John Silke

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Najoua Lalaoui, Delphine Merino, Goknur Giner, Francois Vaillant, Diep Chau, Lin Liu, Tobias Kratina, Bhupinder Pal, James R Whittle, Nima Etemadi, Jean Berthelet, Julius Grasel, Cathrine Hall, Matthew E Ritchie, Matthias Ernst, Gordon K Smyth, David L Vaux, Jane E Visvader, Geoffrey J Lindeman, John Silke

Journal article  |  2020  |  Cell Death & Differentiation

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Her..

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Gregor Ebert, Sash Lopaticki, Matthew T O'Neill, Ryan WJ Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie SP Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A Boddey

Journal article  |  2020  |  Cell Reports

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatoc..

Future Therapeutic Directions for Smac-Mimetics

Emma Morrish, Gabriela Brumatti, John Silke

Journal article  |  2020  |  Cells

It is well accepted that the ability of cancer cells to circumvent the cell death program that untransformed cells are subject to ..

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Najoua Lalaoui, Steven E Boyden, Hirotsugu Oda, Geryl M Wood, Deborah L Stone, Diep Chau, Lin Liu, Monique Stoffels, Tobias Kratina, Kate E Lawlor, Kristien JM Zaal, Patrycja M Hoffmann, Nima Etemadi, Kristy Shield-Artin, Christine Biben, Wanxia Li Tsai, Mary D Blake, Hye Sun Kuehn, Dan Yang, Holly Anderton, et al.

Journal article  |  2020  |  Nature

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post..

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy

Jessica Michie, Conor J Kearney, Edwin D Hawkins, John Silke, Jane Oliaro

Journal article  |  2020  |  Cells

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The inhibitor of apoptosis proteins (IAPs..

Antagonism of IAPs enhances CAR T cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, EJ Lelliott, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Antagonism of inhibitor of apoptosis proteins enhances CAR T-cell efficacy

J Michie, PA Beavis, AJ Freeman, SJ Vervoort, KM Ramsbottom, V Narasimhan, N Lalaoui, RG Ramsay, RW Johnstone, J Silke, PK Darcy, I Voskoboinik, CJ Kearney, J Oliaro

Conference Proceedings  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

Langerhans cells drive TNF induced chronic proliferative dermatitis in SHARPIN deficient mice

H Anderton, M Chopin, C Dawson, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death, and the microbiome in skin inflammation and disease

H Anderton, G Varigos, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  AUSTRALASIAN JOURNAL OF DERMATOLOGY

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

Journal article  |  2019  |  Cell Death & Differentiation

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs (vol 9, pg 4457, 2018)

Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano

Journal article  |  2019  |  Nature Communications

Targeting XIAP and PPAR gamma in Granulosa Cell Tumors Alters Metabolic Signaling

Dilys TH Leung, Adam Rainczuk, Nguyen Trang, Andrew Stephens, John Silke, Peter J Fuller, Simon Chu

Journal article  |  2019  |  Journal of Proteome Research

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, Alessandro Annibaldi, Arnaud J Legrand, David Robertson, Rebecca Feltham, Holly Anderton, Maurice Darding, Nieves Peltzer, Marius Dannappel, Hannah Schunke, Luca L Fava, Manuel D Haschka, Timo Glatter, Alexey Nesvizhskii, Alexander Schmidt, Philip A Harris, John Bertin, Peter J Gough, et al.

Journal article  |  2019  |  Molecular Cell

Combined PPAR gamma Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

Dilys TH Leung, Trang Nguyen, Edwina May Oliver, Juliana Matti, Maria Alexiadis, John Silke, Thomas W Jobling, Peter J Fuller, Simon Chu

Journal article  |  2019  |  Molecular Cancer Therapeutics

Antagonism of IAPs Enhances CAR T-cell Efficacy

Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliaro

Journal article  |  2019  |  Cancer Immunology Research

Physiological role of linear ubiquitination: more to it than meets the eye

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Lucia Taraborrelli, Amanda Fisher, Tobias L Haas, Yutaka Shimizu, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Ciaran Hutchinson, Charlotta Boiers, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, et al.

Conference Proceedings  |  2019  |  CELL DEATH DISCOVERY

TNF in anti-tumour immunity and resistance to immunotherapy

Jane Oliaro, Conor Kearney, Stephin Vervoort, Simon Hogg, Najoua Lalaoui, Kristin Brown, John Silke, Ricky Johnstone

Conference Proceedings  |  2018  |  CANCER SCIENCE

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, Satomi Adachi-Akahane, Sotaro Uemura, John Silke, Hideo Yagita, Masayuki Miura, Hiroyasu Nakano

Journal article  |  2018  |  Nature Communications

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak

Journal article  |  2018  |  Nature Communications

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation (vol 137, pg 2371, 2017)

Holly Anderton, James A Rickard, George A Varigos, Najoua Lalaoui, John Silke

Journal article  |  2018  |  Journal of Investigative Dermatology

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Katherine A Davies, Maria C Tanzer, Michael DW Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy

Journal article  |  2018  |  Cell Death & Differentiation

The Walrus and the Carpenter: Complex Regulation of Tumor Immunity in Colorectal Cancer

Grant Dewson, John Silke

Journal article  |  2018  |  Cell

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy

Journal article  |  2018  |  Nature Communications

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, et al.

Journal article  |  2018  |  Nature

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

Michael D Stutz, Samar Ojaimi, Cody Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J Sandow, Andrew I Webb, John Silke, Warren S Alexander, Marc Pellegrini

Journal article  |  2018  |  Cell Death & Differentiation

Tumor immune evasion arises through loss of TNF sensitivity

Conor J Kearney, Stephin J Vervoort, Simon J Hogg, Kelly M Ramsbottom, Andrew J Freeman, Najoua Lalaoui, Lizzy Pijpers, Jessica Michie, Kristin K Brown, Deborah A Knight, Vivien Sutton, Paul A Beavis, Ilia Voskoboinik, Phil K Darcy, John Silke, Joseph A Trapani, Ricky W Johnstone, Jane Oliaro

Journal article  |  2018  |  Science Immunology

NOD1 is required for Helicobacter pylori induction of IL-33 responses in gastric epithelial cells

Le Son Tran, Darren Tran, Amanda De Paoli, Kimberley D'Costa, Sarah J Creed, Garrett Z Ng, Lena Le, Philip Sutton, J Silke, U Nachbur, Richard L Ferrero

Journal article  |  2018  |  Cellular Microbiology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V Antonov, Eli Arama, Eric H Baehrecke, Nickolai A Barlev, Nicolas G Bazan, Francesca Bernassola, Mathieu JM Bertrand, Katiuscia Bianchi, Mikhail V Blagosklonny, et al.

