 | Science Signaling
The PEAK family of pseudokinases, their role in cell signalling and cancer
Onisha Patel, Michael J Roy, James M Murphy, Isabelle S Lucet
Journal article | 2019 | The FEBS Journal
The study of pseudokinases has uncovered that catalysis-independent functions play a critical role in cell signalling regulation. ..
Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3
Emma J Petrie, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N Young, Wilhelmus JA Kersten, Cheree Fitzgibbon, Andre L Samson, Annette V Jacobsen, Kym N Lowes, Amanda E Au, Helene Jousset Sabroux, Najoua Lalaoui, Andrew I Webb, Guillaume Lessene, Gerard Manning, Isabelle S Lucet, James M Murphy
Journal article | 2019 | Cell Reports
The anticonvulsive Phenhydan (R) suppresses extrinsic cell death
Caroline Moerke, Isabel Jaco, Christin Dewitz, Tammo Mueller, Annette Jacobsen, Jeremie Gautheron, Juergen Fritsch, Jessica Schmitz, Jan Hinrich Braesen, Claudia Guenther, James M Murphy, Ulrich Kunzendorf, Pascal Meier, Stefan Krautwald
Journal article | 2019 | Cell Death & Differentiation
Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions in..
The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1 beta Release
Maryam Rashidi, Daniel S Simpson, Anne Hempel, Daniel Frank, Emma Petrie, Angelina Vince, Rebecca Feltham, Jane Murphy, Simon M Chatfield, Guy S Salvesen, James M Murphy, Ian P Wicks, James E Vince
Journal article | 2019 | The Journal of Immunology
The pyroptotic cell death effector gasdermin D (GSDMD) is required for murine models of hereditary inflammasome-driven, IL-1β-depe..
Regulated necrosis in kidney ischemia-reperfusion injury
Aspasia Pefanis, Francesco L Ierino, James M Murphy, Peter J Cowan
Journal article | 2019 | Kidney International
Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient ..
SMCHD1 is involved in de novo methylation of the DUX4-encoding D4Z4 macrosatellite
Camille Dion, Stephane Roche, Camille Laberthonniere, Natacha Broucqsault, Virginie Mariot, Shifeng Xue, Alexandra D Gurzau, Agnieszka Nowak, Christopher T Gordon, Marie-Cecile Gaillard, Claire El-Yazidi, Morgane Thomas, Andree Schlupp-Robaglia, Chantal Missirian, Valerie Malan, Liham Ratbi, Abdelaziz Sefiani, Bernd Wollnik, Bernard Binetruy, Emmanuelle Salort Campana, et al.
Journal article | 2019 | Nucleic Acids Research
Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway
Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A Breslin, Tracy A Willson, Kelly Rogers, Graham F Kay, Archa H Fox, Haruhiko Koseki, Neil Brockdorff, James M Murphy, Marnie E Blewitt
Journal article | 2018 | Cell Reports
The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
Katherine A Davies, Maria C Tanzer, Michael DW Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy
Journal article | 2018 | Cell Death & Differentiation
Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck, Ian D Tonks, Arne W Mould, Peter Hickey, Kelsey Breslin, Megan Iminitoff, Matthew E Ritchie, Edwina McGlinn, Graham F Kay, James M Murphy, Marnie E Blewitt
Journal article | 2018 | Nature Structural & Molecular Biology
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy
Journal article | 2018 | Nature Communications
Long-range chromatin interactions on the inactive X and at Hox clusters are regulated by the non-canonical SMC protein Smchd1
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck, Ian Tonks, Arne Mould, Peter Hickey, Kelsey Breslin, Megan Iminitoff, Matthew Ritchie, Edwina McGlinn, Graham Kay, James Murphy, Marnie Blewitt
Journal article | 2018
Abstract The regulation of higher order chromatin structure is complex and dynamic; however we do not yet understand the full suit..
