Emma Carrington

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G House, Kevin Sek, Melissa A Henderson, Lauren Giuffrida, Amanda XY Chen, Kirsten L Todd, Emma Petley, Jack D Chan, Emma M Carrington, Andrew M Lew, Benjamin J Solomon, Joseph A Trapani, Katherine Kedzierska, Maximilien Evrard, Stephin J Vervoort, Jason Waithman, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  Nature Immunology

Adoptive cell therapies using genetically engineered T cell receptor or chimeric antigen receptor T cells are emerging forms of im..

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  Cell Death & Differentiation

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

Li Sun, Jai Rautela, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Emma M Carrington, Robyn L Schenk, Marco J Herold, Nicholas D Huntington, Andrew M Lew, Yuekang Xu, Yifan Zhan

Journal article  |  2018  |  Frontiers in Immunology

Life and Death of Activated T Cells: How Are They Different from Naive T Cells?

Yifan Zhan, Emma M Carrington, Yuxia Zhang, Susanne Heinzel, Andrew M Lew

Journal article  |  2017  |  Frontiers in Immunology

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules

Emma M Carrington, David M Tarlinton, Daniel H Gray, Nicholas D Huntington, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  Immunology & Cell Biology

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger

Journal article  |  2017  |  Nature Communications

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  Cell Death & Differentiation

Cognate antigen engagement on parenchymal cells stimulates CD8( ) T cell proliferation in situ

Robyn M Sutherland, Sarah L Londrigan, Jamie L Brady, Emma M Carrington, Julia M Marchingo, Susanne Heinzel, Philip D Hodgkin, Kate L Graham, Thomas W Kay, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  Nature Communications

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation

Kevin V Chow, Emma M Carrington, Yifan Zhan, Andrew M Lew, Robyn M Sutherland

Journal article  |  2017  |  Cell Transplantation

MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Ingela B Vikstrom, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, JH Marco Jansen, Jeanette HW Leusen, Andreas Strasser, David CS Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton

Journal article  |  2016  |  Cell Death & Disease

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Emma M Carrington, Jian-Guo Zhang, Robyn M Sutherland, Ingela B Vikstrom, Jamie L Brady, Priscilla Soo, David Vremec, Cody Allison, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Stephanie Grabow, Eleonora Ottina, Marco J Herold, Marc Pellegrini, David CS Huang, David M Tarlinton, Andreas Strasser, Andrew M Lew, Yifan Zhan

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production

Yifan Zhan, Emma M Carrington, Hyun-Ja Ko, Ingela B Vikstrom, Shereen Oon, Jian-Guo Zhang, David Vremec, Jamie L Brady, Philippe Bouillet, Li Wu, David CS Huang, Ian P Wicks, Eric F Morand, Andreas Strasser, Andrew M Lew

Journal article  |  2015  |  Arthritis & Rheumatology

The Closely Related CD103( ) Dendritic Cells (DCs) and Lymphoid-Resident CD8( ) DCs Differ in Their Inflammatory Functions

Zhijun Jiao, Sammy Bedoui, Jamie L Brady, Anne Walter, Michael Chopin, Emma M Carrington, Robyn M Sutherland, Stephen L Nutt, Yuxia Zhang, Hyun-Ja Ko, Li Wu, Andrew M Lew, Yifan Zhan

Journal article  |  2014  |  PLoS One

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M Carrington, Lina Happo, Warren S Alexander, Jian-Guo Zhang, Marco J Herold, Clare L Scott, Andrew M Lew, Andreas Strasser, Philip D Hodgkin

Journal article  |  2013  |  Nature Communications

Influenza-induced, helper-independent CD8( ) T cell responses use CD40 costimulation at the late phase of the primary response

Shirley GK Seah, Jamie L Brady, Emma M Carrington, Wy Ching Ng, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Andrew M Lew, Yifan Zhan

Journal article  |  2013  |  Journal of Leukocyte Biology

The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells

Yifan Zhan, Javier Vega-Ramos, Emma M Carrington, Jose A Villadangos, Andrew M Lew, Yuekang Xu

Journal article  |  2012  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Shutdown of immunological priming and presentation after in vivo administration of adenovirus

RM Sutherland, SL Londrigan, JL Brady, H Azher, EM Carrington, Y Zhan, J Vega-Ramos, JA Villadangos, AM Lew

Journal article  |  2012  |  Gene Therapy

Unlike CD4( ) T-cell help, CD28 costimulation is necessary for effective primary CD8( ) T-cell influenza-specific immunity

Shirley GK Seah, Emma M Carrington, Wy C Ng, Gabrielle T Belz, Jamie L Brady, Robyn M Sutherland, Manuela S Hancock, Nicole L La Gruta, Lorena E Brown, Stephen J Turner, Yifan Zhan, Andrew M Lew

Journal article  |  2012  |  EUROPEAN JOURNAL OF IMMUNOLOGY

GM-CSF increases cross-presentation and CD103 expression by mouse CD8( ) spleen dendritic cells

Yifan Zhan, Emma M Carrington, Annemarie van Nieuwenhuijze, Sammy Bedoui, Shirley Seah, Yuekang Xu, Nancy Wang, Justine D Mintern, Jose A Villadangos, Ian P Wicks, Andrew M Lew

Journal article  |  2011  |  European Journal of Immunology

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

Jonathan Chee, Eveline Angstetra, Lina Mariana, Kate L Graham, Emma M Carrington, Horst Bluethmann, Pere Santamaria, Janette Allison, Thomas WH Kay, Balasubramanian Krishnamurthy, Helen E Thomas

Journal article  |  2011  |  Journal of Immunology

Reducing or increasing beta-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice

Emma M Carrington, Cameron Kos, Yifan Zhan, Balasubramanian Krishnamurthy, Janette Allison

Journal article  |  2011  |  European Journal of Immunology

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival

Robyn M Sutherland, Yifan Zhan, Emma M Carrington, Sarah L Londrigan, Andrew M Lew

Journal article  |  2011  |  Cell Transplant.

Resident and Monocyte-Derived Dendritic Cells Become Dominant IL-12 Producers under Different Conditions and Signaling Pathways

Yifan Zhan, Yuekang Xu, Shirley Seah, Jamie L Brady, Emma M Carrington, Christina Cheers, Ben A Croker, Li Wu, Jose A Villadangos, Andrew M Lew

Journal article  |  2010  |  Journal of Immunology

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

Emma M Carrington, Ingela B Vikstrom, Amanda Light, Robyn M Sutherland, Sarah L Londrigan, Kylie D Mason, David CS Huang, Andrew M Lew, David M Tarlinton

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Role of regulatory T cells in xenotransplantation

Philip J O'Connell, Shounan Yi, Emma M Carrington, Andrew M Lew

Journal article  |  2010  |  Curr. Opin. Organ Transplant.

Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells

Susan Johnson, Yifan Zhan, Robyn M Sutherland, Adele M Mount, Sammy Bedoui, Jamie L Brady, Emma M Carrington, Lorena E Brown, Gabrielle T Belz, William R Heath, Andrew M Lew

Journal article  |  2009  |  Immunity