Journal article  |  2018  |  Cell Death & Differentiation

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier

Journal article  |  2018  |  Molecular Cell

IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans

Che A Stafford, Kate E Lawlor, Valentin J Heim, Aleksandra Bankovacki, Jonathan P Bernardini, John Silke, Ueli Nachbur

Journal article  |  2018  |  Cell Reports

Methods for Studying TNF-Mediated Necroptosis in Cultured Cells

Zikou Liu, John Silke, Joanne M Hildebrand

Journal article  |  2018  |  Methods in molecular biology (Clifton, N.J.)

Elucidating the 16S rRNA 3 ' boundaries and defining optimal SD/aSD pairing in Escherichia coli and Bacillus subtilis using RNA-Seq data

Yulong Wei, Jordan R Silke, Xuhua Xia

Journal article  |  2017  |  Scientific Reports

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

Holly Anderton, James A Rickard, George A Varigos, Najoua Lalaoui, John Silke

Journal article  |  2017  |  Journal of Investigative Dermatology

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF

Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke, Jane Oliaro

Journal article  |  2017  |  Cell Death & Differentiation

The TNF Receptor Superfamily-NF-kappa B Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F Pascutti, Anna E Oja, Alexandra L Garnham, Renee Gloury, Jessica C Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W Kuijpers, Najoua Lalaoui, Lisa A Mielke, Vanessa L Bryant, Philip D Hodgkin, John Silke, Gordon K Smyth, Martijn A Nolte, Wei Shi, et al.

Journal article  |  2017  |  Cell Reports

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding (vol 285, pg 17525, 2010)

Rebecca L Feltham, Maryline Moulin, James E Vince, Peter D Mace, Wendy Wei-Lynn Wong, Holly Anderton, Catherine L Day, David L Vaux, John Silke

Journal article  |  2017  |  Journal of Biological Chemistry

XIAP Loss Triggers RIPK3-and Caspase-8-Driven IL-1 beta Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation

Kate E Lawlor, Rebecca Feltham, Monica Yabal, Stephanie A Conos, Kaiwen W Chen, Stephanie Ziehe, Carina Grass, Yifan Zhan, Tan A Nguyen, Cathrine Hall, Angelina J Vince, Simon M Chatfield, Damian B D'Silva, Kenneth C Pang, Kate Schroder, John Silke, David L Vaux, Philipp J Jost, James E Vince

Journal article  |  2017  |  Cell Reports

The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes

Rebecca Feltham, John Silke

Journal article  |  2017  |  Cell Death & Differentiation

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke

Journal article  |  2017  |  eLife

Engineered Exosomes as Vehicles for Biologically Active Proteins

Ulrich Sterzenbach, Ulrich Putz, Ley-Hian Low, John Silke, Seong-Seng Tan, Jason Howitt

Journal article  |  2017  |  Molecular Therapy

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier

Journal article  |  2017  |  Molecular Cell

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Jaclyn S Pearson, Cristina Giogha, Sabrina Muhlen, Ueli Nachbur, Chi LL Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, et al.

Journal article  |  2017  |  Nature Microbiology

Combination of IAP antagonist and IFN gamma activates novel caspase-10-and RIPK1-dependent cell death pathways

Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silke

Journal article  |  2017  |  Cell Death & Differentiation

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the `Fearful Symmetry' of Acute Myeloid Leukemia

Gabriela Brumatti, Najoua Lalaoui, Andrew H Wei, John Silke

Journal article  |  2017  |  Trends in Molecular Medicine

Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells

Thomas Grabinger, Konstantin J Bode, Janine Demgenski, Carina Seitz, M Eugenia Delgado, Feodora Kostadinova, Cindy Reinhold, Nima Etemadi, Sabine Wilhelm, Matthias Schweinlin, Kay Hanggi, Janin Knop, Christof Hauck, Heike Walles, John Silke, Harald Wajant, Ueli Nachbur, Wong W Wei-Lynn, Thomas Brunner

Journal article  |  2017  |  Gastroenterology

Jekyll & Hyde: The Other Life of the Death Ligand TRAIL

Najoua Lalaoui, John Silke

Journal article  |  2017  |  Molecular Cell

IAPs and Cell Death

John Silke, James Vince

Book Chapter  |  2017  |  Current Topics in Microbiology and Immunology

In the Midst of Life-Cell Death: What Is It, What Is It Good for, and How to Study It.

John Silke, Ricky W Johnstone

Journal article  |  2016  |  Cold Spring Harbor Protocols

Cell death, one of the most fundamental biological processes, has not made it into the public consciousness in the same way that g..

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  Nature Communications

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  Immunity

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)

Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

Hepatitis C-induced hepatocyte apoptosis following liver transplantation is enhanced by immunosuppressive agents

EJ Lim, R Chin, U Nachbur, J Silke, Z Jia, PW Angus, J Torresi

Journal article  |  2016  |  Journal of Viral Hepatitis

SPATA2-Keeping the TNF signal short and sweet

Rebecca Feltham, Andrew I Webb, John Silke

Journal article  |  2016  |  The EMBO Journal

Evolutionary divergence of the necroptosis effector MLKL

MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, EJ Petrie, AL Mildenhall, DL Vaux, JE Vince, PE Czabotar, J Silke, JM Murphy

Journal article  |  2016  |  Cell Death & Differentiation

The intersection of cell death and inflammasome activation

James E Vince, John Silke

Journal article  |  2016  |  Cellular and Molecular Life Sciences

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.

Journal article  |  2016  |  Science Translational Medicine

Killing Lymphoma with Smac-Mimetics: As Easy as ABC?

Ueli Nachbur, John Silke

Journal article  |  2016  |  Cancer Cell

The importance of being chaperoned: HSP90 and necroptosis

Annette V Jacobsen, John Silke

Journal article  |  2016  |  Cell Chemical Biology

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kB and activation of caspase-8 (vol 286, pg 13282, 2011)

Ian E Gentle, W Wei-Lynn Wong, Joseph M Evans, Alexandra Bankovacki, Wendy D Cook, Nufail R Khan, Ulrich Nachbur, James Rickard, Holly Anderton, Maryline Moulin, Josep Maria Lluis, Donia M Moujalled, John Silke, David L Vaux

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kB and activation of caspase-8 (vol 286, pg 13282, 2011)

Ian E Gentle, W Wei-Lynn Wong, Joseph M Evans, Alexandra Bankovacki, Wendy D Cook, Nufail R Khan, Ulrich Nachbur, James Rickard, Holly Anderton, Maryline Moulin, Josep Maria Lluis, Donia M Moujalled, John Silke, David L Vaux

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappa B and activation of caspase-8 (vol 286, pg 13282, 2011)