An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis
Timothy M Ryan, Jill Trewhella, James M Murphy, Jeremy R Keown, Lachlan Casey, F Grant Pearce, David C Goldstone, Kelan Chen, Zhenyao Luo, Bostjan Kobe, Christopher A McDevitt, Serena A Watkin, Adrian M Hawley, Stephen T Mudie, Vesna Samardzic Boban, Nigel Kirby
Journal article | 2018 | Journal of Applied Crystallography
Identification of a second binding site on the TRIM25 B30.2 domain
Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson
Journal article | 2018 | Biochemical Journal
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax
Jakub Gruszczyk, Usheer Kanjee, Li-Jin Chan, Sebastien Menant, Benoit Malleret, Nicholas TY Lim, Christoph Q Schmidt, Yee-Foong Mok, Kai-Min Lin, Richard D Pearson, Gabriel Rangel, Brian J Smith, Melissa J Call, Michael P Weekes, Michael DW Griffin, James M Murphy, Jonathan Abraham, Kanlaya Sriprawat, Maria J Menezes, Marcelo U Ferreira, et al.
Journal article | 2018 | Science
Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association
Onisha Patel, Michael DW Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M Murphy, Roger J Daly, Isabelle S Lucet
Journal article | 2017 | Nature Communications
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
Tammo Mueller, Christin Dewitz, Jessica Schmitz, Anna Sophia Schroeder, Jan Hinrich Braesen, Brent R Stockwell, James M Murphy, Ulrich Kunzendorf, Stefan Krautwald
Journal article | 2017 | Cellular and Molecular Life Sciences
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier
Journal article | 2017 | Molecular Cell
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Jaclyn S Pearson, Cristina Giogha, Sabrina Muhlen, Ueli Nachbur, Chi LL Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, et al.
Journal article | 2017 | Nature Microbiology
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1
Johannes F Weijman, Abhishek Kumar, Sam A Jamieson, Chontelle M King, Tom T Caradoc-Davies, Elizabeth C Ledgerwood, James M Murphy, Peter D Mace
Journal article | 2017 | Proceedings of the National Academy of Sciences
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils
Cesar Tovar, Ruth J Pye, Alexandre Kreiss, Yuanyuan Cheng, Gabriella K Brown, Jocelyn Darby, Roslyn C Malley, Hannah VT Siddle, Karsten Skjodt, Jim Kaufman, Anabel Silva, Adriana Baz Morelli, Anthony T Papenfuss, Lynn M Corcoran, James M Murphy, Martin J Pearse, Katherine Belov, A Bruce Lyons, Gregory M Woods
Journal article | 2017 | Scientific Reports
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
Stephanie A Conos, Kaiwen W Chen, Dominic De Nardo, Hideki Hara, Lachlan Whitehead, Gabriel Nunez, Seth L Masters, James M Murphy, Kate Schroder, David L Vaux, Kate E Lawlor, Lisa M Lindqvist, James E Vince
Journal article | 2017 | Proceedings of the National Academy of Sciences
De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development
Christopher T Gordon, Shifeng Xue, Goekhan Yigit, Hicham Filali, Kelan Chen, Nadine Rosins, Koh-ichiro Yoshiura, Myriam Oufadem, Tamara J Beck, Ruth McGowan, Alex C Magee, Janine Altmueller, Camille Dion, Holger Thiele, Alexandra D Gurzau, Peter Nuernberg, Dieter Meschede, Wolfgang Muehlbauer, Nobuhiko Okamoto, Vinod Varghese, et al.
Journal article | 2017 | Nature Genetics
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-gamma and Can Be Expressed in the Tumor Microenvironment
Andrew S Flies, A Bruce Lyons, Lynn M Corcoran, Anthony T Papenfuss, James M Murphy, Graeme W Knowles, Gregory M Woods, John D Hayball
Journal article | 2016 | Frontiers in Immunology
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis
Claudia Guenther, Gui-Wei He, Andreas E Kremer, James M Murphy, Emma J Petrie, Kerstin Amann, Peter Vandenabeele, Andreas Linkermann, Christopher Poremba, Ulrike Schleicher, Christin Dewitz, Stefan Krautwald, Markus F Neurath, Christoph Becker, Stefan Wirtz
Journal article | 2016 | Journal of Clinical Investigation
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.
