Francois Vaillant

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.

Johanna F Dekkers, James R Whittle, François Vaillant, Huei-Rong Chen, Caleb Dawson, Kevin Liu, Maarten Geurts, Marco J Herold, Hans Clevers, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2019  |  JNCI: Journal of the National Cancer Institute

Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Em..

Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Anne C Rios, Bianca D Capaldo, Francois Vaillant, Bhupinder Pal, Ravian van Ineveld, Caleb A Dawson, Yunshun Chen, Emma Nolan, Nai Yang Fu, Felicity C Jackling, Sapna Devi, David Clouston, Lachlan Whitehead, Gordon K Smyth, Scott N Mueller, Geoffrey J Lindeman, Jane E Visvader, Jamie R Flynn, William M Palmer, Antony P Martin, et al.

Journal article  |  2019  |  Cancer Cell

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Journal article  |  2019  |  Nature Communications

Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer

Stefano Annunziato, Julian R de Ruiter, Linda Henneman, Chiara S Brambillasca, Catrin Lutz, Francois Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjorn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H van Miltenburg, Ivo J Huijbers, Marieke van de Ven, Jane E Visvader, Geoffrey J Lindeman, Lodewyk FA Wessels, Jos Jonkers

Journal article  |  2019  |  Nature Communications

Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Nai Yang Fu, Bhupinder Pal, Yunshun Chen, Felicity C Jackling, Michael Milevskiy, Francois Vaillant, Bianca D Capaldo, Fusheng Guo, Kevin H Liu, Anne C Rios, Nicholas Lim, Andrew J Kueh, David M Virshup, Marco J Herold, Haley O Tucker, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2018  |  Developmental Cell

Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells

Petra Augstein, Thomas Loudovaris, Esther Bandala-Sanchez, Peter Heinke, Gaetano Naselli, Lily Lee, Wayne J Hawthorne, L Jorge Gonez, Alana M Neale, Francois Vaillant, Helen E Thomas, Thomas W Kay, Ilia Banakh, Leonard C Harrison

Journal article  |  2018  |  Pancreas

Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Paul Jamieson, Lavinia Gordon, Anne C Rios, Stephen Wilcox, Naiyang Fu, Kevin He Liu, Felicity C Jackling, Melissa J Davis, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2017  |  Nature Communications

RE: Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Emma Nolan, Francois Vaillant, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2017  |  JNCI: Journal of the National Cancer Institute

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science Translational Medicine

Identification of quiescent and spatially restricted mammary stem cells that are hormone responsive

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Charity W Law, Paul Jamieson, Ruijie Liu, Francois Vaillant, Felicity Jackling, Kevin He Liu, Gordon K Smyth, Geoffrey J Lindeman, Matthew E Ritchie, Jane E Visvader

Journal article  |  2017  |  Nature Cell Biology

RANK ligand as a target for breast cancer prevention in BRCA1 mutation carriers

GJ Lindeman, E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, GB Mann, K Rohrbach, L-Y Huang, R Soriano, GK Smyth, WC Dougall, JE Visvader

Conference Proceedings  |  2017  |  General Session Abstracts

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Lacey E Dobrolecki, Susie D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, et al.

Journal article  |  2016  |  Cancer and Metastasis Reviews

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

Emma Nolan, Francois Vaillant, Daniel Branstetter, Bhupinder Pal, Goeknur Giner, Lachlan Whitehead, Sheau W Lok, Gregory B Mann, Kathy Rohrbach, Li-Ya Huang, Rosalia Soriano, Gordon K Smyth, William C Dougall, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2016  |  Nature Medicine

Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2

D Merino, SA Best, M-L Asselin-Labat, F Vaillant, B Pal, RA Dickins, RL Anderson, A Strasser, P Bouillet, GJ Lindeman, JE Visvader

Journal article  |  2015  |  Oncogene

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, Francois Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2015  |  BMC Cancer

EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival

Nai Yang Fu, Anne C Rios, Bhupinder Pal, Rina Soetanto, Aaron TL Lun, Kevin Liu, Tamara Beck, Sarah A Best, Francois Vaillant, Philippe Bouillet, Andreas Strasser, Thomas Preiss, Gordon K Smyth, Rey J Lindeman, Jane E Visvader

Journal article  |  2015  |  Nature Cell Biology

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

Sarah A Best, Karla J Hutt, Nai Yang Fu, Francois Vaillant, Seng H Liew, Lynne Hartley, Clare L Scott, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2014  |  Development