Ian E Gentle, W Wei-Lynn Wong, Joseph M Evans, Alexandra Bankovacki, Wendy D Cook, Nufail R Khan, Ulrich Nachbur, James Rickard, Holly Anderton, Maryline Moulin, Josep Maria Lluis, Donia M Moujalled, John Silke, David L Vaux

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, MF van Delft, Z Liu, SA Conos, J-G Zhang, DCS Huang, J Silke, G Lessene, JM Murphy

Journal article  |  2016  |  Cell Death & Disease

TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke

Journal article  |  2015  |  eLife

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Maria C Tanzer, Anne Tripaydonis, Andrew I Webb, Samuel N Young, Leila N Varghese, Cathrine Hall, Warren S Alexander, Joanne M Hildebrand, John Silke, James M Murphy

Journal article  |  2015  |  Biochemical Journal

Response to Heard et al

Maryline Moulin, Anne K Voss, Tim Thomas, Wendy Wei-Lynn Wong, Wendy D Cook, Frank Koentgen, James Vince, John Silke, David L Vaux

Journal article  |  2015  |  The EMBO Journal

Effect of Immunosuppressive Agents on Hepatocyte Apoptosis Post-Liver Transplantation

Eu Jin Lim, Ruth Chin, Ueli Nachbur, John Silke, Zhiyuan Jia, Peter W Angus, Joseph Torresi

Journal article  |  2015  |  PLOS ONE

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

Amelia J Johnston, Kate T Murphy, Laura Jenkinson, David Laine, Kerstin Emmrich, Pierre Faou, Ross Weston, Krishnath M Jayatilleke, Jessie Schloegel, Gert Talbo, Joanne L Casey, Vita Levina, W Wei-Lynn Wong, Helen Dillon, Tushar Sahay, Joan Hoogenraad, Holly Anderton, Cathrine Hall, Pascal Schneider, Maria Tanzer, et al.

Journal article  |  2015  |  Cell

The diverse role of RIP kinases in necroptosis and inflammation (vol 16, pg 930, 2016)

John Silke, James A Rickard, Motti Gerlic

Journal article  |  2015  |  Nature Immunology

The diverse role of RIP kinases in necroptosis and inflammation

John Silke, James A Rickard, Motti Gerlic

Journal article  |  2015  |  Nature Immunology

Fight or flight: regulation of emergency hematopoiesis by pyroptosis and necroptosis

Ben A Croker, John Silke, Motti Gerlic

Journal article  |  2015  |  Current Opinion in Hematology

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

Gregor Ebert, Cody Allison, Simon Preston, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Hamish W Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Lie, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity

Jason Howitt, Ley-Hian Low, Ulrich Putz, Anh Doan, Jenny Lackovic, Choo-Peng Goh, Jenny Gunnersen, John Silke, Seong-Seng Tan

Journal article  |  2015  |  Journal of Molecular Cell Biology

Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response

Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Tan

Journal article  |  2015  |  Journal of Biological Chemistry

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk, Jessica K Holien, Diep Chau, Joanne Hildebrand, James E Vince, Phillip P Sharp, Andrew I Webb, Katherine A Jackman, Sabrina Muehlen, Catherine L Kennedy, Kym N Lowes, et al.

Journal article  |  2015  |  Nature Communications

IAP gene deletion and conditional knockout models

John Silke, David L Vaux

Journal article  |  2015  |  Seminars in Cell & Developmental Biology

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters, Maryam Rashidi, Ian P Wicks, Warren S Alexander, Yasuhiro Mitsuuchi, Christopher A Benetatos, Stephen M Condon, W Wei-Lynn Wong, John Silke, David L Vaux, James E Vince

Journal article  |  2015  |  Nature Communications

Questions & Controversies

J Silke

Journal article  |  2015  |  Cell Death Discovery

CD Discovery

J Silke, G Melino

Journal article  |  2015  |  Cell Death Discovery

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, et al.

Journal article  |  2014  |  eLife

Sharpin is a key regulator of skeletal homeostasis in a TNF-dependent manner

HW McGowan, JA Schuijers, BL Grills, SJ McDonald, JA Rickard, J Silke, AC McDonald

Journal article  |  2014  |  Journal of Musculoskeletal Neuronal Interactions

Inhibitor of apoptosis (IAP) proteins ubiquitylate RIP3 kinase and repress apoptosis, necroptosis, NLRP3 inflammasome activation and systemic inflammation

Kate Lawlor, Alison Mildenhall, Stephen Condon, John Silke, David Vaux, James Vince

Conference Proceedings  |  2014  |  Cytokine

IFN gamma and Smac mimetics induce synergistic killing via necroptosis and apoptosis

Maria Tanzer, Nufail Khan, James Rickard, Nima Etemadi, John Silke

Conference Proceedings  |  2014  |  Cytokine

PPAR-GAMMA AGONISTS AUGMENT ANTICANCER EFFECTS OF XIAP INHIBITION ON HUMAN OVARIAN GRANULOSA CELL TUMOR-DERIVED CELLS

S Chu, DTH Leung, E Oliver, M Alexiadis, J Silke, PJ Fuller

Conference Proceedings  |  2014  |  INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

TRAF2 regulates NF kappa B transcription factors to inhibit cell death and inflammation in the skin

Nima Etemadi, James Rickard, Holly Anderton, Sukhdeep Spall, Catherin Hall, David Vaux, Ueli Nachbur, John Silke

Conference Proceedings  |  2014  |  Cytokine

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

Nieves Peltzer, Eva Rieser, Lucia Taraborrelli, Peter Draber, Maurice Darding, Barbara Pemaute, Yutaka Shimizu, Aida Sarr, Helena Draberova, Antonella Montinaro, Juan Pedro Martinez-Barbera, John Silke, Tristan A Rodriguez, Henning Walczak

Journal article  |  2014  |  Cell Reports

The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8: RIPK1 complex via p38MAPK pathway

Gurpreet Singh Kapoor, Christopher A Benetatos, Yasuhiro Mitsuuchi, Eric M Neiman, Guangyao Yu, Mark A Mckinlay, Jennifer Burns, John Silke, Stephen M Condon, Srinivas K Chunduru

Conference Proceedings  |  2014  |  Molecular and Cellular Biology

Hepatitis C virus-induced hepatocyte cell death and protection by inhibition of apoptosis

Eu Jin Lim, Korri El Khobar, Ruth Chin, Linda Earnest-Silveira, Peter W Angus, C-Thomas Bock, Ueli Nachbur, John Silke, Joseph Torresi

Journal article  |  2014  |  Journal of General Virology

The polycomb repressive complex 2 governs life and death of peripheral T cells

Yuxia Zhang, Sarah Kinkel, Jovana Maksimovic, Esther Bandala-Sanchez, Maria C Tanzer, Gaetano Naselli, Jian-Guo Zhang, Yifan Zhan, Andrew M Lew, John Silke, Alicia Oshlack, Marnie E Blewitt, Leonard C Harrison

Journal article  |  2014  |  Blood

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Stephen M Condon, Yasuhiro Mitsuuchi, Yijun Deng, Matthew G LaPorte, Susan R Rippin, Thomas Haimowitz, Matthew D Alexander, Pavan Tirunahari Kumar, Mukta S Hendi, Yu-Hua Lee, Christopher A Benetatos, Guangyao Yu, Gurpreet Singh Kapoor, Eric Neiman, Martin E Seipel, Jennifer M Burns, Martin A Graham, Mark A McKinlay, Xiaochun Li, Jiawei Wang, et al.

