John Silke

HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis

Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliaro

Journal article  |  2021  |  EMBO REPORTS

The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which t..

NF-κB and pancreatic cancer; chapter and verse

J Silke, LA O’Reilly

Journal article  |  2021  |  Cancers

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the world’s most lethal cancers. An increase in occurrence, coupled with, presen..

Dual roles for LUBAC signaling in thymic epithelial cell development and survival

Reema Jain, Kelin Zhao, Julie M Sheridan, Melanie Heinlein, Fiona Kupresanin, Waruni Abeysekera, Cathrine Hall, James Rickard, Philippe Bouillet, Henning Walczak, Andreas Strasser, John Silke, Daniel HD Gray

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Thymic epithelial cells (TECs) form a unique microenvironment that orchestrates T cell differentiation and immunological tolerance..

Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice

Yanhong Ni, Tami Yap, Natasha Silke, John Silke, Michael McCullough, Antonio Celentano, Lorraine A O'Reilly

Journal article  |  2021  |  ORAL DISEASES

This article is protected by copyright. All rights reserved. Oral squamous cell carcinoma (OSCC) is a major subcategory of head an..

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson

Journal article  |  2021  |  CELL DEATH & DISEASE

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). P..

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity

Valentin J Heim, Laura F Dagley, Che A Stafford, Fynn M Hansen, Elise Clayer, Aleksandra Bankovacki, Andrew Webb, Isabelle S Lucet, John Silke, Ueli Nachbur

Journal article  |  2020  |  EMBO REPORTS

Signaling via the intracellular pathogen receptors nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2 req..

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models

Emma Morrish, Anthony Copeland, Donia M Moujalled, Jason A Powell, Natasha Silke, Ann Lin, Kate E Jarman, Jarrod J Sandow, Gregor Ebert, Liana Mackiewicz, Jessica A Beach, Elizabeth L Christie, Alexander C Lewis, Giovanna Pomilio, Karla C Fischer, Laura MacPherson, David DL Bowtell, Andrew Webb, Marc Pellegrini, Mark A Dawson, et al.

Journal article  |  2020  |  BLOOD ADVANCES

The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in..

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Catia L Pierotti, Maria C Tanzer, Annette Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus JA Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David CS Huang, Peter E Czabotar, John Silke, Mark F van Delft, James M Murphy, et al.

Journal article  |  2020  |  ACS CHEMICAL BIOLOGY

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a m..

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert

Journal article  |  2020  |  VIRUSES-BASEL

Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecul..

Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

Holly Anderton, Ian P Wicks, John Silke

Journal article  |  2020  |  NATURE REVIEWS RHEUMATOLOGY

Cell death is a vital process that occurs in billions of cells in the human body every day. This process helps maintain tissue hom..