Bruce Wong

Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals

Adam P Gunn, Bruce X Wong, Catriona McLean, Chris Fowler, Peter J Barnard, James A Duce, Blaine R Roberts

Journal article  |  2020  |  Journal of Neurochemistry

Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention

Andrew Tsatsanis, Bruce X Wong, Adam P Gunn, Scott Ayton, Ashley I Bush, David Devos, James A Duce

Journal article  |  2020  |  Molecular Psychiatry

The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..

Post Translational Modulation of -Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

Andrew Tsatsanis, Stuart Dickens, Jessica CF Kwok, Bruce X Wong, James A Duce

Journal article  |  2019  |  Neurochemical Research

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  Neurotherapeutics

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

M Isabel G Lopez Sanchez, Hayley S Waugh, Andrew Tsatsanis, Bruce X Wong, Jonathan G Crowston, James A Duce, Ian A Trounce

Journal article  |  2017  |  SCIENTIFIC REPORTS

Post translational changes to alpha-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease

James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devos

Journal article  |  2017  |  Molecular Neurodegeneration

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce

Journal article  |  2017  |  ACS Chemical Neuroscience

Evaluating Iron Flux in the Brain

Bruce X Wong, Linh Q Lam, Andrew Tsatsanis, James A Duce

Journal article  |  2017  |  Neuromethods

Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons

A BUSH, AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, KJ Barnham, JA Duce, RA Cherny

Journal article  |  2016  |  Journal of Biological Chemistry

beta-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

Bruce X Wong, Andrew Tsatsanis, Linh Q Lim, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  PLOS ONE

Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology

Bruce X Wong, Ya Hui Hung, Ashley I Bush, James A Duce

Journal article  |  2014  |  FRONTIERS IN AGING NEUROSCIENCE

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders

Bruce X Wong, James A Duce

Journal article  |  2014  |  Frontiers in Pharmacology

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

Scott Ayton, Peng Lei, James A Duce, Bruce XW Wong, Amelia Sedjahtera, Paul A Adlard, Ashley I Bush, David I Finkelstein

Journal article  |  2013  |  ANNALS OF NEUROLOGY

P2X7 Receptor-mediated Scavenger Activity of Mononuclear Phagocytes toward Non-opsonized Particles and Apoptotic Cells Is Inhibited by Serum Glycoproteins but Remains Active in Cerebrospinal Fluid

Ben J Gu, James A Duce, Valentina A Valova, Bruce Wong, Ashley I Bush, Steven Petrou, James S Wiley

Journal article  |  2012  |  Journal of Biological Chemistry

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce XW Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce, Ashley I Bush

Journal article  |  2012  |  Nature Medicine

Dyslipidemic Diabetic Serum Increases Lipid Accumulation and Expression of Stearoyl-CoA Desaturase in Human Macrophages

Bruce XW Wong, Reece A Kyle, Paul C Myhill, Kevin D Croft, Carmel M Quinn, Wendy Jessup, Bu B Yeap

Journal article  |  2011  |  Lipids

Type 2 diabetes and dyslipidemia are risk factors for cardiovascular disease. However, mechanisms by which hypertriglyceridemia in..

Modulation of Macrophage Fatty Acid Content and Composition by Exposure to Dyslipidemic Serum in Vitro

Bruce XW Wong, Reece A Kyle, Kevin D Croft, Carmel M Quinn, Wendy Jessup, Bu B Yeap

Journal article  |  2011  |  Lipids

Macrophages in arterial walls accumulate lipids leading to the development of atherosclerotic plaques. However, mechanisms underly..