Journal article  |  2014  |  Journal of Medicinal Chemistry

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner

W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke

Journal article  |  2014  |  Blood

Progranulin inhibition of TNF alpha Response

Nima Etemadi, John Silke, Ueli Nachbur

Journal article  |  2014  |  Immunology and Cell Biology

Is SIRT2 required for necroptosis?

Kim Newton, Joanne M Hildebrand, Zhirong Shen, Diego Rodriguez, Silvia Alvarez-Diaz, Sean Petersen, Saumil Shah, Debra L Dugger, Chunzi Huang, Johan Auwerx, Peter Vandenabeele, Douglas R Green, Avi Ashkenazi, Vishva M Dixit, William J Kaiser, Andreas Strasser, Alexei Degterev, John Silke

Journal article  |  2014  |  Nature

Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death

James M Murphy, John Silke

Journal article  |  2014  |  EMBO Reports

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar

Journal article  |  2014  |  Biochemical Journal

IAPs and Necroptotic Cell Death

John Silke, David Vaux

Book Chapter  |  2014

IAP Family of Cell Death and Signaling Regulators

John Silke, Domagoj Vucic

Journal article  |  2014  |  Methods in enzymology

Necroptotic Death Of RIPK1-Deficient HSC Compromises Hematopoiesis

Ben A Croker, O'Donnell A Joanne, Donald Metcalf, Rickard James, Joseph Evans, Seth L Masters, Andrew W Roberts, Motti Gerlic, John Silke

Conference Proceedings  |  2013  |  Blood

An appointment with death,(SIC): 2013 Cold Spring Harbor Asia meeting 'Mechanisms and Functions of Non-Apoptotic Cell Death'

JM Hildebrand, L Sun, J Silke

Journal article  |  2013  |  Cell Death & Differentiation

Progranulin does not inhibit TNF and lymphotoxin-alpha signalling through TNF receptor 1

Nima Etemadi, Andrew Webb, Aleksandra Bankovacki, John Silke, Ueli Nachbur

Journal article  |  2013  |  Immunology and Cell Biology

Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor

Nima Etemadi, Jessica K Holien, Diep Chau, Grant Dewson, James M Murphy, Warren S Alexander, Michael W Parker, John Silke, Ueli Nachbur

Journal article  |  2013  |  The FEBS Journal

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

A type III effector antagonizes death receptor signalling during bacterial gut infection

Jaclyn S Pearson, Cristina Giogha, Sze Ying Ong, Catherine L Kennedy, Michelle Kelly, Keith S Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare VL Oates, Ali Zaid, Sabrina Muehlen, Valerie F Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A Williamson, Lorraine A O'Reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, et al.

Journal article  |  2013  |  Nature

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

V Sagulenko, SJ Thygesen, DP Sester, A Idris, JA Cridland, PR Vajjhala, TL Roberts, K Schroder, JE Vince, JM Hill, J Silke, KJ Stacey

Journal article  |  2013  |  Cell Death & Differentiation

CLL cells are resistant to smac mimetics because of an inability to form a ripoptosome complex

C Maas, JM Tromp, J van Laar, R Thijssen, JA Elias, A Malara, A Krippner-Heidenreich, J Silke, MHJ van Oers, E Eldering

Journal article  |  2013  |  Cell Death & Disease

Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling

John Silke, Elizabeth L Hartland

Journal article  |  2013  |  Current Opinion in Immunology

Inhibitor of Apoptosis (IAP) Proteins-Modulators of Cell Death and Inflammation

John Silke, Pascal Meier

Journal article  |  2013  |  Cold Spring Harbor Perspectives in Biology

The FLIP Side of Life

John Silke, Andreas Strasser

Journal article  |  2013  |  Science Signaling

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Ulrich Putz, Jason Howitt, Anh Doan, Choo-Peng Goh, Ley-Hian Low, John Silke, Seong-Seng Tan

Journal article  |  2012  |  Science Signaling

Is BID required for NOD signalling?

Ueli Nachbur, James E Vince, Lorraine A O'Reilly, Andreas Strasser, John Silke

Journal article  |  2012  |  Nature

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel, Juergen Ruland, Simon Bekker-Jensen, Niels Mailand, Thomas Kaufmann, Andreas Strasser, Henning Walczak, John Silke, Philipp J Jost, Mads Gyrd-Hansen

Journal article  |  2012  |  Molecular Cell

IAPS and ubiquitylation

Rebecca Feltham, Nufail Khan, John Silke

Journal article  |  2012  |  IUBMB Life

Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke

Jenny Lackovic, Jason Howitt, Jennifer K Callaway, John Silke, Perry Bartlett, Seong-Seng Tan

Journal article  |  2012  |  Experimental Neurology

IAPs limit activation of RIP kinases by TNF receptor 1 during development

Maryline Moulin, Holly Anderton, Anne K Voss, Tim Thomas, Wendy Wei-Lynn Wong, Aleksandra Bankovacki, Rebecca Feltham, Diep Chau, Wendy D Cook, John Silke, David L Vaux

Journal article  |  2012  |  EMBO Journal

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

JJ Sandow, AM Jabbour, MR Condina, CP Daunt, FC Stomski, BD Green, CD Riffkin, P Hoffmann, MA Guthridge, J Silke, AF Lopez, PG Ekert

Journal article  |  2012  |  Cell Death & Differentiation

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

James E Vince, W Wei-Lynn Wong, Ian Gentle, Kate E Lawlor, Ramanjaneyulu Allam, Lorraine O'Reilly, Kylie Mason, Olaf Gross, Stephen Ma, Greta Guarda, Holly Anderton, Rosa Castillo, Georg Haecker, John Silke, Juerg Tschopp

