Bruce Wong

Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals

Adam P Gunn, Bruce X Wong, Catriona McLean, Chris Fowler, Peter J Barnard, James A Duce, Blaine R Roberts

Journal article  |  2020  |  Journal of Neurochemistry

Amyloidogenic processing of Alzheimer's disease beta-amyloid precursor protein induces cellular iron retention

Andrew Tsatsanis, Bruce X Wong, Adam P Gunn, Scott Ayton, Ashley I Bush, David Devos, James A Duce

Journal article  |  2020  |  Molecular Psychiatry

The proteolytic cleavage of β-amyloid precursor protein (APP) to form the amyloid beta (Aβ) peptide is related to the pathogenesis..

Post Translational Modulation of -Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis

Andrew Tsatsanis, Stuart Dickens, Jessica CF Kwok, Bruce X Wong, James A Duce

Journal article  |  2019  |  Neurochemical Research

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Abdel A Belaidi, Adam P Gunn, Bruce X Wong, Scott Ayton, Ambili T Appukuttan, Blaine R Roberts, James A Duce, Ashley I Bush

Journal article  |  2018  |  Neurotherapeutics

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

M Isabel G Lopez Sanchez, Hayley S Waugh, Andrew Tsatsanis, Bruce X Wong, Jonathan G Crowston, James A Duce, Ian A Trounce

Journal article  |  2017  |  SCIENTIFIC REPORTS

Post translational changes to alpha-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease

James A Duce, Bruce X Wong, Hannah Durham, Jean-Christophe Devedjian, David P Smith, David Devos

Journal article  |  2017  |  Molecular Neurodegeneration

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects

Linh Q Lam, Bruce X Wong, Tony Frugier, Qao-Xin Li, Steven J Collins, Ashley I Bush, Peter J Crack, James A Duce

Journal article  |  2017  |  ACS Chemical Neuroscience

Evaluating Iron Flux in the Brain

Bruce X Wong, Linh Q Lam, Andrew Tsatsanis, James A Duce

Journal article  |  2017  |  Neuromethods

Amyloid-Beta Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization and Calcium-Influx in Neurons

A BUSH, AP Gunn, BX Wong, T Johanssen, JC Griffith, CL Masters, KJ Barnham, JA Duce, RA Cherny

Journal article  |  2016  |  Journal of Biological Chemistry

beta-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

Bruce X Wong, Andrew Tsatsanis, Linh Q Lim, Paul A Adlard, Ashley I Bush, James A Duce

Journal article  |  2014  |  PLOS ONE