Chris Bye

alpha-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor and RNA processing gene dysregulation are early determinants of selective motor neuron vulnerability in a mouse model of amyotrophic lateral sclerosis

Pardis F Zanganeh, Samantha K Barton, Katherine Lim, Elizabeth L Qian, Duncan E Crombie, Christopher R Bye, Bradley J Turner

Journal article  |  2022  |  BRAIN COMMUNICATIONS

Amyotrophic lateral sclerosis is a late-onset adult neurodegenerative disease, although there is mounting electrophysiological and..

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1

Restuadi Restuadi, Frederik J Steyn, Edor Kabashi, Shyuan T Ngo, Fei-Fei Cheng, Marta F Nabais, Mike J Thompson, Ting Qi, Yang Wu, Anjali K Henders, Leanne Wallace, Chris R Bye, Bradley J Turner, Laura Ziser, Susan Mathers, Pamela A McCombe, Merrilee Needham, David Schultz, Matthew C Kiernan, Wouter van Rheenen, et al.

Journal article  |  2022  |  GENOME MEDICINE

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to..

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, et al.

Journal article  |  2020  |  CELL

Cytoplasmic accumulation of TDP-43 is a disease hallmark for many cases of amyotrophic lateral sclerosis (ALS), associated with a ..

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

Carlos W Gantner, Isabelle R de Luzy, Jessica A Kauhausen, Niamh Moriarty, Jonathan C Niclis, Christopher R Bye, Vanessa Penna, Cameron PJ Hunt, Charlotte M Ermine, Colin W Pouton, Deniz Kirik, Lachlan H Thompson, Clare L Parish

Journal article  |  2020  |  CELL STEM CELL

Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating followin..

Transcriptional Profiling of Xenogeneic Transplants: Examining Human Pluripotent Stem Cell-Derived Grafts in the Rodent Brain

Christopher R Bye, Vanessa Penna, Isabelle R de Luzy, Carlos W Gantner, Cameron PJ Hunt, Lachlan H Thompson, Clare L Parish

Journal article  |  2019  |  STEM CELL REPORTS

Human pluripotent stem cells are a valuable resource for transplantation, yet our ability to profile xenografts is largely limited..

Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins

Christopher R Bye, Valeria Rytova, Walaa F Alsanie, Clare L Parish, Lachlan H Thompson

Journal article  |  2019  |  JOURNAL OF NEUROSCIENCE

The growth of axons corresponding to different neuronal subtypes is governed by unique expression profiles of molecules on the gro..

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis A Study of Humans and a Transgenic Mouse Model

Rebecca K Sheean, Fiona C McKay, Erika Cretney, Christopher R Bye, Nirma D Perera, Doris Tomas, Richard A Weston, Karlene J Scheller, Elvan Djouma, Parvathi Menon, Stephen D Schibeci, Najwa Marmash, Justin J Yerbury, Stephen L Nutt, David R Booth, Graeme J Stewart, Mathew C Kiernan, Steve Vucic, Bradley J Turner

Journal article  |  2018  |  JAMA NEUROLOGY

IMPORTANCE: Neuroinflammation appears to be a key modulator of disease progression in amyotrophic lateral sclerosis (ALS) and ther..

Specification of murine ground state pluripotent stem cells to regional neuronal populations

Walaa F Alsanie, Jonathan C Niclis, Cameron P Hunt, Isabelle R De Luzy, Vanessa Penna, Christopher R Bye, Colin W Pouton, John Haynes, Jaber Firas, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  SCIENTIFIC REPORTS

Pluripotent stem cells (PSCs) are a valuable tool for interrogating development, disease modelling, drug discovery and transplanta..

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents

Jonathan C Niclis, Carlos W Gantner, Walaa F Alsanie, Stuart J McDougall, Chris R Bye, Andrew G Elefanty, Edouard G Stanley, John M Haynes, Colin W Pouton, Lachlan H Thompson, Clare L Parish

Journal article  |  2017  |  STEM CELLS TRANSLATIONAL MEDICINE

: Recent studies have shown evidence for the functional integration of human pluripotent stem cell (hPSC)-derived ventral midbrain..

Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats

Isabel C Zbukvic, Despina E Ganella, Christina J Perry, Heather B Madsen, Christopher R Bye, Andrew J Lawrence, Jee Hyun Kim

Journal article  |  2016  |  CEREBRAL CORTEX

Adolescent drug users display resistance to treatment such as cue exposure therapy (CET), as well as increased liability to relaps..