Journal article  |  2012  |  Immunity

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

Jason Howitt, Jenny Lackovic, Ley-Hian Low, Adam Naguib, Alison Macintyre, Choo-Peng Goh, Jennifer K Callaway, Vicki Hammond, Tim Thomas, Matthew Dixon, Ulrich Putz, John Silke, Perry Bartlett, Baoli Yang, Sharad Kumar, Lloyd C Trotman, Seong-Seng Tan

Journal article  |  2012  |  Journal of Cell Biology

IAPs, TNF, inflammation and Jurg TSCHOPP; a personal perspective

J Silke, JE Vince

Journal article  |  2012  |  Cell Death & Differentiation

The regulation of TNF signalling: what a tangled web we weave

John Silke

Journal article  |  2011  |  Current Opinion in Immunology

Inhibition of NOD2 signalling by mutations in the RING domain of XIAP contribute to development of X-linked lymphoproliferative syndrome

M Yabal, RB Damgaard, U Nachbur, J Ruland, C Peschel, A Strasser, J Silke, M Gyrd-Hansen, PJ Jost

Conference Proceedings  |  2011  |  ONKOLOGIE

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

M Darding, R Feltham, T Tenev, K Bianchi, C Benetatos, J Silke, P Meier

Journal article  |  2011  |  Cell Death & Differentiation

LINEAR UBIQUITINATION PREVENTS INFLAMMATION AND REGULATES IMMUNE SIGNALLING

B Gerlach, S Cordier, AC Schmukle, CH Emmerich, E Rieser, TL Haas, AI Webb, JA Rickard, H Anderton, WW-L Wong, U Nachbur, L Gangoda, U Warnken, AW Purcell, J Silke, H Walczak

Conference Proceedings  |  2011  |  INFLAMMATION RESEARCH

Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization

Rebecca Feltham, Bodhi Bettjeman, Rhesa Budhidarmo, Peter D Mace, Sarah Shirley, Stephen M Condon, Srinivas K Chunduru, Mark A McKinlay, David L Vaux, John Silke, Catherine L Day

Journal article  |  2011  |  J. Biol. Chem.

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-kappa B and Activation of Caspase-8

Ian E Gentle, W Wei-Lynn Wong, Joseph M Evans, Alexandra Bankovacki, Wendy D Cook, Nufail R Khan, Ulrich Nachbur, James Rickard, Holly Anderton, Maryline Moulin, Josep Maria Lluis, Donia M Moujalled, John Silke, David L Vaux

Journal article  |  2011  |  J. Biol. Chem.

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

Sandra Gardam, Vivian M Turner, Holly Anderton, Sandhya Limaye, Antony Basten, Frank Koentgen, David L Vaux, John Silke, Robert Brink

Journal article  |  2011  |  Blood

Linear ubiquitination prevents inflammation and regulates immune signalling

Bjoern Gerlach, Stefanie M Cordier, Anna C Schmukle, Christoph H Emmerich, Eva Rieser, Tobias L Haas, Andrew I Webb, James A Rickard, Holly Anderton, Wendy W-L Wong, Ueli Nachbur, Lahiru Gangoda, Uwe Warnken, Anthony W Purcell, John Silke, Henning Walczak

Journal article  |  2011  |  Nature

HEPATITIS B VIRUS INDUCES LOSS OF CIAP1 AND SENSITIVITY TO TNF-ALPHA IN PRIMARY HEPATOCYTES

U Nachbur, R Chin, M Nguyen, A Bankovacki, L Earnest-Silveira, C-T Bock, J Silke, J Torresi

Conference Proceedings  |  2011  |  Journal of Hepatology

DYSREGULATION OF HEPATOCYTE SIGNAL TRANSDUCTION, CIAP1 AND APOPTOSIS BY HEPATITIS C VIRUS

K El Khobar, R Chin, L Earnest-Silveira, U Nachbur, J Silke, C-T Bock, J Torresi

Conference Proceedings  |  2011  |  Journal of Hepatology

THE cIAP1 AND cIAP2 INTERACTING DOMAIN OF TRAF2 IS IMPORTANT FOR TNF AND TWEAK INDUCED NF-kappa B AND PROTECTION AGAINST TNF INDUCED APOPTOSIS

James E Vince, Rebecca Feltham, Delara Panthaki, Maria Miasari, John Silke

Conference Proceedings  |  2011  |  ADVANCES IN TNF FAMILY RESEARCH

XIAP LOSS CONVERTS FAS-INDUCED APOPTOSIS SIGNALING IN HEPATOCYTES FROM TYPE II INTO TYPE I

Philipp J Jost, John Silke, Stephanie Grabow, David CS Huang, Philippe Bouillet, Christoph Borner, Andreas Strasser, Thomas Kaufmann

Conference Proceedings  |  2011  |  ADVANCES IN TNF FAMILY RESEARCH

A NOVEL UBIQUITIN LIGASE RECRUITED TO THE TNF-R1 SIGNALLING COMPLEX IS REQUIRED FOR EFFICIENT TNF-INDUCED NF-kappa B ACTIVATION AND GENE INDUCTION

Tobias L Haas, Christoph H Emmerich, Bjoern Gerlach, Uwe Warnken, Till Wenger, Ronald Koschny, John Silke, Henning Walczak

Conference Proceedings  |  2011  |  ADVANCES IN TNF FAMILY RESEARCH

Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs

John Silke, Domagoj Vucic

Conference Proceedings  |  2011  |  Advances in Experimental Medicine and Biology

New Perspectives in TNF-R1-Induced NF-kappa B Signaling

Ian E Gentle, John Silke

Conference Proceedings  |  2011  |  Advances in Experimental Medicine and Biology

Systematic In Vivo RNAi Analysis Identifies IAPs as NEDD8-E3 Ligases

Meike Broemer, Tencho Tenev, Kristoffer TG Rigbolt, Sophie Hempel, Blagoy Blagoev, John Silke, Mark Ditzel, Pascal Meier

Journal article  |  2010  |  Molecular Cell

Anti-cancer SMAC-mimetic compounds accelerate hepatocyte cell death upon FAS or TNF-alpha signalling

PJ Jost, U Nachbur, S Grabow, DC Huang, P Bouillet, J Silke, A Strasser, T Kaufmann

Conference Proceedings  |  2010  |  ONKOLOGIE

In vivo control of B-cell survival and antigen-specific B-cell responses

Tyani D Chan, Sandra Gardam, Dominique Gatto, Vivian M Turner, John Silke, Robert Brink

Journal article  |  2010  |  Immunological Reviews

c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18

Yvonne YC Yeap, Ivan HW Ng, Bahareh Badrian, Tuong-Vi Nguyen, Yan Y Yip, Amardeep S Dhillon, Steven E Mutsaers, John Silke, Marie A Bogoyevitch, Dominic CH Ng

Journal article  |  2010  |  Biochemical Journal

RIP-in CD95-induced cell death The control of alternative death receptors pathways by cIAPs

Peter Geserick, Mike Hupe, Maryline Moulin, Martin Leverkus

Journal article  |  2010  |  Cell Cycle

Asymmetric Recruitment of cIAPs by TRAF2

Peter D Mace, Callum Smits, David L Vaux, John Silke, Catherine L Day

Journal article  |  2010  |  J. Mol. Biol.