Claudia Günther, Gui-Wei He, Andreas E Kremer, James M Murphy, Emma J Petrie, Kerstin Amann, Peter Vandenabeele, Andreas Linkermann, Christopher Poremba, Ulrike Schleicher, Christin Dewitz, Stefan Krautwald, Markus F Neurath, Christoph Becker, Stefan Wirtz
Journal article | 2016 | Journal of Clinical Investigation
Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the contex..
Mitogen-activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells
Gabriella K Brown, Cesar Tovar, Anne A Cooray, Alexandre Kreiss, Jocelyn Darby, James M Murphy, Lynn M Corcoran, Silvana S Bettiol, A Bruce Lyons, Gregory M Woods
Journal article | 2016 | Immunology & Cell Biology
Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability
Nicholas J Fraser, Jian-Wei Liu, Peter D Mabbitt, Galen J Correy, Chris W Coppin, Mathilde Lethier, Matthew A Perugini, James M Murphy, John G Oakeshott, Martin Weik, Colin J Jackson
Journal article | 2016 | Journal of Molecular Biology
Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement
Jakub Gruszczyk, Nicholas TY Lim, Alicia Arnott, Wen-Qiang He, Wang Nguitragool, Wanlapa Roobsoong, Yee-Foong Mok, James M Murphy, Katherine R Smith, Stuart Lee, Melanie Bahlo, Ivo Mueller, Alyssa E Barry, Wai-Hong Tham
Journal article | 2016 | Proceedings of the National Academy of Sciences
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy
Journal article | 2016 | Cell Death & Disease
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
Maria C Tanzer, Anne Tripaydonis, Andrew I Webb, Samuel N Young, Leila N Varghese, Cathrine Hall, Warren S Alexander, Joanne M Hildebrand, John Silke, James M Murphy
Journal article | 2015 | Biochemical Journal
Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5
Indu R Chandrashekaran, Biswaranjan Mohanty, Edmond M Linossi, Laura F Dagley, Eleanor WW Leung, James M Murphy, Jeffrey J Babon, Sandra E Nicholson, Raymond S Norton
Journal article | 2015 | Biochemistry
SCREENING FOR AND CHARACTERISING MAMMALIAN EPIGENETIC MODIFIERS
Kelan Chen, Jiang Hu, Darcy L Moore, Ruijie Liu, Kelsey Breslin, Natasha Jansz, Sarah A Kessans, Isabelle S Lucet, Andrew Keniry, Huei San Leong, Clare L Parish, Douglas J Hilton, Richard JLF Lemmers, Silvere M van der Maarel, Peter E Czabotar, Renwick C Dobson, Matthew E Ritchie, Graham F Kay, James M Murphy, Marnie E Blewitt
Conference Proceedings | 2015 | JOURNAL OF GENE MEDICINE
Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation
Kelan Chen, Jiang Hu, Darcy L Moore, Ruijie Liu, Sarah A Kessans, Kelsey Breslin, Isabelle S Lucet, Andrew Keniry, Huei San Leong, Clare L Parish, Douglas J Hilton, Richard JLF Lemmers, Silvere M van der Maarel, Peter E Czabotar, Renwick CJ Dobson, Matthew E Ritchie, Graham F Kay, James M Murphy, Marnie E Blewitt
Journal article | 2015 | Proceedings of the National Academy of Sciences
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.
Journal article | 2015 | Nature Communications
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, et al.
Journal article | 2014 | eLife
A mass spectrometry-based approach for studying kinase activity
Laura F Dagley, Tatiana B Kolesnik, Ee Shan Pang, Phillip P Sharp, Edmond M Linossi, Gabrielle L Goldberg, James M Murphy, Andrew I Webb, Christopher J Burns, Ian P Wicks, Nicos A Nicola, Isabelle S Lucet, Sandra E Nicholson
Conference Proceedings | 2014 | Cytokine
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke
Journal article | 2014 | Proceedings of the National Academy of Sciences
RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.
