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Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resoluti..
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined w..
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic trip..
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1..
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cell..
Displaying the 59 most recent scholarly works by Francois Vaillant.
Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.
Johanna F Dekkers, James R Whittle, François Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2019 | JNCI: Journal of the National Cancer Institute
Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..
Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging
Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.
Journal article | 2019 | Cancer Cell
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer
Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.
Journal article | 2019 | Cancer Discovery
Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik
Journal article | 2019 | Nature Communications
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers
Journal article | 2019 | Nature Communications
Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence
Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2018 | Developmental Cell
Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells
Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Gonez, Alana M Neale, Francois Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison
Journal article | 2018 | Pancreas
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2017 | Nature Communications
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.
Journal article | 2017 | Science Translational Medicine
Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman
Journal article | 2017 | Science Translational Medicine
Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader
Journal article | 2017 | Nature Cell Biology
RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers
GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader
Conference Proceedings | 2017 | General Session Abstracts
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.
Journal article | 2016 | Cancer and Metastasis Reviews
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers
Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2016 | Nature Medicine
A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1
Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2015 | BMC Cancer
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader
Journal article | 2015 | Nature Cell Biology
Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2013 | Cancer Cell
Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2
Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2013 | Cell Reports
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14
Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2011 | Molecular and Cellular Biology
Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations
Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson
Journal article | 2011 | Proteomics
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Journal article | 2010 | Breast Cancer Research
Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers
Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger
Journal article | 2009 | Stem Cells
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman
Journal article | 2009 | Nature Medicine
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader
Journal article | 2006 | The EMBO Journal
Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (rho0).
Safarina G Malik, François Vaillant, Alfons Lawen
Journal article | 2004 | BioFactors
The mammalian plasma membrane (PM) NADH-oxidoreductase (PMOR) system is a multi-enzyme complex located in the plasma membrane of a..
Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis.
DR Grubb, JD Ly, F Vaillant, KL Johnson, A Lawen
Journal article | 2001 | Oncogene
Permeability transition, and a subsequent drop in mitochondrial membrane potential (DeltaPsi(m)), have been suggested to be mechan..
A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc.
F Vaillant, K Blyth, A Terry, M Bell, ER Cameron, J Neil, M Stewart
Journal article | 1999 | Oncogene
The Cbfa1/PEBP2 alpha A/AML3 gene plays an essential role in osteogenesis but is also expressed in the T-cell lineage where it has..
Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators.
F Vaillant, JA Larm, GL McMullen, EJ Wolvetang, A Lawen
Journal article | 1996 | Journal of Bioenergetics and Biomembranes
In the presence of effectors variations in the two recognized activities of the plasma membrane NADH-oxidoreductase system were st..
Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells.
JA Larm, F Vaillant, AW Linnane, A Lawen
Journal article | 1994 | Journal of Biological Chemistry
We have studied aspects of the regulatory interrelationship between the plasma membrane oxidoreductase (PMOR) system and the mitoc..
The universality of bioenergetic disease: the role of mitochondrial mutation and the putative inter-relationship between mitochondria and plasma membrane NADH oxidoreductase.
A Lawen, RD Martinus, GL McMullen, P Nagley, F Vaillant, EJ Wolvetang, AW Linnane
Journal article | 1994 | Molecular Aspects of Medicine
Mitochondrial DNA mutation associated with aging and degenerative disease.
P Nagley, IR Mackay, A Baumer, RJ Maxwell, F Vaillant, ZX Wang, C Zhang, AW Linnane
Journal article | 1992 | Annals of the New York Academy of Sciences
Previous theories of aging based on somatic mutation neglected mtDNA, which has a high propensity for mutational error. Knowledge ..
Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays.
BE Loveland, TG Johns, IR Mackay, F Vaillant, ZX Wang, PJ Hertzog
Journal article | 1992 | Biochemistry International
Increasing use is being made of colorimetric assays to quantitate viable cells, e.g., the cellular reduction of the tetrazolium sa..
Some biochemical properties of human lymphoblastoid Namalwa cells grown anaerobically.
F Vaillant, BE Loveland, P Nagley, AW Linnane
Journal article | 1991 | Biochemistry International
Using cultured lymphoblastoid Namalwa cells, we have demonstrated that humans cells can be grown for long periods in the absence o..