Tumor Necrosis Factor (TNF) Signaling, but Not TWEAK (TNF-like Weak Inducer of Apoptosis)-triggered cIAP1 (Cellular Inhibitor of Apoptosis Protein 1) Degradation, Requires cIAP1 RING Dimerization and E2 Binding

Rebecca Feltham, Maryline Moulin, James E Vince, Peter D Mace, Wendy Wei-Lynn Wong, Holly Anderton, Catherine L Day, David L Vaux, John Silke

Journal article  |  2010  |  Journal of Biological Chemistry

RIPK1 is not essential for TNFR1-induced activation of NF-kappa B

WW-L Wong, IE Gentle, U Nachbur, H Anderton, DL Vaux, J Silke

Journal article  |  2010  |  Cell Death Differ.

Cellular inhibitor of apoptosis proteins (cIAPs), but not XIAP inhibit a crypticCD95-induced cell death by limiting RIP1 kinase recruitment to the death receptor complex (DISC)

P Geserick, M Hupe, M Moulin, W Wong, M Feoktistova, B Kellert, H Gollnick, J Silke, M Leverkus

Conference Proceedings  |  2010  |  EXPERIMENTAL DERMATOLOGY

TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-kappa B Dependent Induction of cFLIPL

Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux

Journal article  |  2010  |  PLoS ONE

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

J Silke, R Brink

Journal article  |  2010  |  Cell Death & Differentiation

Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus

Ruth Chin, Ulrich Nachbur, Linda Earnest-Silveira, Aleksandra Bankovacki, Bernd Koeberlein, Hanswalter Zentgraf, C-Thomas Bock, John Silke, Joseph Torresi

Journal article  |  2010  |  Virus Research

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

Peter Geserick, Mike Hupe, Maryline Moulin, W Wei-Lynn Wong, Maria Feoktistova, Beate Kellert, Harald Gollnick, John Silke, Martin Leverkus

Journal article  |  2009  |  The Journal of Cell Biology

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-kappa B and to Prevent TNF-induced Apoptosis

James E Vince, Delara Pantaki, Rebecca Feltham, Peter D Mace, Stephanie M Cordier, Anna C Schmukle, Angelina J Davidson, Bernard A Callus, Wendy Wei-Lynn Wong, Ian E Gentle, Holly Carter, Erinna F Lee, Henning Walczak, Catherine L Day, David L Vaux, John Silke

Journal article  |  2009  |  J. Biol. Chem.

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

Tobias L Haas, Christoph H Emmerich, Bjoern Gerlach, Anna C Schmukle, Stefanie M Cordier, Eva Rieser, Rebecca Feltham, James Vince, Uwe Warnken, Till Wenger, Ronald Koschny, David Komander, John Silke, Henning Walczak

Journal article  |  2009  |  Molecular Cell

Another Facet of Ubiquitylation: Death

W Wei-Lynn Wong, John Silke

Journal article  |  2009  |  Journal of Molecular Cell Biology

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

Jason Howitt, Ulrich Putz, Jenny Lackovic, Anh Doan, Loretta Dorstyn, Hong Cheng, Baoli Yang, Chan-Ling Tailoi, John Silke, Sharad Kumar, Seong-Seng Tan

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J Jost, Stephanie Grabow, Daniel Gray, Mark D McKenzie, Ueli Nachbur, David CS Huang, Philippe Bouillet, Helen E Thomas, Christoph Borner, John Silke, Andreas Strasser, Thomas Kaufmann

Journal article  |  2009  |  Nature

Contribution of specific Inhibitor of Apoptosis Proteins in distinct apoptotic pathways

Christopher Benetatos, Alireza Alavi, Yasuhiro Mitsuuichi, Stephen Condon, John Silke, David Vaux, Mark McKinlay, Srinivas Chunduru

Conference Proceedings  |  2009  |  CANCER RESEARCH

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNF alpha Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

Thomas Kaufmann, Philipp J Jost, Marc Pellegrini, Hamsa Puthalakath, Raffi Gugasyan, Steve Gerondakis, Erika Cretney, Mark J Smyth, John Silke, Razq Hakem, Philippe Bouillet, Tak W Mak, Vishva M Dixit, Andreas Strasser

Journal article  |  2009  |  Immunity

CARP2 deficiency does not alter induction of NF-kappa B by TNF alpha

Afsar U Ahmed, Maryline Moulin, Franck Coumailleau, W Wei-Lynn Wong, Maria Miasari, Holly Carter, John Silke, Michel Cohen-Tannoudji, James E Vince, David L Vaux

Journal article  |  2009  |  Curr. Biol.

MODULATION OF AKT, NFKB ACTIVITY, APOPTOSIS AND CELL CYCLE IN HEPATOCYTES BY THE LAMIVUDINE RESISTANT RTM2041 HBV MUTANT

R Chin, U Nachbur, L Earnest-Silveira, A Bankovacki, H Zentgraf, C-T Bock, J Silke, J Torresi

Conference Proceedings  |  2009  |  Journal of Hepatology

Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins

Bernard A Callus, Donia M Moujallad, John Silke, Robert Gerl, Anissa M Jabbour, Paul G Ekert, David L Vaux

Journal article  |  2008  |  J. Mol. Biol.

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

Ulrich Putz, Jason Howitt, Jenny Lackovic, Natalie Foot, Sharad Kumar, John Silke, Seong-Seng Tan

Journal article  |  2008  |  Journal of Biological Chemistry

Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment

Peter D Mace, Katrin Linke, Rebecca Feltham, Frances-Rose Schumacher, Clyde A Smith, David L Vaux, John Silke, Catherine L Day

Journal article  |  2008  |  J. Biol. Chem.

