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A/Prof

James Murphy

Honorary
Medical Biology (W.E.H.I.)
science & technology
life sciences & biomedicine
animals
humans
biochemistry & molecular biology
mice
cell biology
activation
signal transduction
James Murphy's Profile Picture
A/Prof

James Murphy

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Cell signalling
James Murphy's Profile Picture
A/Prof

James Murphy

 

Research interest
My lab studies the protein-protein interactions that underpin signal transduction. Much of our work is focused on understanding the molecular mechanisms by which protein kinases and their relatives, pseudokinases, regulate cell signalling.

Long considered the poor cousins of conventional protein kinases owing to their lack of catalytic activity, pseudokinases have emerged over the past decade as crucial components of signalling pathways across the kingdoms of life.

To date there have been few detailed studies of members of the mammalian ‘pseudokinome’, but already it is evident that this protein family exhibits functional diversity consistent with their diverse evolutionary origins.

My lab has focused on the pseudokinase, MLKL, the most terminal (known) effector in the necroptosis cell death pathway. Detailed knowledge of MLKL activation, regulation and downstream activity has set the scene for therapeutic targeting of MLKL. This work provides a template for developing a detailed understanding of how the remaining ~50 uncharacterised pseudokinases modulate cell signalling.

www.wehi.edu.au/people/james-murphy

Scholarly Works

Displaying the 125 most recent scholarly works by James Murphy.

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)