Bruce Wong

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of A beta burden through induction of APP amyloidogenic processing

Andrew Tsatsanis, Andrew N McCorkindale, Bruce X Wong, Ellis Patrick, Tim M Ryan, Robert W Evans, Ashley I Bush, Greg T Sutherland, Asipu Sivaprasadarao, Boris Guennewig, James A Duce

Journal article  |  2021  |  MOLECULAR PSYCHIATRY

Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extrac..

Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals

Adam P Gunn, Bruce X Wong, Catriona McLean, Chris Fowler, Peter J Barnard, James A Duce, Blaine R Roberts

Journal article  |  2020  |  JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu-modified amyloid-β peptides found in the brains of people with ..

Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention

Andrew Tsatsanis, Bruce X Wong, Adam P Gunn, Scott Ayton, Ashley I Bush, David Devos, James A Duce

Journal article  |  2020  |  MOLECULAR PSYCHIATRY

The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..

Post Translational Modulation of -Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

Andrew Tsatsanis, Stuart Dickens, Jessica CF Kwok, Bruce X Wong, James A Duce

Journal article  |  2019  |  NEUROCHEMICAL RESEARCH

Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron..

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  NEUROTHERAPEUTICS

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for A..

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

M Isabel G Lopez Sanchez, Hayley S Waugh, Andrew Tsatsanis, Bruce X Wong, Jonathan G Crowston, James A Duce, Ian A Trounce

Journal article  |  2017  |  SCIENTIFIC REPORTS

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprot..

[P1–169]: LACTOFERRIN IS AN IRON TRANSPORTER AND KEY INNATE IMMUNE RESPONSE PROTEIN THAT DIRECTLY BINDS AMYLOID‐β PRECURSOR PROTEIN TO PROMOTE AMYLOIDOGENIC PROCESSING

Andrew Tsatsanis, Tim M Ryan, Bruce X Wong, Robert W Evans, Ashley I Bush, James A Duce

Journal article  |  2017  |  Alzheimer's & Dementia

[P3–153]: THE INFLUENCE OF AMYLOID‐B PRECURSOR PROTEIN PROTEOLYTIC PROCESSING ON NEURONAL IRON HOMEOSTASIS

Bruce X Wong, Andrew Tsatsanis, Linh Q Lam, Scott Ayton, Adam P Gunn, David Devos, Ashley I Bush, James A Duce

Journal article  |  2017  |  Alzheimer's & Dementia

Post translational changes to alpha-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease

James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devos

Journal article  |  2017  |  MOLECULAR NEURODEGENERATION

Parkinson's disease is a multifactorial neurodegenerative disorder, the aetiology of which remains elusive. The primary clinical f..

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce

Journal article  |  2017  |  ACS CHEMICAL NEUROSCIENCE

Ferroxidase activity has been reported to be altered in various biological fluids in neurodegenerative disease, but the sources co..