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappa B as well as cell survival and oncogenesis

Mads Gyrd-Hansen, Maurice Darding, Maria Miasari, Massimo M Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula CA da Fonseca, Marketa Zvelebil, Janusz M Bujnicki, Scott Lowe, John Silke, Pascal Meier

Journal article  |  2008  |  Nature Cell Biology

MODULATION OF ERK, AKT, APOPTOSIS AND CELL CYCLE IN PRIMARY MOUSE HEPATOCYTES AND HUH7 CELLS BY WILD-TYPE AND RTM2041 HBV

Ruth Chin, Ulrich Nachbur, C-Thomas Bock, John Silke, Joseph Torresi

Conference Proceedings  |  2008  |  HEPATOLOGY

Lack of reproducible growth inhibition by Schlafen1 and Schlafen2 in vitro

Liang Zhao, Brent Neumann, Kathleen Murphy, John Silke, Thomas J Gonda

Journal article  |  2008  |  Blood Cells, Molecules, and Diseases

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNF alpha

James E Vince, Diep Chau, Bernard Callus, W Wei-Lynn Wong, Christine J Hawkins, Pascal Schneider, Mark McKinlay, Christopher A Benetatos, Stephen M Condon, Srinivas K Chunduru, George Yeoh, Robert Brink, David L Vaux, John Silke

Journal article  |  2008  |  JOURNAL OF CELL BIOLOGY

NF-kappa B inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2

Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverkus

Journal article  |  2008  |  Journal of Investigative Dermatology

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

K Linke, PD Mace, CA Smith, DL Vaux, J Silke, CL Day

Journal article  |  2008  |  Cell Death Differ.

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity

KA Sedelies, A Ciccone, CJP Clarke, J Oliaro, VR Sutton, FL Scott, J Silke, O Susanto, DR Green, RW Johnstone, PI Bird, JA Trapani, NJ Waterhouse

Journal article  |  2008  |  Cell Death & Differentiation

Ubiquitylation and cancer development

Maria Miasari, Hamsa Puthalakath, John Silke

Journal article  |  2008  |  Current Cancer Drug Targets

Cytoplasmic p53 is not required for PUMA-induced apoptosis

BA Callus, PG Ekert, JE Heraud, AM Jabbour, A Kotevski, JE Vince, J Silke, DL Vaux

Journal article  |  2008  |  Cell Death & Differentiation

Inhibitor of apoptosis proteins and caspases

JY Yu, J Silke, PG Ekert

Book Chapter  |  2007

IAP antagonists kill tumor cells by targeting cIAP1, resulting in NIF-kappa B dependent induction of TNF alpha and TNF receptor mediated apoptosis

Wendy W Wong, James Vince, Nufail Khan, Afsar U Ahmed, Diep Chau, Rebecca Feltham, Christopher Benetatos, Srinivas Chunduru, Stephen Condon, Mark McKinlay, Martin Leverkus, Vinay Tergaonkar, Pascal Schneiders, Bernard A Callus, Frank Koentgen, David L Vaux, John Silke

Conference Proceedings  |  2007  |  MOLECULAR CANCER THERAPEUTICS

IAP antagonists target cIAP1 to induce TNF alpha- dependent apoptosis

James E Vince, W Wei-Lynn Wong, Nufail Khan, Rebecca Feltham, Diep Chau, Afsar U Ahmed, Christopher A Benetatos, Srinivas K Chunduru, Stephen M Condon, Mark McKinlay, Robert Brink, Martin Leverkus, Vinay Tergaonkar, Pascal Schneider, Bernard A Callus, Frank Koentgen, David L Vaux, John Silke

Journal article  |  2007  |  Cell

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

CJR Dunning, M McKenzie, C Sugiana, M Lazarou, J Silke, A Connelly, JM Fletcher, DM Kirby, DR Thorburn, MT Ryan

Journal article  |  2007  |  EMBO Journal

Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation

Marlyse A Debrincat, Jian-Guo Zhang, Tracy A Willson, John Silke, Lisa M Connolly, Richard J Simpson, Warren S Alexander, Nicos A Nicola, Benjamin T Kile, Douglas J Hilton

Journal article  |  2007  |  Journal of Biological Chemistry

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

AM Verhagen, TK Kratina, CJ Hawkins, J Silke, PG Ekert, DL Vaux

Journal article  |  2007  |  Cell Death & Differentiation

TWEAK shall inherit the earth

JE Vince, J Silke

Journal article  |  2006  |  Cell Death & Differentiation

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

Paul G Ekert, Anissa M Jabbour, Anand Manoharan, Jacki E Heraud, Jai Yu, Miha Pakusch, Ewa M Michalak, Priscilla N Kelly, Bernard Callus, Thomas Kiefer, Anne Verhagen, John Silke, Andreas Strasser, Christoph Borner, David L Vaux

Journal article  |  2006  |  Blood

Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury

Qian Sang, Mary H Kim, Sharad Kumar, Nicole Bye, Maria C Morganti-Kossman, Jenny Gunnersen, Stephanie Fuller, Jason Howitt, Lavinia Hyde, Tim Beissbarth, Hamish S Scott, John Silke, Seong-Seng Tan

Journal article  |  2006  |  Journal of Neuroscience

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Lars Zender, Mona S Spector, Wen Xue, Peer Flemming, Carlos Cordon-Cardo, John Silke, Sheung-Tat Fan, John M Luk, Michael Wigler, Gregory J Hannon, David Mu, Robert Lucito, Scott Powers, Scott W Lowe

Journal article  |  2006  |  Cell

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

J Silke, T Kratina, D Chu, PG Ekert, CL Day, M Pakusch, DCS Huang, DL Vaux

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

IAPs - the ubiquitin connection

DL Vaux, J Silke

Journal article  |  2005  |  Cell Death & Differentiation

IAPs, RINGs and ubiquitylation

DL Vaux, J Silke

Journal article  |  2005  |  Nature Reviews Molecular Cell Biology

More than cell death: Caspases and caspase inhibitors on the move

GP Dotto, J Silke

Journal article  |  2004  |  Developmental Cell

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

PG Ekert, SH Read, J Silke, VS Marsden, H Kaufmann, CJ Hawkins, R Gerl, S Kumar, DL Vaux

Journal article  |  2004  |  Journal of Cell Biology

Apaf-1, Caspase-2 and Caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die

PG Ekert, S Read, J Silke, VS Marsden, H Kaufmann, CJ Hawkins, R Gerl, S Kumar, DL Vaux

Conference Proceedings  |  2004  |  PEDIATRIC RESEARCH

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

J Silke, T Kratina, PG Ekert, M Pakusch, DL Vaux

Journal article  |  2004  |  Journal of Biological Chemistry

Programmed cell death: Superman meets Dr Death

Pascal Meier, John Silke

Conference Proceedings  |  2003  |  Nature Cell Biology

This year's Cold Spring Harbor meeting on programmed cell death (September 17-21, 2003), organised by Craig Thompson and Junying Y..