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2013  |  Cancer Cell

Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2

Bhupinder Pal, Toula Bouras, Wei Shi, Francois Vaillant, Julie M Sheridan, Naiyang Fu, Kelsey Breslin, Kun Jiang, Matthew E Ritchie, Matthew Young, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2013  |  Cell Reports

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal Cells

Peter Eirew, Nagarajan Kannan, David JHF Knapp, Francois Vaillant, Joanne T Emerman, Geoffrey J Lindeman, Jane E Visvader, Connie J Eaves

Journal article  |  2012  |  Stem Cells

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Molecular and Cellular Biology

Proteomic profiling of secretome and adherent plasma membranes from distinct mammary epithelial cell subpopulations

Hong Ji, Robert JA Goode, Francois Vaillant, Suresh Mathivanan, Eugene A Kapp, Rommel A Mathias, Geoffrey J Lindeman, Jane E Visvader, Richard J Simpson

Journal article  |  2011  |  Proteomics

Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Breast Cancer Research

ROAST: rotation gene set tests for complex microarray experiments

Di Wu, Elgene Lim, Francois Vaillant, Marie-Liesse Asselin-Labat, Jane E Visvader, Gordon K Smyth

Journal article  |  2010  |  Bioinformatics

Runx2 in normal tissues and cancer cells: A developing story

Karen Blyth, Francois Vaillant, Alma Jenkins, Laura McDonald, Marie Anne Pringle, Camille Huser, Torsten Stein, James Neil, Ewan R Cameron

Journal article  |  2010  |  BLOOD CELLS MOLECULES AND DISEASES

Control of mammary stem cell function by steroid hormone signalling

Marie-Liesse Asselin-Labat, Francois Vaillant, Julie M Sheridan, Bhupinder Pal, Di Wu, Evan R Simpson, Hisataka Yasuda, Gordon K Smyth, T John Martin, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2010  |  Nature

Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

Elgene Lim, Di Wu, Bhupinder Pal, Toula Bouras, Marie-Liesse Asselin-Labat, Francois Vaillant, Hideo Yagita, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2010  |  Breast Cancer Research

Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers

Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara L Britt, Francois Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John, Gail P Risbridger

Journal article  |  2009  |  Stem Cells

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Nature Medicine

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

Toula Bouras, Bhupinder Pal, Francois Vaillant, Gwyndolen Harburg, Marie-Liesse Asselin-Labat, Samantha R Oakes, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CELL STEM CELL

The mammary progenitor marker CD61/beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2008  |  CANCER RESEARCH

Delineating the Epithelial Hierarchy in the Mouse Mammary Gland

M-L Asselin-Labat, F Vaillant, M Shackleton, T Bouras, GJ Lindeman, JE Visvader

Journal article  |  2008  |  Cold Spring Harbor Symposia on Quantitative Biology

The emerging picture of the mouse mammary stem cell

Francois Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2007  |  Stem Cell Reviews

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3

Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  The EMBO Journal

Steroid hormone receptor status of mouse mammary stem cells

Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, Francois Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2006  |  JOURNAL OF THE NATIONAL CANCER INSTITUTE

Purification and unique properties of mammary epithelial stem cells

J Stingl, P Eirew, I Ricketson, M Shackleton, F Vaillant, D Choi, HYI Li, CJ Eaves

Journal article  |  2006  |  NATURE

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo

K Blyth, F Vaillant, L Hanlon, N Mackay, M Bell, A Jenkins, JC Neil, ER Cameron

Journal article  |  2006  |  Cancer Research

Generation of a functional mammary gland from a single stem cell

M Shackleton, F Vaillant, KJ Simpson, J Stingl, GK Smyth, ML Asselin-Labat, L Wu, GJ Lindeman, JE Visvader

Journal article  |  2006  |  Nature

Conservation and expression of an alternative 3 ' exon of Runx2 encoding a novel proline-rich C-terminal domain

A Terry, A Kilbey, F Vaillant, M Stewart, A Jenkins, E Cameron, JC Neil

Journal article  |  2004  |  Gene

Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (rho0).

Safarina G Malik, François Vaillant, Alfons Lawen

Journal article  |  2004  |  BioFactors

The mammalian plasma membrane (PM) NADH-oxidoreductase (PMOR) system is a multi-enzyme complex located in the plasma membrane of a..