Journal article | 2014 | Cell
cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner
W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke
Journal article | 2014 | Blood
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses
Leila N Varghese, Daniela Ungureanu, Nicholas PD Liau, Samuel N Young, Artem Laktyushin, Henrik Hammaren, Isabelle S Lucet, Nicos A Nicola, Olli Silvennoinen, Jeffrey J Babon, James M Murphy
Journal article | 2014 | Biochemical Journal
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar
Journal article | 2014 | Biochemical Journal
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
James M Murphy, Qingwei Zhang, Samuel N Young, Michael L Reese, Fiona P Bailey, Patrick A Eyers, Daniela Ungureanu, Henrik Hammaren, Olli Silvennoinen, Leila N Varghese, Kelan Chen, Anne Tripaydonis, Natalia Jura, Koichi Fukuda, Jun Qin, Zachary Nimchuk, Mary Beth Mudgett, Sabine Elowe, Christine L Gee, Ling Liu, et al.
Journal article | 2014 | Biochemical Journal
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.
Journal article | 2013 | Immunity
Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1
Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Journal article | 2013 | PLoS One
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
Nadia J Kershaw, James M Murphy, Nicholas PD Liau, Leila N Varghese, Artem Laktyushin, Eden L Whitlock, Isabelle S Lucet, Nicos A Nicola, Jeffrey J Babon
Journal article | 2013 | Nature Structural and Molecular Biology
Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
Jeffrey J Babon, Nadia J Kershaw, James M Murphy, Leila N Varghese, Artem Laktyushin, Samuel N Young, Isabelle S Lucet, Raymond S Norton, Nicos A Nicola
Journal article | 2012 | Immunity
An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets
Hendrik Falk, Theresa Connor, Hong Yang, Karen J Loft, Joanne L Alcindor, George Nikolakopoulos, Regina N Surjadi, John D Bentley, Meghan K Hattarki, Olan Dolezal, James M Murphy, Brendon J Monahan, Thomas S Peat, Tim Thomas, Jonathan B Baell, John P Parisot, Ian P Street
Journal article | 2011 | Journal of Biomolecular Screening
Structural Studies of FF Domains of the Transcription Factor CA150 Provide Insights into the Organization of FF Domain Tandem Arrays
James M Murphy, D Flemming Hansen, Silke Wiesner, D Ranjith Muhandiram, Mikael Borg, Matthew J Smith, Frank Sicheri, Lewis E Kay, Julie D Forman-Kay, Tony Pawson
Journal article | 2009 | Journal of Molecular Biology
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl(-/-) mice
Maria Kauppi, James M Murphy, Carolyn A de Graaf, Craig D Hyland, Kylie T Greig, Donald Metcalf, Adrienne A Hilton, Nicos A Nicola, Benjamin T Kile, Douglas J Hilton, Warren S Alexander
Journal article | 2008 | Blood
Clarification of the role of N-glycans on the common beta-subunit of the human IL-3, IL-5 and GM-CSF receptors and the murine IL-3 beta-receptor in ligand-binding and receptor activation
James M Murphy, Tatiana A Soboleva, Shamaruh Mirza, Sally C Ford, Jane E Olsen, Jinglong Chen, Ian G Young
Journal article | 2008 | Cytokine
Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain
James M Murphy, Dmitry M Korzhnev, Derek F Ceccarelli, Douglas J Briant, Arash Zarrine-Afsar, Frank Sicheri, Lewis E Kay, Tony Pawson
Journal article | 2007 | Proceedings of the National Academy of Sciences
A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5
JM Murphy, SC Ford, UA Wiedemann, PD Carr, DL Ollis, IG Young
Journal article | 2003 | Journal of Biological Chemistry