HtrA2/Omi, a sheep in wolf's clothing

DL Vaux, J Silke

Journal article  |  2003  |  Cell

Mammalian mitochondrial IAP binding proteins

DL Vaux, J Silke

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Caspase-9 can be activated in the absence of APAF-1 and bcl-2 provides clonal protection from growth-factor withdrawal induced apoptosis independent of APAF1 and Caspase-9

PG Ekert, S Read, CJ Hawkins, V Marsden, J Silke, S Kumar, DL Vaux

Conference Proceedings  |  2003  |  PEDIATRIC RESEARCH

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

VS Marsden, L O'Connor, LA O'Reilly, J Silke, D Metcalf, PG Ekert, DCS Huang, F Cecconi, K Kuida, KJ Tomaselli, S Roy, DW Nicholson, DL Vaux, P Bouillet, JM Adams, A Strasser

Journal article  |  2002  |  Nature

Jekyll and Hyde; changing places, changing faces

J Silke, AM Verhagen

Journal article  |  2002  |  Cell Death & Differentiation

Jekyll and Hyde; changing places, changing faces

J Silke, AM Verhagen

Journal article  |  2002  |  Cell death and differentiation

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3-and caspase 9-interacting sites

J Silke, CJ Hawkins, PG Ekert, J Chew, CL Day, M Pakusch, AM Verhagen, DL Vaux

Journal article  |  2002  |  Journal of Cell Biology

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

AM Verhagen, J Silke, PG Ekert, M Pakusch, H Kaufmann, LM Connolly, CL Day, A Tikoo, R Burke, C Wrobel, RL Moritz, RJ Simpson, DL Vaux

Journal article  |  2002  |  Journal of Biological Chemistry

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

CJ Hawkins, J Silke, AM Verhagen, R Foster, PG Ekert, DM Ashley

Journal article  |  2001  |  APOPTOSIS

TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells

AM Verhagen, M Pakusch, J Silke, DL Vaux

Journal article  |  2001  |  Cytokine

Till death do us part

PG Ekert, J Silke

Journal article  |  2001  |  Cell Death & Differentiation

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP

J Silke, PG Ekert, CL Day, CJ Hawkins, M Baca, J Chew, M Pakusch, AM Verhagen, DL Vaux

Journal article  |  2001  |  EMBO Journal

Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis

J Silke, DL Vaux

Journal article  |  2001  |  Journal of Cell Science

DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

PG Ekert, J Silke, CJ Hawkins, AM Verhagen, DL Vaux

Journal article  |  2001  |  Journal of Cell Biology

DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

PG Ekert, J Silke, CJ Hawkins, AM Verhagen, DL Vaux

Journal article  |  2001  |  Journal of Cell Biology

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

J Silke, AM Verhagen, PG Ekert, DL Vaux

Journal article  |  2000  |  Cell Death & Differentiation

Characterization of the ectromelia virus serpin, SPI-2

SJ Turner, J Silke, B Kenshole, J Ruby

Journal article  |  2000  |  Journal of General Virology

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

AM Verhagen, PG Ekert, M Pakusch, J Silke, LM Connolly, GE Reid, RL Moritz, RJ Simpson, DL Vaux

Journal article  |  2000  |  Cell

MIHA/XIAP blocks apoptosis induced by an auto-activating caspase 3 and UV irradiation and can bind to endogenous, activated caspase 3

PG Ekert, J Silke, DL Vaux

Conference Proceedings  |  2000  |  PEDIATRIC RESEARCH

The Drosophila caspase DRONC is regulated by DIAP1

P Meier, J Silke, SJ Leevers, GI Evan

Journal article  |  2000  |  The EMBO Journal

Caspase inhibitors

PG Ekert, J Silke, DL Vaux

Journal article  |  1999  |  Cell Death & Differentiation

Genes inhibiting caspases rescue neuronal cells from apoptosis and allow functional survival of cells exposed to a death stimulus

PG Ekert, J Silke, DL Vaux

Conference Proceedings  |  1999  |  Pediatric Research

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

PG Ekert, J Silke, DL Vaux

Journal article  |  1999  |  The EMBO Journal

Cell death: Shadow Baxing

J Silke, DL Vaux

Journal article  |  1998  |  Current Biology

An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA

K Matsuo, J Silke, O Georgiev, P Marti, N Giovannini, D Rungger

Journal article  |  1998  |  The EMBO Journal

Long non-stop reading frames on the antisense strand of heat shock protein 70 genes and prion protein (PrP) genes are conserved between species

KI Rother, OK Clay, JP Bourquin, J Silke, W Schaffner

Journal article  |  1997  |  Biological Chemistry

The majority of long non-stop reading frames on the antisense strand can be explained by biased codon usage

J Silke

Journal article  |  1997  |  Gene

A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II

JP Bourquin, I Stagljar, P Meier, P Moosman, J Silke, T Baechi, O Georgiev, W Schaffner

Journal article  |  1997  |  Nucleic Acids Research

Transcriptional repression by methylation: Cooperativity between a CpG cluster in the promoter and remote CpG-rich regions

M Hug, J Silke, O Georgiev, S Rusconi, W Schaffner, K Matsuo

Journal article  |  1996  |  FEBS Letters

INFLUENCE OF DNA-SEQUENCE AND METHYLATION STATUS ON BISULFITE CONVERSION OF CYTOSINE RESIDUES

KI ROTHER, J SILKE, O GEORGIEV, W SCHAFFNER, K MATSUO

Journal article  |  1995  |  Analytical Biochemistry

COMPLEX DEMETHYLATION PATTERNS AT SP1 BINDING-SITES IN F9 EMBRYONAL CARCINOMA-CELLS

J SILKE, KI ROTHER, O GEORGIEV, W SCHAFFNER, K MATSUO

Journal article  |  1995  |  FEBS Letters

The Afterlife: A Historical Enquiry

JJ Silke

Journal article  |  1995  |  Irish Theological Quarterly

THE CPG-SPECIFIC METHYLASE SSSI HAS TOPOISOMERASE ACTIVITY IN THE PRESENCE OF MG2

K MATSUO, J SILKE, K GRAMATIKOFF, W SCHAFFNER

Journal article  |  1994  |  Nucleic Acids Research

EVIDENCE FOR EROSION OF MOUSE CPG ISLANDS DURING MAMMALIAN EVOLUTION

K MATSUO, O CLAY, T TAKAHASHI, J SILKE, W SCHAFFNER

Journal article  |  1993  |  Somatic Cell and Molecular Genetics

Cornelius Denvir and the 'Spirit of Fear'

JJ Silke

Journal article  |  1987  |  Irish Theological Quarterly

Re: Correspondence

JJ Silke

Journal article  |  1972  |  The Mariner's Mirror

Later Relations between Primate Peter Lombard and Hugh O'neill

JJ Silke

Journal article  |  1955  |  Irish Theological Quarterly

Primate Lombard and James I

JJ Silke

Journal article  |  1955  |  Irish Theological Quarterly