The Runx genes as dominant oncogenes

ER Cameron, K Blyth, L Hanlon, A Kilbey, N Mackay, M Stewart, A Terry, F Vaillant, S Wotton, JC Neil

Conference Proceedings  |  2003  |  Blood Cells, Molecules, and Diseases

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma

S Wotton, M Stewart, K Blyth, F Vaillant, A Kilbey, JC Neil, ER Cameron

Journal article  |  2002  |  Cancer Research

Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection

F Vaillant, K Blyth, L Andrew, JC Neil, ER Cameron

Journal article  |  2002  |  The Journal of Immunology

Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis.

DR Grubb, JD Ly, F Vaillant, KL Johnson, A Lawen

Journal article  |  2001  |  Oncogene

Permeability transition, and a subsequent drop in mitochondrial membrane potential (DeltaPsi(m)), have been suggested to be mechan..

Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging

K Blyth, A Terry, N Mackay, F Vaillant, M Bell, ER Cameron, JC Neil, M Stewart

Journal article  |  2001  |  Oncogene

A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc.

F Vaillant, K Blyth, A Terry, M Bell, ER Cameron, J Neil, M Stewart

Journal article  |  1999  |  Oncogene

The Cbfa1/PEBP2 alpha A/AML3 gene plays an essential role in osteogenesis but is also expressed in the T-cell lineage where it has..

Effectors of the mammalian plasma membrane NADH-oxidoreductase system. Short-chain ubiquinone analogues as potent stimulators.

F Vaillant, JA Larm, GL McMullen, EJ Wolvetang, A Lawen

Journal article  |  1996  |  Journal of Bioenergetics and Biomembranes

In the presence of effectors variations in the two recognized activities of the plasma membrane NADH-oxidoreductase system were st..

Protein tyrosine kinase inhibitors prevent didemnin B-induced apoptosis in HL-60 cells.

KL Johnson, F Vaillant, A Lawen

Journal article  |  1996  |  FEBS Letters

Didemnin B induces rapid apoptosis in human promyeloid HL-60 cells with an optimal concentration of 1 microM (Grubb et al. (1995) ..

Reversible denaturation of cyclosporin synthetase by urea.

J Dittmann, F Vaillant, H Kleinkauf, A Lawen

Journal article  |  1996  |  FEBS Letters

The reversible denaturation of the multifunctional polypeptide, cyclosporin synthetase, by urea was analyzed. It is possible to di..

Human cell mutants with very low mitochondrial DNA copy number (rho d).

F Vaillant, P Nagley

Journal article  |  1995  |  Human Molecular Genetics

Mutants of human Namalwa cells are described, denoted rho d (mtDNA-depleted), which contain a very low mtDNA copy number. Three is..

Increase of plasma membrane oxidoreductase activity is not correlated with the production of extracellular Superoxide radicals in human Namalwa cells

JA Larm, EJ Wolvetang, F Vaillant, RD Martinus, A Lawen, AW Linnane

Journal article  |  1995  |  Protoplasma

Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells.

JA Larm, F Vaillant, AW Linnane, A Lawen

Journal article  |  1994  |  Journal of Biological Chemistry

We have studied aspects of the regulatory interrelationship between the plasma membrane oxidoreductase (PMOR) system and the mitoc..

The universality of bioenergetic disease: the role of mitochondrial mutation and the putative inter-relationship between mitochondria and plasma membrane NADH oxidoreductase.

A Lawen, RD Martinus, GL McMullen, P Nagley, F Vaillant, EJ Wolvetang, AW Linnane

Journal article  |  1994  |  Molecular Aspects of Medicine

Mitochondrial DNA mutation associated with aging and degenerative disease.

P Nagley, IR Mackay, A Baumer, RJ Maxwell, F Vaillant, ZX Wang, C Zhang, AW Linnane

Journal article  |  1992  |  Annals of the New York Academy of Sciences

Previous theories of aging based on somatic mutation neglected mtDNA, which has a high propensity for mutational error. Knowledge ..

Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays.

BE Loveland, TG Johns, IR Mackay, F Vaillant, ZX Wang, PJ Hertzog

Journal article  |  1992  |  Biochemistry International

Increasing use is being made of colorimetric assays to quantitate viable cells, e.g., the cellular reduction of the tetrazolium sa..

Some biochemical properties of human lymphoblastoid Namalwa cells grown anaerobically.

F Vaillant, BE Loveland, P Nagley, AW Linnane

Journal article  |  1991  |  Biochemistry International

Using cultured lymphoblastoid Namalwa cells, we have demonstrated that humans cells can be grown for long periods in the absence o..